Assignee: Isotechnika, Inc.

Location: Edmonton, CA
No. of patents: 21

Number	Title	Issue Date
7358229	Deuterated cyclosporin analogs and their use as immunomodulating agents Cyclosporine derivatives are disclosed which possess enhanced efficacy and reduced toxicity over naturally occurring and other presently known cyclosporins and cyclosporine derivatives. The cyclosporine derivatives of the present invention are produced by chemical a...	04/15/2008
7332472	Cyclosporine analogue mixtures and their use as immunomodulating agents The invention is directed to isomeric mixtures of cyclosporine analogues that are structurally similar to cyclosporine A. The mixtures possess enhanced efficacy and reduced toxicity over the individual isomers and over naturally occurring and other presently known c...	02/19/2008
7160867	Rapamycin carbohydrate derivatives This invention provides modified rapamycins that have specific monosaccharide(s), oligosaccharide(s), pseudosugar(s) or derivatives thereof attached through a linker to create rapamycin carbohydrate derivatives having enhanced pharmacokinetic and/or pharmacodynamic ...	01/09/2007
7141648	Synthesis of cyclosporin analogs The invention is directed to isomeric mixtures of cyclosporine analogues that are structurally similar to cyclosporine A. The mixtures possess enhanced efficacy and reduced toxicity over the individual isomers and over naturally occurring and other presently known c...	11/28/2006
7060672	Cyclosporin analog formulations The present invention relates to formulations containing cyclosporin analogs that are structurally similar to cyclosporin A, in particular isomeric mixtures of cyclosporin analogs that are structurally similar to cyclosporin A. The formulations form stable microemul...	06/13/2006
6998385	Cyclosporine analogue mixtures and their use as immunomodulating agents The invention is directed to isomeric mixtures of cyclosporine analogues that are structurally similar to cyclosporine A. The mixtures possess enhanced efficacy and reduced toxicity over the individual isomers and over naturally occurring and other presently known c...	02/14/2006
6818200	Method of using deuterated calcium channel blockers A method of enhancing the efficiency and increasing the duration of action of drugs (e.g. dihydropyridines and anti-bacterials) and particularly of nifedipine and penicillins wherein one or more hydrogen atoms are deuterated and wherein the deuterated drug has unexp...	11/16/2004
6780995	Activated iododerivatives for the treatment of cancer and aids A series of activated iodo-benzamide derivatives are described as antineoplastic and antiviral drug compounds. The compounds generally possess a chelating group, a thiol trapping group and an activating group. The presumptive mechanism of action in preventing cancer...	08/24/2004
6686454	Antibodies to specific regions of cyclosporine related compounds This invention relates to the production of polyclonal and monoclonal antibodies to specific regions of cyclosporine (CSA) and/or CSA metabolites/derivatives. The reactivity of these polyclonal and monoclonal antibodies make them particularly useful for i...	02/03/2004
6613739	Deuterated cyclosporine analogs and their use as immunomodulating agents Cyclosporine derivatives are disclosed which possess enhanced efficacy and reduced toxicity over naturally occurring and other presently known cyclosporins and cyclosporine derivatives. The cyclosporine derivatives of the present invention are produced by...	09/02/2003
6605593	Deuterated cyclosporine analogs and their use as immunomodulating agents Cyclosporine derivatives are disclosed which possess enhanced efficacy and reduced toxicity over naturally occurring and other presently known cyclosporins and cyclosporine derivatives. The cyclosporine derivatives of the present invention are produced by...	08/12/2003
6602715	13C glucose breath test for the diagnosis of diabetic indications and monitoring glycemic control A breath test and kit for performing the breath test are described for the diagnosis of diabetic indications and monitoring of glycemic control. The breath test utilizes the measurement of expired 13 C-labeled CO2 following the inges...	08/05/2003
6599750	13C glucose breath test for the diagnosis of diabetic indications and monitoring glycemic control Use of 13 C glucose in an analytical assay to monitor glucose metabolism by measurement of labeled exhaled CO2 is provided. A breath test and kit for performing the breath test are described for the diagnosis of diabetic indications ...	07/29/2003
6511988	Activated iododerivatives for the treatment of cancer and aids A series of activated iodo-benzamide derivatives are described as antineoplastic and antiviral drug compounds. The compounds generally possess a chelating group, a thiol trapping group and an activating group. The presumptive mechanism of action in preven...	01/28/2003
6503921	Deuterated rapamycin compounds, methods and uses thereof The synthesis of deuterated analogues of rapamycin is disclosed together with a method for use for inducing immunosupression and in the treatment of transplantation rejection, graft vs host disease, autoimmune diseases, diseases of inflammation leukemia/l...	01/07/2003
6468802	13C glucose breath test for the diagnosis of diabetic indications and monitoring glycemic control A breath test and kit for performing the breath test are described for the diagnosis of diabetic indications and monitoring of glycemic control. The breath test utilizes the measurement of expired 13 C-labeled CO2 following the inges...	10/22/2002
6461870	13C glucose breath test for the diagnosis of diabetic indications and monitoring glycemic control Use of 13 C glucose in an analytical assay to monitor glucose metabolism by measurement of labeled exhaled CO2 is provided. A breath test and kit for performing the breath test are described for the diagnosis of diabetic indications ...	10/08/2002
6342507	Deuterated rapamycin compounds, method and uses thereof The synthesis of deuterated analogues of rapamycin is disclosed together with a method for use for inducing immunosupression and in the treatment of transplantation rejection, graft vs host disease, autoimmune diseases, diseases of inflammation leukemia/l...	01/29/2002
6334997	Method of using deuterated calcium channel blockers A method of enhancing the efficiency and increasing the duration of action of drugs (e.g. dihydropyridines and anti-bacterials) and particularly of nifedipine and penicillins wherein one or more hydrogen atoms are deuterated and wherein the deuterated dru...	01/01/2002
6221335	Method of using deuterated calcium channel blockers Therapeutic methods and compositions using deuterated enriched 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyri dinedicarboxylic acid 3-ethyl 5-methyl ester and other deuterated dihydropyridine compounds are described. The deutera...	04/24/2001
5846514	Enhancement of the efficacy of nifedipine by deuteration A method of enhancing the efficiency and increasing the duration of action of drugs (e.g. dihydropyridines and anti-bacterials) and particularly of nifedipine and penicillins wherein one or more hydrogen atoms are deuterated and wherein the deuterated dru...	12/08/1998

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Assignee: Isotechnika, Inc.