Assignee: Glycomed Incorporated

Location: Alameda, CA
No. of patents: 45

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Number	Title	Issue Date
5892112	Process for preparing synthetic matrix metalloprotease inhibitors Synthetic mammalian matrix metalloprotease inhibitors are disclosed that are useful for treating or preventing diseases wherein said diseases are caused by unwanted mammalian matrix metalloprotease activity and include skin disorders, keratoconus, resteno...	04/06/1999
5874411	Oligosaccharide glycosides having mammalian immunosuppresive and tolerogenic properties Disclosed are novel oligosaccharide glycosides having mammalian immunosuppressive and tolerogenic properties, pharmaceutical compositions containing such oligosaccharide glycosides and to methods of using such oligosaccharide glycosides to modulate cell-m...	02/23/1999
5849709	Saccharopeptides and derivatives thereof Saccharopeptides and methods of using the novel saccharopeptides are described having the following structural formula I: W----Y--W--!m (I) wherein W is independently one or more saccharide(s); Y is independently ...	12/15/1998
5837689	Sialyl lewis-x mimetics containing naphthyl backbones Compounds that possess selectin binding activity are described that have a three-dimensionally stable configuration for sialic acid and fucose, or analogs, derivatives, or mimics of these groups, such that sialic acid and fucose or their mimics are separa...	11/17/1998
5837690	Derivatives of triterpenoid acids and uses thereof. Triterpenoid acid derivatives are described that exhibit dual pharmacophobic activities, specifically selectin ligand and leukotriene biosynthetic inhibitory activities, and that thus have significant applications for the treatment or prevention of certai...	11/17/1998
5808021	Method for controlling O-desulfation of heparin Methods of making and using, as prophylactics or therapeutics for preventing or treating certain diseases including cancer, O-desulfated heparin compositions, preferably 2-O, 3-O desulfated heparin compositions, wherein the methods permit regulating the d...	09/15/1998
5795875	Therapeutic methods of using O-desulfated heparin derivatives Compositions and methods of making selectively O-desulfated heparin compositions, preferably 6-O-desulfated heparin compositions, wherein the methods permit regulating the degree of 6-O-desulfation. The compositions are useful for treating various disease...	08/18/1998
5789385	Sialyl Lewis^x mimetics containing phenyl backbones Compounds that possess selectin binding activity are described that have a three-dimensionally stable configuration for sialic acid and fucose, or analogs, derivatives, or mimics of these groups, such that sialic acid and fucose or their mimics are separa...	08/04/1998
5773438	Synthetic matrix metalloprotease inhibitors and use thereof Synthetic mammalian matrix metalloprotease inhibitors are disclosed that are useful for treating or preventing diseases wherein said diseases are caused by unwanted mammalian matrix metalloprotease activity and include skin disorders, keratoconus, resteno...	06/30/1998
5763582	Derivatives of triterpenoid acids and uses thereof Triterpenoid acid derivatives are described that exhibit dual pharmacophobic activities, specifically selectin ligand and leukotriene biosynthetic inhibitory activities, and that thus have significant applications for the treatment or prevention of certai...	06/09/1998
5750508	Sialic acid/fucose based medicaments Compounds that are synthetically inexpensive to make relative to the naturally occurring selectin ligands and that retain selectin binding activity are described that have a three-dimensionally stable configuration for sialic acid and fucose, or analogs o...	05/12/1998
5739115	Sulfated maltooligosaccharides with heparin-like properties A novel class of highly sulfated maltooligosaccharide having heparin-like activity is described, as well as methods for using these oligosaccharides to treat certain diseases including cancer, and retinopathies....	04/14/1998
5728685	Methods of treating inflammation using cell adhesion inhibitors Compounds and methods of making them having the following formula are described which bind to selectin receptors and thus modulate the course of inflammation, cancer and related diseases by modulating cell-cell adhesion events: ##STR1## wherein ...	03/17/1998
5696100	Method for controlling O-desulfation of heparin and compositions produced thereby Methods of making and using, as prophylactics or therapeutics for preventing or treating certain diseases including cancer, O-desulfated heparin compositions, preferably 2-O, 3-O desulfated heparin compositions, wherein the methods permit regulating the d...	12/09/1997
5695738	Steroidal C-glycosides Compositions of sterodial glycosides are described wherein the glycoside is linked directly, or indirectly to a desired steroidal compound via a carbon, or similar stable linkage, and methods of using the compositions to treat patients by binding to and/o...	12/09/1997
5688922	Substituted fucopyranosides 2-Chloromethyl-3-(tri-O-benzyl-଱-L-C-fucopyranoside)-1-propene and methods of making the same are described. Methods of combining this substituted fucopyranose with triterpenoid acid also are described....	11/18/1997
5679321	Sialic acid/fucose based medicaments Compounds that are synthetically inexpensive to make relative to the naturally occurring selectin ligands and that retain selectin binding activity are described that have a three-dimensionally stable configuration for sialic acid and fucose, or analogs o...	10/21/1997
5679644	Methods of treating diseases using triterpenoid acid derivatives Triterpenoid acid derivatives are described that exhibit dual pharmacophobic activities, specifically selectin ligand and leukotriene biosynthetic inhibitory activities, and that thus have significant applications for the treatment or prevention of certai...	10/21/1997
5660992	Sialic acid/fucose based assay reagents and assay methods Compounds that are synthetically inexpensive to make relative to the naturally occurring selectin ligands and that retain selectin binding activity are described that have a three-dimensionally stable configuration for sialic acid and fucose, or analogs o...	08/26/1997
5658880	Sialic acid/fucose based medicaments Compounds that exhibit selectin binding activity are described and have the following structural formula: ##STR1## where W is selected from a group including structures a-d below ##STR2## wherein p is an integer of from 0-2, q is an integer of f...	08/19/1997
5654412	Processes for the synthesis of sialyl Lewis^x compounds Disclosed are processes for the chemical synthesis of sialyl Lewisx -Y compounds where Y is --OH, --NHR, --SH, --SR or --OR, and R is an aglycon of at least one carbon atom....	08/05/1997
5654282	Selectin binding glycopeptides Glyco-amino acids and glycopeptides having three-dimensionally stable configurations are described. These glyco-amino acids and glycopeptides have glycoside functional groups, such as fucose and analogues and derivatives thereof, covalently bound to an am...	08/05/1997
5643884	Lupane triterpenoid derivatives This invention relates generally to the field of medicinal chemistry, and more specifically to derivatives of a subclass of triterpenoid acids that have multi-medicament properties, that is derivatives of the lupane, betulinic acid, formulations containin...	07/01/1997
5624909	Derivatives of triterpenoid acids as inhibitors of cell-adhesion molecules ELAM-1 (e-selectin) and LECAM-1 (l-selectin) Triterpenoid acid derivatives have been found to have structures similar to natural ligands to the extent that these derivatives bind to natural selectin receptors including endothelial leukocyte adhesion molecule-1 (ELAM-1) and leukocyte/endothelial cell...	04/29/1997
5591835	Substituted lactose derivatives Compounds and methods of making them having the following formula are described which bind to selectin receptors and thus modulate the course of inflammation, cancer and related diseases by modulating cell-cell adhesion events: ##STR1## wherein ...	01/07/1997
5583121	Non-anticoagulant chemically modified heparinoids for treating hypovolemic shock and related shock syndromes A method of treating hypovolemic shock and related shock syndromes by the administration of substantially non-anticoagulant heparinoids without the hemorrhaging problems generally associated with heparin; such syndromes include degradation of the microvas...	12/10/1996
5567683	Substituted lactose and lactosamine derivatives as cell adhesion inhibitors Simple lactose or lactosamine related compounds which behave as ligands for the ELAM-1 and related receptors are described. These compounds are useful in the treatment of conditions characterized by excess inflammation. These compounds are of the formula ...	10/22/1996
5527890	Derivatives of triterpenoid acids and uses thereof Triterpenoid acid derivatives are described that exhibit dual pharmacophobic activities, specifically selectin ligand and leukotriene biosynthetic inhibitory activities, and that thus have significant applications for the treatment or prevention of certai...	06/18/1996
5519008	Derivatives of triterpenoid acids as inhibitors of cell-adhesion molecules ELAM-1 (E-selectin) and LECAM-1 (L-selectin) Triterpenoid acid derivatives have been found to have structures similar to natural ligands to the extent that these derivatives bind to natural selectin receptors including endothelial leukocyte adhesion molecule-1 (ELAM-1) and leukocyte/endothelial cell...	05/21/1996
5508387	Selectin binding glycopeptides Glyco-amino acids or glycopeptides that have three-dimensionally stable configuration for the presentation of functional groups, fucose, or an analogue or derivative thereof, covalently linked to an amino acid or peptide with a free carboxylic acid group,...	04/16/1996
5470842	Carbohydrate-based anti-inflammatory agents Ligands in the form of N-acetyllactosamines which bind to endothelial leukocyte adhesion molecule-1 (ELAM-1) are disclosed. The ligand compounds can be formulated into pharmaceutical compositions and/or assay compositions used to alleviate inflammation an...	11/28/1995
5440015	Selectin peptide medicaments for treating disease Peptides are described and methods of using the peptides to treat or prevent disease which peptides are described by the formula: SEQ. ID NO:1 wherein X is an aromatic amino acid, and n is 1, 2, or 3; X' is either a non-polar or polar uncharged amino acid, and...	08/08/1995
5428025	Method of treating inflammation by blocking ELAM-1 receptor sites Ligands in the form of N-acetyllactosamines which bind to endothelial leukocyte adhesion molecule-1 (ELAM-1) are disclosed. The ligand compounds can be formulated into pharmaceutical compositions and/or assay compositions used to alleviate inflammation an...	06/27/1995
5412123	Anthraquinone and anthracene derivatives as inhibitors of the cell-adhesion molecules of the immune system Derivatives of anthraquinone and anthracene are synthesized and formulated into pharmaceutical formulations. When the formulations are administered the derivatives act as ligands binding to an interrupting the biological chain of events associated with se...	05/02/1995
5326752	Substituted lactose and lactosamine derivatives as cell adhesion inhibitors The compounds are of the formula ##STR1## wherein each R1 is independently H or lower alkyl (1-4C); R2 is H, lower alkyl (1-4C), alkylaryl or one or more additional saccharide residues; R3 and R4 are indepe...	07/05/1994
5296471	Method for controlling o-desulfation of heparin and compositions produced thereby Methods of making and using, as prophylatics or therapeutics for preventing or treating certain diseases including cancer, O-desulfated heparin compositions, preferably 2-O, 3-O desulfated heparin compositions, wherein the methods permit regulating the de...	03/22/1994
5280016	Non-anticoagulant heparin derivatives A non-anticoagulant (NAC) form of heparin which shows antiproliferative activity with respect to smooth muscle cells is useful in the prevention of restenosis and other conditions benefited by antiproliferative activity with respect to smooth muscle cells...	01/18/1994
5250519	Non-anticoagulant heparin derivatives A non-anticoagulant (NAC) form of heparin which shows antiproliferative activity with respect to smooth muscle cells is useful in the prevention of restenosis and other conditions benefited by antiproliferative activity with respect to smooth muscle cells...	10/05/1993
5239078	Matrix metalloprotease inhibitors Compounds of the formulas ##STR1## wherein each R1 is independently H or alkyl (1-8C) and R2 is alkyl (1-8C) or wherein the proximal R1 and R2 taken together are --(CH2)p -- wherein p=...	08/24/1993
5211937	Method of determining a site of inflammation utilizing ELAM-1 ligands Ligands in the form of N-acetyllactosamines which bind to endothelial leukocyte adhesion molecule-1 (ELAM-1) are disclosed. The ligand compounds can be formulated into pharmaceutical compositions and/or assay compositions used to alleviate inflammation an...	05/18/1993

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Assignee: Glycomed Incorporated