Assignee: Institut Pasteur

Location: Paris, FR
No. of patents: 492

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Number	Title	Issue Date
8173767	Synthetic peptide vaccines for HIV: the CBD epitope as an effective immunogen to elicit broadly neutralizing antibodies against HIV The present invention relates to peptides, referred to as CBD-1, CBD-2, CBM-1/TH-1, CBM-1/TH-2, CBM-2/TH-1, CBM-2/TH-2 and C-20 peptides, which are antigenic and elicit a protective immune response against HIV infection. Compositions, pharmaceutical compositions and...	05/08/2012
8173429	Characterization of the I-endonuclease from fission yeast Isolated DNAs encoding the enzyme I-SpomI and its recognition and cutting site are provided. The DNA sequences can be incorporated in cloning and expression vectors, transformed cell lines and transgenic animals. The vectors are useful in gene mapping and site-direc...	05/08/2012
8158413	Lentiviral vector-based vaccine Methods of eliciting humoral responses, methods of immunization, and methods of vaccination using lentiviral vector are disclosed. Additionally, immunogenic compositions and vaccines for West Nile Virus are disclosed. ...	04/17/2012
8147841	toxin, and process for the preparation of immunogenic composition The present invention relates to the field of bacterial toxic proteins, in particular toxins from Clostridium or other pathogenic organisms using, for example, promoter nucleic acids to control expression of polypeptides such as bacterial toxins. ...	04/03/2012
8143000	Mutation within the connexin 26 gene responsible for prelingual non-syndromic deafness and method of detection A purified polynucleotide having a chain of nucleotides corresponding to a mutated sequence, which in a wild form encodes a polypeptide implicated in hereditary sensory defect, wherein said mutated purified polynucleotide presents a mutation responsible for prelingu...	03/27/2012
8124380	Glycoconjugates and their use as potential vaccines against infection by A conjugate molecule comprising an oligo- or polysaccharide covalently bound to a carrier and its use as potential vaccine against infection by S. Flexneri. ...	02/28/2012
8124332	Methods of using sIP-10, CD26 inhibitors and CXCR3 levels in a sample to assess clearance of infection, response to interferon therapy, and treating chronic infections The present invention relates to methods for the treatment of infection, a disease, or a condition using CD26 (DPIV) inhibitors. The present invention also relates to an antibody that binds to the IP-10 protein and a method of monitoring the necessity for administer...	02/28/2012
8103122	Feature adapted beamlet transform apparatus and associated methodology of detecting curvilinear objects of an image A method of detecting a curvilinear object of a noisy image. The method includes filtering the noisy image in accordance with a two dimensional line profile. The line profile is selected within a class of steerable filters. A beamlet coefficient is calculated in acc...	01/24/2012
8099245	Crystallographic structure of proline racemase and uses therefor The present invention provides the crystal structure of the Trypanosoma cruzi PRACA proline racemase. Methods of modelling drugs that treat or prevent infection by T. cruzi are also provided, as are the drugs that are identified. ...	01/17/2012
8093042	Lentiviral triplex DNA, and vectors and recombinant cells containing lentiviral triplex DNA The present invention provides nucleic acid, vectors, viruses, and recombinant cells comprising triple-stranded structures, such as those resulting from central initiation and termination of HIV-1 reverse transcription at the center of HIV-1 linear DNA genomes. Thes...	01/10/2012
8092989	Targeting the histone code as a bacterial strategy for selectively modulating gene expression The ospF gene of Shigella flexneri encodes a phosphatase, which is a member of a new class of phosphatases. The OspF phosphatase inhibits the activity of several proteins either by direct protein modification or transcription downregulation. These proteins in...	01/10/2012
8026354	Recombinant merozoite surface proteins 4 and 5 and their use Accordingly, the invention provides constructs in which the nucleic acids encoding Plasmodium falciparum MSP4 and MSP5, and the resulting polypeptides, have been modified. More particularly, this invention provides constructs encoding recombinant MSP4 and MSP...	09/27/2011
8017571	Peptides derived from human BPLP protein The invention relates to a peptide that is a maturation product of the Basic Prolin-rich Lacrinal Protein (BPLP) or a peptide derivative of said maturation product, wherein the peptide or peptide derivative exhibits an inhibitory property against a metallo-ectopepti...	09/13/2011
8017132	Mutant CyaA polypeptides and polypeptide derivatives suitable for the delivery of immunogenic molecules into a cell The invention relates to mutant CyaA/E570Q+K860 polypeptides suitable for use as proteinaceous vectors for delivering one or more molecules of interest into a cell, in particular into a cell expressing the CD11b receptor. The invention further relates to polypeptide...	09/13/2011
8012706	Methods for detecting virulent , for evaluating virulence, and for screening new drugs employing the 3′UTR of SUB2 and the SUB2 serine protease Methods for regulating the serine protease of Plasmodium. Recombinant DNA constructs which express the Plasmodium serine protease, especially those comprising a sub2 3′UTR and coding segment which express a SUB2 a serine protease. Recombinant Plas...	09/06/2011
8003773	Polynucleotides encoding MHC class I-restricted hTERT epitopes, analogues thereof or polyepitopes This invention relates to the field of anticancer therapy, and to the identification of immunogenic peptides derived from the human telomerase reverse transcriptase (hTERT). The present invention relates to polynucleotides encoding hTERT epitopes restricted to MHC c...	08/23/2011
7985542	Genomic morse code The present invention relates to a method of detection of the presence of at least one domain of interest on a macromolecule to test, wherein said method comprises the following steps: a) determining beforehand at least two target ...	07/26/2011
7981671	Use of triplex structure DNA in transferring nucleotide sequences The invention concerns a recombinant vector characterized in that it comprises a polynucleotide comprising a central initiation cis-active region (cPPT) and a termination cis-active region (CTS) of retroviral or retroviral-like origin, further comprising a predeterm...	07/19/2011
7977047	Delete sequence in , method for detecting mycobacteria using these sequences and vaccines The present invention is the identification of a nucleotide sequence which make it possible in particular to distinguish an infection resulting from the vast majority of Mycobacterium tuberculosis strains from an infection resulting from Mycobacterium afri...	07/12/2011
7968332	Lentiviral vectors for the preparation of immunotherapeutical compositions The invention relates to an immunogenic composition comprising a recombinant vector characterized in that it comprises a polynucleotide comprising the cis-acting central initiation region (cPPT) and the cis-acting termination region (CTS), these regions being of ret...	06/28/2011
7960107	Method of determining the susceptibility of a subject to developing insulin-dependent diabetes The present application identifies the involvement of the HIFβ-homologous Arntl2 gene in the control of type 1 (insulin-dependent) diabetes. Accordingly, the present invention provides a method of determining the susceptibility of a subject to developing insulin-de...	06/14/2011
7960103	Method for obtaining new life forms The present invention relates to a method for generating a novel form of life comprising the steps consisting of: a) irreversible alteration of the genome of a microbial clone; b) cultivation of a vast population of microbial cells originating from the altered clone...	06/14/2011
7935807	Chicken RNA polymerase I promoter and the use thereof The invention relates to a novel polynucleotide exhibiting a promoting transcription activity, polynucleotide-containing vectors and to the use thereof for the transcription of interesting sequences such as the production of non-cap RNA virus. Said invention also re...	05/03/2011
7923216	In vivo modulation of neuronal transport A hybrid protein (GFP-TTC) comprising the non-toxic proteolytic C fragment of tetanus toxin fused to green fluorescent protein was used to analyze the functional synaptic organization of neural networks. When injected intramuscularly in vivo, the GFP-TTC hybrid prot...	04/12/2011
7923015	Methods for direct visualization of active synapses A method for visualizing an active synapse wherein said method comprises: (a) exposing cells forming the active synapse to a biomarker comprising at least fragment C of tetanus toxin and a reporter protein; and (b) visualizing the biomarker; wherein the accumulation...	04/12/2011
7906640	Polynucleotide and protein involved in synaptogenesis, variants thereof, and their therapeutic and diagnostic uses The invention relates to a kit for diagnosing autism linked to a mutation in a protein belonging to the family of human neuroligins. ...	03/15/2011
7906123	Modified adenylate cyclase comprising or lacking CD11b/CD18 interaction domain and uses thereof The invention relates to modified Bordetella adenylate cyclase toxins which are deficient for CD11b/CD18 binding and to their use in the preparation of pharmaceutical composition for the treatment of whooping cough and/or for the protection against Bordete...	03/15/2011
7902349	Nucleic acids encoding protective epitopes of adenyl cyclase-haemolysin (AC-Hly) Purified nucleic acids comprising a nucleotide sequence encoding an immunogenic polypeptide of adenyl cyclase-haemolysin (AC-Hly), which induces formation of protective antibodies against an infection by a bacteria selected from the group consisting of B. pertuss...	03/08/2011
7892838	Method for the in vivo modification of the synthesis activity of a metabolite by means of the modification of a gene the activity of which is not the original activity The invention relates to a method for altering a protein X such as to modify the characteristics thereof by a) obtaining the mutants X* of the sequence coding for protein X, by means of aleatory mutagenesis, b) transformation of cells with a phenotype [P-] with vect...	02/22/2011
7888492	Polypeptides of and polynucleotides encoding same and vaccinal, therapeutical and diagnostic applications thereof The present invention relates to new proteins of Leishmania major and to therapeutical and diagnostic applications thereof. More particularly, the present invention relates to excreted/secreted polypeptides and polynucleotides encoding same, compositions comp...	02/15/2011
7888041	In vitro diagnostic method and kit for an infection The present invention relates to a method for the in vitro diagnosis of an Aspergillus infection by determining in the serum or plasma sample of a subject the quantity of antibodies directed against a combination of at least two of the ribonuclease (RNU), cat...	02/15/2011
7883712	Identification of virulence associated regions RD1 and RD5 leading to improve vaccine of BCG and The present invention relates to a strain of M. bovis BCG or M. microti, wherein said strain has integrated part or all of the RD1 region responsible for enhanced immunogenicity of the tubercle bacilli, especially the ESAT-6 and CFP-10 genes. These str...	02/08/2011
7871627	Gram positive bacteria preparations for the treatment of disease comprising an immune dysregulation Compositions comprising components prepared from Gram positive bacteria such as Gram positive facultative intra-cellular bacteria, for example mycobacteria, including extended freeze-dried killed Gram positive bacteria, their method of preparation and their use in h...	01/18/2011
7842781	Method for isolating a polynucleotide of interest from the genome of a using a BAC-based DNA library. application to the detection of mycobacteria The present invention is directed to a method for isolating a polynucleotide of interest that is present or is expressed in a genome of a first mycobacterium strain and that is absent or altered in a genome of a second mycobacterium strain which is different from th...	11/30/2010
7842462	Identification of substances that inhibit NEMO oligomerization The present invention provides methods for screening for substances which inhibit the oligomerization of NEMO and/or IKK-related complexes and/or signaling pathways based on the interference with NEMO oligomerization. ...	11/30/2010
7838002	HCV core+1 protein, methods for diagnosis of HCV infections, prophylaxis, and for screening of anti-HCV agents The present invention relates to a novel form of core+1 protein of Hepatitis C virus (HCV), designated shorter form core+1 protein. The shorter form core+1 protein of Hepatitis C virus is the product of translation of a coding sequence consisting of all or part of a...	11/23/2010
7825097	Nucleotide vector vaccine for immunization against hepatitis Nucleotide vector comprising at least one gene or one complementary DNA coding for at least a portion of a virus, and a promoter providing for the expression of such gene in muscle cells. The gene may be the S gene of the hepatitis B virus. A vaccine preparat...	11/02/2010
7820876	Mouse mutant for expression of the alpha6 subunit of the nicotinic acetylcholine receptor The invention concerns a non-human mammal carrying a mutation in the gene coding for the alpha6 subunit of the nicotinic acetylcholine receptor (nAChR), said mutation preventing expression of said nAChR alpha6 subunit in a functional form in the mammal. The i...	10/26/2010
7820795	N-desoxyribosyl transferases and the use thereof for enzymatic synthesis of 2′, 3′—didesoxynucleosides and 2′,3′- didehydro-2′,3′- didesoxynucleosides N-deoxyribosyl transferases of Lactobacillus fermentum and their analogues, as well their use for the enzymatic synthesis of 2′,3′-dideoxynucleosides and 2′,3′-didehydro-2′,3′-dideoxynucleosides. These transferases and their analogues include a N-...	10/26/2010
7820142	Immunogenic glycopeptides, screening, preparation and uses The invention relates to immunogenic glycopeptides derived from pathogenic microorganisms, which can be used for immunization and diagnosing infections dye to such pathogenic microorganisms and also to method for the selection and preparation thereof. ...	10/26/2010

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Assignee: Institut Pasteur