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| Number | Title | Issue Date |
| 6514713 | Methods of detecting BRCA1 mutations Methods for detecting BRCA1 mutations are provided. The methods include the steps of determining the amount of the BRCA1 polypeptide contained in a sample of the subject, and correlating the amount of BRCA1 to the presence of the BRCA1 gene mutation in th... | 02/04/2003 |
| 6482599 | Forms of prostate specific antigen (PSA) specific for benign prostatic hyperplasia (BPH) and methods of using such A substantially pure and isolated novel form of prostate specific antigen (PSA) is provided. The novel form of PSA of the present invention comprises at least one clip at Lys 182 of the amino acid sequence of a mature form of PSA. Preferably, the novel fo... | 11/19/2002 |
| 6284873 | Complex of human kallikrein 2 (hK2) and protease inhibitor-6 (PI-6) in prostate tumor tissue and methods of using the complex The present invention provides a novel complex of hK2 and PI-6 and methods of using the novel complex. The novel complexes of hK2 and PI-6 of the present invention exist at an elevated level in prostate cancer tissues. Therefore, the hK2-PI6 complexes of ... | 09/04/2001 |
| 6103237 | Stable variant hK2 polypeptide An isolated, purified variant hK2 polypeptide useful in preparing immunogenic compositions and vaccines is provided. The variant hK2 polypeptides are more stable to purification than wild type mature hK2 polypeptide.... | 08/15/2000 |
| 6093796 | Recombinant hK2 polypeptide An isolated, substantially homogenous pre-pro, pro or mature hK2 polypeptide is provided as well as biologically active variants or subunits thereof, including a biologically active variant pre-pro hK2 polypeptide having SEQ ID NO:19.... | 07/25/2000 |
| 6013471 | DNA encoding hK2 variant polypeptides Isolated nucleic acid molecules encoding variant hK2 polypeptides and fragments thereof, as well as expression cassettes and host cells comprising said nucleic acid molecules, are provided. Also provided is a method to express a nucleic acid molecule enco... | 01/11/2000 |
| 5879881 | Solid phase system for use in ligand-receptor assays A solid phase system for use in ligand-receptor assays, particularly immunoassays using monoclonal antibodies, is disclosed. The solid phase system comprises a porous matrix in which microspheres, bound with a receptor capable of capturing a target ligand... | 03/09/1999 |
| 5589574 | Assay for bone alkaline phosphatase Monoclonal antibodies highly specific for human bone alkaline phosphatase, especially in the presence of human liver alkaline phosphatase, and their use in assays for human bone alkaline phosphatase are disclosed. A kit using the antibodies in an assay fo... | 12/31/1996 |
| 5525473 | Assay for bone alkaline phosphatase Monoclonal antibodies highly specific for human bone alkaline phosphatase, especially in the presence of human liver alkaline phosphatase, and their use in assays for human bone alkaline phosphatase are disclosed. A kit using the antibodies in an assay fo... | 06/11/1996 |
| 5447838 | Protein-dye conjugate for confirmation of correct dilution of calibrators The present invention has multiple aspects that include an intermediate composition (i.e., a marked stock calibrator solution) for preparing diluted calibrator solutions that are marked in proportion to the amount of calibrator contained therein; a dilute... | 09/05/1995 |
| 5439829 | Immobilization of biologically active molecules by changing the Oxidation state of a chelated transition metal ion A chelating agent is covalently bonded to a biologically active molecule such as an enzyme or antibody, the biologically active molecule is contacted with a support containing a bound transition metal ion whereby the metal ion is chelated by the chelating... | 08/08/1995 |
| 5395754 | Membrane-based immunoassay method The present invention is directed to a membrane-based immunoassay method for an analyte of interest having at least two sterically separate antigenic sites. The method comprises providing a reactive membrane having a calibration zone and a test zone, wher... | 03/07/1995 |
| 5273743 | Trifunctional antibody-like compounds as a combined diagnostic and therapeutic agent The present invention has multiple aspects. In its first aspect the present invention is directed to a trifunctional antibody-like compound that has tissue, organ, cell or molecule specificity and which is capable of being bifunctional when immobilized, v... | 12/28/1993 |
| 5262524 | Method for the synthesis of trifunctional maleimide-antibody complex The present invention is directed to a method for extending the length of one of the three linker arms of the compound of Formula I in the production of novel trifunctional antibody-like compounds. Formula I is defined as follows: ##STR1## where... | 11/16/1993 |
| 5250297 | Tumor-associated antigen, antibodies, compositions and uses therefor A novel tumor-associated antigen expressed by lung adenocarcinoma is disclosed. The antigen, characterized by monoclonal antibody LA20207, has a molecular weight in the range of about 50,000 to about 80,000 daltons and an isoelectric point in the range of... | 10/05/1993 |
| 5242802 | Processes for the stabilization of prostate specific antigen in natural matrices Processes for preparing stable natural matrices for prostrate specific antigen (PSA) are disclosed. Biological carrier fluids for PSA obtained from a suitable mammal are modified to inhibit the activity of components of the biological fluids destabilizing... | 09/07/1993 |
| 5126250 | Method for the reduction of heterogeneity of monoclonal antibodies Novel methods for reducing the heterogeneity of secreted monoclonal antibodies are disclosed. The first method comprises incubating the heterogeneous antibodies at low pH for a length of time sufficient to convert the heterogeneous forms of antibodies int... | 06/30/1992 |
| 5120504 | Apparatus for immunoassays with vent chennels in the container side wall Disclosed herein is an improved apparatus for conducting immunoassays. The apparatus comprises a container, and a test zone to which is bound an antibody, typically a monoclonal antibody, or which is capable of extracting cells from a fluid sample. The te... | 06/09/1992 |
| 5112951 | Separation of anti-metal chelate antibodies The present invention provides a method for the separation of anti-metal chelate antibodies from non-specific proteins, including antibodies, by applying a preparation containing the anti-metal chelate antibodies to an oxo acid derivatized solid support a... | 05/12/1992 |
| 5091542 | Tris-maleimido compounds as intermediates in trifunctional antibody synthesis The present invention is directed to a compound for use as an intermediate in the production of novel trifunctional antibody-like compounds. More particularly, the present invention is directed to a compound of the formula: ##STR1## wherein X is... | 02/25/1992 |
| 5055289 | Interferon antibody therapeutic compositions having an extended serum half-life A complex of alpha-interferon with a monoclonal antibody complexes with the alpha-interferon without impairing its antiviral activity. The serum half-life of the interferon administered as the complex is substantially increased when compared to that of al... | 10/08/1991 |
| 5004606 | Non-covalent antibody-anthracycline immunocomplexes A composition comprising a non-covalent immunocomplex of an anthracycline agent and an antibody selected to bind a target antigen and enhance the cytotoxicity of the anthracycline agent is disclosed. In accordance with the invention, the efficacy of an an... | 04/02/1991 |
| 4754771 | Apparatus for washing beads An apparatus for washing and aspirating the wash solution from beads contained in receptacles. Adequate bead agitation and the washing of the entire bead surface is insured by use of a bearing surface at the interface between the bead and the apparatus.... | 07/05/1988 |
| 4727019 | Method and apparatus for immunoassays Disclosed herein is an apparatus and process for conducting ligand receptor assays. The apparatus comprises a first member which is a membrane or a filter to which is bound a receptor for the ligand or which is capable of extracting cells carrying the lig... | 02/23/1988 |
| 4632901 | Method and apparatus for immunoassays Disclosed herein is an apparatus and process for conducting immunoassays. The apparatus comprises a first member which is a membrane or a filter to which is bound an antibody, typically a monoclonal antibody, or which is capable of extracting cells from a... | 12/30/1986 |
| 4486530 | Immunometric assays using monoclonal antibodies "Two-site" or "sandwich" immunometric assay techniques for determination of the presence and/or concentration of antigenic substances in fluids using monoclonal antibodies are described and compared to conventional assays using polyclonal antibodies. Also... | 12/04/1984 |
