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| Number | Title | Issue Date |
| 8048993 | Heparanase specific molecular probes and their use in research and medical applications According to the present invention there is provided an antibody that specifically binds an epitope of a heparanase protein, the heparanase protein including an amino acid sequence as set forth in SEQ ID NO:2, provided that phenylalanine replaces tyrosine at positio... | 11/01/2011 |
| 7897145 | Methods for the treatment of renal failure The present invention relates to methods for treating renal failure. Particularly, the present invention relates to methods for treating renal failure by administering to a subject complexes that include a member of the IL-6 family linked to a soluble receptor of th... | 03/01/2011 |
| 7855075 | Methods of controlling proliferation and differentiation of stem and progenitor cells A method of ex-vivo expanding a population of stem cells, while at the same time inhibiting differentiation of the stem cells. The method comprises ex-vivo providing the stem cells with conditions for cell proliferation and with at least one copper chelator in an am... | 12/21/2010 |
| 7812142 | Pentose derivatives as anti-hyperglycemic drugs The present invention relates to pentose and pentose derivatives that are effective at increasing glucose transport in a non-insulin dependent manner, and to uses thereof for a) treating and/or preventing hyperglycemia; b) treating and/or preventing the complication... | 10/12/2010 |
| 7790376 | Heparanase specific molecular probes and their use in research and medical applications Heparanase specific molecular probes which can be used for detection of the presence, absence or level of heparanase expression and methods of utilizing same are provided. ... | 09/07/2010 |
| 7666651 | Polypeptide having heparanase activity A polynucleotide (hpa) encoding a polypeptide having heparanase activity, vectors including same, genetically modified cells expressing heparanase, a recombinant protein having heparanase activity and antisense oligonucleotides and constructs for modulating heparana... | 02/23/2010 |
| D597591 | Dosage calculator | 08/04/2009 |
| 7429489 | Methods of controlling proliferation and differentiation of stem and progenitor cells A method of ex-vivo expanding a population of stem cells, while at the same time inhibiting differentiation of the stem cells. The method comprises ex-vivo providing the stem cells with conditions for cell proliferation and with at least one copper chelator in an am... | 09/30/2008 |
| 7339038 | Heparanase specific molecular probes and their use in research and medical applications A variety of heparanase specific molecular probes which can be used for research and medical applications including diagnosis and therapy. Specific applications include the use of a heparanase specific molecular probe for detection of the presence, absence or level ... | 03/04/2008 |
| 7312078 | Methods of controlling proliferation and differentiation of stem and progenitor cells A method of ex-vivo expanding a population of stem cells, while at the same time inhibiting differentiation of the stem cells. The method comprises ex-vivo providing the stem cells with conditions for cell proliferation and with at least one copper chelator in an am... | 12/25/2007 |
| 7172749 | Radiolabeled irreversible inhibitors of epidermal growth factor receptor tyrosine kinase and their use in radioimaging and radiotherapy Radiolabeled epidermal growth factor receptor tyrosine kinase (EGFR-TK) irreversible inhibitors and their use as biomarkers for medicinal radioimaging such as Positron Emission Tomography (PET) and Single Photon Emission Computed Tomography (SPECT) and as radiopharm... | 02/06/2007 |
| 7169605 | Methods of controlling proliferation and differentiation of stem and progenitor cells A method of ex-vivo expanding a population of stem cells, while at the same time inhibiting differentiation of the stem cells. The method comprises ex-vivo providing the stem cells with conditions for cell proliferation and with at least one copper chelator in an am... | 01/30/2007 |
| 7049407 | Heparanase specific antibodies and their use in research and medical applications A variety of heparanase specific antibodies which can be used for research and medical applications including diagnosis and therapy. Specific applications include the use of a heparanase specific antibodies for detection of the presence, absence or level of heparana... | 05/23/2006 |
| 6986996 | Heparanase specific molecular probes and their use in research and medical applications A variety of heparanase specific molecular probes which can be used for research and medical applications including diagnosis and therapy. Specific applications include the use of a heparanase specific molecular probe for detection of the presence, absence or level ... | 01/17/2006 |
| 6960471 | Polynucleotide encoding a polypeptide having heparanase activity and expression of same in genetically modified cells A polynucleotide (hpa) encoding a polypeptide having heparanase activity, vectors including same, genetically modified cells expressing heparanase, a recombinant protein having heparanase activity and antisense oligonucleotides and constructs for modulating heparana... | 11/01/2005 |
| 6946131 | Heparanase activity neutralizing anti-heparanase monoclonal antibody A method of treating a condition associated with heparanase expression by administering a heparanase activity neutralizing monoclonal anti-heparanase antibody, the monoclonal anti-heparanase antibody being for neutralizing heparanase catalytic activity. ... | 09/20/2005 |
| 6830929 | In vitro construction of SV40 viruses and pseudoviruses The invention relates to constructs capable of infecting mammalian cells comprising at least one semi-purified or pure SV40 capsid protein and a constituent selected from the group consisting of an exogenous DNA, a vector comprising an exogenous DNA, an exogenous RN... | 12/14/2004 |
| 6800441 | Heparanase specific molecular probes and their use in research and medical applications A variety of heparanase specific molecular probes which can be used for research and medical applications including diagnosis and therapy. Specific applications include the use of a heparanase specific molecular probe for detection of the presence, absence or level ... | 10/05/2004 |
| 6790658 | Polynucleotide encoding a polypeptide having heparanase activity and expression of same in genetically modified cells A polynucleotide (hpa) encoding a polypeptide having heparanase activity, vectors including same, genetically modified cells expressing heparanase, a recombinant protein having heparanase activity and antisense oligonucleotides and constructs for modulating heparana... | 09/14/2004 |
| 6783775 | Serum-derived factor inducing cell differentiation and medical uses thereof The present invention relates to a biologically active serum-derived composition of matter (SDF), having a low molecular weight, being electrically charged at acidic pH and having absorption at 280 nm. The molecular weight of said SDF was determined by electron spra... | 08/31/2004 |
| 6719998 | Treatment of restenosis Bisphosphonate (BP), pyrophosphate (PP) a complex of BP or PP, a polymer of BP or PP or pharmaceutically acceptable salt or ester thereof, are used for the prevention or treatment of vascular restenosis. ... | 04/13/2004 |
| 6562829 | Treatment of hepatic cirrhosis A composition for treating hepatic fibrosis and a method of using and manufacturing the composition are provided. The composition includes a quinazolinone derivative, preferably Halofuginone.... | 05/13/2003 |
| 6562319 | Radiolabeled irreversible inhibitors of epidermal growth factor receptor tyrosine kinase and their use in radioimaging and radiotherapy Radiolabeled epidermal growth factor receptor tyrosine kinase (EGFR-TK) irreversible inhibitors and their use as biomarkers for medicinal radioimaging such as Positron Emission Tomography (PET) and Single Photon Emission Computed Tomography (SPECT) and as... | 05/13/2003 |
| 6562950 | Heparanase activity neutralizing anti-heparanase monoclonal antibody A monoclonal antibody elicited by a heparanase protein or an immunogenical portion thereof, the monoclonal antibody specifically inhibits heparanase activity.... | 05/13/2003 |
| 6544787 | Non-myeloablative/lymphoablative conditioning regimen to induce patient anti-donor unresponsiveness in stem cell transplantation Serious hematologic malignancies are treated through high dose or lethal chemotherapy and/or radiation therapy conditioning regimens followed by rescue with allogeneic stem cell transplantation (allo-SCT) or autologous stem cell transplantation (ASCT). Th... | 04/08/2003 |
| 6531129 | Heparanase specific molecular probes and their use in research and medical applications A variety of heparanase specific molecular probes which can be used for research and medical applications including diagnosis and therapy are disclosed. Specific applications include the use of a heparanase specific molecular probe for detection of the pr... | 03/11/2003 |
| 6447767 | Non-myeloablative tolerogenic treatment The present invention features a method of inducing donor-specific tolerance in a host. Tolerogenic treatments of the present invention may be administered to a host prior to transplantation of donor-derived materials. The tolerogenic treatment involves (... | 09/10/2002 |
| 6428782 | Non-myeloablative tolerogenic treatment The present invention features a method of inducing donor-specific tolerance in a host. Tolerogenic treatments of the present invention may be administered to a host prior to transplantation of donor-derived materials. The tolerogenic treatment involves (... | 08/06/2002 |
| 6410009 | Pharmaceutical composition for treating hepatitis B virus (HBV) infection The invention provides a pharmaceutical composition for the treatment of hepatitis B virus (HBV) infection, comprising an amount of a soluble active agent which interacts with at least one of the binding sites between hIL6 and pS1 and between hIL6 and hep... | 06/25/2002 |
| 6395496 | Method and kit for evaluating the metastatic tendency of tumors The present invention concerns a method for evaluating the metastatic tendency of tumor cells by determining the level of expression (mRNA level) of the gene coding for the thrombin receptor (ThR) or by determining the level of the thrombin receptor prese... | 05/28/2002 |
| 6368602 | Mucosal immunization against hepatitis A virus (HAV) through rectal administration of HAV vaccine A method for administering the HAV vaccine to a subject by absorption through a mucosal tissue, particularly through the mucosa of the rectum. The method of the present invention enables the HAV vaccine to be administered to the subject rectally, for exam... | 04/09/2002 |
| 6303155 | Treatment of conditions associated with impairment in the level of the parathyroid hormone A method for restoration of the circadian rhythm of parathyroid hormone (PTH) serum levels in a subject having osteoporosis, so as to restore a circadian rhythm of PTH levels which is similar to that existing in normal subjects is disclosed by administeri... | 10/16/2001 |
| 6190302 | Stereotactic radiotreatment and prevention of restenosis A method and apparatus for dynaimic stereotactic radiotreatment and prevention of restenosis. A stent is implanted in a coronary artery, following percutaneous transluminal coronary angioplasty. Subsequent restenosis is minimized by external irradiation o... | 02/20/2001 |
| 6183954 | Method for evaluating the metastatic tendency of tumors The present invention concerns a method for evaluating the metastatic tendency of tumor cells by determining the level of expression (mRNA level) of the gene coding for the thrombin receptor (ThR) or by determining the level of the thrombin receptor prese... | 02/06/2001 |
| 6146824 | Method for determining tumor cell adhesion The present invention concerns novel pharmaceutical compositions for the atment of cancer, either by inhibition of the tumor metastatic tendency or alternatively by inhibiting formation of new blood vessels (angiogenesis) and thus depriving the tumor fro... | 11/14/2000 |
| 6143292 | Allogeneic cell therapy for cancer following allogeneic stem cell transplantation A method of treating a human cancer patient having a solid tumor comprising malignant cells is disclosed, wherein the patient having undergone a cancer therapy regimen comprising allogeneic stem cell transplantation. The method comprises administering all... | 11/07/2000 |
| 6126917 | Epidermal growth factor receptor binding compounds for positron emission tomography A radiolabeled compound of a formula: ##STR1## is described. R1 and R2 are each independently selected from the group consisting of hydrogen, alkyl, hydroxy, alkoxy, halo, haloalkyl, carboxy, carbalkoxy and salts thereof; and A, B, C and D are each i... | 10/03/2000 |
| 6090608 | SV-40 derived DNA constructs comprising exogenous DNA sequences The invention relates to DNA constructs comprising an exogenous DNA sequence encoding a therapeutic protein product or itself a therapeutic product, DNA sequences derived from SV40 for replication and packaging of said construct into pseudovirions, and a ... | 07/18/2000 |
| 5935607 | Treatment of osteoporosis A method of treating osteoporosis is disclosed by administering orally a single daily dosage of phosphate in the evening in an amount, e.g., about 10 mg/kg body weight or less which is effective to raise serum parathyroid hormone levels of the subject bei... | 08/10/1999 |
| 5928639 | Immunotherapy of cancer with allogeneic lymphocytes Methods have been discovered for treating minimal residual disease following removal of most or a substantial fraction of malignant cells from a cancer patient. An autologous stem cell transplant is performed on the patient. Following partial hematopoiesi... | 07/27/1999 |
