Assignee: Gruenenthal GmbH

Location: Aachen, DE
No. of patents: 234

Number	Title	Issue Date
8178684	Substituted nicotinamides as KCNQ2/3 modulators The invention relates to substituted nicotinamides, to processes for their preparation, to medicaments comprising these compounds and to the use of these compounds in the preparation of medicaments. ...	05/15/2012
8178535	Substituted sulfonamide compounds having bradykinin 1 receptor activity and use thereof as medicaments Substituted sulfonamide compounds corresponding to the formula I′ wherein m, n, p, X, Y, Z, R1, RA and RB have specified meanings, processes for their preparation, pharmaceutical compositions containing these compounds, a...	05/15/2012
8173700	Salts of substituted allophanates and their use in drugs The present invention relates to salts of substituted allophanates, methods for their production, medicaments containing said compounds and the use of said compound for the production of medicaments. ...	05/08/2012
8173164	Oral administration forms for administering a fixed tramadol and diclofenac combination An oral administration unit containing the active substances Tramadol and Diclofenac and/or physiologically acceptable salts thereof, in which both active substances are contained in the same administration unit as two separately formulated subunits. ...	05/08/2012
8158628	Sulfonylated 1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine compounds and their use as pharmaceuticals Sulfonylated tetrahydroazolopyrazine compounds corresponding to the formula I wherein R1, R2a, R2b, R3a, R3b, R4, R8, R9a, R9b	04/17/2012
8153795	Substituted 1-oxa-3,8-diazaspiro[4.5]-decan-2-one-compounds and the use thereof for producing drugs The present invention relates to substituted 1-oxa-3,8-diazaspiro[4.5]-decan-2-one compounds, to methods for the production thereof, to medicaments containing these compounds and to the use of these compounds for producing medicaments. ...	04/10/2012
8147874	Coated pellets Coated pellets which comprise an active pharmaceutical ingredient that is poorly soluble in water, release at least 80% of the active ingredient under in vitro conditions in phosphate buffer at pH 5.0 after 30 minutes and are bioeq...	04/03/2012
8138187	Substituted heteroaryl derivatives The invention relates to substituted heteroaryl derivatives, to methods for the production thereof, to medicaments containing said compounds and to the use of substituted heteroaryl derivatives for producing medicaments. ...	03/20/2012
8134032	Crystalline modifications of (1R,2R)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol Crystalline modifications of (1R,2R)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol, pharmaceutical compositions which contain these modifications, and the use thereof to treat pain or other conditions. ...	03/13/2012
8124788	Spirocyclic cyclohexane compounds with analgesic activity Spirocyclic cyclohexane compounds corresponding to formula I a process for manufacturing such compounds, pharmaceutical compositions that contain such compounds, and the use of such spirocyclic cyclohexane compounds for the...	02/28/2012
8124624	Substituted sulfonamide compounds Substituted sulfonamide compounds corresponding to formula I: a process for their preparation, pharmaceutical compositions comprising such compounds, and the use of such substituted sulfonamide compounds in pharmaceutical c...	02/28/2012
8119805	Substituted disulfonamide compounds Substituted disulfonamide compounds corresponding to formula I: In which R1, R2, R3, R4a, R4b, R5a, R5b, R8, R9a, R9b	02/21/2012
8119633	Substituted sulfonamide compounds Substituted sulfonamide compounds corresponding to formula I pharmaceutical compositions comprising them, a process for preparing them, and the use of such compounds to treat or inhibit pain and other disorders or disease s...	02/21/2012
8119620	Dosage form for hormonal contraception A dosage form for hormonal contraception containing a specific number of gestagen-containing daily units A and a specific number of gestagen-containing daily units B for uninterrupted, daily, oral administration of daily units A and then immediately subsequently of ...	02/21/2012
8114384	Process for the production of an abuse-proofed solid dosage form The present invention relates to a process for the production of an abuse-proofed solid dosage form containing at least one active ingredient with potential for abuse and a synthetic or natural polymer with a breaking strength of =500 N, characterized in that a corr...	02/14/2012
8114383	Abuse-proofed dosage form The present invention relates to an abuse-proofed, thermoformed dosage form containing, in addition to one or more active ingredients with abuse potential optionally together with physiologically acceptable auxiliary substances, at least one synthetic or natural pol...	02/14/2012
8106055	Substituted amide compounds Substituted amide compounds corresponding to formula I: processes for preparing them, pharmaceutical compositions containing these compounds, and the use of substituted amide derivatives for the preparation of medicaments f...	01/31/2012
8097604	Combination of gestagen and insulin sensitizer for treating PCOS The present invention relates to a medicament which contains as the active ingredient combination at least one gestagen with a contraceptive action as the sole hormone component and at least one insulin sensitizer, which medicament is in particular suitable for prev...	01/17/2012
8093272	Heteroaryl substituted cyclohexyl-1,4-diamine compounds Novel cyclohexyl-1,4-diamine compounds corresponding to formula I, processes for the production thereof, pharmaceutical compositions containing these compounds, methods of producing pharmaceutical compositions including the...	01/10/2012
8088763	Cyclohexyl-1, 4-diamine compounds Novel cyclohexyl-1,4-diamine compounds corresponding to formula I, processes for the production thereof, pharmaceutical compositions containing these compounds, methods of producing pharmaceutical compositions including the...	01/03/2012
8088322	Method and device for ultrasound-pressing a tablet or a multiparticulate medicament The present invention relates to a method and a device for shaping a pharmaceutically active substance in the form of powders, granules, multiparticulate medicaments, in particular pellets and microcapsules, for the production of a tablet or a multiparticulate medic...	01/03/2012
8084497	-(2-phenyl-cyclohexyl)-methylamine compounds for therapy of fibromyalgia Pharmaceutical formulations of [2-(3-methoxyphenyl)-cyclohexylmethyl]-dimethylamine and the metabolites thereof suitable for treating fibromyalgia or chronic pain due to fibromyalgia, and related methods of treating fibromyalgia or chronic pain due to fibromyalgia a...	12/27/2011
8084484	Vanilloid receptor ligands, pharmaceutical compositions containing them, process for making them, and use thereof for treating pain and other conditions Vanilloid receptor ligand compounds corresponding to formula I: pharmaceutical compositions containing such compounds, a process for producing such compounds, and methods of using such compounds for treating or inhibiting p...	12/27/2011
8084470	Substituted nicotinamide compounds and uses thereof Substituted nicotinamide compounds corresponding to formula I a process for their preparation, pharmaceutical compositions containing these compounds, and the use thereof for the treatment or inhibition conditions such as p...	12/27/2011
8075872	Abuse-proofed dosage form The invention relates to a dosage form that is thermoshaped without being extruded and that is safeguarded from abuse, comprising at least one synthetic or natural polymer having a breaking strength of at least 500 N in addition to one or more active substances that...	12/13/2011
8058476	HCI polymorphs of 3-((2-(dimethylamino)methyl(cyclohex-1-yl)) phenol A crystalline salt of 3-[2-(dimethylamino)methyl(cyclohex-1-yl)]phenol and hydrogen chloride, preferably in a 1:1 composition, including various crystalline forms of this salt, processes for preparing the various crystalline forms of this salt, pharmaceutical compos...	11/15/2011
8058475	Substituted cyclohexylmethyl compounds Novel cyclohexylmethyl compounds corresponding to formula I wherein R1, R2, R3, R4 and R5, have the meanings given in the description. Pharmaceutical formulations conta...	11/15/2011
8053576	Compositions containing spirocyclic cyclohexane compounds Spirocyclic cyclohexane compounds corresponding to formula I a method for producing them, pharmaceutical compositions containing them, and methods of using them. ...	11/08/2011
8048890	Substituted 1-oxa-2,8-diaza-spiro[4,5]dec-2-ene derivatives and related treatment methods Substituted 1-oxa-2,8-diaza-spiro[4,5]dec-2-ene compounds and processes for their production, the use thereof for producing pharmaceutical compositions, pharmaceutical compositions containing these compounds and methods of treatment using these compounds. ...	11/01/2011
8048879	Substituted 4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyridine compounds and use thereof for producing medicaments The present invention relates to substituted 4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyridine compound corresponding to formula I, methods for producing them, to medicaments containing these compounds, the use of these compounds for producing medicaments and related trea...	11/01/2011
8034936	Spirocyclic cyclohexane compounds useful to treat substance dependency Spirocyclic cyclohexane compounds useful in pharmaceutical compositions for use in the treatment of substance dependency. ...	10/11/2011
8017772	Substituted tetrahydropyrrolopyrazine compounds and the use thereof in the treatment and/or inhibition of pain Substituted tetrahydropyrrolopyrazine compounds corresponding to the formula I: processes for their preparation, pharmaceutical compositions comprising these compounds and the use of these compounds for the treatment and/or...	09/13/2011
8017630	Cyclohexylacetic acid compounds Novel cyclohexylacetic acid compounds corresponding to formula I: processes for the production thereof, pharmaceutical compositions containing these compounds, methods of producing pharmaceutical compositions including thes...	09/13/2011
8003701	Method of inhibiting inflammatory pain A method of treating or inhibiting, in particular, pain caused by inflammation in a mammal by administering to the mammal an effective inflammatory pain alleviating amount of a (1RS,3RS,6RS)-6-dimethyl-aminomethyl-1-(3-methoxyphenyl)-cyclohexane-1,3-diol compound, p...	08/23/2011
7994382	Application system for a plaster containing an active ingredient and a controlled-release agent for said active ingredient The present invention relates to an application system for an active ingredient release system, comprising a film-form application strip, which is in each case bonded detachably to an active ingredient-containing plaster and a separate active ingredient release regu...	08/09/2011
7994364	Crystalline forms of (−)-(1R,2R)-3-(3-dimethylamino-1-ethyl-2-methylpropyl)-phenol hydrochloride A hitherto unknown crystalline form of (−)-(1R,2R)-3-(3-dimethylamino-1-ethyl-2-methylpropyl)-phenol hydrochloride, pharmaceutical compositions containing the new crystalline form, methods of producing the new crystalline form, and a related method of use includin...	08/09/2011
7994167	Pentafluorosulphanyl-substituted compound and its use for producing medicaments The present invention relates to pentafluorosulphanyl-substituted compounds, methods for their production, medicaments containing such compounds and the use of such compounds for producing medicaments. ...	08/09/2011
7981883	Substituted spiro-compounds and the use thereof for producing medicaments The present invention relates to substituted spiro compounds, to processes for preparing them, to medicaments comprising these compounds and to the use of these compounds for producing medicaments. ...	07/19/2011
7977370	(Hetero)aryl cyclohexane derivatives The invention relates to compounds that have an affinity to the μ-opioid receptor and the ORL 1-receptor, methods for their production, medications containing these compounds and the use of these compounds for the treatment of pain and other conditions. ...	07/12/2011
7977360	Benzo[d]isoxazol-3-yl-amine compounds and their use as vanilloid receptor ligands The present invention relates to substituted benzo[d]isoxazol-3-yl-amine compounds, methods for their production, medicaments containing these compounds and the use of these compounds to produce medicaments. ...	07/12/2011

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Assignee: Gruenenthal GmbH