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...that Thomas Edison's patent application on his phonograph was approved by the Patent Office in just seven weeks? In contrast, it took Gordon Gould, the inventor of the laser, 30 years to obtain his patent -- finally awarded in 1988!
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| Number | Title | Issue Date |
| 8101351 | Process for typing of HCV isolates The invention relates to a process for genotyping any HCV isolate present in a biological sample, previously identified as being HCV positive, and for classifying said isolate according to the percentage of homology with other HCV isolates, comprising the steps of: ... | 01/24/2012 |
| 7741461 | Nucleic acid probes and methods for detecting clinically important fungal pathogens The current invention relates to the field of detection and identification of clinically important fungi. More particularly, the present invention relates to species specific probes originating from the Internal Transcribed Spacer (ITS) region of rDNA for the detect... | 06/22/2010 |
| 7422848 | Hepatitis-B viral variants with reduced susceptibility to nucleoside analogs and uses thereof The present invention relates generally to the field of Hepatitis B variants exhibiting a reduced sensitivity to nucleoside analogues, both in vivo and in vitro. More in particular, reverse transcriptase mutant rtA181S is provided. Present invention provides assays ... | 09/09/2008 |
| 7413741 | HCV E1 comprising specific disulfide bridges The invention relates to recombinantly or synthetically produced HCV E1 envelope proteins or parts thereof comprising disulfides between specific cysteine residues. The invention further relates to viral-like particles and compositions comprising said HCV E1 envelop... | 08/19/2008 |
| 7390623 | Detection and identification of and epidermidis using the 16S-23S rRNA spacer The present invention relates to 16S-23S rRNA spacer sequences from Staphylococcus aureus and their use in a method for detection and/or identification of Staphylococcus aureus . The invention further relates to a method for detection and identificatio... | 06/24/2008 |
| 7387879 | Diagnosis of tauopathies The present invention provides a method for the diagnosis of tauopathies in an individual and/or for the differential diagnosis of a tauopathy versus a non-tauopathy based on the detection of the ratio of phospho-tau (181)/total tau in said individual. The present i... | 06/17/2008 |
| 7314925 | Constructs and methods for expression of recombinant HCV envelope proteins The current invention relates to vectors and methods for efficient expression of HCV envelope proteins in eukaryotic cells. More particularly said vectors comprise the coding sequence for an avian lysozyme signal peptide or a functional equivalent thereof joined to ... | 01/01/2008 |
| 7313357 | Method for typing and detecting HBV The present invention relates to a method for detection and/or genetic analysis of HBV in a biological sample, comprising hybridizing the polynucleic acids of the sample with a combination of at least two nucleotide probes, with said combination hybridizing specific... | 12/25/2007 |
| 7258977 | Process for typing of HCV isolates The invention relates to a process for genotyping any HCV isolate present in a biological sample, previously identified as being HCV positive, and for classifying said isolate according to the percentage of homology with other HCV isolates, comprising the steps of: ... | 08/21/2007 |
| 7258861 | TNF-derived peptides for use in treating oedema The present invention is based on the finding that peptides derived from a specific domain of tumor necrosis factor-alpha (TNF-α) can efficiently be used to treat oedema. More specifically, the present invention relates to the usage of peptides derived from the reg... | 08/21/2007 |
| 7252936 | Method for the detection of the antibiotic resistance spectrum of Mycobacterium species Method for the detection of the antibiotic resistance spectrum of Mycobacterium species present in a sample, possibly coupled to the identification of the Micobacterium species involved, comprising the steps of: (i) if need be releasing, isolating or c... | 08/07/2007 |
| 7238356 | Core-glycosylated HCV envelope proteins The current invention relates to HCV envelope proteins or parts thereof which are the product of expression in eukaryotic cells. More particularly said HCV envelope proteins are characterized in that on average up to 80% of their N-glycosylation sites are core-glyco... | 07/03/2007 |
| 7196183 | Hepatitis C virus genotype, and its use as prophylactic, therapeutic and diagnostic agent The present invention relates to genomic nucleotide sequences and amino acid sequences corresponding to the non-coding and coding region of a new type of HCV. The invention relates to new HCV types and subtypes sequences which are different from the known HCV types ... | 03/27/2007 |
| 7157226 | Sequences of hepatitis C virus genotypes and their use as therapeutic and diagnostic agents The present invention relates to a polynucleic acid composition comprising or consisting of at least one polynucleic acid containing 8 or more contiguous nucleotides corresponding to a nucleotide sequence from the region spanning positions 417 to 957 of the Core/E1 ... | 01/02/2007 |
| 7129337 | Sequences of hepatitis C virus genotypes and their use as prophylactic, therapeutic and diagnostic agents The present invention relates to new genomic nucleotide sequences and amino acid sequences corresponding to the coding region of these genomes. The invention relates to new HCV types and subtypes sequences which are different from the known HCV types and subtypes se... | 10/31/2006 |
| 7108855 | Purified hepatitis C virus envelope proteins for diagnostic and therapeutic use The present invention relates to a method for purifying recombinant HCV single or specific oligomeric envelope proteins selected from the group consisting of E1 and/or E2 and/or E1/E2, characterized in that upon lysing the transformed host cells to isolate the recom... | 09/19/2006 |
| 7101561 | Purified hepatitis C virus envelope proteins for diagnostic and therapeutic use The present invention relates to a method for purifying recombinant HCV single or specific oligomeric envelope proteins selected from the group consisting of E1 and/or E2 and/or E1/E2, characterized in that upon lysing the transformed host cells to isolate the recom... | 09/05/2006 |
| 7048930 | Expression of core-glycosylated HCV envelope proteins in yeast The present invention relates to the general field of recombinant protein expression, purification of recombinant proteins, diagnosis of HCV infection, prophylactic treatment against HCV infection and to the prognosing/monitoring of the clinical efficiency of treatm... | 05/23/2006 |
| 7026457 | Purified hepatitis C virus envelope proteins for diagnostic and therapeutic use The present invention relates to a method for purifying recombinant HCV single or specific oligomeric envelope proteins selected from the group consisting of E1 and/or E1/E2 characterized in that upon lysing the transformed host cells to isolate the recombinantly ex... | 04/11/2006 |
| 6974864 | Sequences of hepatitis C virus genotypes and their use as prophylactic, therapeutic and diagnostic agents The present invention relates to new genomic nucleotide sequences and amino acid sequences corresponding to the coding region of these genomes. The invention relates to new HCV types and subtypes sequences which are different from the known HCV types and subtypes. M... | 12/13/2005 |
| 6890737 | Purified hepatitis C virus envelope proteins for diagnostic and therapeutic use The present invention relates to a method for purifying recombinant HCV single or specific oligomeric envelope proteins selected from the group consisting of E1 and/or E1/E2, characterized in that upon lysing the transformed host cells to isolate the recombinantly e... | 05/10/2005 |
| 6891026 | Process for typing of HCV isolates The invention relates to a process for genotyping any HCV isolate present in a biological sample, previously identified as being HCV positive, and for classifying said isolate according to the percentage of homology with other HCV isolates, comprising the steps of: ... | 05/10/2005 |
| 6887985 | Process for typing of HCV isolates The invention relates to a process for genotyping any HCV isolate present in a biological sample, previously identified as being HCV positive, and for classifying said isolate according to the percentage of homology with other HCV isolates, comprising the steps of: ... | 05/03/2005 |
| 6872520 | Synthetic antigens for the detection of antibodies to hepatitis C virus Peptide sequences are provided which are capable of mimicking proteins encoded by HCV for use as reagents for screening of blood and blood products for prior exposure to HCV. The peptides are at least 5 amino acids long and can be used in various specific assays for... | 03/29/2005 |
| 6858387 | Nucleic acid probes and methods for detecting clinically important fungal pathogens The current invention relates to the field of detection and identification of clinically important fungi. More particularely, the present invention relates to species specific probes originating from the Internal Transcribed Spacer (ITS) region of rDNA for the detec... | 02/22/2005 |
| 6841353 | Epitopes in viral envelope proteins and specific antibodies directed against these epitopes: use for detection of HCV viral antigen in host tissue Antibodies to two new epitopes on the HCV envelope proteins were identified which allow routine detection of native HCV envelope antigens, in tissue or cells derived from the host. The new epitopes are: the E1 region aa 307-326 and the N-terminal hyper variable regi... | 01/11/2005 |
| 6811978 | Detection and identification of pseudomonas species using the 16S-23S rRNA spacer The present invention relates to 16S-23S rRNA spacer sequences from Pseudomonas species and their use in a method for detection and/or identification of Pseudomonas species. The invention further it relates to a method for detection and identification of at least on... | 11/02/2004 |
| 6803187 | Method for detection of drug-selected mutations in the HIV protease gene The present invention relates to a method for the rapid and reliable detection of drug-selected mutations in the HIV protease gene allowing the simultaneous charaterization of a range of codons involved in drug resistance using specific sets of probes optimized to f... | 10/12/2004 |
| 6713251 | Method for detection of drug-induced mutations in the reverse transcriptase gene The present invention relates to a method for the rapid and reliable detection of drug-induced mutations in the reverse transcriptase gene allowing the simultaneous characterization of a range of codons involved in drug resistance using specific sets of probes optim... | 03/30/2004 |
| 6709812 | Method for typing and detecting HBV The present invention relates to a method for detection and/or genetic analysis of HBV in a biological sample, comprising hybridizing the polynucleic acids of the sample with a combination of at least two nucleotide probes, with said combination hybridizing specific... | 03/23/2004 |
| 6689368 | Immunodominant human T-cell epitopes of hepatitis C virus The present invention relates to a polypeptide of about 8 to about 100 amino acids comprising or consisting of at least 8 contiguous amino acids selected from the core, and/or the NS3 regions of the HCV polyprotein, with said contiguous amino acids contai... | 02/10/2004 |
| 6635257 | Particles of HCV envelope proteins: use for vaccination The present invention is based on the finding that the envelope proteins of HCV induce a beneficial immune response in chronically HCV-infected chimpanzees. The immunization can preferentially be carried out using HCV envelope proteins in the form of part... | 10/21/2003 |
| 6632607 | Mycobacterium antibiotic resistance detection Method for the detection of the antibiotic resistance spectrum of Mycobacterium species present in a sample, possibly caused to the identification of the Mycobacterium species involved, comprising the steps of: (i) if need be releasing, isolating or conce... | 10/14/2003 |
| 6613333 | Immunodominant human T-cell epitopes of hepatitis C virus The present invention relates to a polypeptide of about 8 to about 100 amino acids comprising or consisting of at least 8 contiguous amino acids selected from the core, and/or the NS3 regions of the HCV polyprotein, with said contiguous amino acids contai... | 09/02/2003 |
| 6576417 | Synthetic antigens for the detection of antibodies to hepatitis C virus Peptide sequences are provided which are capable of mimicking proteins encoded by HCV for use as reagents for screening of blood and blood products for prior exposure to HCV. The peptides are at least 5 amino acids long and can be used in various specific... | 06/10/2003 |
| 6555114 | Immunodominant human T-cell epitopes of hepatitis C virus The present invention relates to a polypeptide of about 8 to about 100 amino acids containing at least about 8 contiguous amino acids selected from the core, and/or the E1, and/or E2, and/or the NS3 regions of the HCV polyprotein, with the contiguous amin... | 04/29/2003 |
| 6548244 | Process for typing HCV isolates The invention relates to a process for genotyping any HCV isolate present in a biological sample, previously identified as being HCV positive, and for classifying said isolate according to the percentage of homology with other HCV isolates, comprising the... | 04/15/2003 |
| 6528261 | Method for typing of HLA alleles The present invention relates to the typing of HLA alleles. The sequence of exon 2 and exon 3 of the alleles HLA-B*3913, HLA-B*1406 and HLA-B*51new and of exon 2 of the alleles HLA-DRB1*0820, HLA-DRB1*04new and HLA-DRB4*01new are disclosed. The present in... | 03/04/2003 |
| 6521403 | Epitopes in viral envelope proteins and specific antibodies directed against these epitopes: use for detection of HCV viral antigen in host tissue Antibodies to two new epitopes on the HCV envelope proteins we, identified which allow routine detection of native HCV envelope antigens, in tissue or cells derived from the host. The new epitopes are: the E1 region aa 307-326 and the N-terminal hyper var... | 02/18/2003 |
| 6500674 | Method for the diagnosis of brain/neurological disease using monoclonal antibodies specific for PHF-tau, hybridomas secreting them, and antigen recognition by these antibodies and their applications A method for the diagnosis of brain/neurological disease involving abnormally phosphorylated tau protein using at least one antibody chosen from the group consisting of monoclonal antibody AT180 secreted by the hybridoma deposited at ECACC on Dec. 22, 199... | 12/31/2002 |
