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| Number | Title | Issue Date |
| 8158616 | Azetidine and cyclobutane derivatives as JAK inhibitors The present invention relates to azetidine and cyclobutane derivatives, as well as their compositions, methods of use, and processes for preparation, which are JAK inhibitors useful in the treatment of JAK-associated diseases including, for example, inflammatory and... | 04/17/2012 |
| 8143251 | Triazolotriazines as kinase inhibitors The present invention is directed to [1,2,4]triazolo[4,3-b][1,2,4]triazines, and pharmaceutical compositions thereof, which are inhibitors of kinases such as c-Met and are useful in the treatment of cancer and other diseases related to the dysregulation of kinase pa... | 03/27/2012 |
| 8110581 | Lactam compounds and their use as pharmaceuticals The present invention relates to inhibitors of 11-βhydroxyl steroid dehydrogenase type 1, antagonists of the mineralocorticoid receptor (MR), and pharmaceutical compositions thereof. The compounds of the invention can be useful in the treatment of various diseases ... | 02/07/2012 |
| 8088803 | 1,2,5-oxadiazoles as inhibitors of indoleamine 2,3-dioxygenase The present invention is directed to 1,2,5-oxadiazole derivatives, and compositions of the same, which are inhibitors of indoleamine 2,3-dioxygenase and are useful in the treatment of cancer and other disorders, and to the processes and intermediates for making such... | 01/03/2012 |
| 8088737 | Compositions, methods and kits relating to Her-2 cleavage The present invention relates to compositions, methods and kits based on the ADAM-mediated cleavage of Her-2. The present invention also relates to treatments for cancer, and in particular, breast cancer, by modulating the ADAM-mediated cleavage of Her-2. Further, t... | 01/03/2012 |
| 8071624 | N-substituted piperidines and their use as pharmaceuticals The present invention relates to inhibitors of 11-β hydroxyl steroid dehydrogenase type 1, antagonists of the mineralocorticoid receptor (MR), and pharmaceutical compositions thereof. The compounds of the invention can be useful in the treatment of various diseases... | 12/06/2011 |
| 8058288 | Amido compounds and their use as pharmaceuticals The present invention relates to inhibitors of 11-β hydroxyl steroid dehydrogenase type 1, antagonists of the mineralocorticoid receptor (MR), and pharmaceutical compositions thereof. The compounds of the invention can be useful in the treatment of various diseases... | 11/15/2011 |
| 8043818 | Methods for detecting expression of human protease molecules The invention provides human protease molecules (HUPM) and polynucleotides which identify and encode HUPM. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for treating or preventi... | 10/25/2011 |
| 8039478 | Purinone derivatives as HM74A agonists The present invention relates to purinone derivatives which are agonists of the HM74a receptor. Further provided are compositions and methods of using the compounds herein, and their pharmaceutically acceptable salts for the treatment of disease. ... | 10/18/2011 |
| 8039471 | Aza spiro alkane derivatives as inhibitors of metalloproteases The present invention provides a compound of Formula I or Formula II: enantiomer, diastereomer, prodrug, solvate, metabolite, or pharmaceutically acceptable salt thereof, wherein constituent variables are provided herein. T... | 10/18/2011 |
| 8034953 | Modulators of indoleamine 2,3-dioxygenase and methods of using the same The present invention is directed to modulators of indoleamine 2,3-dioxygenase (IDO), as well as compositions and pharmaceutical methods thereof. ... | 10/11/2011 |
| 8008027 | Methods of screening for compounds that modulate the activity of ADEC, a chemokine expressed in inflamed adenoid The present invention provides nucleotide and amino acid sequences that identify and encode a novel expressed chemokine (ADEC) from inflamed adenoid tissue. The present invention also provides for antisense molecules to the nucleotide sequences which encode ADEC, ex... | 08/30/2011 |
| 7998959 | Modulators of 11-β hydroxyl steroid dehydrogenase type 1, pharmaceutical compositions thereof, and methods of using the same The present invention relates to inhibitors of 11-β hydroxyl steroid dehydrogenase type 1 and pharmaceutical compositions thereof. The compounds of the invention can be useful in the treatment of various diseases associated with expression or activity of 11-β hydr... | 08/16/2011 |
| 7985730 | 3-aminopyrrolidine derivatives as modulators of chemokine receptors The present invention relates to 3-aminopyrrolidine derivatives of the formula I: (wherein R1, R2, R3, R4, R5, R6, R7, R8, X, Y and X a... | 07/26/2011 |
| 7973041 | Substituted cyclic hydroxamates as inhibitors of matrix metalloproteinases The present invention provides compounds of the formula: its enantiomers, diastereomers, racemic mixtures thereof, prodrugs, crystalline forms, non-crystalline forms, amorphous forms thereof, solvates thereof, metabolites t... | 07/05/2011 |
| 7947804 | Vesicle trafficking proteins The invention provides three human vesicle trafficking proteins (VTP) and polynucleotides which identify and encode VTP. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for prevent... | 05/24/2011 |
| 7932363 | Antibody that binds human eosinophil-derived basic protein The present invention provides a human eosinophil-derived basic protein (EBPH) and polynucleotides which identify and encode EBPH. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding EBP... | 04/26/2011 |
| 7915408 | Triazolotriazines as kinase inhibitors The present invention is directed to [1,2,4]triazolo[4,3-b][1,2,4]triazines, and pharmaceutical compositions thereof, which are inhibitors of kinases such as c-Met and are useful in the treatment of cancer and other diseases related to the dysregulation of kinase pa... | 03/29/2011 |
| 7910108 | Sheddase inhibitors combined with CD30-binding immunotherapeutics for the treatment of CD30 positive diseases The present invention is directed to pharmaceutical methods for the treatment of CD30 positive diseases, such as Hodgkin's disease, by administration of a combination of at least one sheddase inhibitor and at least one anti-CD30 immunotherapeutic. ... | 03/22/2011 |
| 7902205 | Purinone derivatives as HM74A agonists The present invention relates to purinone derivatives which are agonists of the HM74a receptor. Further provided are compositions and methods of using the compounds herein, and their pharmaceutically acceptable salts for the treatment of disease. ... | 03/08/2011 |
| 7863285 | Purinone derivatives as HM74A agonists The present invention relates to purinone derivatives which are agonists of the HM74a receptor. Further provided are compositions and methods of using the compounds herein, and their pharmaceutically acceptable salts for the treatment of disease. ... | 01/04/2011 |
| 7838544 | Heterocyclic inhibitors of 11-β hydroxyl steroid dehydrogenase type 1 and methods of using the same The present invention relates to inhibitors of 11-β hydroxyl steroid dehydrogenase type 1 and pharmaceutical compositions thereof. The compounds of the invention can be useful in the treatment of various diseases associated with expression or activity of 11-β hydr... | 11/23/2010 |
| 7834022 | Metabolites of the Janus kinase inhibitor (R)-3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile The present invention provides active metabolites of 3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile that modulate the activity of Janus kinases and are useful in the treatment of diseases related to activity of Janus kinases incl... | 11/16/2010 |
| 7834021 | 3-aminopyrrolidine derivatives as modulators of chemokine receptors The present invention relates to 3-aminopyrrolidine derivatives of the formula I: (wherein R1, R2, R3, R4, R5, R6, R7, R8, X, Y and X a... | 11/16/2010 |
| 7829682 | Human β-adrenergic receptor kinase nucleic acid molecule Various embodiments of the invention provide human kinases and phosphatases (KPP) and polynucleotides which identify and encode KPP. Embodiments of the invention also provide expression vectors, host cells, antibodies, agonists, and antagonists. Other embodiments pr... | 11/09/2010 |
| 7776874 | Amido compounds and their use as pharmaceuticals The present invention relates to inhibitors of 11-β hydroxyl steroid dehydrogenase type 1, antagonists of the mineralocorticoid receptor (MR), and pharmaceutical compositions thereof. The compounds of the invention can be useful in the treatment of various diseases... | 08/17/2010 |
| 7767675 | Imidazotriazines and imidazopyrimidines as kinase inhibitors The present invention is directed to imidazo[1,2-b][1,2,4]triazines and imidazo[1,2-a]pyrimidines, and pharmaceutical compositions thereof, which are inhibitors of kinases such as c-Met and are useful in the treatment of cancer and other diseases related to the dysr... | 08/03/2010 |
| 7723349 | Aza spiro alkane derivatives as inhibitors of metalloproteases The present invention provides a compound of Formula I or Formula II: enantiomer, diastereomer, prodrug, solvate, metabolite, or pharmaceutically acceptable salt thereof, wherein constituent variables are provided herein. T... | 05/25/2010 |
| 7708984 | Methods of treatment with anitbodies to a chemokine expressed in inflamed adenoid The present invention provides nucleotide and amino acid sequences that identify and encode a novel expressed chemokine (ADEC) from inflamed adenoid tissue. The present invention also provides for antisense molecules to the nucleotide sequences which encode ADEC, ex... | 05/04/2010 |
| 7700624 | 3-aminocyclopentanecrboxamides as modulators of chemokine receptors The present invention is directed to compounds of Formula I: which are modulators of chemokine receptors. The compounds of the invention, and compositions thereof, are useful in the treatment of diseases related to chemokin... | 04/20/2010 |
| 7687665 | 2-methylprop anamides and their use as pharmaceuticals The present invention relates to inhibitors of 11-β hydroxyl steroid dehydrogenase type 1, antagonists of the mineralocorticoid receptor (MR), and pharmaceutical compositions thereof. The compounds of the invention can be useful in the treatment of various diseases... | 03/30/2010 |
| 7683060 | Triazolotriazines as kinase inhibitors The present invention is directed to [1,2,4]triazolo[4,3-b][1,2,4]triazines, and pharmaceutical compositions thereof, which are inhibitors of kinases such as c-Met and are useful in the treatment of cancer and other diseases related to the dysregulation of kinase pa... | 03/23/2010 |
| 7678798 | Piperazinylpiperidine derivatives as chemokine receptor antagonists The present invention relates to compounds of Formula I: wherein variable substituents are defined herein, that modulate the activity of or bind to chemokine receptors such as CCR5. In some embodiments, the compounds of the... | 03/16/2010 |
| 7618970 | 3-aminocyclopentanecarboxamides as modulators of chemokine receptors The present invention is directed to compounds of Formula I: which are modulators of chemokine receptors. The compounds of the invention, and compositions thereof, are useful in the treatment of diseases related to chemokin... | 11/17/2009 |
| 7598257 | Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as janus kinase inhibitors The present invention provides heteroaryl substituted pyrrolo[2,3-b]pyridines and heteroaryl substituted pyrrolo[2,3-b]pyrimidines that modulate the activity of Janus kinases and are useful in the treatment of diseases related to activity of Janus kinases including,... | 10/06/2009 |
| 7511050 | Purinone derivatives as HM74A agonists The present invention relates to purinone derivatives which are agonists of the HM74a receptor. Further provided are compositions and methods of using the compounds herein, and their pharmaceutically acceptable salts for the treatment of disease. ... | 03/31/2009 |
| 7491724 | Substituted cyclic hydroxamates as inhibitors of matrix metalloproteinases The present invention provides compounds of the formula I: its enantiomers, diastereomers, racemic mixtures thereof, prodrugs, crystalline forms, non-crystalline forms, amorphous forms thereof, solvates thereof, metabolites... | 02/17/2009 |
| 7462624 | Purinone derivatives as HM74a agonists The present invention relates to purinone derivatives which are agonists of the HM74a receptor. Further provided are compositions and methods of using the compounds herein, and their pharmaceutically acceptable salts for the treatment of disease. ... | 12/09/2008 |
| 7396663 | Isolated polynucleotide encoding a G-protein coupled receptor The invention provides human G-protein coupled receptors (GCREC) and polynucleotides which identify and encode GCREC. The invention also provides expression vectors, host, cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosi... | 07/08/2008 |
| 7396652 | Chemokine PANEC-2 polypeptides and compositions and methods related thereto The present invention provides nucleotide and amino acid sequences that identify and encode novel expressed chemokines (PANEC-1 and PANEC-2) from human pancreas cells. The present invention also provides for antisense molecules to the nucleotide sequences which enco... | 07/08/2008 |
