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Assignee: Hyal Pharmaceutical Corporation


Location: Mississauga, CA
No. of patents: 41

1    
NumberTitleIssue Date
6218373Formulations containing hyaluronic acid
A method of treating a disease of condition administering topically to the skin or exposed tissue of a human, a dosage amount of a pharmaceutical composition, said dosage comprising a therapeutically effective amount of a drug to treat said disease or con...
04/17/2001
6194392Treatment of conditions and disease
A combination for administration to a mammal which combination employs a therapeutically effective amount of a medicinal and/or therapeutic agent to treat a disease or condition and an amount of hyaluronic acid and/or salts thereof and/or homologues, anal...
02/27/2001
6147059Formulations containing hyaluronic acid
Pharmaceutical compositions from which effective non-toxic (to the patient) dosage amounts may be taken and applied to the skin and/or exposed tissue of a human, each effective dosage amount comprising pharmaceutical excipients suitable for topical applic...
11/14/2000
6140312Formulations containing hyaluronic acid
The invention relates to a method of rapidly transporting a drug to the epidermis and accumulating and maintaining the drug therein for a prolonged period of time comprising administration of a therapeutically efective non-toxic amount of the drug with an...
10/31/2000
6136793Formulations containing hyaluronic acid
A method of treating a disease or condition comprising administering topically to the skin or exposed tissue of a human, a dosage amount of a pharmaceutical composition, said dosage comprising a therapeutically effective amount of a drug to treat said dis...
10/24/2000
6103704Therapeutic methods using hyaluronic acid
A method of accumulating a drug and a form of hyaluronic acid in the skin and/or exposed tissue of a human includes topically administering a therapeutically effective dosage amount of a formulation which comprises at least 5 mg/cm2 of the form...
08/15/2000
6087344Formulations containing hyaluronic acid
Pharmaceutical compositions from which effective non-toxic (to the patient) dosage amounts may be taken and applied to the skin and/or exposed tissue of a human, each effective dosage amount comprising pharmaceutical excipients suitable for topical applic...
07/11/2000
6069135Use of hyaluronic acid or its derivatives to enhance delivery of therapeutic agents
A pharmaceutical composition is provided comprising: (1) an agent selected from a medicinal agent and a therapeutic agent and combinations thereof in a therapeutically effective amount to treat a disease or condition in humans who will benefit from the treatme...
05/30/2000
6048844Treatment of conditions and disease
A combination for administration to a mammal which combination employes a therapeutically effective amount of medicinal and/or therepeutic agent to treat a disease or condition and an amount of hyaluronic acid and/or salts thereof and/or homologues, analo...
04/11/2000
6022866Use of hyaluronic acid and forms to prevent arterial restenosis
A method is provided of inhibiting the narrowing of the vascular tubular walls of an animal by the proliferation of endothelial cells in the area of trauma after the vascular tubular walls have been traumatized, the method comprising the administration of...
02/08/2000
6017900Topical composition containing hyaluronic acid and nsaids
A pharmaceutical composition comprising a plurality of effective non-toxic dosage amounts of a composition for topical administration to the site of pathology or trauma of skin or exposed tissue of a human patient in need of treatment suffering from a dis...
01/25/2000
5990095Use of hyaluronic acid and forms to prevent arterial restenosis
This invention relates to a method of inhibiting the narrowing of the tubular walls of an animal with a form of hyaluronic acid....
11/23/1999
5990096Formulations containing hyaluronic acid
The invention relates to a method of controlling the unloading of a drug from the skin or exposed tissue of a human into the lymphatic system comprising transporting an effective dosage amount of the drug into the skin or exposed tissue by an effective no...
11/23/1999
5985850Compositions comprising hyaluronic acid and drugs
A dosage amount of a pharmaceutical composition comprising a therapeutically effective amount of an agent to treat a disease or condition involving underperfused tissue and pathological tissue in humans and a form of hyaluronic acid, wherein the form of h...
11/16/1999
5985851Use of hyaluronic acid or its derivatives in peritoneal dialysis and formulations thereof
A method of detoxifying a patient by peritoneal dialysis which patient will benefit from peritoneal dialysis treatment by involving underperfused or pathological tissue the administration of an agent suitable for peritoneal dialysis treatment, comprising ...
11/16/1999
5977088Formulations containing hyaluronic acid
Pharmaceutical compositions from which effective non-toxic (to the patient) dosage amounts may be taken and applied to the skin and/or exposed tissue of a human, each effective dosage amount comprising pharmaceutical excipients suitable for topical applic...
11/02/1999
5972906Treatment of mucous membrane disease, trauma or condition and for the relief of pain thereof
A method for the treatment of mucous membrane trauma disease or condition for the relief of pain associated therewith comprising administering topically an effective amount of a composition comprising an N.S.A.I.D. and a form of hyaluronic acid selected f...
10/26/1999
5962433Topical composition containing hyaluronic acid and NSAIDS
A pharmaceutical composition is provided comprising a plurality of effective non-toxic dosage amounts of a composition for topical administration to the site of pathology and/or trauma of skin and/or exposed tissue of a human patient in need of treatment ...
10/05/1999
5942498Formulations containing hyaluronic acid
Topically applied transdermally quick penetrating compositions containing a drug and hyaluronic acid and/or salts thereof and methods of treating diseases and conditions employing said compositions....
08/24/1999
5932560Treatment of conditions and disease
A combination for administration to a mammal which combination employs a therapeutically effective amount of a medicinal and/or therapeutic agent to treat a disease or condition and an amount of hyaluronic acid and/or salts thereof and/or homologues, anal...
08/03/1999
5929048Treatment of conditions and disease
A combination for administration to a mammal which combination employs a therapeutically effective amount of a medicinal and/or therapeutic agent to treat a disease or condition and an amount of hyaluronic acid and/or salts thereof and/or homologues, anal...
07/27/1999
5914322Treatment of disease and conditions
A topically applied transdermally penetrating systemic independent acting pharmaceutical combination and formulation for the treatment of a disease or condition of the skin and exposed tissue for example, basal cell carcinoma, the precancerous, often recu...
06/22/1999
5914314Use of a form of hyaluronic acid and a medicinal agent for reducing rejection of organs transplantation in mammals
A combination for administration to a mammal which combination employs a therapeutically effective amount of a medicinal and/or therapeutic agent to treat a disease or condition and an amount of hyaluronic acid and/or salts thereof and/or homologues, anal...
06/22/1999
5910489Topical composition containing hyaluronic acid and NSAIDS
A pharmaceutical composition comprising a plurality of effective non-toxic dosage amounts of a composition for topical administration to the site of pathology and/or trauma of skin and/or exposed tissue of a human patient in need of treatment suffering fr...
06/08/1999
5852002Treatment of conditions and disease
A combination for administration to a mammal which combination employs a therapeutically effective amount of a medicinal and/or therapeutic agent to treat a disease or condition and an amount of hyaluronic acid and/or salts thereof and/or homologues, anal...
12/22/1998
5847002Compositions, for inhibition, control and regression of angiogenesis, containing hyaluronic acid and NSAID
The use of: (a) a non-steroidal anti-inflammatory agent, and (b) hyaluronic acid and/or salts thereof and/or homologues, analogues, derivatives, complexes, esters, fragments, and subunits of hyaluronic acid, in the manufacture of a pharmaceutical composition f...
12/08/1998
5834444Hyaluronic acid and salts thereof inhibit arterial restenosis
A method is provided of preventing arterial restenosis of an animal after the arteries have been traumatized. The method comprises the administration of a therapeutically effective non-toxic amount of hyaluronic acid and/or pharmaceutically acceptable sal...
11/10/1998
5830882Compositions containing a form of hyaluronic acid and a medicinal agent for treating acne in mammals and methods for administration of such composition
A combination for administration to a mammal which combination employs a therapeutically effective amount of a medicinal and/or therapeutic agent to treat a disease or condition and an amount of hyaluronic acid and/or salts thereof and/or homologues, anal...
11/03/1998
5827834Method of using hyaluronic acid or its pharmaceutically acceptable salts for the treatment of disease
A method of treating anorectal disease is provided which comprises applying to anorectal tissue in need of such treatment an effective amount of a composition comprising a pharmaceutically acceptable carrier and hyaluronic acid or a pharmaceutically accep...
10/27/1998
5824658Topical composition containing hyaluronic acid and NSAIDS
A method of treating pain topically, said method comprising administering topically to the skin or exposed tissue of a human, a dosage amount of a pharmaceutical composition, said dosage amount comprising (1) a non-steroidal anti-inflammatory drug (NSAID)...
10/20/1998
5817642Clearing of atherosclerosis
A method of clearing atherosclerosis comprising the step of administering to a patient, at least one dosage amount of a pharmaceutical composition comprising an effective non-toxic amount of each of a chelating agent, a non-steroidal anti-inflammatory dru...
10/06/1998
5817644Targeting of dosages of medicine and therapeutic agents
A method of treating a disease or condition in a human treatable by a medicine and/or therapeutic agent which may be transported by an agent to the site in need of treatment in the body and which agent may also transport the medicine and/or therapeutic ag...
10/06/1998
5811410Method of administering of a hyaluronic acid and an NSAID to decrease side effects of the NSAID
A method of administering a medicinal agent and an effective amount of a form of hyaluronic acid for decreasing side effects associated with using the agent alone in treating a disease or condition in mammals is disclosed. The agent may be a non-steroidal...
09/22/1998
5792753Compositions comprising hyaluronic acid and prostaglandin-synthesis-inhibiting drugs
A topically administrable pharmaceutical composition is disclosed which comprises a therapeutically effective amount of a drug which inhibits prostaglandin synthesis, and an amount of a form of hyaluronic acid sufficient to transport the composition throu...
08/11/1998
5767106Treatment of disease and conditions associated with macrophage infiltration
A method of treating a human having a disease or condition characterized by macrophage, neutrophile or other white blood cell infiltration into the area damaged by the disease or condition, the method comprising administering to the human an effective amo...
06/16/1998
5674857Use of hyaluronic acid to repair ischemia reperfusion damage
A pharmaceutical composition comprising an effective non-toxic amount of hyaluronic acid (HA) and or salts thereof and/or homologues, analogues, derivatives, complexes, esters, fragments and units of HA in association with a suitable diluent or pharmaceut...
10/07/1997
5639738Treatment of basal cell carcinoma and actinic keratosis employing hyaluronic acid and NSAIDs
A method of treating a mammal for a condition of the skin or exposed tissue selected from the group consisting of basal cell carcinoma and actinic keratosis is provided. The method consists essentially of topically administering to the site of the conditi...
06/17/1997
5614506Use of hyaluronic acid and forms to prevent arterial restenosis
For the prevention of the narrowing of the tubular walls of an animal after the tubular walls have been traumatized, the administration of a therapeutically effective non-toxic amount of hyaluronic acid and/or salts thereof and/or homologues, analogues, d...
03/25/1997
5079236Pure, sterile, pyrogen-free hyaluronic acid formulations their methods of preparation and methods of use
A heat stable, purified, pyrogen-free, heat sterilized fraction of hyaluronic acid suitable for use in formulations for intra-articular treatment of animals which includes minor amounts of sulphated mucopolysaccharides, sulphated ash, chlorides, solvents ...
01/07/1992
5077296Method for treating equine navicular disease with pentoxifylline, and composition containing pentoxifylline for administrating to horses
A method of treating a horse suffering from navicular disease which involves administering an amount of a composition including pentoxifylline in a daily dose for a sufficient period of time effective to alleviate lameness in horses resulting from navicul...
12/31/1991
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