Assignee: Immunivest Corporation

Location: Wilmington, DE
No. of patents: 34

Browse patents
Browse applications

Number	Title	Issue Date
7332288	Methods and reagents for the rapid and efficient isolation of circulating cancer cells A highly sensitive assay is disclosed which combines immunomagnetic enrichment with multiparameter flow cytometric and immunocytochemical analysis to detect, enumerate and characterize carcinoma cells in the blood. The assay can detect one epithelial cell or less in...	02/19/2008
7282180	Devices and methods to image objects Devices and methods for automated collection and image analysis are disclosed that enable identification or classification of microscopic objects aligned or deposited on surfaces. Such objects, e.g. detectably labeled rare target cells, are magnetically or non-magne...	10/16/2007
7282350	Labeled cell sets for use as functional controls in rare cell detection assays Methods and kits for used as an internal or external control in rare cell analysis are disclosed. A plurality of fluorescently distinct sets of cells is used to define a range to assess the isolation of rare target cells from a sample. Thus, a known number of cells,...	10/16/2007
7011794	Upon a cartridge for containing a specimen sample for optical analysis An improved cartridge for holding a fluid sample with a small volume is disclosed herein. The cartridge has a test chamber and a vestibule through which the test fluids are inserted into the test chamber. Improved grips are flared-out to aid manipulation. The handle...	03/14/2006
6890426	Magnetic separation apparatus and methods Apparatuses and methods for separating, immobilizing, and quantifying biological substances from within a fluid medium. Biological substances are observed by employing a vessel (6) having a chamber therein, the vessel comprising a transparent collection wall ...	05/10/2005
6861259	Method of using a cartridge for containing a specimen sample for optical analysis A cartridge for holding a test specimen with an extremely small volume. The cartridge has a test chamber and a vestibule through which the test fluids are inserted into the test chamber. The cartridge has a stopper having a pair of seals, the first of which seals th...	03/01/2005
6790366	Magnetic separation apparatus and methods Apparatuses and methods for separating, immobilizing, and quantifying biological substances from within a fluid medium. Biological substances are observed by employing a vessel (6) having a chamber therein, the vessel comprising a transparent collection wall ...	09/14/2004
D491272	Autoprep instrument	06/08/2004
6660159	Magnetic separation apparatus and methods Apparatuses and methods for separating, immobilizing, and quantifying biological substances from within a fluid medium. Biological substances are observed by employing a vessel having a chamber therein, the vessel comprising a transparent collection wall....	12/09/2003
6645731	Methods and reagents for the rapid and efficient isolation of circulating cancer cells A highly sensitive assay is disclosed which combines immunomagnetic enrichment with multiparameter flow cytometric and immunocytochemical analysis to detect, enumerate and characterize carcinoma cells in the blood. The assay can detect one epithelial cell...	11/11/2003
6623982	Increased separation efficiency via controlled aggregation of magnetic nanoparticles Compositions and methods are disclosed which enhance the microscopic observation and analysis of biological entities such as cells, bacteria and viruses by eliminating interfering magnetic clusters created by naturally occurring aggregators of colloidal m...	09/23/2003
6623983	Apparatus and methods for capture and analysis of particulate entities Apparatus and methods are disclosed which facilitate immobilization of magnetically labelled particulate entities, e.g., cells, preferably in a defined pattern, on a collection surface via binding between specific binding pair members, as an aid to partic...	09/23/2003
6620627	Increased separation efficiency via controlled aggregation of magnetic nanoparticles Compositions and methods are disclosed which enhance the microscopic observation and analysis of biological entities such as cells, bacteria and viruses by eliminating interfering magnetic clusters created by naturally occurring aggregators of colloidal m...	09/16/2003
6551843	Methods for enhancing binding interactions between members of specific binding pairs Disclosed is a method that improves the efficiency of reactions between specific binding pairs. By translating one member of the pair through a suspension of the second member, or across a surface to which the second member is immobilized, collision and b...	04/22/2003
6365362	Methods and reagents for the rapid and efficient isolation of circulating cancer cells A highly sensitive assay is disclosed which combines immunomagnetic enrichment with multiparameter flow cytometric and immunocytochemical analysis to detect, enumerate and characterize carcinoma cells in the blood. The assay can detect one epithelial cell...	04/02/2002
6361749	Apparatus and methods for magnetic separation Separation apparatus and method for separating magnetic and/or magnetically-labeled particles from a test medium in a reaction chamber which incorporates baffles, a spinner, a stirrer, or a plunger operable to be displaced along a collection surface to de...	03/26/2002
6228624	Method to select and transfect cell subpopulations A method for transfecting and separating cells is disclosed. The method comprises preparing magnetic particles coated with genetic material and a cell-specific ligand, and using the particles to transfect target cells. The target cells may then be separat...	05/08/2001
6136182	Magnetic devices and sample chambers for examination and manipulation of cells An apparatus for observation of magnetically labeled cells comprises an arrangement of magnets that are configured in confrontation across a horizontal gap. The magnets are further configured to produce a substantially uniform vertically-directed gradient...	10/24/2000
6120856	Coated, resuspendable magnetically responsive, transition metal oxide particles and method for the preparation thereof The invention relates to an improved method for the manufacture of magnetically responsive particles, also called ferrofluids. The improved method involves a heat treatment step, which may occur at various times during the preparation of the materials, in...	09/19/2000
6013532	Methods for magnetic immobilization and manipulation of cells Microbiological entities, such as cells or microbes, are immobilized in a single-file linear array for optical analysis. Colloidal magnetic particles having a binding agent, such as ligand for attachment with a corresponding receptor, are bound to the ent...	01/11/2000
6013188	Methods for biological substance analysis employing internal magnetic gradients separation and an externally-applied transport force A method of qualitative analysis of microscopic biological specimens is disclosed in which the specimens are rendered magnetically responsive by immunosspecific binding with feuromagnetic colloid. The specimens are placed in a vessel having a feuromagneti...	01/11/2000
5993665	Quantitative cell analysis methods employing magnetic separation A method of quantitative analysis of microscopic biological specimens in a fluid medium is disclosed in which the specimens are rendered magnetically responsive by immunospecific binding with ferromagnetic colloid. A known quantity of magnetically-respons...	11/30/1999
5985153	Magnetic separation apparatus and methods employing an internal magnetic capture gradient and an external transport force The present invention relates to apparatus and methods for separating, immobilizing, and quantifying biological substances from within a fluid medium. Biological substances are observed by employing a high internal gradient magnetic capture structure form...	11/16/1999
5876593	Magnetic immobilization and manipulation of biological entities Biological entities such as cells, microbes, or components thereof are labeled with a magnetic colloid containing microscopic magnetic particles. The magnetic particles have a coating capable of biospecific or non-specific binding with the entities. An im...	03/02/1999
5795470	Magnetic separation apparatus A magnetic separation apparatus is disclosed herein. The apparatus includes a flow-through vessel defining a plenum and an inlet port for introducing fluid into the plenum. A hydrodynamic damping structure is provided between the inlet port and plenum for...	08/18/1998
5741714	Detection of bound analyte by magnetic partitioning and masking A method and apparatus for determining qualitatively or quantitatively the presence of analyte bound to a separation media without doing a bound/free separation. In the method, the bound fraction is collected in an assay region of a body of liquid which i...	04/21/1998
5698271	Methods for the manufacture of magnetically responsive particles The invention relates to an improved method for the manufacture of magnetically responsive particles, also called ferrofluids. The improved method involves a heat treatment step, which may occur at various times during the preparation of the materials, in...	12/16/1997
5660990	Surface immobilization of magnetically collected materials A method for determining the presence and/or concentration of a target substance e.g. protein, nucleic acid, bioparticle etc. in a fluid sample is provided. The method disclosed combines elements of immunoassays, coated cup assays and magnetic particle se...	08/26/1997
5646001	Affinity-binding separation and release of one or more selected subset of biological entities from a mixed population thereof A method for separation of a mixture of biological entities into at least three distinct, subpopulations. Different antibodies are provided, with each antibody bound to a solid support in a unique manner such that by a manipulation of the physical or chem...	07/08/1997
5622831	Methods and devices for manipulation of magnetically collected material Methods and devices are disclosed which are useful for collecting magnetic materials in either internally or externally generated magnetic gradient fields, followed by resuspension into solution with a simple manipulation of the magnetic device. The metho...	04/22/1997
5597531	Resuspendable coated magnetic particles and stable magnetic particle suspensions Stable suspensions of coated magnetic particles, preferably resuspendable bioactive particles particularly useful in Magnetic Resonance Imaging, are produced by disrupting, what are presumed to be, crystalline agglomerates of a parent particulate magnetic...	01/28/1997
5541072	Method for magnetic separation featuring magnetic particles in a multi-phase system Methods and devices are provided for separation of magnetic particles and/or magnetic-associated substances from non-magnetic associated substances and media. The methods are specifically applicable to biological separation, and utilize a phase phenomenon...	07/30/1996
5512332	Process of making resuspendable coated magnetic particles A method is provided for direct coating of transiently stable, colloidal particulate magnetic substrates with various synthetic or naturally-occurring polymers, particularly biologically-active peptides and proteins. The resulting coated resuspendable, co...	04/30/1996
5466574	Apparatus and methods for magnetic separation featuring external magnetic means A magnetic separator for isolating magnetically-labeled substances of interest, such as immunological agents, from a non-magnetic test medium using a method of high gradient magnetic separation. The target substance is contacted with microscopic magnetic ...	11/14/1995

PatentStorm

Quotables

PatentStorm News

Assignee: Immunivest Corporation