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| Number | Title | Issue Date |
| 7655425 | Uses of a chemokine receptor able to bind to MCP-1, MIP-1α and/or RANTES A chemokine receptor binds to MCP-1, MIP-1α and/or RANTES. It can be used in screening for agents which act as antagonists to MCP-1, MIP-1α and/or RANTES. Such agents may be useful in treating various disorders, including allergies, atheromas and diseases mediated... | 02/02/2010 |
| 7601729 | Matrix metalloproteinase inhibitors Compounds of Formula (I): wherein: A represents bond, C1-6alkyl or CH═CH—C1-4alkyl; B represents bond, O, S, SO, SO2, CO, CR7R8, CO2 | 10/13/2009 |
| 7476759 | Matrix metalloproteinase inhibitors Compounds of Formula (I): wherein: R1 is optionally substituted —C4-12 alkyl, —C2-10alkylcycloalkyl, —C2-6alkylheterocycloalkyl, ... | 01/13/2009 |
| 7462622 | Pyrrolo[2, 3-d] pyrimidine derivatives as corticotropin releasing factor antagonists The present invention provides compounds of formula (I) including stereoisomers, prodrugs and pharmaceutically acceptable salts or solvates thereof wherein R is aryl or heteroaryl and each... | 12/09/2008 |
| 7461650 | Medicament dispenser A medicament dispenser including a housing, a medicament container having a dispensing outlet; an agitator for agitating the contents; and a driver for driving the agitator independent of any container movement. The driver includes an energy storeage for storing ene... | 12/09/2008 |
| 7459456 | Quinoline and quinazoline derivatives having affinity for 5HT1-type receptors Compounds of formula (I) and pharmaceutically acceptable salts thereof are provided: wherein R1, m, X, R2, n, W, p, Y, Z, R3, R4, R5 and q have the meanings as defined ... | 12/02/2008 |
| 7454267 | Medicament dispenser A method of controlling the functioning of a portable medicament dispenser, said portable medicament dispenser being for use with a refill container, said method comprising: (a) providing a memory for storing one or more parameters relating to the functioning of sai... | 11/18/2008 |
| 7452888 | Quinoline derivatives and their use as 5-ht6 ligands Disclosed are novel quinoline compounds of formula (I), processes for their preparation, compositions containing them and their use in the treatment of CNS disorders. ... | 11/18/2008 |
| 7448184 | Method for forming a laminate assembly with an ultrasonic welder A laminate assembly, comprising a base sheet having at least one blister formed therein, a pharmaceutical composition displaced in the blister, a lid sheet bonded to the base sheet to form a primary seal therebetween, thus forming a primarily sealed laminate assembl... | 11/11/2008 |
| 7446222 | Phenyl compounds Compounds of formula (I) or derivatives thereof: wherein A, B, Z, R1, R2a, R2b, Rx, R8, and R9 are as defined in the specification, a process for the prepara... | 11/04/2008 |
| 7446117 | Cox-2 inhibiting pyridine derivatives Compounds of formula (I) or pharmaceutically acceptable salts thereof are potent and selective inhibitors of COX-2 and are of use in the treatment of the pain, fever and inflammation of a variety of conditions and diseases.... | 11/04/2008 |
| 7442839 | Phenethanolamine derivative for the treatment of respiratory diseases The present invention relates to novel compounds of formula (I), to a process for their manufacture, to pharmaceutical compositions containing them, and to their use in therapy, in particular their use in the prophylaxis an... | 10/28/2008 |
| 7442837 | Phenethanolamine derivatives for treatment of respiratory diseases The present invention relates to novel compounds of Formula (I), to a process for their manufacture, to pharmaceutical compositions containing them, and to their use in therapy, in particular their use in the prophylaxis and treatment of respiratory diseases. ... | 10/28/2008 |
| 7442836 | Phenethanolamine derivatives for treatment of respiratory diseases The present invention relates to novel compounds of Formula (I), to a process for their manufacture, to pharmaceutical compositions containing them, and to their use in therapy, in particular their use in the prophylaxis and treatment of respiratory diseases. ... | 10/28/2008 |
| 7442719 | Methods using phenethanolamine derivatives for treatment of respiratory diseases The present invention relates to novel compounds of Formula (I), to a process for their manufacture, to pharmaceutical compositions containing them, and to their use in therapy, in particular their use in the prophylaxis and treatment of respiratory diseases. ... | 10/28/2008 |
| 7439393 | Phenethanolamine derivatives for treatment of respiratory diseases The invention relates to 4-{(1R)-2-[(6-{2-[(2,6-dichlorobenzyl)oxy]ethoxy}hexyl)amino]-1-hydroxyethyl}-2-(hydroxymethyl)phenol; and salts and solvates thereof, including those which are pharmaceutically acceptable, along with formulations thereof, combinations there... | 10/21/2008 |
| 7439255 | Muscarinic acetylcholine receptor antagonists Muscarinic Acetylcholine receptor antagonists and methods of using them are provided. ... | 10/21/2008 |
| 7439245 | Compounds Disclosed is a method for use of phenyl sulfone compounds of formula (I) in the treatment of anxiety. ... | 10/21/2008 |
| 7439243 | Piperazinyl-quinoline derivatives useful for the treatment of CNS disorders Disclosed are quinoline compounds of formula (I) having pharmacological activity, processes for their preparation, compositions containing them, and methods for the treatment of CNS and other disorders. ... | 10/21/2008 |
| 7439244 | Quinoline compounds and pharmeceutical compositions containing them Disclosed are quinoline compounds of formula (I) having pharmacological activity, processes for their preparation, compositions containing them, and methods for the treatment of CNS and other disorders. ... | 10/21/2008 |
| 7432289 | 5-Acylamino-1,1′-biphenyl-4-carboxamide derivatives and their use as P38 kinase inhibitors Compounds of formula (I): or pharmaceutically acceptable salts or solvates thereof, and their use as pharmaceuticals, particularly as p38 kinase inhibitors. ... | 10/07/2008 |
| 7429587 | Pyrrolidine derivatives as factor Xa inhibitors The invention relates to compounds of formula (I) processes for their preparation, pharmaceutical compositions containing them and to their use in medicine, particularly use in the amelioration of a clinical condition for w... | 09/30/2008 |
| 7429127 | Magnetoacoustic sensor system and associated method for sensing environmental conditions A remote sensor system (60) and method for passively sensing environmental conditions, such as temperature and humidity, uses a magnetic impulse from an AC interrogation coil (68) to stimulate a magnetoelastic sensor (62) to generate an acoustic... | 09/30/2008 |
| 7425645 | Ester-linked gemini surfactant compounds for use in gene therapy This invention relates to newly identified ester-linked Gemini surfactant compounds of formula (I), where Y is either H or (Aa)x where (Aa) is a basic amino acid and x is 1 to 6, to the use of such compounds and to their production. The invention also relates to the... | 09/16/2008 |
| 7424888 | Medicament dispenser The medicament dispenser has a base unit and a replaceable refill container. The base unit has one or more sensors for sensing one or more conditions of the medicament dispenser and a display for displaying indicia representing a state of the medicament dispenser. F... | 09/16/2008 |
| 7423042 | Compounds This invention relates to a novel group of 8-Alkyl/Aryl-4-aryl-2-N-(alkylamino)-N″-substituted-N′-cyanoguanidino-8H-pyrido[2,3-d]pyrimidin-7-one compounds, processes for the preparation thereof, the use thereof in treating CSBP/p38 kinase mediated diseases and p... | 09/09/2008 |
| 7405206 | Anti-inflammatory androstane derivatives There are provided compounds of formula (I) wherein R1 represents O, S or NH; R2 represents —C(═O)-aryl or —C(═O)-heteroaryl; R3 represents hyd... | 07/29/2008 |
| 7402598 | Arylethanolamine β-adrenoreceptor agonist compounds The present invention relates to compounds of formula (I) as defined herein and salts or solvates thereof. Processes for preparing these compounds and pharmaceutical formulations containing them are also disclosed, as well as methods for the prophylaxis of treatment... | 07/22/2008 |
| D573019 | Cap | 07/15/2008 |
| 7396843 | 5′-carbamoyl-1,1′-biphenyl-4-carboxamide derivatives and their use as p38 kinase inhibitors Compounds of formula (I): or pharmaceutically acceptable salts or solvates thereof, and their use as pharmaceuticals, particularly as p38 kinase inhibitors. ... | 07/08/2008 |
| 7390817 | Combinations of a vanilloid antagonist and an NSAID for the treatment of pain A method of treating conditions associated with pain and alleviating the symptoms associated therewith which comprises administering to a mammal, including man, a vanilloid VR-1 antagonist or a pharmaceutically acceptable derivative thereof and an NSAID or a pharmac... | 06/24/2008 |
| 7384946 | Mmuscarinic acetylcholine receptor antagonists Novel dimeric benzoazabicyclohepatane compounds, pharmaceutical compositions, processes for their preparation and use thereof in treating M3 muscarinic acetylcholine receptor mediated diseases are disclosed. ... | 06/10/2008 |
| 7384478 | Apparatus and process for preparing crystalline particles A process for preparing crystalline particles, especially particles of a pharmaceutical or carrier substance suitable for inhalation therapy, in addition to apparatus for the preparation of such particles. ... | 06/10/2008 |
| 7383970 | Valve with a two-component seal A valve that includes a valve body, a valve stem having a dispensing passage, and a sealing ring that contacts the valve stem is described. The sealing ring includes a flexible component and a rigid component. ... | 06/10/2008 |
| 7375248 | Inhibitors of matrix metalloproteinase Compounds of formula (I): wherein R1 represents optionally substituted C4-12 alkyl, optionally substituted C2-6alkylaryl, or optionally substituted 5- or 6-membered aryl or hete... | 05/20/2008 |
| 7361787 | Phenethanolamine derivatives for treatment of respiratory diseases The present invention relates to novel compounds of formula (I), to a process for their manufacture, to pharmaceutical compositions containing them, and to their use in therapy, in particular their use in the prophylaxis and treatment of respiratory diseases ... | 04/22/2008 |
| 7354966 | Compounds for use as surfactants Compounds of formula (I): and uses of such compounds are described. ... | 04/08/2008 |
| 7351696 | Compounds The present invention relates to compounds of formula (I) and pharmaceutically acceptable derivatives thereof, to processes for their preparation and their use in therapy or prophylaxis of systemic or topical microbial infe... | 04/01/2008 |
| 7348339 | Imidazopyridine derivatives as kinase inhibitors A compound of the formula and physiologically acceptable salts and or N-oxides thereof wherein, X1 is N or CR3; X2 is N or CR4; X3 is N or CR5; ... | 03/25/2008 |
| 7329685 | 1-Phenyl-2-oxo-3-sulfonylamino-pyrrolidine derivatives and related compounds as factor Xa inhibitors for the treatment of acute vascular diseases The invention relates to compounds of formula (I): wherein substituents are as defined. ... | 02/12/2008 |
