Did You Know...
...that Robert Adler has the dubious distinction of being the Father of the Couch Potato? Back in 1955 Adler was employed by what was then Zenith Radio Corp., where he was charged to invent something that would allow viewers to turn down the TV volume without leaving their chairs. After a series of flops (such as a wired contraption that people tripped over), Adler hit on the idea of using sound waves. Thus the Remote Control was born...
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| Number | Title | Issue Date |
| 6878549 | Packaging systems for human recombinant adenovirus to be used in gene therapy Methods and corresponding compounds for generating adenoviral vectors. One such method entails a method for generating an adenoviral vector comprising welding together two nucleic acid molecules wherein the molecules comprise partially overlapping sequences capable ... | 04/12/2005 |
| 6602706 | Packaging systems for human recombinant adenovirus to be used in gene therapy Presented are ways to address the problem of replication competent adenovirus in adenoviral production for use with, for example, gene therapy. Packaging cells having no overlapping sequences with a selected vector and are suited for large scale productio... | 08/05/2003 |
| 6500919 | Melanoma associated antigenic polypeptide, epitopes thereof and vaccines against melanoma A melanoma associated antigen known as gp100. Furthermore, peptides derived from the antigen are described. Gp100 and its peptides can be used in vaccines for the treatment of melanoma. Another aspect of the invention is host cells capable of expressing g... | 12/31/2002 |
| 6498027 | Targeted delivery through a cationic amino acid transporter The invention relates to the targeted delivery of substances to cells. The invention provides a virus-like particle or gene delivery vehicle provided with a ligand capable of binding to a human amino acid transporter. Provided are, for example, ligands th... | 12/24/2002 |
| 6472212 | Methods and compositions for genetically modifying primate bone marrow cells A method is provided for genetically modifying primate bone marrow cells, comprising isolating bone marrow cells from a primate and, by means which enhance the local concentration of retroviral contacting the isolated bone marrow cells to cells that produ... | 10/29/2002 |
| 6447768 | Methods of gene therapy with a DNA sequence encoding NOS A nucleic acid delivery vehicle for enhancing and/or inducing angiogenesis. This nucleic acid delivery vehicle includes a nucleic acid having at least one sequence coding for a protein capable of increasing nitric oxide production, and further includes a ... | 09/10/2002 |
| 6395519 | Means and methods for nucleic acid delivery vehicle design and nucleic acid transfer Cells capable of at least, in part, complementing adenovirus E2A function of an adenovirus defective in E2A function. Such cells include a nucleic acid encoding adenovirus E2A or a functional part, derivative and/or analogue thereof, integrated into the g... | 05/28/2002 |
| 6306652 | Packaging systems for human recombinant adenovirus to be used in gene therapy Presented are ways to address the problem of replication competent adenovirus in adenoviral production for use with, for example, gene therapy. Packaging cells having no overlapping sequences with a selected vector and are suited for large scale productio... | 10/23/2001 |
| 6265212 | Packaging systems for human recombinant adenovirus to be used in gene therapy The problem of replication competent adenovirus in virus production is solved in that we have developed packaging cells that have no overlapping sequences with a new basic vector and, thus, are suited for safe large scale production of recombinant adenovi... | 07/24/2001 |
| 6261554 | Compositions for targeted gene delivery A method of producing viral gene delivery vehicles which can be transferred to pre-selected cell types by using targeting conjugates. The gene delivery vehicles comprise: 1) the gene of interest; 2) a viral capsid or envelope carrying a member of a specif... | 07/17/2001 |
| 6238893 | Method for intracellular DNA amplification A method for intracellular amplification of DNA is disclosed. The method includes providing a mammalian cell with a first nucleic acid sequence encoding functional adenoviral E2A and E2B gene products and with a second nucleic acid sequence encoding a lin... | 05/29/2001 |
| 6204052 | Adenoviral vectors with reduced TNF response and partial E3 region deletion Adenoviral vectors with a deletion of the E3 region such that the remaining E3 region reduces the TNF response of a host mammalian cell infected with the virus. The portion of the E3 region remaining in these vectors encodes the 14.7 kD protein, and may a... | 03/20/2001 |
| 6140103 | Regulated protein expression in stably transfected mammalian cells The invention is in the field of recombinant genetic materials, especially for use in gene therapy. Vectors used for transferring additional genetic information to cells in the field of gene therapy are often based on viruses. A group of viruses which has... | 10/31/2000 |
| 6051430 | Vectors and methods for providing cells with additional nucleic acid material integrated in the genome of said cells The present invention provides novel elements for improving genetic engineering techniques for producing recombinant nucleic acid molecules and/or recombinant cells. The novel elements are capable of integrating desired nucleic acid material into other nu... | 04/18/2000 |
| 5994128 | Packaging systems for human recombinant adenovirus to be used in gene therapy Presented are ways to address the problem of replication competent adenovirus in adenoviral production for use with, for example, gene therapy. Packaging cells having no overlapping sequences with a selected vector and are suited for large scale productio... | 11/30/1999 |
