Assignee: Janssen Pharmaceutica N.V.

Location: BE
No. of patents: 160

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Number	Title	Issue Date
8158792	Spiropiperidines for use as tryptase inhibitors The present invention is directed to a compound of Formula (I): or a form thereof, wherein X1, X2, X3, X4, R1, R2 and R3 are as defined herein, us...	04/17/2012
8158643	Substituted diaza-spiro-pyridinone derivatives for use in MCH-1 mediated diseases The present invention concerns aryl and heteroaryl substituted diaza-spiro-pyridinone derivatives having antagonistic melanin-concentrating hormone (MCH) activity, in particular MCH-1 activity according to the general Formula (I)	04/17/2012
8148385	Substituted [1,2,3] triazolo[4,5-d]pyrimidine derivatives as ADP P2Yreceptor antagonists The present invention is directed to novel bicyclic triazolopyrimidine compounds of Formula (I) or a form thereof: wherein X1, X2, R1, R2, R3 and R4 are as d...	04/03/2012
8143432	Process for regioselective mono-tosylation of diols The present invention concerns the use of dibutyl tin oxide for regioselective catalytic diol mono-tosylation at a concentration lower than 2 mol %. The present invention also concerns the use of a generic acetal compound of Formula (Ic) in a catalytic process for r...	03/27/2012
8138334	Substituted oxa-diaza-spiro-[5.5]-undecanone derivatives and their use as neurokinin antagonists This invention concerns substituted oxa-diaza-spiro-[5.5]-undecanone derivatives having neurokinin antagonistic activity, in particular an NK1 antagonistic activity, an NK3 antagonistic activity, a combined NK1/NK2 antagon...	03/20/2012
8110683	Piperidinyl compounds that selectively bind integrins The invention is directed to piperidinyl compounds that selectively bind integrin receptors and methods for treating an integrin mediated disorder. ...	02/07/2012
8084490	Sulfamate and sulfamide derivatives useful for the treatment of epilepsy and related disorders The present invention is directed to novel sulfamide and sulfamate derivatives, pharmaceutical compositions containing them and their use in the treatment of epilepsy and related disorders. ...	12/27/2011
8080551	HIV inhibiting pyrimidines derivatives HIV replication inhibitors having formula (I) defined herein are disclosed. Pharmaceutical compositions containing the HIV replication inhibitors; the use of the HIV replication inhibitors in the treatment of HIV; and processes for preparing the HIV replication inhi...	12/20/2011
8030305	Triazolopyridazines as kinase modulators The invention is directed to triazolopyridazine compounds of Formula I: where R1, R5, R6, R7, R8, and A are as defined herein, the use of such compounds as protein tyro...	10/04/2011
8012963	3,4-dihydro-2H-benzo[1,4]oxazine and thiazine derivatives as CETP inhibitors The invention is directed to compounds of Formula (I) described herein useful as CETP inhibitors, compositions containing them, and methods of using them. ...	09/06/2011
8008513	4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs The invention features 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs, compositions containing them, and methods of using them as PPAR delta modulators to treat or inhibit the progression of, for example, dyslipidemia. ...	08/30/2011
8008230	Synergistic antifungal DDAC compositions The present invention relates to synergistic antifungal compositions comprising didecyl ammonium chloride (DDAC) and a post-harvest antifungal agent selected from the group consisting of imazalil, boscalid, fenhexamid, pyrimethanil, thiophanate-methyl, triflumizole,...	08/30/2011
7981927	Steroids derivatives as selective progesterone receptor modulators The present invention is directed to novel steroid derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by at least one progesterone or glucocorticoid receptor. ...	07/19/2011
7968601	Adamantyl acetamides as 11-β hydroxysteroid dehydrogenase inhibitors the N-oxide forms, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein n represents an integer being 1 or 2; R1 and R2 each independently represents hydr...	06/28/2011
7947713	Tripeptidyl peptidase inhibitors The present invention is concerned with novel compounds of formula (I) which are inhibitors of a membrane tripeptidyl peptidase responsible for the inactivation of endogenous neuropeptides such as cholecystokinis (CCKs). The invention further relates to methods for ...	05/24/2011
7943653	Substituted 5-vinylphenyl-1-phenyl-pyrazole cannabinoid modulators This invention is directed to a cannabinoid modulator compound of formula (I): or a form thereof, and methods for use in treating, ameliorating or preventing a cannabinoid receptor mediated syndrome, disorder or disease.	05/17/2011
7803795	Phthalazine derivatives as parp inhibitors The present invention provides compounds of formula (I), their use as PARP inhibitors as well as pharmaceutical compositions comprising said compounds of formula (I) wherein R1, R2 L1, L2, X, Y, Q and Z have defined meanin...	09/28/2010
7795294	Tetrahydro-2H-indazole pyrazole cannabinoid modulators This invention is directed to a tetrahydro-2H-indazole pyrazole cannabinoid modulator compound of formula (I): or a form thereof, wherein p, R1, R2 and Ar are as herein described and * represents a chi...	09/14/2010
7723518	Preparation of 9-hydroxy-3-(2-hydroxyethyl)-2-methyl-4-pyrido[1,2-A]pyrimidin-4-one The present invention concerns a process for preparing crystalline 3-(2-chloro-ethyl)-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one substantially free of 2-acetylbutyrolactone. ...	05/25/2010
7709498	Quinoline derivatives as antibacterial agents The present invention relates to a method for the treatment of a bacterial infection comprising administering a therapeutically effective amount of a compound of formula or a pharmaceutically acceptable acid or base additio...	05/04/2010
7705148	Processes for the preparation of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile Processes for the preparation of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]-amino]-2-pyrimidinyl]amino]benzonitrile of formula (I), a N-oxide, a pharmaceutically acceptable acid addition salt, a quaternary amine or a stereochemically isomeric form thereof are pr...	04/27/2010
7704998	Sulfonyl-derivatives as novel inhibitors or histone deacetylase This invention comprises the novel compounds of formula (I) wherein n, m, t, R1, R2, R3, R4, L, Q, X, Y, Z and have defined meanings, h...	04/27/2010
7678781	11-phosphorous steroid derivatives useful as progesterone receptor modulators The present invention is directed to novel 11-phosphorous steroid derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by a progesterone or glucocorticoid receptor. ...	03/16/2010
7662837	Inhibitors of c-fms kinase The invention is directed to compounds of Formula I: wherein A, X, R2 and W are set forth in the specification, as well as solvates, hydrates, tautomers and pharmaceutically acceptable salts thereof, that inhibit...	02/16/2010
7652005	Tricyclic δ-opioid modulators The invention is directed to delta opioid receptor modulators. More specifically, the invention relates to tricyclic δ-opioid modulators. Pharmaceutical and veterinary compositions and methods of treating mild to severe pain and various diseases using compounds of ...	01/26/2010
7629319	Heteroaryl peptidomimetics as thrombin receptor antagonists The invention is directed to novel heteroaryl peptidomimetic compounds which are useful as thrombin receptor antagonists for the treatment of diseases associated with thrombosis, restenosis, hypertension, heart failure, arrhythmia, inflammation, angina, stroke, athe...	12/08/2009
7579352	Retinoic acid mimetic anilides The present invention is concerned with compounds of formula the N-oxides, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein X represents O, S or NR3; R1...	08/25/2009
7544788	Isolated nucleic acid molecule encoding a neurotrophic growth factor There is disclosed an isolated nucleic acid molecule encoding a human neurotrophic growth factor designated enovin and having the amino acid sequence illustrated in FIG. 1, 21, 23 or 24 or encoding a functional equivalent, derivative or bioprecursor of...	06/09/2009
7541359	N-heteroarylpiperazinyl ureas as modulators of fatty acid amide hydrolase Certain N-heteroarylpiperazinyl urea compounds of Formula (I), as defined in the specification, are described, which are useful as FAAH inhibitors. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, ...	06/02/2009
7488826	Substituted pyrroline kinase inhibitors The present invention is directed to novel substituted pyrroline compounds useful as kinase or dual-kinase inhibitors and methods for treating or ameliorating a kinase or dual-kinase mediated disorder. ...	02/10/2009
7470711	Piperidinyl substituted cyclohexane-1,4-diamines The present invention relates to piperidine substituted cyclohexane-1,4-diamine compounds of Formula (I) and pharmaceutically acceptable forms thereof, as α1a/α1d adrenoreceptor modulators for the tr...	12/30/2008
7459444	Inhibitors of chymase The present invention is directed to a compound of formula (I), methods for preparing these compounds, compositions, intermediates and derivatives thereof, and methods for treating inflammatory and serine protease mediated ...	12/02/2008
7452914	Spiro-benzo[c]chromene derivatives useful as modulators of the estrogen receptors The present invention is directed to novel spiro-benzo[C]chromene derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders mediated by one or more estrogen receptors. The compounds of the invention are useful in the treatm...	11/18/2008
7432378	Benzoimidazole compounds Benzoimidazole compounds, compositions, and methods of using them in leukocyte recruitment inhibition, in modulating H4 receptor, and in treating conditions such as inflammation, H4 receptor-mediated conditions, and related conditions. ...	10/07/2008
7429659	Furan compounds as histamine H modulators Certain furan compounds are histamine H3 modulators useful in the treatment of histamine H3 receptor mediated diseases. ...	09/30/2008
7427682	Indole derivatives as selective androgen receptor modulators (SARMS) The present invention is directed to novel insole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by the androgen receptor. ...	09/23/2008
7427625	Substituted thiatriazaacenaphthylene-6-carbonitrile kinase inhibitors The present invention is directed to substituted thiatriazaacenaphthylene-6-carbonitrile compounds of formula (I): and forms thereof, their synthesis and use for treating, preventing or ameliorating a chronic or acute prote...	09/23/2008
7425649	4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs The invention features 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs, compositions containing them, and methods of using them as PPAR modulators to treat or inhibit the progression of, for example, dyslipidemia. ...	09/16/2008
7416736	Antimicrobial compositions This invention concerns antimicrobial compositions that are useful for industrial applications. More specifically, it concerns antimicrobial compositions that, by combining 3-benzo[b]thiene-2-yl-5,6-dihydro-1,4,2-oxathiazine-4-oxide and one or more of 1-[[(3-iodo-2-...	08/26/2008
7414047	Piperazinyl and diazapanyl benzamides and benzthioamides Substituted piperazinyl and diazepanyl benzamides and benzthioamides of formula (I), compositions containing them, and methods of making and using them to treat histamine-mediated conditions. ...	08/19/2008

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Assignee: Janssen Pharmaceutica N.V.