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| Number | Title | Issue Date |
| 8178689 | Tricyclic compounds The present invention provides novel compounds of formula I, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the tre... | 05/15/2012 |
| 8163793 | Proline derivatives The invention relates to a compound of formula (I) wherein A, R1-R6 are as defined in the description and in the claims. The compound of formula (I) can be used as a medicament. ... | 04/24/2012 |
| 8163781 | Bi-aryl aminotetralines The invention is concerned with the compounds of formula I: and pharmaceutically acceptable salts and esters thereof, wherein R1-R5, A, B, Q, W, and X are defined in the detailed description and claims... | 04/24/2012 |
| 8153815 | Pseudoproline dipeptides Disclosed is a process for the manufacture of pseudo proline dipeptides of the formula wherein R1 is a side chain of an alpha amino acid, R2 is an amino protecting group and R3 and R4 | 04/10/2012 |
| 8143273 | Quinolizidine and indolizidine derivatives The present invention relates to a compound of formula I-A or I-B wherein X, R1, R2 and R3 are defined herein; or to a pharmaceutically acceptable acid add... | 03/27/2012 |
| 8138189 | Substituted benzene compounds as modulators of the glucocorticoid receptor The present invention relates to compounds of formula I wherein R.sup.1a to R.sup.1e and R.sup.2 to R.sup.5 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are gluc... | 03/20/2012 |
| 8129423 | Imidazolone and imidazoloidinone derivatives as 11b-HSD1 inhibitors Compounds of formula as well as pharmaceutically acceptable salts and esters thereof, wherein R1 to R6 have the significance given in claim 1 can be used in the form of pharmaceutical compositio... | 03/06/2012 |
| 8110187 | Purification and characterization of cytotoxic lymphocyte maturation factor and monoclonal antibodies thereto The present invention is a novel cytokine protein called IL-12 or Cytotoxic Lymphocyte Maturation Factor (CLMF) which is produced and synthesized by human NC-37 B lymphoblastoid cells (American Type Culture Collection, Rockville, Md.). CLMF synergistically induces w... | 02/07/2012 |
| 8088936 | Leukotriene B4 inhibitors Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositi... | 01/03/2012 |
| 8088815 | Spiroindolinone pyrrolidines There are provided compounds of the formula wherein X, Y and R1 to R8 are described herein along with the enantiomers, pharmaceutically acceptable salts and esters thereof. The compounds are useful as ... | 01/03/2012 |
| 8084609 | Spiropiperidine derivatives The present invention is concerned with novel spiro-piperidine derivatives as V1a receptor antagonists, their manufacture, pharmaceutical compositions containing them and their use for the treatment of anxiety and depressive disorders and other diseases. The compoun... | 12/27/2011 |
| 8076360 | Indoles The present invention is concerned with novel indol-2-yl-carbonyl-piperidine derivatives as V1a receptor antagonists, their manufacture, pharmaceutical compositions containing them and their use as medicaments. The active compounds of the present invention are usefu... | 12/13/2011 |
| 8071622 | Indoles The present invention is concerned with novel indol-2-yl-carbonyl-piperidin-benzoimidazolon and indol-2-yl-carbonyl-piperidin-benzoxazolon derivatives as V1a receptor antagonists, their manufacture, pharmaceutical compositions containing them and their use for the t... | 12/06/2011 |
| 8071571 | Orlistat compositions A pharmaceutical combination or composition containing a lipase inhibitor, preferably orlistat, and a bile acid sequestrant is useful for treating obesity. ... | 12/06/2011 |
| 8067599 | Imidazo [4,5-B] pyridine and pyrrolo [2,3-B] pyridine protein kinase inhibitors Objects of the present invention are the compounds of formula I their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, medicaments cont... | 11/29/2011 |
| 8067598 | Heterofused piperidines as orexin antagonists The present invention relates to compounds of formula wherein R1, R2, R3, and R4 are as defined herein and hetaryl is a one or two ring-membered heteroaromatic ring s... | 11/29/2011 |
| 8058269 | Oxindole derivatives There is provided compounds of the formula wherein R6, V, W, X, Y, Q and n are as described. The compounds exhibit activity as anticancer agents. ... | 11/15/2011 |
| 8044047 | 5-substituted benzoxazines The present invention is concerned with 5-substituted benzoxazine derivatives of formula (I) wherein X, R1 and R2 are as described herein, as well as their manufacture, pharmaceutical compositions cont... | 10/25/2011 |
| 8039624 | Azaspiro derivatives The present invention is concerned with novel indol-3-yl-carbonyl-azaspiropiperidine derivatives as V1a receptor antagonists, their manufacture, pharmaceutical compositions containing them and their use for the treatment of anxiety and depressive disorders and other... | 10/18/2011 |
| 8039495 | Biphenyl carboxylic acids and bioisosteres as glycogen synthase activators Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositi... | 10/18/2011 |
| 8026365 | 4,4-disubstituted piperidine derivatives This invention relates to 4,4-disubstituted piperidine derivatives of the formula wherein A and R1 to R5 are as defined in the specification, and pharmaceutically acceptable salts thereof. The inventio... | 09/27/2011 |
| 8026255 | Substituted piperidines as somatostatin receptor subtype 5 (SSTR5) antagonists This invention is concerned with compounds of the formula and pharmaceutically acceptable salts thereof. The invention further relates to pharmaceutical compositions containing such compounds, to a process for their prepara... | 09/27/2011 |
| 7989449 | 4,5-dihydro-oxazol-2-yl amine derivatives The present invention relates to a compounds of formula I wherein R1, R1′, R2, R3, R4, X, Ar, and m are as defined in the specification and claims and pharmaceuticall... | 08/02/2011 |
| 7973051 | Aminothiazoles as FBPase inhibitors for diabetes Compounds of formula (I) as well as pharmaceutically acceptable salts and esters thereof, wherein R1 to R3 have the significance given in claim 1 and which can be used in the form of pharmaceuti... | 07/05/2011 |
| 7968554 | Pyrazolo[3,4-d]pyrimidine derivatives Disclosed are novel pyrazolo[3,4-d]pyrimidine derivatives that are inhibitors of Raf kinase. These compounds and their pharmaceutically-acceptable salts and esters are anti-proliferative agents useful in the treatment or control of proliferative disorders such as so... | 06/28/2011 |
| 7956201 | Process for the preparation of (S)-4-fluoromethyl-dihydro-furan-2-one The present invention relates to a process of the preparation of (S)-4-fluoromethyl-dihydro-furan-2-one of the formula by employing a dialkylmalonate of the formula wherein R... | 06/07/2011 |
| 7956074 | Aryl-isoxazolo-4-yl-oxadiazole derivatives The present invention is concerned with isoxazol-4-yl-oxadiazole derivatives of formula wherein R1, R2, and R3, are as defined in the specification and... | 06/07/2011 |
| 7951824 | 4-aryl-pyridine-2-carboxyamide derivatives The present invention relates to novel pyridine-2-carboxyamide derivatives of formula (I) useful as metabotropic glutamate receptor antagonists: wherein Y, Z, R1, R2 and R3 are as defined in... | 05/31/2011 |
| 7939661 | Pyridine, quinoline and pyrimidine derivatives This invention is concerned with compounds of the formula wherein A, R1 to R5 are as defined in the specification and G is a pyridine, quinoline or pyrimidine group as defined in the specification, and... | 05/10/2011 |
| 7939535 | Benzo[D]isoxazol-3-yl-piperazin derivatives useful as modulators of dopamine D3 receptors The present invention provides compounds of the general formula (I), having affinity and selectivity for the dopamine D3 receptors, their manufacture, pharmaceutical compositions containing them and their use for the therapeutic and/or prophylactic treatment of cogn... | 05/10/2011 |
| 7935707 | Imidazole derivatives The invention is concerned with novel imidazole derivatives of formula (I), wherein m, E, R1, R2, R3, R4, R5, R6 ... | 05/03/2011 |
| 7932390 | Substituted thieno[3,2-C]pyridine carboxylic acid derivatives There are provided compounds of the formula wherein R1, R2, R3, X, ring A and ring B are as described. The compounds exhibit anticancer properties. ... | 04/26/2011 |
| 7928248 | Benzopyran and benzoxepin PI3K inhibitor compounds and methods of use Benzopyran and benzoxepin compounds of Formulas I and II, and including stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting lipid kinases including p110 alpha and other isoforms ... | 04/19/2011 |
| 7923028 | High dose oral formulation of bisphosphonate and a process for making thereof The invention relates to a high dose oral formulation of bisphosphonates and to a process for the preparation of such formulations. ... | 04/12/2011 |
| 7893278 | CIS-imidazolines The present invention relates to compounds of the formula and the pharmaceutically acceptable salts and esters thereof, a process for their manufacture, medicaments containing them as well as the use of these compounds as p... | 02/22/2011 |
| 7893099 | Cyclopentane derivatives The invention relates to a compound of formula (I) wherein A1 and R1 to R5 are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament. ... | 02/22/2011 |
| 7846896 | PEG conjugates of NK4 The present invention provides a conjugate consisting essentially of a NK4 molecule and a polyethylene glycol group having a molecular weight of from about 20 to about 40 kDa. The invention also provides a composition in which the monoPEGylated conjugates comprise a... | 12/07/2010 |
| 7875645 | Method for the treatment of CNS disorders with substituted 2-imidazoles or imidazole derivatives The present invention relates a method for treating depression, anxiety disorders, bipolar disorder, attention deficit hyperactivity disorder, stress-related disorders, psychotic disorders such as schizophrenia, neurological diseases such as Parkinson's disease, neu... | 01/25/2011 |
| 7858653 | 2-imidazoles The present invention relates to compounds of formula I, wherein X is —CH2— or —NH—; Y is —CH(lower alkoxy)-, —CH(lower alkyl)-, —O—, —S—, —S(O)—, —S(O)2 | 12/28/2010 |
| 7812161 | Synthesis of GlyT-1 inhibitors The present invention relates to a process for preparation of a compound of formula I wherein Het, R1, R2, R3, and n are as defined herein and pharmaceutic... | 10/12/2010 |
