Did You Know...
...that a workman who left the soap mixing machine on too long was responsible for making Ivory Soap? He was so embarrassed by his mistake that he threw the mess in a stream. Imagine his dismay when the evidence of his error floated to the surface! Result: Ivory soap, the soap that floats.
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| Number | Title | Issue Date |
| 8168753 | Thrombin cleavable factor X analogues The invention relates to factor X analogues containing the thrombin-cleavable sequence Pro-Arg-Ala in place of the-sequence Thr-Arg-Ile of the activation site of native factor X. These factor X analogues can be used to obtain procoagulant medicinal products. ... | 05/01/2012 |
| 8106179 | Small interfering RNA specific to sub-units α, α′and β of the Kinase Protein ck2, and the applications of the same The invention relates to small interfering RNA specific to sub-units α, α′ and β of the kinase protein CK2, and to the applications of the same, especially for treating cancer and viral illnesses. ... | 01/31/2012 |
| 8093366 | Dbait and standalone uses thereof The invention relates to compositions and methods for interfering with the DNA repair of double strand breaks (DSBs). The invention discloses double-stranded nucleic acid molecules that act as baits and hijack the holocomplex of enzymes responsible for DNA DSB sensi... | 01/10/2012 |
| 8057162 | Composition comprising the polyprotein NS3/NS4 and the polypeptide NS5B of HCV, expression vectors including the corresponding nucleic sequences and their therapeutic use The invention relates to a peptidic compound containing a polyprotein NS3/NS4 of a hepatitis C virus and a polypeptide NS5b of hepatitis C virus. Said invention also relates to expression vectors such as adenovirus and poxvirus in which nucleic sequences coding for ... | 11/15/2011 |
| 7981400 | Shiga toxin B-subunit as a vector for tumor diagnosis and drug delivery to GB3 expressing tumors The invention relates to new compounds for cancer therapy or diagnosis and more specifically to the use of a non-toxic B subunit of Shiga toxin mutant as a vector for diagnostic products or drugs in over-expressing Gb3 receptor cells, such compounds havin... | 07/19/2011 |
| 7919085 | Means for the diagnosis and therapy of CTCL The invention relates to a novel molecule, termed SC5 by the inventors, to a novel allelic form of p140, and to the biological applications of SC5 and p140 molecules, notably in the diagnosis and therapy of CTCL. ... | 04/05/2011 |
| 7884084 | Oligonucleotides which inhibit expression of the OB-RGRP protein The present application relates to antisense oligonucleotides which inhibit expression of the OB-RGRP protein and to uses thereof for preventing and/or treating leptin-related pathological conditions. It also relates to a method for detecting compounds which ... | 02/08/2011 |
| 7825097 | Nucleotide vector vaccine for immunization against hepatitis Nucleotide vector comprising at least one gene or one complementary DNA coding for at least a portion of a virus, and a promoter providing for the expression of such gene in muscle cells. The gene may be the S gene of the hepatitis B virus. A vaccine preparat... | 11/02/2010 |
| 7816370 | Use of epothilones in the treatment of neuronal connectivity defects such as schizophrenia and autism The present invention is about the use of at least one epothilone or derivative thereof as an active ingredient for manufacturing a medicament for use in the treatment of disease(s) involving a neuronal connectivity defect, such as schizophrenia or autism. ... | 10/19/2010 |
| 7777020 | Nucleotide sequences derived from the gene of HIV-1 This invention encompasses an env nucleic acid product produced by a process comprising providing a sample containing HIV-1 nucleic acid and amplifying the nucleic acid using primer pairs. ... | 08/17/2010 |
| 7759477 | HIV-1, HIV-2, and SIV nucleotide fragments The invention relates to polypeptide fragments of HIV-1, HIV-2, and SIV, antibodies that bind to the polypeptides of the invention, methods of using the antibodies, and kits containing the antibodies. The invention also relates to polynucleotides that encode the pol... | 07/20/2010 |
| 7741288 | Methods of screening of PP1-interacting polypeptides or proteins, peptides inhibiting PP1c binding to Bcl-2 proteins, Bcl-xand Bcl-w, and uses thereof The present invention relates to methods for identifying novel PP1-interacting polypeptides and proteins, compounds which are able to inhibit the binding of PP1c to certain factors naturally interacting with it, especially proteins of the Bcl-2 family (such as BCl-x... | 06/22/2010 |
| 7732423 | Nucleotide vector, composition containing such vector, and vaccine for immunization against hepatitis Nucleotide composition containing a vector and vaccine for immunization against hepatitis. Nucleotide vector comprising at least one gene or one complementary DNA coding for at least a portion of a virus, and a promoter providing for the expression of the gene in mu... | 06/08/2010 |
| 7700569 | Use of stabilised oligonucleotides for preparing a medicine with antitumor activity The invention concerns the use of stabilized oligonucleotides comprising at least an octamer motif of the type: 5′-purine-purine-CG-pyrimdine-pyrimidine-X1X2-3′ wherein the pair X1-X2 is AT, AA, CT or TT, for preparing... | 04/20/2010 |
| 7700294 | Method of isolating cytotoxic heterocomplex associated with multiple sclerosis The invention relates to an isolated cytotoxic factor which is associated with multiple sclerosis and which is selected from the heterocomplex GM2AP/GM2/MRP14 and mutated GM2AP/GM2/MRP14, and to the method of detecting said factor in a biological sample to be tested... | 04/20/2010 |
| 7666420 | Composition for treating pathology associated with MSRV/HERV-W The inventive composition comprises at least one type of antibody selected in a group (i) of anti-Env-SU MSRV/HERV-W antibodies or in a group of anti-TLR4 antibodies specifically linkable with the soluble fraction of an Env protein of MSRV/HERV-W or to a TLR4 recept... | 02/23/2010 |
| 7659055 | Fragments of nucleic acids specific to mycobacteria which are members of the complex and their applications for the detection and the differential diagnosis of members of the complex A fragment of a nucleic acid specific to mycobacteria of M. tuberculosis complex having a nucleotide sequence of SEQ ID No: 1 and SEQ ID No: 2 and their complimentary sequences. ... | 02/09/2010 |
| 7651838 | Prenatal diagnosis method on isolated foetal cell of maternal blood The invention concerns a novel non-invasive prenatal diagnostic method implemented with a sample of maternal blood. Said method enables prenatal diagnosis on isolated non-apoptotic epithelial foetal cells of maternal blood after they have been enriched by filtration... | 01/26/2010 |
| 7642051 | Screening methods for the identification of inhibitors of human immunodeficiency virus (HIV) viral protein R (Vpr) binding to the adenine nucleotide translocator (ANT) The invention is directed to the induction of mitochondrial membrane permeabilization via the physical and functional interaction of the HIV-1 Vpr protein with the mitochondrial inner membrane protein ANT (adenine nucleotide translocator, also called adenine nucleot... | 01/05/2010 |
| 7632514 | Universal carrier for targeting molecules to Gb3 receptor expressing cells The present invention concerns an universal polypeptidic carrier for targeting directly or indirectly a molecule to Gb3 receptor expressing cells and having the following formula STxB-Z(n)-Cys, wherein: STxB is the Shiga Toxin B subunit or a functional equivalent th... | 12/15/2009 |
| 7625879 | Phosphohalohydrins, process for the production thereof and use thereof The invention provides compounds comprising at least one phosphohalohydrin group of the formula: where X is a halogen selected from among I, Br, Cl, R1 is selected from among —CH | 12/01/2009 |
| 7569666 | Polypeptides associated with activatory receptors and their biological applications The invention concerns novel means for diagnosing, preventing, compensating, treating an abnormal or unwanted functioning of KAR receptors (Killer cell Activatory Receptor), counterparts of non-inhibiting KIR receptors (Keller cell Inhibitory Receptors) of the immun... | 08/04/2009 |
| 7557193 | Glycopeptides derived from pancreatic structures, antibodies and applications thereof in diagnostics and therapeutics The invention relates to a glycopeptide comprising between 1 and 40 repeated C-terminal polypeptides, with 11 amino acids, of BSDL or FAPP, whereby the aforementioned polypeptides are glycosylated and bear glycosylated epitopes giving rise to a specific immunologica... | 07/07/2009 |
| 7521436 | Modified phosphocalcic compound, injectable composition containing same The invention concerns a phosphocalcic compound modified by a gem-bisphosphonic acid or one of its salts, a method for preparing same, as well as its use for preparing an injectable composition. The modified phosphocalcic compound is obtained by adding a gem-bisphos... | 04/21/2009 |
| 7473564 | Kit and method for detecting the ESM-1 protein The invention concerns a kit for the detection of protein ESM-1 in a sample, comprising: a) a first antibody specifically binding to the N-terminal region of protein ESM-1 contained between the amino acid in position 20 and the ami... | 01/06/2009 |
| 7442550 | Method for detecting the expression of an envelope protein of a human endogenous retrovirus and uses of a gene coding for said protein A method for detecting the expression of a polypeptide in cells and for detecting the interaction between a polypeptide and cells, ex vivo or in vitro, wherein the polypeptide is selected from the group consisting of: a peptide comprising the cyt domain of the envel... | 10/28/2008 |
| 7439053 | Transformed A method for modifying a wild strain of an entero-invasive Shigella to produce a modified strain of Shigella that can be used for making a vaccine against the wild strain of Shigella. The genome of the wild strain of Shigella is transform... | 10/21/2008 |
| 7432253 | Phosphoepoxides, method for making same and uses The invention provides compounds comprising at least one phosphoepoxide group of the formula: where R1 is selected from among —CH3 and —CH2—CH3. Cat+... | 10/07/2008 |
| 7419669 | Peptide epitopes common to antigens of the same multigene family The invention relates to the production of peptide epitopes common to a plurality of antigens of the same multigene family, said epitopes containing at least one common pentapeptide sequence preceded by three amino acids at the N-terminal end and optionally followed... | 09/02/2008 |
| 7407753 | Methods, kits and pharmaceutical compositions for diagnosing, delaying onset of, preventing and/or treating osteoporosis The present invention uncovers a highly significant association of SNPs in the CNR2 locus, encoding the cannabinoid receptor 2 protein, with osteoporosis. Methods and kits for determining predisposition to osteoporosis, improving diagnosis in individuals suspected o... | 08/05/2008 |
| 7396812 | Method for modulating Nod1 activity, use of a MTP related molecule for modulating Nod1 activity, and therapeutic applications thereof A method for modulating Nod1 activity wherein said method comprises the steps of providing cells expressing a functional Nod1; and bringing said cells into contact with a molecule related to compositions comprising a molecule related to MTP and use of a molecule rel... | 07/08/2008 |
| 7384768 | Nucleic acids and polypeptides specific for pathogenic strains of the genus The invention concerns nucleic acids coding for polypeptides specific of the Neisseria genus pathogenic strains, the corresponding polypeptides, and their diagnostic and therapeutic applications. ... | 06/10/2008 |
| 7381710 | Combined DNA vaccine and biological modifiers for cancer therapy The present invention relates to the combination of a DNA vaccination strategy that makes use of a nucleic acid encoding an immunogenic polypeptide, with a non-immunosuppressive inducer of tumor cell differentiation and/or apoptosis or a tumor cell modifier, useful ... | 06/03/2008 |
| 7368556 | DNA and proteins or peptides specific of bacteria of the species, methods for obtaining them and biological applications thereof The DNA of the invention are characterised in that they concern the whole or part of genes, with their reading frame, to be found in Neisseria meningitidis, but not in Neisseria gonorrhoeae, or in Neisseria lactamica except the genes involved in... | 05/06/2008 |
| 7368287 | Use of L-α-lysophosphatidylcholine to obtain the differentiation of monocytes into mature dendritic cells in vitro The present invention relates to the use of L-α-lysophosphatidylcholine and/or an equivalent compound for the differentiation of monocytes into mature denditric cell. The present invention also relates to a method for differentiation monocytes into mature de... | 05/06/2008 |
| 7364844 | Use of the gene in the field of angiogenesis The invention concerns a method for diagnosing cavernous angiomas for detecting mutations in the Krit1 gene. More particularly, said detection is performed by using nucleotide sequences. The invention further concerns the use of the Krit1 gene for therapeutic purpos... | 04/29/2008 |
| 7309690 | Use of thymulin-like peptides for making pain-relieving medicines The present invention relates to the utilization of peptide analogues of thymulin that are inactive relative to the immune system, not comprising zinc and having anti-pain activity, for manufacturing a medicine for the treatment of pain. ... | 12/18/2007 |
| 7288258 | Polyepitopic protein fragments of the E6 and E7 proteins of HPV, their production and their use particularly in vaccination Polyepitopic peptides of E6 and E7 proteins of Human Papillomavirus, their production, and methods of treating pathologies in which a polyepitopic peptide of the E6 and E7 protein of Human Papillomavirus is recognized by the cellular immune system. ... | 10/30/2007 |
| 7259012 | Use of oxidized lipoproteins for differentiation of precursor cells into mature dendritic cells The invention concerns a method for differentiating precursor cells into mature dendritic cells, comprising placing the precursor cells in a medium suitable for their differentiation and adding to the medium, in a predetermined amount, at least one fraction of oxidi... | 08/21/2007 |
| 7235687 | Derivatives of 4,4′-dithiobis-(3-aminobutane-1-sulfphonates) and compositions containing same The invention relates to the bis-hydrochloride of 4,4′-dithiobis-(3-aminobutane-1-sodium sulphonate) and the bis-trifluoracetate of 4,4′-dithiobis-(3-aminobutane-1-sulphonate of 2,2-dimethylpropyl). The invention also relates to a pharmaceutical composition comp... | 06/26/2007 |
