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Napoleon Bonaparte ; When told of the Robert Fulton steamboat
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| Number | Title | Issue Date |
| 7943749 | Antimicrobial 2-deoxystreptamine compounds The present invention is directed to analogs of paromomycin having a variety of chemical functional groups attached at the 2″-O-position as well as their preparation and use as prophylactic or therapeutics against microbial infection. ... | 05/17/2011 |
| 7507810 | Compositions and their uses directed to IL-4R alpha Disclosed herein are compounds, compositions and methods for modulating the expression of IL-4R alpha in a cell, tissue or animal. Also provided are methods of target validation. Also provided are uses of disclosed compounds and compositions in the manufacture of a ... | 03/24/2009 |
| 7507808 | Modulation of endothelial lipase expression Compounds, compositions and methods are provided for modulating the expression of endothelial lipase. The compositions comprise oligonucleotides, targeted to nucleic acid encoding endothelial lipase. Methods of using these compounds for modulation of endothelial lip... | 03/24/2009 |
| 7491815 | Antisense modulation of C-reactive protein expression Antisense compounds, compositions and methods are provided for modulating the expression of C-reactive protein. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding C-reactive protein. Methods of ... | 02/17/2009 |
| 7425544 | Modulation of eIF4E expression Oligomeric compounds, compositions and methods are provided for modulating the expression of eIF4E. The antisense compounds may be single- or double-stranded and are targeted to nucleic acid encoding eIF4E. Methods of using these compounds for modulation of eIF4E ex... | 09/16/2008 |
| 7407943 | Antisense modulation of apolipoprotein B expression Antisense compounds, compositions and methods are provided for modulating the expression of apolipoprotein B. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding apolipoprotein B. Methods of usin... | 08/05/2008 |
| 7378516 | Synthesis of sulfurized oligonucleotides Methods for the formation of sulfurized oligonucleotides are provided. The methods allow for the formation of phosphorothioate linkages in the oligonucleotides or derivatives, without the need for complex solvent mixtures and repeated washing or solvent changes. Oli... | 05/27/2008 |
| 7312036 | Compositions for use in identification of viral hemorrhagic fever viruses The present invention provides oligonucleotide primers, compositions, and kits containing the same for rapid identification of viruses that cause viral hemorrhagic fevers by amplification of a segment of viral nucleic acid followed by molecular mass analysis. ... | 12/25/2007 |
| 7307069 | Antisense oligonucleotide modulation of STAT3 expression Compounds, compositions and methods are provided for inhibiting the expression of human STAT3. The compositions comprise antisense oligonucleotides targeted to nucleic acids encoding STAT3. Methods of using these oligonucleotides for inhibition of STAT3 expression a... | 12/11/2007 |
| 7285537 | Oligonucleotide therapeutic agent and methods of making same For use in controlling biologic functions in an organism, a stabilized oligonucleotide, preferably in a phosphotriester form, having a base sequence substantially complementary to a portion of messenger ribonucleic acid coding for a biological component, such as a p... | 10/23/2007 |
| 7235653 | Oligonucleotide compositions and methods for the modulation of the expression of B7 protein Compositions and methods for the treatment of asthma with oligonucleotides which specifically hybridize with nucleic acids encoding B7 proteins. ... | 06/26/2007 |
| 7227015 | Synthesis of sulfurized oligonucleotides Methods for the formation of sulfurized oligonucleotides are provided. The methods allow for the formation of phosphorothioate linkages in the oligonucleotides or derivatives, without the need for complex solvent mixtures and repeated washing or solvent changes. Oli... | 06/05/2007 |
| 7217510 | Methods for providing bacterial bioagent characterizing information The present invention relates generally to the field of investigational bioinformatics and more particularly to secondary structure defining databases. The present invention further relates to methods for interrogating a database as a source of molecular masses of k... | 05/15/2007 |
| 7202224 | Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase The present invention provides nucleoside compounds and certain derivatives thereof which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RN... | 04/10/2007 |
| 7199107 | Antisense modulation of kinesin-like 1 expression Antisense compounds, compositions and methods are provided for modulating the expression of kinesin-like 1. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding kinesin-like 1. Methods of using th... | 04/03/2007 |
| 7176303 | Modulation of STAT5 expression Compounds, compositions and methods are provided for modulating the expression of STAT5. The compositions comprise oligonucleotides, targeted to nucleic acid encoding STAT5. Methods of using these compounds for modulation of STAT5 expression and for diagnosis and tr... | 02/13/2007 |
| 7115580 | Antisense modulation of B7 protein expression Compositions and methods for the diagnosis, prevention and treatment of immune states and disorders amenable to treatment through modulation of T cell activation are provided. In accordance with preferred embodiments, oligonucleotides are provided which are specific... | 10/03/2006 |
| RE39324 | Pyrimidine derivatives and oligonucleotides containing same Compounds having structure (1) wherein R1 is —H a protecting group, a linker or a binding partner; and R2 and R34 are as defined in the specification. The invention also provides intermediates a... | 10/03/2006 |
| 7101993 | Oligonucleotides containing 2′-O-modified purines Compounds are provided containing purine nucleotides that bear moieties X at the 2′ position thereof wherein X is R1—(R2)n; R1 is C3-C20 alkyl, C4-C20 alkenyl or C2 | 09/05/2006 |
| 7067497 | Modulation of telomere length by oligonucleotides having a G-core sequence Modified oligonucleotides having a GGG motif sequence and a sufficient number of flanking nucleotides to modulate the telomere length of a chromosome are provided. Methods of modulating telomere length of a mammalian chromosome in vitro and in vivo are also provided... | 06/27/2006 |
| 7057062 | Process for manufacturing purified phosphorodiamidite A scalable process for purification of phosphorodiamidite includes steps of solubilizing a crude phosphorodiamidite in an apolar organic solvent, contacting the non-polar organic solvent with a polar phase comprising a polar organic solvent to remove impurities from... | 06/06/2006 |
| 7057027 | Enhanced triple-helix and double-helix formation with oligomers containing modified pyrimidines Novel oligomers are disclosed which have enhanced ability with respect to forming duplexes or triplexes compared with oligomers containing only conventional bases. The oligomers contain the bases 5-(1-propynyl)uracil, 5-(1-propynyl)cytosine or related analogs. The o... | 06/06/2006 |
| 7056896 | Carbohydrate or 2′-modified oligonucleotides having alternating internucleoside linkages Novel compounds that mimic and/or modulate the activity of wild-type nucleic acids. In general, the compounds are oligonucleotides which contain at least one region of 2′-modified nucleosides connected by alternating phosphodiester and phosphorothioate linkages. | 06/06/2006 |
| 7049432 | Oligonucleotides having alkylphosphonate linkages and methods for their preparation The present invention provides alkylphosphonate dimers and oligonucleotides prepared therefrom. The invention further provides novel methods for the preparation of these alkylphosphonate dimers. Methods for the preparation of substantially diastereomerically pure al... | 05/23/2006 |
| 7041816 | Process for the synthesis of oligomeric compounds Synthetic processes are provided wherein oligomeric compounds are prepared having phosphodiester, phosphorothioate, phosphorodithioate, or other covalent linkages. The oligomers have substantially reduced exocyclic adducts deriving from acrylonitrile or related cont... | 05/09/2006 |
| 7038037 | Method for sequential support-bound synthesis of conjugated oligomeric compounds A sequential support-bound synthesis method is disclosed for preparing a conjugated oligomeric compound, preferably a PNA-peptide conjugate or an oligonucleotide-peptide conjugate, using a bridging molecule having at least two N-protecting amino groups. A conjugated... | 05/02/2006 |
| 7037646 | Amine-derivatized nucleosides and oligonucleosides Nucleosides and oligonucleosides functionalized to include alkylamino functionality, and derivatives thereof. In certain embodiments, the compounds of the invention further include steroids, reporter molecules, reporter enzymes, lipophilic molecules, peptides or pro... | 05/02/2006 |
| 7033830 | Antisense modulation of MyD88 expression Antisense compounds, compositions and methods are provided for modulating the expression of MyD88. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding MyD88. Methods of using these compounds for ... | 04/25/2006 |
| 7030230 | Process of purifying phosphoramidites A process of purifying phosphoramidite precursors useful in inter alia synthesis of oligonucleotides comprises dissolving a crude phosphoramidite in a polar phase, adding a basic compound to the polar phase, adding a portion of water to the polar phase, contacting t... | 04/18/2006 |
| 7015315 | Gapped oligonucleotides Oligonucleotides and other macromolecules are provided which have increased nuclease resistance, substituent groups for increasing binding affinity to complementary strand, and subsequences of 2′-deoxy-erythro-pentofuranosyl nucleotides that activate RNase H. Such... | 03/21/2006 |
| 7002006 | Protection of nucleosides A process of manufacturing protected nucleosides comprises reacting a nucleoside with a protecting reagent in the presence of a regioselective activator to produce a regioselectively protected nucleoside. In some embodiments of the inventive method, an optionally su... | 02/21/2006 |
| 6991902 | Nucleobase heterocyclic combinatorialization Mixtures of chemical compounds are provided having antibacterial and other utility. The mixtures are formed, preferably in solution phase, from the reaction of a purine or pyrimiding heterocyclic scaffold with a set of related chemical substituients, optionally thro... | 01/31/2006 |
| 6974865 | C3′ -methylene hydrogen phosphonate oligomers and related compounds The present invention is directed to nucleoside monomers wherein the 3′-O atom is replaced with a methylene group. The present invention also provides oligomers comprising a plurality of such monomers which are linked by methylene phosphonate linkages. Further, me... | 12/13/2005 |
| 6967242 | Antimicrobial 2-deoxystreptamine compounds The present invention is directed to analogs of aminoglycoside compounds of the class having a glycosylated 2-deoxystreptamine (2-DOS) ring as well as their preparation and use as prophylactic or therapeutics against microbial infection. Compounds of the invention c... | 11/22/2005 |
| 6967247 | Deprotection of phosphorus in oligonucleotide synthesis A process for removing a phosphorus protecting group from a protected phosphate triester or phosphorothioate triester includes contacting a protected phosphate or phosphorothioate triester with a thiol compound that is not offensive to the olfactory senses. ... | 11/22/2005 |
| 6967079 | Pyrimidine derivatives for labeled binding partners Compounds having particular interest as labels and various novel uses in diagnostics and therapeutics are provided which have structure (1) wherein R1 is a binding partner, a linker or H; | 11/22/2005 |
| 6964950 | Antisense modulation of C-reactive protein expression Antisense compounds, compositions and methods are provided for modulating the expression of C-reactive protein. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding C-reactive protein. Methods of ... | 11/15/2005 |
| 6965025 | Antisense modulation of connective tissue growth factor expression Antisense compounds, compositions and methods are provided for modulating the expression of connective tissue growth factor. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding connective tissue ... | 11/15/2005 |
| 6951931 | Pyrimidine derivatives for labeled binding partners Compounds having structure (1) wherein R1 is —H a protecting group, a linker or a binding partner; and R2 and R34 are as defined in the specification. The invention also provides inte... | 10/04/2005 |
| 6942966 | Methods for processing chemical compounds having reactive functional groups Novel macrocyclic compounds are constructed to include large cyclic structures that are interrupted by at least one ring system. Each interrupting ring system includes two bridgehead atoms. Bridgehead atoms are bonded to one or more bridges that interconnect one or ... | 09/13/2005 |
