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| Number | Title | Issue Date |
| 8440710 | HSL inhibitors useful in the treatment of diabetes The present invention relates to compounds of formula (I) as well as pharmaceutically acceptable salts thereof. The are useful as HSL inhibitors and may, for example, be used in treatment of diabetes, metabolic syndrome, dy... | 05/14/2013 |
| 8420818 | Process for the preparation of pyrido[2,1-a] isoquinoline derivatives The present invention relates to a novel process for the preparation of pyrido[2,1-a]isoquinoline derivatives of the formula wherein R2, R3 and R4 are each independently selected from the gr... | 04/16/2013 |
| 8420675 | Aminotetrahydroindazoloacetic acids The invention is concerned with the compounds of formula I: and pharmaceutically acceptable salts and esters thereof, wherein Q, W, X, R1—R5 and n are defined in the detailed description and claims. ... | 04/16/2013 |
| 8420661 | Arylethynyl derivatives The present invention relates to ethynyl compounds of formula I wherein R1, R2, R2′, R3, R3′, R4, R4′, U, V, W, Y, m, and n are as defined herein and to a pharmaceutically acceptable acid addition salts, ... | 04/16/2013 |
| 8420647 | 4-phenoxy-nicotinamide or 4-phenoxy-pyrimidine-5-carboxamide compounds This invention relates to novel phenyl amide or pyridyl amide derivatives of the formula wherein A1, A2, B1, B2 and R1 to R11 are as defined in the descripti... | 04/16/2013 |
| 8420633 | Aryl-cyclohexyl-tetraazabenzo[e]azulenes The present invention is concerned with aryl-cyclohexyl-tetraazabenzo[e]azulenes of formula I wherein R1, R2 and R3 are as described herein. The invention further provides methods for the ma... | 04/16/2013 |
| 8415380 | Pyridine and pyrimidine derivatives as MGLUR2 antagonists The present invention relates to compounds of formula (I) wherein A, B, Q, X, Y, R1, and R2 are as defined herein; pharmaceutical compositions containing them; a process for their manufacture; and meth... | 04/09/2013 |
| 8415379 | Pyridines The present invention is concerned with isoxazole-pyridines of formula I, having affinity and selectivity for GABA A α5 receptor, their manufacture, pharmaceutical compositions containing them and their use as pharmaceuticals. The active compounds of the present in... | 04/09/2013 |
| 8415350 | Benzoyl-piperidine derivatives as dual modulators of the 5-HTand Dreceptors The present invention relates to compounds of the general formula as dual modulators of the 5-HT2a and D3 receptors useful against CNS disorders, wherein A, R1, R2, n, p, q and r ... | 04/09/2013 |
| 8410117 | Imidazopyrimidine derivatives The invention is concerned with novel imidazopyrimidine derivatives of formula (I) wherein R1, R2 and R8 are as defined in the description and in the claims, as well as physiologically accep... | 04/02/2013 |
| 8410107 | -pyridin-3-yl or -pyrazin-2-yl carboxamides The present invention relates to compounds of formula I, wherein A, R1 to R7 are defined in the description, and to pharmaceutically acceptable salts thereof. The present invention also relates to the ... | 04/02/2013 |
| 8410104 | Pyridazines The present invention is concerned with isoxazole-pyridazines of formula I, having affinity and selectivity for GABA A α5 receptor, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compoun... | 04/02/2013 |
| 8404859 | Thiazole and thiophene compounds Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositi... | 03/26/2013 |
| 8404738 | 4-amino-N-hydroxy-benzamides for the treatment of cancer The present invention provides compounds of formula or pharmaceutically acceptable salts, esters or stereoisomers thereof, wherein R1 to R4, A and Y have the meanings given herein, as well as methods f... | 03/26/2013 |
| 8404708 | Dual NK1/NK3 receptor antagonists The present invention provides a method for the treatment of schizophrenia which comprises administering a compound of formula wherein the substituents are as described herein or a pharmaceutically ... | 03/26/2013 |
| 8404680 | N-[3-(5-amino-3,3a,7,7a-tetrahydro-1H-2,4-dioxa-6-aza-inden-7-yl)-phenyl]-amides as BACE1 and/or BACE2 inhibitors The present invention relates to N-[3-(5-Amino-3,3a,7,7a-tetrahydro-1H-2,4-dioxa-6-aza-inden-7-yl)-phenyl]-amides of formula I having BACE1 and/or BACE2 inhibitory activity, their manufacture, pharmaceutical compositions co... | 03/26/2013 |
| 8404679 | Pyrrolidine derivatives as NK2 receptor antagonists The present invention relates to compounds of formula I wherein R1, R2, R3, Ar and n are as defined herein and pharmaceutically active salts, racemic mixtures, enantiomers, optical isomers o... | 03/26/2013 |
| 8404673 | Carbocyclic GlyT1 receptor antagonists The present invention relates to the use of a compound of formula I wherein R1, R2, R3, R4, X and n are as defined herein or to a pharmaceutically acceptable acid additi... | 03/26/2013 |
| 8399626 | Antibodies against human angiopoietin 2 The present invention relates to antibodies against human Angiopoietin 2 (anti-ANG-2 antibodies), methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof. ... | 03/19/2013 |
| 8399463 | Imidazole derivatives The invention relates to imidazole derivatives which have a good affinity to the trace amine associated receptors (TAARs), especially for TAAR1. The invention also relates to a pharmaceutically-suitable acid-addition salt of the above compound. The inv... | 03/19/2013 |
| 8399459 | 1,4 oxazines as BACE1 and/or BACE2 inhibitors The present invention provides 1,4 Oxazines of formula I having BACE1 and/or BACE2 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The ... | 03/19/2013 |
| 8389717 | Modulators for amyloid beta The invention relates to compounds of formula wherein R1, R2, R3, R4, and Ar are as defined in the specification and claims, or to pharmaceutically active acid addition salts of such compounds. Compoun... | 03/05/2013 |
| 8389550 | Isoxazoles / O-pyridines with ethyl and ethenyl linker The present invention is concerned with novel isoxazole-pyridines of formula I wherein R1, R2, R3 and L are as described herein, as well as pharmaceutically acceptable salts and esters there... | 03/05/2013 |
| 8389536 | Positive allosteric modulators (PAM) The present invention relates to phenylethynyl compounds of formula I wherein R1, R2, X, L, R3, R4, R4′, cyc, and n are as defined in the specification and ... | 03/05/2013 |
| 8389513 | 2-amino-5,5-difluoro-5,6-dihydro-4H-[1,3]oxazin-4-yl)-phenyl]-amides The present invention relates to 2-Amino-5,5-difluoro-5,6-dihydro-4H-[1,3]oxazin-4-yl)-phenyl]-amides of formula I having BACE1 and/or BACE2 inhibitory activity, their manufacture, pharmaceutical compositions containing the... | 03/05/2013 |
| 8389507 | 2-azetidinemethaneamines and 2-pyrrolidinemethaneamines as TAAR-ligands The present invention relates to compounds of formula I wherein R1, R2, R3, Ar, n and o are as defined herein and to their pharmaceutically acceptable active salts. Compounds of fo... | 03/05/2013 |
| 8388961 | Cytotoxicity mediation of cells evidencing surface expression of CD44 This invention relates to the diagnosis and treatment of cancerous diseases, particularly to the mediation of cytotoxicity of primary and metastatic human tumor cells; and most particularly to the use of an isolated monoclonal antibody or cancerous disease modifying... | 03/05/2013 |
| 8367838 | Amines or amino alcohols as GLYT1 inhibitors The invention relates to the use of compounds of formula I wherein the substituents are described in the description and claims for the treatment of psychoses, dysfunction in memory and learning, schizophrenia, dementia, at... | 02/05/2013 |
| 8362023 | Pyrazolo pyrimidines Compounds of formula and pharmaceutically acceptable salts thereof are described, as well as the pharmaceutical compositions containing said compounds and their pharmaceutically acceptable salts, an... | 01/29/2013 |
| 8361747 | Antibodies against human angiopoietin 2 The present invention relates to antibodies against human Angiopoietin 2 (anti-ANG-2 antibodies), methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof. ... | 01/29/2013 |
| 8357712 | 4,5-dihydro-oxazol-2yl derivatives The invention relates to compounds of formula I wherein R1, R2, X, Y, and n are defined in the specification and to pharmaceutically acceptable acid addition salts thereof. The invention also... | 01/22/2013 |
| 8357703 | Pyridines The present invention is concerned with novel isoxazoles of formula I wherein X, R1, R2, R3 and R4 are as described herein, as well as pharmaceutically acceptable salts and esters... | 01/22/2013 |
| 8354516 | Polypeptide producing cells The current invention describes a nucleic acid comprising in a 5′ to 3′ direction a) a first nucleic acid encoding a heterologous polypeptide without an in frame stop codon, b) a second nucleic acid beginning with a 5′ splice donor site and terminated by a 3â€... | 01/15/2013 |
| 8354444 | Substituted pyrrolidine-2-carboxamides There are provided compounds of the formula wherein X, Y, R1, R2, R3, R3, R4, R5, R6 and R7 are as described herein and enant... | 01/15/2013 |
| 8354443 | Cyclopropane indolinone derivatives The present invention relates to a compound of formula (I) as well as pharmaceutically acceptable salt thereof, wherein R1 to R4 have the significance given in claim 1. The compound may be used,... | 01/15/2013 |
| 8354441 | Oxazoline derivatives The invention relates to compounds of formula I wherein the definitions of X, R and R1 are as defined herein. The compounds of formula I have a good affinity to the trace amine associated receptors (TAARs), espec... | 01/15/2013 |
| 8354102 | Antibodies directed to mGluR7 The present invention provides an antibody directed to an epitope of a G-protein coupled receptor, wherein the antibody binds to the extracellular N-terminal region of the receptor and the binding of the antibody to the G-protein coupled receptor induces receptor in... | 01/15/2013 |
| 8349893 | 4-trimethylammonio-butyrates as CPT2 inhibitors This invention relates to novel 4-trimethylammoniobutyrates of the formula wherein A1, R1, m and n are as defined in the description and in the claims, as well as pharmaceutically acceptable salts ther... | 01/08/2013 |
| 8349844 | Substituted pyrazolo [1,5-A] pyrimidines as metabotropic glutamate antagonists The present invention relates to compounds of formula (I) wherein A, E G, J, L, M, R1, R2, and R3 are as defined in the specification and claims. The invention also relates to pharmaceutical... | 01/08/2013 |
