Assignee: Gist-Brocades N.V.

Location: Delft, NL
No. of patents: 178

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Number	Title	Issue Date
7033627	Production of enzymes in seeds and their use A method of catalyzing in vitro reactions using seeds containing enhanced amounts of enzymes is disclosed. The method involves adding transgenic, non-wild type seeds, preferably in a ground form, to a reaction mixture, especially a bakery process and allowing the en...	04/25/2006
6503727	Process for the preparation of an antibiotic The invention relates to a process for the preparation of an antibiotic, in particular cefalexin, ampicillin, amoxicillin, cefaclor, cefradin, cefadroxil, cefotaxim and the like, wherein a beta-lactam core is acylated, the antibiotic is recovered from the...	01/07/2003
6361808	Process for the production of alcoholic beverages using maltseed The invention relates to a process for the production of alcoholic beverages such as beer or whiskey with a mixture of enzymes comprising an endo-ଲ(1,4)-xylanase, an arabinofuranosidase, an alpha-amylase, an endo-protease and a ଲ-(1,3, 1,4)-gl...	03/26/2002
6306635	Fungal cellulases The present invention provides polypeptides with cellulase activity, corresponding DNA sequences, vectors, transformed hosts and a method for the production of these polypeptides, which are obtainable from Aspergillus niger var. niger or Aspergillus niger...	10/23/2001
6255505	Microbial polyunsaturated fatty acid containing oil from pasteurised biomass The present invention discloses a microbial polyunsaturated fatty acid(PUFA)-containing oil with a high triglyceride content and a high oxidative stability. In addition, a method is described for the recovery of such oil from a microbial biomass derived f...	07/03/2001
6180360	Process of producing ଲ-lactam antibiotics applying micro-organisms with increased ligase activity The present invention relates to the biosynthesis of ଲ-lactam antibiotics. More specifically, the invention relates to processes of producing ଲ-lactam antibiotics in vivo and in vitro. Also contemplated is a novel enzyme capable of catalyzing ...	01/30/2001
5955321	Production and use of compositions comprising high concentrations of vitamin B12 activity The present invention provides a process for the preparation of a composition comprising natural vitamin B12, wherein said process comprises the steps of: a) obtaining microbial cells containing natural vitamin B12, b) causing opening of the microbial cells su...	09/21/1999
5935831	Mutated ଲ-lactam acylase genes New mutant ଲ-lactam acylases are provided exhibiting altered substrate specificities. These ଲ-lactam acylases are obtained by expression of a gene encoding said ଲ-lactam acylase and having an amino acid sequence which differs at least in...	08/10/1999
5910425	Microbial strains producing sphingolipid bases Microbial strains capable of producing enhanced levels of sphingosine, dihydrosphingosine, phytosphingosine and/or derivatives thereof are disclosed. Additionally, there are disclosed methods based on mutagenesis, or other selection techniques, whereby su...	06/08/1999
5882879	Method for influencing ଲ-lactam antibiotic production and for isolation of large quantities of ACV synthetase Novel methods and compositions are provided for the enhanced production of ଲ-lactam antibiotics. The process is exemplified by the production of penicillin. In addition, the P. chrysogenum and A. chrysogenum δ-(L-଱-aminoadipyl)-L-cysteinyl-D-...	03/16/1999
5879927	Strains of phaffia rhodozyma containing high levels of astaxanthin and low levels of 3-hydroxy-3', 4'-didehydro-ଲ, .psi.-caroten-4-one (HDCO) The present invention provides Phaffia rhodozyma strains having increased levels of astaxantin and a low percentage of 3-hydroxy-3',4'-didehydro-ଲ,.psi.-caroten-4-one (HDCO). Such strains are obtained by a combination of mutagenesis and selection. T...	03/09/1999
5858764	Yeast strains for saccharide fermentation New yeast strains providing for an enhanced rate of the fermentation of sugars, and a process to obtain such yeasts and the use of these yeasts. Yeasts capable of improved fermentation of sugars, a process to obtain these yeasts and the use of these yeast...	01/12/1999
5849874	Process for the purification of serum albumin Recombinantly produced serum albumin is purified in a series of steps, optionally by incubation with an anion-exchange adsorbent, followed by affinity chromatography employing a hydrophobic solid phase and using a water-soluble lipid anion as desorbens in...	12/15/1998
5830735	Method for producing lipolytic enzymes using transformed Pseudomonas Novel microbial host strains are provided which are transformed by a vector molecule comprising a DNA fragment encoding a lipolytic enzyme and a marker for selection, capable of producing active lipase. Said DNA fragment is preferably derived from a Pseud...	11/03/1998
5830737	Cloning and expression of the exo-polygalacturonase gene from aspergillus The exo-polygalacturonase gene from Aspergillus is identified, and the enzyme encoded thereby is expressed. Specifically, the exo-polygalacturonase gene from Aspergillus tubingensis is is cloned and expressed, and DNA sequences from other Aspergillus stra...	11/03/1998
5821233	Antifungal composition Novel compositions that comprise solvates, salts, or other modified crystalline forms of polyene-type antifungal compounds are provided. Representative of such compositions are formulations that comprise the novel cystalline substances δ-natamycin and γ...	10/13/1998
5795733	Process for the efficient production of 7-ADCA via 3-(carboxyethylthio) propionyl-7-ADCA An overall efficient process for the preparation and recovery of 7-aminodesacetoxycephalosporanic acid (7-ADCA) via 3-(carboxyethylthio)propionyl-7-ADCA, using a Penicillium chrysogenum transformant strain expressing expandase in conjunction with acy...	08/18/1998
5792794	Retinoylamide based derivatives of sphingoid bases The present invention relates to active derivatives of sphingoid bases. Specifically, the invention relates to retinoylamide based derivatives of sphingoid bases. The present invention describes a method for obtaining these compounds. The invention also r...	08/11/1998
5753435	Oxido reductase enzyme system obtainable from P. chrysogenum, the set of genes encoding the same and the use of oxido reductase enzyme systems or genes encoding the same for increasing antibiotic production A new oxido reductase enzyme activity obtainable from P. chrysogenum, involved in the production of ଲ-lactams, the set of genes encoding said enzyme activity, and a method to enhance said production by using the above-mentioned oxido reductase syste...	05/19/1998
5733723	Stable gene amplification in chromosomal DNA of prokaryotic microorganisms Transformed prokaryotic hosts are provided comprising two or more copies of a DNA sequence stably maintained in their chromosome, said DNA sequence comprising a gene encoding a polypeptide of interest wherein said copies are separated by endogenous chromo...	03/31/1998
5719047	Gram-negative alkaliphilic microorganisms Gram-negative bacteria, which are obligate alkaliphiles, have been isolated from samples of soil, water and sediment and a number of other sources obtained from in and around soda lakes. These bacteria have been analyzed according to the principles of num...	02/17/1998
5716655	Method for the preparation of feed pellets The present invention discloses a method for obtaining feed pellets. The method comprises the addition of active ingredients to feed pellets after the pellets have been extruded. The method further comprises the addition of a solution or suspension of the...	02/10/1998
5716807	Transformed industrial bacillus strains and methods for making and using them Novel methods and novel industrial unicellular microorganism strains, particularly industrial Bacillus strains, are provided for enhanced production of endogenous and exogenous polypeptides. Cloning vehicles containing the gene expressing the polypeptide ...	02/10/1998
5709856	Astaxanthin-producing yeast cells, methods for their preparation and their use An isolated pure culture of a strain of Phaffia rhodozyma which produces astaxanthin in an amount of at least 600 μg per g Phaffia rhodozyma dry matter, as determined by HPLC analysis....	01/20/1998
5695978	Penicillin G acylase, a gene encoding the same and a method for the production of this enzyme The invention provides a gene encoding penicillin G acylase, the enzyme encoded by said gene and a method for the production of said enzyme by incorporating said gene in a host and bringing the same to expression. The gene is preferably obtained from a st...	12/09/1997
5674707	Production of heterologous proteins in filamentous fungi Expression of proteins in filamentous fungal hosts is achieved in the presence of glucose using promoter variants in which creA binding sites are functionally disrupted....	10/07/1997
5652132	Oxido reductase enzyme system obtainable from P. chrysogenum, the set of genes encoding the same and the use of oxido reductase enzyme systems or genes encoding the same for increasing antibiotic production A new oxido reductase enzyme activity obtainable from P. chrysogenum, involved in the production of ଲ-lactams, the set of genes encoding said enzyme activity, and a method to enhance said production by using the above-mentioned oxido reductase syste...	07/29/1997
5648261	Strains of Phaffia rhodozyma containing high levels of astaxanthin and low levels of 3-hydroxy-3',4'-didehydro-ଲ, .PSI.-caroten-4-one (HDCO) The present invention provides Phaffia rhodozyma strains having increased levels of astaxantin and a low percentage of 3-hydroxy-3',4'-didehydro-ଲ,.psi.-caroten-4-one (HDCO). Such strains are obtained by a combination of mutagenesis and selection. T...	07/15/1997
5643719	Intersexual heterozygous phycomyces The present invention discloses intersexual heterozygous Phycomyces strains. These strains show an improved ଲ-carotene productivity and an increased stability when compared with both the wild type and heterokaryotic Phycomyces strains. The present i...	07/01/1997
5639494	Pectinesterase in the treatment of fruit and vegetables A method to prepare a food containing a gel of a low-methoxylated pectin of at least one fruit or vegetable is disclosed. The method comprises adding pectin esterase to the fruit or vegetable or to the pulp thereof in an amount effective to demethoxylate ...	06/17/1997
5624829	Transformed industrial bacillus strains and methods for making and using them Novel methods and novel industrial unicellular microorganism strains, particularly industrial Bacillus strains, are provided for enhanced production of endogenous and exogenous polypeptides. Cloning vehicles containing the gene expressing the polypeptide ...	04/29/1997
5610046	Cloning and expression of xylanase B Method and expression constructs are provided for the cloning of genes from fungal origin which encode polypeptides having the activity of the Aspergillus tubigensis XYL B enzyme and their overexpression in a selected microbial host cell. The present inve...	03/11/1997
5599711	Astaxanthin-producing yeast cells, methods for their preparation and their use An isolated pure culture of a strain of Phaffia rhodozyma which produces astaxanthin in an amount of at least 600 μg per g Phaffia rhodozyma dry matter, as determined by HPLC analysis....	02/04/1997
5571716	Gram-negative alkaliphilic microorganisms Gram-negative bacteria, which are obligate alkaliphiles, have been isolated from samples of soil, water and sediment and a number of other sources obtained from in and around soda lakes. These bacteria have been analyzed according to the principles of num...	11/05/1996
5543576	Production of enzymes in seeds and their use A method of catalyzing in vitro reactions using seeds containing enhanced amounts of enzymes is disclosed. The method involves adding transgenic, non-wild type seeds, preferably in a ground form, to a reaction mixture and allowing the enzymes in the seeds...	08/06/1996
5538876	Stabilization of carboxyl esterase Carboxyl esterase is inactivated by several chemical compounds such as naproxen or diclofop. By substituting or modifying certain basic residues of the carboxyl esterase, this enzyme shows improved stability properties during application. In this way it i...	07/23/1996
5516512	N- and C-terminal truncation and deletion mutants of human interleukin-3 Biologically active deletion and substitution mutants of hIL-3 are provided. Preferred mutants are those having one or more deletions at the N-terminus (amino acids 1-14) and/or the C-terminus (amino acids 116-133, 120-130 and/or 130-133). Preferred subst...	05/14/1996
5514575	Gram-negative alkaliphilic microorganisms Gram-negative bacteria, which are obligate alkaliphiles, have been isolated from samples of soil, water and sediment and a number of other sources obtained from in and around soda lakes. These bacteria have been analyzed according to the principles of num...	05/07/1996
5503991	Vectors for use in filamentous fungi Novel vectors are disclosed for use in filamentous fungi such as Aspergillus sp. in particular, whereby protein coding regions may be inserted therein to achieve expression or expression followed by secretion of the coded protein from the host. Signal pep...	04/02/1996
5462862	Method and compositions for enhancing production of secondary metabolites using clustered biosynthetic genes Clustered antibiotic biosynthetic genes are employed for improvement of production of the antibiotic in microorganisms and for the isolation of other genes involved in the biosynthesis of the antibiotic. The invention is exemplified with improved producti...	10/31/1995

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Assignee: Gist-Brocades N.V.