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| Number | Title | Issue Date |
| 7863019 | Interleukin-15 receptors There are disclosed Interleukin-15 Receptor (IL-15R) proteins, DNAs and expression vectors encoding IL-15R, and processes for producing IL-15R as products of recombinant cell cultures. ... | 01/04/2011 |
| 7736637 | Use of TRAIL polypeptides to induce apoptosis A novel cytokine designated TRAIL induces apoptosis of certain target cells, including cancer cells and virally infected cells. Isolated DNA sequences encoding TRAIL are disclosed, along with expression vectors and transformed host cells useful in producing TRAIL po... | 06/15/2010 |
| 7625553 | Method of treating cancer by administering an epithelum-derived T-cell factor Nucleic acid sequences which encode biologically active ETF, expression vectors which direct the expression of ETF, ETF polypeptides, antibodies which specifically bind ETF and processes for preparing the same are disclosed. Also disclosed are methods for treating o... | 12/01/2009 |
| 7446171 | SIGIRR DNA and polypeptides DNA encoding SIGIRR polypeptides and methods for using the encoded polypeptides are disclosed. ... | 11/04/2008 |
| 7384765 | Cell culture performance with betaine This invention relates generally to the field of cell culture. More particularly, the invention relates to improving viability of recombinant cell cultures and the yields of secreted polypeptides therefrom by the addition of betaine to the tissue culture medium.... | 06/10/2008 |
| 7361330 | Methods of using flt3-ligand in the treatment of fibrosarcoma Methods of treating a fibrosacroma using flt-3 ligand are disclosed, as well as methods of increasing the number of dendritic cells in a patient having a fibrosarcoma. ... | 04/22/2008 |
| 7288633 | Modified human thymic stromal lymphopoietin Modified, furin resistant human TSLP polypeptides and polynucleotides encoding the modified human TSLP polypeptides are provided. Pharmaceutical compositions, B and T cell activation agents, assays and methods of use are also described. ... | 10/30/2007 |
| 7285648 | IL-1 delta DNA and polypeptides DNA encoding IL-1 delta polypeptides and methods for using the DNA and encoded polypeptides are disclosed. ... | 10/23/2007 |
| 7264809 | Methods of inhibiting platelet activation and recruitment The present invention provides soluble CD39 polypeptides and compositions, and methods for inhibiting platelet activation and recruitment in a mammal comprising administering a soluble CD39 polypeptide. ... | 09/04/2007 |
| 7238499 | Trimeric macrophage scavenger receptor fusion proteins and encoding nucleic acids The present invention relates, in part, to a polypeptide domain having reduced immunogenicity that is capable of inducing trimers in heterologous polypeptides, fusion polypeptides comprising the trimer inducing domain, nucleic acids encoding the polypeptides of the ... | 07/03/2007 |
| 7211259 | 4-1BB polypeptides and DNA encoding 4-1BB polypeptides Novel 4-1BB ligand (4-1BB-L) polypeptides and a human cell surface receptor designated 4-1BB that binds 4-1BB-L are provided. Isolated 4-1BB-L-encoding and human 4-1BB-encoding DNA sequences, recombinant expression vectors comprising the isolated DNA sequences, and ... | 05/01/2007 |
| 7101982 | Control of ph transitions during chromatography The invention provides methods of controlling pH variations during chromatography. In particular embodiments, the invention includes equilibrating and eluting proteins from chromatography resins have a solid phase that possesses a charged functional group on its bac... | 09/05/2006 |
| 7091004 | Regulation of translation for recombinant protein production The invention provides cells that produce increased levels of recombinant protein by modulating the activity of translational regulator gene products that are downstream targets of PKB alpha, methods of making such cells, and methods of using such cells. Such transl... | 08/15/2006 |
| 7074408 | Use of integrin antagonists to inhibit angiogenesis The present invention provides methods and compositions for inhibiting the biological activity of integrins, for inhibiting endothelial cell migration. and for inhibiting angiogenesis. In particular, the invention provides compositions comprising ADAM disintegrin do... | 07/11/2006 |
| 7067118 | Methods of using mutant flt3-ligand polypeptides to induce cellular expansion A screening method for identifying mutant polypeptides having at least one amino acid difference from a wild type protein involved in a receptor-ligand interaction is disclosed. Also disclosed are mutant polypeptides of the hematopoietic growth factor flt3-Ligand (f... | 06/27/2006 |
| 7067475 | Tek antagonists The present invention provides Tek antagonists and methods of inhibiting angiogenesis in a mammal by administering Tek antagonists. The methods are particularly useful in treating diseases or conditions mediated by angiogenesis, such as solid tumors and diseases or ... | 06/27/2006 |
| 7067279 | Cell culture performance with betaine This invention relates generally to the field of cell culture. More particularly, the invention relates to improving viability of recombinant cell cultures and the yields of secreted polypeptides therefrom by the addition of betaine to the tissue culture medium.... | 06/27/2006 |
| 7057022 | Antibodies which specifically bind to TNF-R Tumor necrosis factor receptor proteins, DNAs and expression vectors encoding TNF receptors, and processes for producing TNF receptors as products of recombinant cell culture, are disclosed. ... | 06/06/2006 |
| 7052916 | Polypeptide analyses using stable isotope labeling Methods for incorporating a stable isotope into a protein or peptide fragment are disclosed. The methods include providing isolated isotope-labeled protein or peptide fragments and analyzing the isolated labeld fragments. In another aspect of the invention, methods ... | 05/30/2006 |
| 7045128 | Antibodies against flt3-ligand Ligands for flt3 receptors capable of transducing self-renewal signals to regulate the growth, proliferation or differentiation of progenitor cells and stem cells are disclosed. The invention is directed to anti-flt3-L antibodies and enzyme-linked immunosorbent assa... | 05/16/2006 |
| 7041282 | Ligands for flt3 receptors Ligands for flt3 receptors capable of transducing self-renewal signals to regulate the growth, proliferation or differentiation of progenitor cells and stem cells are disclosed. The invention is directed to flt3-L as an isolated protein, the DNA encoding the flt3-L,... | 05/09/2006 |
| 7041782 | Lectin ss3939 DNA and polypeptides The invention is directed to purified and isolated novel ss3939 polypeptides, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides, fragmented peptides deriv... | 05/09/2006 |
| 7037675 | Nucleic acid molecules encoding SIGIRR polypeptides The invention is directed to purified and isolated SIGIRR polypeptides and fragments thereof, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides, fragmente... | 05/02/2006 |
| 7014853 | Family of immunoregulators designated leukocyte immunoglobulin-like receptors (LIR) A new family of immunoreceptor molecules of the immunoglobulin superfamily, (LIR) polypeptides is described. Disclosed are sequences encoding LIR family members and their deduced amino acid sequences, polypeptides encoded by DNA that hybridize to oligonucleotide pro... | 03/21/2006 |
| 7001752 | Murine and human kinases The inventions is directed to purified and isolated novel murine and human kinase polypeptides, the nucleic acid encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides, fragment... | 02/21/2006 |
| 6974681 | Cell culture performance with vanadate The invention provides methods and compositions for improved in vitro culture of cells that make use of vanadate. The methods enhance cell survival thereby recovery of the polypeptide of interest produced in the cells is increased relative to cells grown without van... | 12/13/2005 |
| 6972327 | Regeneration of chromatography material The invention provides improved methods of regenerating and using affinity chromatography material, in particular Protein A affinity chromatography resins. ... | 12/06/2005 |
| 6958387 | Human serpin polypeptides This invention relates to Thypin, a new member of the human serpin polypeptide family, methods of making Thypin polypeptides and using these polypeptides to treat various medical disorders and to methods of screening for compounds that agonize or antagonize Thypin p... | 10/25/2005 |
| 6924124 | Feeding strategies for cell culture The invention is in the field of cell culture, particularly recombinant cell culture. More specifically, the invention relates to methods of fed batch CHO cell culture. ... | 08/02/2005 |
| 6897040 | Methods and host cells for improved cell culture The invention provides improved methods of recombinant protein production in cell culture. More specifically, the invention relates to the modulation of the IGF-1 signaling pathway in cells so as to improve production characteristics. ... | 05/24/2005 |
| 6887684 | MyD88 adapter-like proteins There are disclosed MAL-1 polypeptides and active fragments of MAL-1, including fragments that associate with IRAK2. Further disclosed are DNAs encoding the polypeptides and fragments as well as methods of using the DNAs and polypeptides. ... | 05/03/2005 |
| 6842704 | Crystalline TNF-α-converting enzyme and uses thereof A tumor necrosis factor-α converting enzyme (TACE) is produced, purified, and crystallized. The three-dimensional coordinates of the crystal are obtained by X-ray diffraction. The coordinates can be recorded on a computer readable medium, or are part of a video mem... | 01/11/2005 |
| 6838262 | Isolated DNA molecule encoding rank ligand Isolated ligands, DNAs encoding such ligands, and pharmaceutical compositions made therefrom, are disclosed. The isolated ligands can be used to regulate an immune response. The ligands are also useful in screening for inhibitors thereof. ... | 01/04/2005 |
| 6824773 | TWEAK receptor The present invention provides the TWEAK receptor and methods for identifying and using agonists and antagonists of the TWEAK receptor. In particular, the invention provides methods of screening for agonists and antagonists and for treating diseases or conditions me... | 11/30/2004 |
| 6794173 | Dendritic cell transmembrane serine protease Isolated Dendritic Cell Transmembrane Serine Proteases (DCTSPs), DNAs encoding such DCTSPs, and pharmaceutical and/or diagnostic compositions made therefrom, are disclosed. The isolated DCTSPs can be used to hydrolyze peptide bonds. The DCTSPs are also useful in scr... | 09/21/2004 |
| 6793919 | Methods for treating rheumatoid arthritis using IL-17 antagonists A method of treating a mammal afflicted with rheumatoid arthritis by administering to the mammal an antibody that binds IL-17R is disclosed. ... | 09/21/2004 |
| 6774224 | ULBP DNA and polypeptides The invention is directed to purified and isolated novel ULBP polypeptides, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides, fragmented peptides derived... | 08/10/2004 |
| 6762030 | Ligand for CD7 and methods for use thereof The invention relates to CD7 and the discovery of its cognate ligand, the K12 protein, and the identification and cloning of polynucletides that encode the murine homolog of the human K12. Also disclosed are methods of screening candidate molecules to determine pote... | 07/13/2004 |
| 6759223 | Calcium/calmodulin-dependent kinase The invention is directed to purified and isolated novel murine and human kinase polypeptides, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides, fragment... | 07/06/2004 |
| 6753166 | IL-1 eta DNA and polypeptides The invention is directed to novel, purified and isolated IL-1 eta polypeptides and fragments thereof, the polynucleotides encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides... | 06/22/2004 |
