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| Number | Title | Issue Date |
| 8163291 | Methods for generating stably linked complexes composed of homodimers, homotetramers or dimers of dimers and uses The present invention concerns methods and compositions for stably tethered structures of defined compositions, which may have multiple functionalities and/or binding specificities. Particular embodiments concern homodimers comprising monomers that contain a dimeriz... | 04/24/2012 |
| 8158129 | Dimeric alpha interferon PEGylated site-specifically shows enhanced and prolonged efficacy in vivo The present invention concerns methods and compositions for forming PEGylated complexes of defined stoichiometry and structure. In preferred embodiments, the PEGylated complex is formed using dock-and-lock technology, by attaching a therapeutic agent to a DDD sequen... | 04/17/2012 |
| 8034352 | Tetrameric cytokines with improved biological activity The present invention concerns methods and compositions for forming cytokine-antibody complexes using dock-and-lock technology. In preferred embodiments, the cytokine-MAb DNL complex comprises an IgG antibody attached to two AD (anchor domain) moieties and four cyto... | 10/11/2011 |
| 8003111 | Dimeric alpha interferon pegylated site-specifically shows enhanced and prolonged efficacy in vivo The present invention concerns methods and compositions for forming PEGylated complexes of defined stoichiometry and structure. In preferred embodiments, the PEGylated complex is formed using dock-and-lock technology, by attaching a therapeutic agent to a DDD sequen... | 08/23/2011 |
| 7981398 | PEGylation by the dock and lock (DNL) technique The present invention concerns methods and compositions for forming PEGylated complexes of defined stoichiometry and structure. In preferred embodiments, the PEGylated complex is formed using dock-and-lock technology, by attaching a target agent to a DDD sequence an... | 07/19/2011 |
| 7906121 | Methods and compositions for generating bioactive assemblies of increased complexity and uses The present invention concerns methods and compositions for making and using bioactive assemblies of defined compositions, which may have multiple functionalities and/or binding specificities. In particular embodiments, the bioactive assembly is formed using dock-an... | 03/15/2011 |
| 7906118 | Modular method to prepare tetrameric cytokines with improved pharmacokinetics by the dock-and-lock (DNL) technology The present invention concerns methods and compositions for forming cytokine-antibody complexes using dock-and-lock technology. In preferred embodiments, the cytokine-MAb DNL complex comprises an IgG antibody attached to two AD (anchor domain) moieties and four cyto... | 03/15/2011 |
| 7901680 | Dock-and-lock (DNL) vaccines for cancer therapy The present invention concerns methods and compositions for forming anti-cancer vaccine DNL complexes using dock-and-lock technology. In preferred embodiments, the anti-cancer vaccine DNL complex comprises an antibody moiety that binds to dendritic cells, such as an... | 03/08/2011 |
| 7871622 | Stably tethered structures of defined compositions with multiple functions or binding specificities The present invention concerns methods and compositions for stably tethered structures of defined compositions with multiple functionalities and/or binding specificities. Particular embodiments concern stably tethered structures comprising a homodimer of a first mon... | 01/18/2011 |
| 7858070 | Multivalent immunoglobulin-based bioactive assemblies The present invention concerns methods and compositions for stably tethered structures of defined compositions, which may have multiple functionalities and/or binding specificities. Preferred embodiments concern hexameric stably tethered structures comprising one or... | 12/28/2010 |
| 7666400 | PEGylation by the dock and lock (DNL) technique The present invention concerns methods and compositions for forming PEGylated complexes of defined stoichiometry and structure. In preferred embodiments, the PEGylated complex is formed using dock-and-lock technology, by attaching a therapeutic agent to a DDD sequen... | 02/23/2010 |
| 7550143 | Methods for generating stably linked complexes composed of homodimers, homotetramers or dimers of dimers and uses The present invention concerns methods and compositions for stably tethered structures of defined compositions, which may have multiple functionalities and/or binding specificities. Particular embodiments concern homodimers comprising monomers that contain a dimeriz... | 06/23/2009 |
| 7534866 | Methods and compositions for generating bioactive assemblies of increased complexity and uses The present invention concerns methods and compositions for making and using bioactive assemblies of defined compositions, which may have multiple functionalities and/or binding specificities. In particular embodiments, the bioactive assembly is formed using dock-an... | 05/19/2009 |
| 7527787 | Multivalent immunoglobulin-based bioactive assemblies The present invention concerns methods and compositions for stably tethered structures of defined compositions, which may have multiple functionalities and/or binding specificities. Preferred embodiments concern hexameric stably tethered structures comprising one or... | 05/05/2009 |
| 7521056 | Stably tethered structures of defined compositions with multiple functions or binding specificities The present invention concerns methods and compositions for stably tethered structures of defined compositions with multiple functionalities and/or binding specificities. Particular embodiments concern stably tethered structures comprising a homodimer of a first mon... | 04/21/2009 |
| RE40535 | Anti-KC4 humanized monoclonal antibody and cells that express the antibody An anti-KC-4 humanized monoclonal antibody that comprises the variable regions of the light and heavy chains of the anti-KC-4 murine antibody, wherein the light chain has 7 amino acids and the heavy chain has 12 amino acids of the framework regions substituted with ... | 10/07/2008 |
