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| Number | Title | Issue Date |
| 8044137 | Materials formable in situ within a medical device Certain embodiments of the invention include forming a material in situ by introducing into a space within a patient a water soluble polymer precursor of at least about 10,000 molecular weight solubilized in a flowable aqueous solution. Functional groups on the poly... | 10/25/2011 |
| 7648713 | Methods of using in situ hydration of hydrogel articles for sealing or augmentation of tissue or vessels Pharmaceutically acceptable hydrogel polymers of natural, recombinant or synthetic origin, or hybrids thereof, are introduced in a dry, less hydrated, or substantially deswollen state and rehydrate in a physiological environment to undergo a volumetric expansion and... | 01/19/2010 |
| 7605232 | Hydrogels for protein concentration A method of concentrating proteins from whole blood comprising exposing whole blood to covalently crosslinked hydrogel to remove water from the blood into the hydrogel to thereby concentrate the proteins in the whole blood. The hydrogel may absorb, for example, 50% ... | 10/20/2009 |
| 7597882 | Protein crosslinkers, crosslinking methods and applications thereof Some aspects of this disclosure relate to a method for crosslinking a biological fluid comprising combining a biological fluid with a crosslinker to covalently crosslink proteins endogenous to the biological fluid to form a crosslinked gel. Examples of a biological ... | 10/06/2009 |
| 7592418 | Biocompatible crosslinked polymers with visualization agents Biocompatible crosslinked polymers, and methods for their preparation and use, are disclosed in which the biocompatible crosslinked polymers are formed from water soluble precursors having electrophilic and nucleophilic functional groups capable of reacting and cros... | 09/22/2009 |
| 7413752 | Composite hydrogel drug delivery systems Compositions and methods are provided to control the release of relatively low molecular weight therapeutic species through hydrogels by first dispersing or dissolving such therapeutic species within relatively hydrophobic rate modifying agents to form a mixture. Th... | 08/19/2008 |
| 7347850 | Adhesion barriers applicable by minimally invasive surgery and methods of use thereof Biocompatible crosslinked polymers, and methods for their preparation and use with minimally invasive surgery applicators are disclosed. The disclosure includes compositions and methods for in situ formation of hydrogels using minimally invasive surgical techniques.... | 03/25/2008 |
| 7332566 | Biocompatible crosslinked polymers with visualization agents Biocompatible crosslinked polymers, and methods for their preparation and use, are disclosed in which the biocompatible crosslinked polymers are formed from water soluble precursors having electrophilic and nucleophilic functional groups capable of reacting and cros... | 02/19/2008 |
| 7220270 | Methods and apparatus for intraluminal deposition of hydrogels Methods and apparatus of forming hydrogel systems in situ are provided using a delivery system configured to deliver two or more fluent prepolymer solutions without premature crosslinking. The delivery system comprises separate first and second lumens coupling first... | 05/22/2007 |
| 7211651 | Proteinaceous gels having visualization agents and methods of use thereof Proteinaceous gels having visualization agents and methods of use thereof are disclosed herein. Further, polymeric crosslinking agents are disclosed that have an inert water soluble polymeric component, biodegradable components, functional components reactive with c... | 05/01/2007 |
| 7057019 | Crosslinked albumin hydrogels Materials, methods, and compositions for making crosslinked albumin hydrogels are included in the application. Embodiments include a biocompatible material of albumin crosslinked with an n-functional crosslinking agent wherein n is at least 3. Other embodiments incl... | 06/06/2006 |
| 7025990 | Methods for forming regional tissue adherent barriers and drug delivery systems Methods are provided for forming hydrogel barriers in situ that adhere to tissue and prevent the formation of post-surgical adhesions or deliver drugs or other therapeutic agents to a body cavity. The hydrogels are crosslinked, resorb or degrade over a period of tim... | 04/11/2006 |
| 7009034 | Biocompatible crosslinked polymers Biocompatible crosslinked polymers, and methods for their preparation and use, are disclosed in which the biocompatible crosslinked polymers are formed from water soluble precursors having electrophilic and nucleophilic functional groups capable of reacting and cros... | 03/07/2006 |
| 6887974 | Crosslinking agents and methods of use Polymeric crosslinking agents are disclosed that have an inert water soluble polymeric component, biodegradable components, functional components reactive with chemical groups on a protein, for example, amine or thiol groups. The inert polymeric component may be fla... | 05/03/2005 |
| 6818018 | In situ polymerizable hydrogels Compositions and methods for forming hydrogels in situ through a combination of physical and chemical crosslinking processes are provided in which physical crosslinking is mediated by one or more natural or synthetic components that stabilize the a hydrogel-forming ... | 11/16/2004 |
| 6703047 | Dehydrated hydrogel precursor-based, tissue adherent compositions and methods of use Compositions and methods are provided for forming tissue-adherent hydrogels using substantially dry precursors. The dehydrated precursors are premixed prior to in situ therapy and utilize naturally-occurring body fluids as an aqueous environment that init... | 03/09/2004 |
| 6689148 | Methods and apparatus for intraluminal deposition of hydrogels Methods and apparatus of forming hydrogel systems in situ are provided using a delivery system configured to deliver two or more fluent prepolymer solutions without premature crosslinking. The delivery system comprises separate first and second lumens cou... | 02/10/2004 |
| 6673093 | Methods and apparatus for in situ formation of hydrogels Methods and apparatus of forming in situ tissue adherent barriers are provided using a sprayer capable of applying two or more viscous crosslinkable components to tissue. The sprayer comprises separate spray nozzles for each of two or more crosslinkable s... | 01/06/2004 |
| 6632457 | Composite hydrogel drug delivery systems Compositions and methods are provided to control the release of relatively low molecular weight therapeutic species through hydrogels by first dispersing or dissolving such therapeutic species within relatively hydrophobic rate modifying agents to form a ... | 10/14/2003 |
| 6610033 | Dual component medicinal polymer delivery system and methods of use The present invention provides apparatus and methods for making and using a medicinal polymer formed from two components. The apparatus includes a double syringe holder housing first and second syringes that is adapted to be coupled with a predetermined o... | 08/26/2003 |
| 6566406 | Biocompatible crosslinked polymers Biocompatible crosslinked polymers, and methods for their preparation and use, are disclosed in which the biocompatible crosslinked polymers are formed from water soluble precursors having electrophilic and nucleophilic groups capable of reacting and cros... | 05/20/2003 |
| 6514534 | Methods for forming regional tissue adherent barriers and drug delivery systems Methods are provided for forming hydrogel barriers in situ that adhere to tissue and prevent the formation of post-surgical adhesions or deliver drugs or other therapeutic agents to a body cavity. The hydrogels are crosslinked, resorb or degrade over a pe... | 02/04/2003 |
