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| Number | Title | Issue Date |
| 7122669 | Purine derivatives, preparation method and pharmaceutical compositions containing same Derivatives of purine having anti-proliferative properties and in particular, derivatives of purine endowed with an inhibitory effect vis-a-vis cycline-dependent kinase proteins i.e. abbreviated to “cdk”. ... | 10/17/2006 |
| 6455505 | Derivatives . . . use as medicaments A subject of the invention is, as new chemical products, the compounds of formula (I) ##STR1## in which X represents a hydrogen atom or a halogen atom and Z represents a hydrogen atom or the remainder of an acid as well as their addition salts with a... | 09/24/2002 |
| 6437157 | 20-substituted steroids A compound selected from the group consisting of a compound of the formula ##STR1## wherein R1 and R2 are individually selected from the group consisting of alkyl of 1 to 12 carbon atoms and aralkyl of 7 to 15 carbon atoms or taken t... | 08/20/2002 |
| 6328963 | Anti-human MP52 monoclonal antibody A mouse anti-human MP52 monoclonal antibody which binds to dimeric human MP52 but not to monomeric human MP52. This mouse monoclonal antibody comprising IgG and having a high specificity can be obtained by sensitizing mice with human MP52 (CHO-MP52) produ... | 12/11/2001 |
| 6313305 | Cephalosporins A compound having the formula selected from the group consisting of ##STR1## wherein either R3p and R4p are identical and selected from the group consisting of --OH, protected --OH and acyloxy of 1 to 8 carbon atoms, R2p i... | 11/06/2001 |
| 6271395 | Substituted with an N-methyl benzene-acetamide and 1-pyrrolidinyl A compound selected from the group consisting of enantiomers and diastereoisomer forms and mixtures thereof of the formula ##STR1## wherein the substituents are defined as in the application having a strong affinity for optical receptors, central analgesi... | 08/07/2001 |
| 6268520 | Tricyclic compounds Novel tricyclic compounds of formula I as defined in the specification, a process for their preparation and their use for the preparation of optically active or racemic colchicine and thiocolchicine derivatives.... | 07/31/2001 |
| 6235899 | Method for preparing alkyloxy furanone derivatives, compounds obtained by said method and use of said compounds The invention relates to a novel process for preparing compounds of the formula (IV) or (I): ##STR1## from the racemic alkoxyfuranone of the formula (II): ##STR2## R1 and R2 being as defined in the description, to the novel comp... | 05/22/2001 |
| 6221907 | Tricyclic compounds having activity specific for integrins, particularly alphanubeta3 integrins, method for preparing same, intermediates therefor, use of said compounds as drugs, and pharmaceutical compositions containing same The subject of the invention is the products of formula (I): ##STR1## in which R1, R2, R3, R4, R5 and G are as defined in the description, the dotted lines represent an optional second bond, as well a... | 04/24/2001 |
| 6218139 | Yeast strains possessing the interrupted ATF2 gene and their applications A subject of the invention is a modified yeast strain in which the acetyl-CoA pregnenolone acetyltransferase (APAT) activity is eliminated by altering the gene coding for this activity with resultant stabilization of 3ଲ-hydroxysteroids.... | 04/17/2001 |
| 6207657 | Steroids substituted in position 11, method of preparation, application as medicines and pharmaceutical compositions containing them The invention concerns steroid compounds of general formula (I) in which n=2, 3, either R1 and R2.dbd.H, (C1 -C4) alkyl, or R1 and R2 form with nitrogen a heterocyclic compound, X.dbd.OH op... | 03/27/2001 |
| 6194380 | Agents for promoting bone formation The object is to provide a promoting agent for bone formation, a therapeutic method for bone formation and a process for preparing a promoting agent for bone formation. A promoting agent for bone formation which comprises at least one of kistrin, echstati... | 02/27/2001 |
| 6194565 | Process for preparing 16 -methyl-steroids Intermediates for the compound of the formula ##STR1##... | 02/27/2001 |
| 6180386 | DNA sequences coding for the human proteins Tx and Ty related to the interleukin-1beta converting enzyme DNA sequences coding for human polypeptides with protease activity and capable of inducing apoptosis, related to the interleukin-1beta converting enzyme are disclosed.... | 01/30/2001 |
| 6177474 | Polyhydroxyphenol derivatives and preventive and therapeutic agents for bone and cartilage diseases containing the same Compounds useful as preventive and therapeutic agents for bone and cartilage diseases; and drug compositions containing the same. The compounds are polyhydroxyphenol derivatives of general formula (I) ##STR1## and quinione analogues derived therefrom (whe... | 01/23/2001 |
| 6171836 | Process for oxidation of steroids and genetically engineered cells used therein An expression cassette, operable in a recombinant host, comprising a heterologous DNA coding sequence encoding a protein, which is functional, alone or in cooperation with one or more additional proteins, of catalyzing an oxidation step in the biological ... | 01/09/2001 |
| 6162444 | Cosmetic or pharmaceutical compositions A cosmetic or pharmaceutical composition containing a dermatologically effective amount of at least one liposome containing a compound of the formula ##STR1##... | 12/19/2000 |
| 6162793 | Erythromycin derivatives, method for preparing same and use thereof as drugs The compounds of formula (I): ##STR1## in which R is a hydrogen atom, an alkyl, optionally substituted by a halogen atom or a (CH2)m Ar radical or a ##STR2## in which m represents an integer (1-8), n and p, identical or dif... | 12/19/2000 |
| 6147119 | Biphenyl compounds and use thereof as oestrogenic agents Compounds of formula (I), wherein [X] represents aromatic carbocyclic rings (A) and (B), where R1, R2, R3, R4, R5, R6 and R7 are as defined in the description, salts thereof, a method... | 11/14/2000 |
| 6143774 | Imidazole n-benzyldioxol derivatives, method for preparing same, resulting intermediates, pharmaceutical compositions and use of said derivatives as endothelin antagonists The invention relates to the new products of formula (I): ##STR1## in which: R1 represents alkyl, optionally substituted or cycloalkyl optionally interrupted by heteroatoms, R2 ; R3 both represent or carry an acid function... | 11/07/2000 |
| 6140340 | Derivatives of 2-[3-phenyl-2-propenyl]-1,2,3,4-tetrahydro isoquinoline, their process and their use as fungicides Derivatives of 2-[3-phenyl-2-propenyl]-1,2,3,4-tetrahydro-isoquinoline compounds of the formula in all their possible stereoisomer forms as well as their mixtures ##STR1## wherein X is nitrogen or --CH.dbd., R1, R2, --R3, R4, R5, R6 are individu... | 10/31/2000 |
| 6136981 | Preparation of 4-phenyl-1,2,3,6-tetrahydropyridines A process for the preparation of a compound of the formula ##STR1## wherein R1 is selected from the group consisting of hydrogen and alkyl of 1 to 8 carbon atoms, R2 and R4 are alkyl of 1 to 4 carbon atoms and R3... | 10/24/2000 |
| 6136842 | Sulphur derivatives comprising an amide bond, method for preparing same, use thereof as drugs, and pharmaceutical compositions containing such derivatives Products of formula (I), wherein n is 0 or 1, R1 is particularly phenyl or biphenyl optionally substituted particularly by benzyloxy, dioxol or halogen, R2 is particularly hydrogen or methyl substituted particularly by indolyl, pheny... | 10/24/2000 |
| 6121432 | Erythromycins Novel compounds of the formula ##STR1## wherein A is --OH and B forms with the 10-carbon a carbon--carbon double bond or A and B together form a carbonate or a carbamate, --OZ is selected from the group consisting of --OH, etherified hydroxy or ester... | 09/19/2000 |
| 6117994 | Intermediates for 16ଲ-methyl steroids A new process for the preparation of 16ଲ-methyl-steroids of the formula ##STR1## and novel intermediates.... | 09/12/2000 |
| 6114516 | Nucleotide sequences coding for variable regions of the 댜hains of human T lymphocyte receptors, corresponding peptide segments and the diagnostic and therapeutic muses The present invention relates to new nucleotide sequences coding for variable regions of the chains of human T lymphocyte receptors, corresponding peptide segments and the diagnostic and therapeutic uses.... | 09/05/2000 |
| 6107488 | Phenylimidazolidine preparation process A subject of the invention is a preparation process for the products of formula (I): ##STR1## in which R1 and R2 represent in particular hydrogen, cyano, halogen or amino,R3 represents in particular hydrogen or hydrox... | 08/22/2000 |
| 6103256 | Intravaginal drug delivery device An intravaginal drug delivery device comprising at least one active agent dispersed in a polymer matrix, wherein the concentration of active agent at the outer surface of the device at the time of use is not substantially higher than the concentration of ... | 08/15/2000 |
| 6100404 | Erythromycin compounds Intermediates for the preparation of compounds selected from the group consisting of a compound of the formula ##STR1## wherein R is ##STR2## n is an integer from 3 to 5, Ar is an optionally substituted heterocyclic selected from the group ... | 08/08/2000 |
| 6096714 | Erythromycin derivatives, method for preparing same, and use thereof as drugs A subject of the invention is the compounds of formula (I): ##STR1## in which: X represents a CH2 or SO2 radical or an oxygen atom, Y represents a (CH2)m --(CH.dbd.CH)n (CH2)o ... | 08/01/2000 |
| 6087509 | 1-Imidazolidinyl-phenyls A particular subject of the invention is the products of formula (I): ##STR1## in which: R1 and R2 represent in particular cyano and trifluoromethyl, R3 represents in particular alkyl, alkenyl or alkynyl, optionally s... | 07/11/2000 |
| 6039968 | Intravaginal drug delivery device The invention provides an intravaginal drug delivery system having a first intravaginal part comprising at least one active agent in a polymer matrix, said first part being provided in association with a second part comprising a removable polymer membrane... | 03/21/2000 |
| 6022965 | Method for isomerising the 10-methyl radical of erythromycin derivatives An isomerization method wherein a compound of formula ##STR1## wherein X and y together form a 3-oxo radical, or X is a hydrogen atom and Y is either a radical a ##STR2## where R2 is OH or O-acyl, or an O-alkyl or NH2 radic... | 02/08/2000 |
| 6020477 | DNA sequences coding for the human proteins Tx and Ty related to the interleukin-1ଲ converting enzyme An isolated DNA molecule consisting of SEQ I.D. No: 22 encoding a polypeptide having a protease activity and capable of inducing a apoptosis and the method of producing a polypeptide consisting of the said sequence.... | 02/01/2000 |
| 6013837 | Aromatic amides, method for preparing and compositions containing same, and use thereof as pesticides The subject of the invention is the compounds of formula (I): Q(CH2)a-(X1)b -Q1 -Q2 -C(X2)--N(R1)(R2) (I) in which: Q represents an aryl radical, X... | 01/11/2000 |
| 6011142 | 5-O-deosaminyl 6-O-methyl erythronolide A derivatives, preparation method therefor and use thereof for preparing biologically active materials A subject of the invention is the compounds of formula (I): ##STR1## in which R represents a carboxylic acid remainder containing up to 18 carbon atoms the products of formula (I) can be used to prepare antibiotic products.... | 01/04/2000 |
| 6005003 | Derivatives of dihydro or tetrahydronaphthalene, and the pharmaceutical compositions containing them A subject of the invention is the compounds of general formula (I): ##STR1## in which R1=H, alkyl, acyl, R2 and R3=H, alkyl, R4=aryl, heteroaryl, X=O, CH2, Y=OH, O-alkyl or NRaRb, as well as the salts, their preparation processes, the intermediates o... | 12/21/1999 |
| 6004979 | Nitrogenous bicycles Compounds of the formula ##STR1## in all possible racemic, enantiomeric and diastereoisomeric forms and their non-toxic, pharmaceutically acceptable salts with acids and bases having antagonistic properties for angiotensin II receptors and a process ... | 12/21/1999 |
| 6002006 | 1(2H) quinoline carboxylic acid derivatives, method for preparing same, and use thereof for synthesizing substances having antibiotic properties A compound of the formula ##STR1## wherein alc1, alc2 and alc3 are alkyl of up to 8 carbon atoms, n is an integer from 0 to 8, R1 and R2 are O-alkyl of up to 8 carbon atoms, or form together with... | 12/14/1999 |
| 5989881 | Nucleic acid molecules encoding delta-5,7-sterol, delta-7 reductase from arabidopsis thaliana A nucleic acid sequence containing a sequence coding for a protein having a delta-5,7 sterol, delta-7 reductase activity, said nucleic acid being a DNA or an RNA, production process, strains of transformed yeasts and uses thereof.... | 11/23/1999 |
