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| Number | Title | Issue Date |
| 8138220 | [2-(6-fluoro-1H-indol-3-ylsulfanyl)benzyl]methyl amine for the treatment of affective disorders [2-(6-fluoro-1H-indol-3-ylsulfanyl)benzyl]methyl amine and pharmaceutically acceptable salts thereof, provided it is not the free base in a non-crystalline form are provided for the treatment of affective disorders. ... | 03/20/2012 |
| 8110567 | Phenyl-piperazine derivatives as serotonin reuptake inhibitors The invention provides compounds represented by the general formula I wherein the substituents are defined in the application. The compounds are useful in the treatment of an affective disorder, including depression, anxiet... | 02/07/2012 |
| 8067640 | Method for the separation of intermediates which may be used for the preparation of escitalopram The present invention relates to a novel method for the preparation of diol intermediates having the formula (II) and/or the opposite enantiomer of an acylated diol having the formula (IV) useful for the preparation of escitalopram involving selective enzymatic acyl... | 11/29/2011 |
| 8067410 | Phenolic and catecholic amines and prodrugs thereof The present invention relates to novel phenolic and catecholic amines of Formula I, to processes for their preparation, pharmaceutical compositions containing them, to their use in therapy and to their use in radiolabeled form as PET- or SPECT ligands. ... | 11/29/2011 |
| 8022232 | Method for manufacture of escitalopram This patent discloses a method for resolution of 4-[4-(dimethylamino)-1-(4′-fluorophenyl)-1-hydroxybutyl]-3-(hydroxymethyl)-benzonitrile as a racemic or non-racemic enantiomer mixture into its isolated enantiomers, said method comprising the step of fractionally c... | 09/20/2011 |
| 8012962 | Substituted thiomorpholine derivatives The present invention relates to thiomorpholine derivatives of formula I or pharmaceutically acceptable salts thereof and their use in treating seizure disorders, anxiety disorders, bipolar disorders, neuropathic pain disorders and migraine pain disorders. | 09/06/2011 |
| 7910613 | 2-acylaminothiazole derivatives The Invention relates to compounds of the formula I, wherein the variables are as defined in the claims, for use as a medicament. The compounds are A2A-receptor legends and are useful in the treatment of neurological and psychiatric disorders where an A | 03/22/2011 |
| 7906537 | Substituted p-diaminobenzene derivatives The present invention relates to aniline derivatives of the general formula I or pharmaceutically acceptable salts thereof and their use. ... | 03/15/2011 |
| 7834201 | Crystalline base of escitalopram and orodispersible tablets comprising escitalopram base The present invention relates to the crystalline base of the well known antidepressant drug escitalopram, S-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofurancarbonitrile, formulations of said base, a process for the preparation of purified s... | 11/16/2010 |
| 7834008 | Cyclopropyl derivatives as NK3 receptor antagonists The present invention relates to cyclopropyl derivatives of formula (I) and salt thereof. These compounds are NK3 receptor antagonists and may therefore be useful for treatment of diseases where the NK3 receptor is implicated, e.g. psychotic disorders. | 11/16/2010 |
| 7772240 | -1(6-chloro-3-phenylindan-1-yl)-3,3-dimethylpiperazine A compound 4-((1R,3S)-6-Chloro-3-phenylindan-1-yl)-2,2-dimethylpiperazine and salts thereof, pharmaceutical compositions comprising the compound and salts, and medical use thereof, including for treatment of schizophrenia and other psychotic disorders. ... | 08/10/2010 |
| 7767683 | Hydrogen succinate salts of trans-4-((1R, 3S)-6-chloro-3-phenylindan-1-YL)-1,2,2-trimethylpiperazine and the use as a medicament 4-((1R,3S)-6-Chloro-3-phenylindan-1-yl)-1,2,2-trimethylpiperazine hydrogen succinate, pharmaceutical compositions containing the salt and the medical use thereof, including for the treatment of schizophrenia and other psychotic disorders. Also described are methods ... | 08/03/2010 |
| 7737171 | Uses of 2-(1H-indolylsulfanyl)-benzyl amine derivatives as SSRIS The present invention relates to uses of 2-(1H-indolylsulfanyl)-benzyl amine derivatives of general formula (I): in the treatment of affective disorders. ... | 06/15/2010 |
| 7737170 | Uses of 2-(1H-indolylsulfanyl)-benzyl amine derivatives as SSRIS The present invention relates to uses of 2-(1H-indolylsulfanyl)-benzyl amine derivatives of general formula (I): in the treatment of affective disorders. ... | 06/15/2010 |
| 7732463 | 4-(2-phenylsulfanyl-phenyl)-piperidine derivatives as serotonin reuptake inhibitors The invention provides compounds represented by the general formula (I) wherein the substituents are defined in the application. The compounds are useful in the treatment of an affective disorder, including depression, anxiety disorders including general anxiety dis... | 06/08/2010 |
| 7723533 | Crystalline base of escitalopram and orodispersible tablets comprising escitalopram base The present invention relates to the crystalline base of the well known antidepressant drug escitalopram, S-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzo-furancarbonitrile, formulations of said base, a process for the preparation of purified ... | 05/25/2010 |
| 7687645 | Intermediates for the preparation of citalopram and escitalopram Methods for manufacture of 5-alkoxycarbonylphthtalides are disclosed. The 5-alkoxycarbonylphthtalides are useful in syntheses of the well-known antidepresssants citalopram and escitalopram. ... | 03/30/2010 |
| 7683053 | Phenyl-piperazine derivatives as serotonin reuptake inhibitors The invention provides compounds represented by the general formula I wherein the substituents are defined in the application. The compounds are useful in the treatment of an affective disorder, including depression, anxiet... | 03/23/2010 |
| 7678800 | 2-(1H-indolylsulfanyl)-aryl amine derivatives for use in the treatment of affective disorders, pain, ADHD and stress urinary incontinence The present invention relates to 2-(1H-indolylsulfanyl)-aryl amine derivatives of the general formula I as the free base or salts thereof and their use for the treatment of affective disorders, pain... | 03/16/2010 |
| 7652150 | 2-(1H-indolylsulfanyl)-benzyl amine derivatives as SSRIs The present invention relates to 2-(1H-indolylsulfanyl)-benzyl amine derivatives of general formula (I): which are useful as SSRIs, and pharmaceutical compositions comprising the compounds. ... | 01/26/2010 |
| 7648991 | Crystalline base of -1-(()-6-chloro-3-phenylindan-1-yl)-3,3-dimethylpiperazine Crystalline base of compound trans-1-((1R,3S)-6-chloro-3-phenylindan-1-yl)-3,3-dimethylpiperazine, processes for the preparation of purified free base or salts of this compound, pharmaceutical compositions comprising the base and medical use thereof, including for t... | 01/19/2010 |
| 7632835 | Substituted morpholine and thiomorpholine derivatives The present invention relates to morpholine and thiomorpholine derivatives or the general formula I or pharmaceutically acceptable salts thereof and their use. ... | 12/15/2009 |
| 7629473 | 2-(1H-indolylsulfanyl)-aryl amine derivatives The present invention relates to compounds of formula IV and their use. ... | 12/08/2009 |
| 7618967 | Indane compounds The invention provides novel indane compounds which are useful in the treatment of affective disorders, pain disorders, attention deficit hyperactivity disorder (ADHD), cognitive disorders, substance abuse, smoking cessation and stress urinary incontinence. ... | 11/17/2009 |
| 7612068 | Aromatic oxyphenyl and aromatic sulfanylphenyl derivatives The present invention relates to compounds of formula I wherein the substituents are as defined below. The compounds of formula I are useful for the treatment of diseases such as schizophrenia, including both the positive and the negative symptoms of schizophrenia a... | 11/03/2009 |
| 7601870 | Substituted aniline derivatives The present invention relates to aniline derivatives of the general formula I or salts thereof, described therein, and their use. ... | 10/13/2009 |
| 7560576 | Crystalline base of escitalopram and orodispersible tablets comprising escitalopram base The present invention relates to the crystalline base of the well known antidepressant drug escitalopram, S-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzo-furancarbonitrile, formulations of said base, a process for the preparation of purified ... | 07/14/2009 |
| 7544685 | 2,3-dihydroindole compounds The invention relates to compounds of the formula I wherein the variables are as defined in the claims. The compounds are useful in the treatment of a disease where a D4 receptor and/or a 5-HT2A receptor is impli... | 06/09/2009 |
| 7534791 | Benzo[b]furane and benzo[b]thiophene derivatives The present invention relates to benzo[b]furane and benzo[b]thiophene derivatives of the general formula IV as the free base or salts thereof and their use. ... | 05/19/2009 |
| 7517658 | Methods for preparing compositions using a SNORF33 receptor This invention provides isolated nucleic acids encoding mammalian SNORF33 receptors, purified mammalian SNORF33 receptors, vectors comprising nucleic acid encoding mammalian SNORF33 receptors, cells comprising such vectors, antibodies directed to mammalian SNORF33 r... | 04/14/2009 |
| 7501414 | Substituted morpholine and thiomorpholine derivatives The present invention relates to morpholine and thiomorpholine derivatives of the general formula I or pharmaceutically acceptable salts thereof and their use. ... | 03/10/2009 |
| 7446204 | Amino substituted aryloxybenzylpiperidine derivatives This invention is directed to Amino substituted Aryloxybenzylpiperidine derivatives which are ligands at the MCH1 receptor. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmac... | 11/04/2008 |
| 7416848 | DNA encoding SNORF25 receptor This invention provides isolated nucleic acids encoding mammalian SNORF25 receptors, purified mammalian SNORF25 receptors, vectors comprising nucleic acid encoding mammalian SNORF25 receptors, cells comprising such vectors, antibodies directed to mammalian SNORF25 r... | 08/26/2008 |
| 7393845 | Heteroaryl derivates, their preparation and use A heteroaryl derivative having the formula (I). The compounds of the invention are considered useful for the treatment of affective disorders such as general anxiety disorder, panic disorder, obsessive compulsive disorder, depression, social phobia and eating disord... | 07/01/2008 |
| 7393655 | Methods of identifying melanin concentrating hormone receptor antagonists This invention provides an isolated nucleic acid encoding a human MCH1 receptor, a purified human MCH1 receptor, vectors comprising isolated nucleic acid encoding a human MCH1 receptor, cells comprising such vectors, antibodies directed to a human MCH1 receptor, nuc... | 07/01/2008 |
| 7390913 | Process for the preparation of racemic citalopram diol and/or - or -citalopram diols and the use of such diols for the preparation of racemic citalopram, -citalopram and/or -citalopram In the following, citalopram diol means 4-(4-(dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl)-3-(hydroxymethyl)-benzonitrile, as free base and/or acid addition salt. The invention relates to a process for the preparation of racemic citalopram diol and/or R- or S-c... | 06/24/2008 |
| 7384957 | 3,4-dihydro-1H-isoquinolin-2-yl-derivatives The present invention relates to novel compounds of formula I wherein the variable groups are as defined in the claims or a pharmaceutically acceptable acid addition salt thereof. The compounds of the invention are NK2 antagonists. | 06/10/2008 |
| 7371863 | Method for manufacture of THIP The present invention relates to a new method of preparing gaboxadol (THIP), which is useful for treating sleep disorders. In particular a method of preparing THIP comprising reacting a compound of formula (8b) or a salt thereof with an acid, typically a mineral aci... | 05/13/2008 |
| 7371535 | Processes for determining compounds that interact with snorf33 receptor This invention provides isolated nucleic acids encoding mammalian SNORF33 receptors, purified mammalian SNORF33 receptors, vectors comprising nucleic acid encoding mammalian SNORF33 receptors, cells comprising such vectors, antibodies directed to mammalian SNORF33 r... | 05/13/2008 |
| 7368472 | 1,2,4-Triaminobenzene derivatives useful for treating disorders of the central nervous system The present invention concerns 1,2,4-triaminobenzene derivatives of the general formula I or pharmaceutically acceptable salts thereof and the use thereof. ... | 05/06/2008 |
