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| Number | Title | Issue Date |
| 7572631 | Activation and expansion of T cells The present invention relates generally to methods for activating and expanding cells, and more particularly, to a novel method to activate and/or stimulate cells that maximizes the expansion of such cells to achieve dramatically high densities. In the various embod... | 08/11/2009 |
| 7541184 | Activation and expansion of cells The present invention relates generally to methods for activating and expanding cells, and more particularly, to a novel method to activate and/or stimulate cells that maximizes the expansion of such cells to achieve dramatically high densities. In the various embod... | 06/02/2009 |
| 7501542 | Highly-packed polycationic ammonium, sulfonium and phosphonium lipids The present invention discloses highly packed polycationic ammonium, sulfonium and phosphonium lipid compounds useful for making lipid aggregates for delivery of macromolecules and other compounds into cells. They are especially useful for the DNA-dependent transfor... | 03/10/2009 |
| 7501288 | Plasmon resonant particles, methods and apparatus A method and apparatus for interrogating a target having a plurality of plasmon resonant particles (PREs) distributed in the target are disclosed. In the method, a field containing the target is illuminated, and one or more spectral emission characteristics of the l... | 03/10/2009 |
| 7479573 | Transfection reagents Disclosed are compounds capable of facilitating transport of biologically active agents or substances into cells having the general structure: wherein Q is selected from the group consisting of N, O and S; L is any ... | 01/20/2009 |
| 7470817 | Transfection reagents Disclosed are compounds capable of facilitating transport of biologically active agents or substances into cells having the general structure: wherein Q is selected from the group consisting of N, O and S; L is any ... | 12/30/2008 |
| 7455974 | Nucleic acid marker ladder for estimating mass The invention relates to a nucleic acid marker ladder which is a restriction endonuclease digest, wherein a nucleic acid restriction endonuclease digest is a collection of nucleic acid fragments resulting from complete digestion of one or more nucleic acids by one o... | 11/25/2008 |
| 7452453 | System for pH-neutral stable electrophoresis gel A gel and buffer system for gel electrophoresis wherein separation occurs at neutral pH. ... | 11/18/2008 |
| D580285 | Fluorometer | 11/11/2008 |
| 7432372 | Fluorinated resorufin compounds and their application The invention provides novel fluorinated resorufin compounds that are of use in a variety of assay formats. Also provided are methods of using the compounds and kits that include a compound of the invention and instructions detailing the use of the compound in one o... | 10/07/2008 |
| 7408049 | Recombinational cloning using nucleic acids having recombination sites Recombinational cloning is provided by the use of nucleic acids, vectors and methods, in vitro and in vivo, for moving or exchanging segments of DNA molecules using engineered recombination sites and recombination proteins to provide chimeric DNA molecules that have... | 08/05/2008 |
| 7368086 | Functionalized fluorescent nanocrystals, and methods for their preparation and use Functionalized fluorescent nanocrystal compositions and methods for making and using these compositions are disclosed. The compositions are fluorescent nanocrystals coated with at least one material. The coating material has chemical compounds or ligands with functi... | 05/06/2008 |
| 7361472 | Methods for providing extended dynamic range in analyte assays Methods for enhancing the dynamic range for specific detection of one or more analytes in assays using scattered-light detectable particle labels. The methods involve utilizing variations in detection technique and/or signal processing to extend the dynamic range to... | 04/22/2008 |
| 7344863 | Methods for producing polypeptides through enhanced synthesis of encoding nucleic acid molecules The present invention is directed to compositions and methods for enhancing synthesis of nucleic acid molecules, particularly GC-rich nucleic acid molecules. Specifically, the invention provides compositions comprising one or more nitrogen-containing organic compoun... | 03/18/2008 |
| 7344835 | Methods for preventing inhibition of nucleic acid synthesis by pyrophosphate Methods for preventing inhibition of nucleic acid synthesis by pyrophosphate are disclosed. More specifically, the present invention concerns inhibiting or preventing pyrophosphorolysis in sequencing and amplification of nucleic acid molecules. According to the pres... | 03/18/2008 |
| D564100 | Electroporation vessel | 03/11/2008 |
| 7323594 | Transfection reagents Disclosed are compounds capable of facilitating transport of biologically active agents or substances into cells having the general structure: wherein Q is selected from the gro... | 01/29/2008 |
| 7319004 | Materials and methods relating to polyions and substance delivery Materials and method are disclose for delivering a desired substance to a target site, using a layered carrier in which the carrier and the substance together form at least three layers which associate by ionic interaction at the first pH, where at least one layer c... | 01/15/2008 |
| 7304130 | Recombinational cloning using engineered recombination sites Recombinational cloning is provided by the use of nucleic acids, vectors and methods, in vitro and in vivo, for moving or exchanging segments of DNA molecules using engineered recombination sites and recombination proteins to provide chimeric DNA molecules that have... | 12/04/2007 |
| 7282339 | Competitive immunoassay The present invention provides ligand-detection reagents, ligand analogs and methods for determining the presence of a ligand in a sample. The ligand-detection reagent comprises a ligand-binding antibody and a ligand analog to form an antibody-ligand analog complex ... | 10/16/2007 |
| 7282326 | Recombinational cloning using engineered recombination sites Recombinational cloning is provided by the use of nucleic acids, vectors and methods, in vitro and in vivo, for moving or exchanging segments of DNA molecules using engineered recombination sites and recombination proteins to provide chimeric DNA molecules that have... | 10/16/2007 |
| 7273730 | Nested PCR employing degradable primers The invention is directed to one-tube nested nucleic acid amplification methods, as well as compositions for performing these methods, which employ one or more outer primers containing one or more exo-sample nucleotides and inner primers. Nested amplification reacti... | 09/25/2007 |
| 7271265 | Cyanine compounds and their application as quenching compounds The present invention provides methods and non-fluorescent carbocyanine quencher compounds having the general formula: Wherein the A moiety is a substituted pyridinium, unsubstituted pyridinium, substituted quino... | 09/18/2007 |
| 7265206 | Methods of production of proteins The current invention provides methods for producing a polypeptide as inclusion bodies in bacterial host cells. The present methods are carried out by forming a gene construct comprising the genetic sequence encoding a polypeptide operatively linked to that of an in... | 09/04/2007 |
| 7259242 | Methods for production of proteins The current invention provides methods for producing a polypeptide as inclusion bodies in bacterial host cells. The present methods are carried out by forming a gene construct comprising the genetic sequence encoding a polypeptide operatively linked to that of an in... | 08/21/2007 |
| 7255995 | Analyte assay using particulate labels Method for specific detection of one or more analytes in a sample. The method includes specifically associating any one or more analytes in the sample with a scattered-light detectable particle, illuminating any particle associated with the analytes with light under... | 08/14/2007 |
| 7244560 | Methods and compositions for synthesis of nucleic acid molecules using multiple recognition sites The present invention provides compositions and methods for recombinational cloning. The compositions include vectors having multiple recombination sites and/or multiple topoisomerase recognition sites. The methods permit the simultaneous cloning of two or more diff... | 07/17/2007 |
| 7244413 | Functionalized encapsulated fluorescent nanocrystals Provided are a functionalized, encapsulated fluorescent nanocrystal comprising a liposome having encapsulated therein one or more fluorescent nanocrystals; use of the functionalized, encapsulated fluorescent nanocrystals in detection systems; and a method of produci... | 07/17/2007 |
| 7232884 | Methods of production of proteins The current invention provides methods for producing a polypeptide as inclusion bodies in bacterial host cells. The present methods are carried out by forming a gene construct comprising the genetic sequence encoding a polypeptide operatively linked to that of an in... | 06/19/2007 |
| 7232883 | Methods for production of proteins The current invention provides methods for producing a polypeptide as inclusion bodies in bacterial host cells. The present methods are carried out by forming a gene construct comprising the genetic sequence encoding a polypeptide operatively linked to that of an in... | 06/19/2007 |
| 7226740 | Aza-benzazolium containing cyanine dyes Unsymmetrical cyanine dyes that incorporate an aza-benzazolium ring moiety are described, including cyanine dyes substituted by a cationic side chain, monomeric and dimeric cyanine dyes, chemically reactive cyanine dyes, and conjugates of cyanine dyes. The subject d... | 06/05/2007 |
| 7223576 | Recombinational cloning using engineered recombination sites Recombinational cloning is provided by the use of nucleic acids, vectors and methods, in vitro and in vivo, for moving or exchanging segments of DNA molecules using engineered recombination sites and recombination proteins to provide chimeric DNA molecules that have... | 05/29/2007 |
| 7223566 | Methods for production of proteins The current invention provides methods for producing a polypeptide as inclusion bodies in bacterial host cells. The present methods are carried out by forming a gene construct comprising the genetic sequence encoding a polypeptide operatively linked to that of an in... | 05/29/2007 |
| 7217762 | Process for the preparation of monodisperse polymer particles A process for the preparation of monodisperse polymer particles which are formed by contacting monomers with aqueous dispersions comprising monodisperse swellable seed polymers/oligomers, and initiating polymerization in the presence of a steric stabilizer. The resu... | 05/15/2007 |
| 7217566 | Attached cell lines The present invention provides novel cell lines that may have improved adhesive qualities, transgene expression level, growth rate, and/or growth rate in serum free medium or even chemically defined compared to cells of the prior art. ... | 05/15/2007 |
| 7214428 | Highly luminescent functionalized semiconductor nanocrystals for biological and physical applications The present invention provides for detection apparatus with functionalized fluorescent nanocrystal compositions and methods for making and using these compositions in biological detection applications, material separations, and in the production of biosensors. The c... | 05/08/2007 |
| 7205048 | Functionalized fluorescent nanocrystal compositions and methods of making The present invention provides for functionalized fluorescent nanocrystal compositions and methods for making these compositions. The compositions are fluorescent nanocrystals coated with at least one material. The coating material has chemical compounds or ligands ... | 04/17/2007 |
| 7198924 | Methods and compositions for synthesis of nucleic acid molecules using multiple recognition sites The present invention provides compositions and methods for recombinational cloning. The compositions include vectors having multiple recombination sites and/or multiple topoisomerase recognition sites. The methods permit the simultaneous cloning of two or more diff... | 04/03/2007 |
| 7198703 | Chamber-forming electrophoresis cassette cover A multielevational cover for assembling a fluid retaining chamber on a face of an electrophoresis cassette is presented. The cover comprises a cassette-containing member, at least one chamber-defining member, and sealing means, typically sealing means that are capab... | 04/03/2007 |
| 7198847 | Nanocrystals Provided herein are compositions of functionalized, fluorescent nanocrystals comprising fluorescent nanocrystals coated with an imidazole-containing compound; compositions of functionalized, fluorescent nanocrystals comprising fluorescent nanocrystals coated with an... | 04/03/2007 |
