Assignee: Gilead Sciences, Inc.

Location: Foster City, CA
No. of patents: 110

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Number	Title	Issue Date
8183226	Myocardial perfusion imaging method The present disclosure provides 2-adenosine N-pyrazole compounds exemplified by the structure shown below that are potent and selective agonists for A2A adenosine receptor, compositions comprising these compounds, and methods for using these compounds in ...	05/22/2012
8178491	Antiviral compounds The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds. ...	05/15/2012
8173623	Process for preparation of HIV protease inhibitors A process for the synthesis of bisfuran intermediates useful for preparing antiviral HIV protease inhibitor compounds is hereby disclosed. ...	05/08/2012
8163718	Nucleoside analogues containing phosphonate or phosphonamide groups Novel compounds having structure (1) wherein Z, is N or CH to form a purine, Y, R1, R2′ and R2 are defined in the specification, are provided for use in the treatment of tumors and ...	04/24/2012
8158810	ALDH-2 inhibitors in the treatment of addiction Disclosed are novel isoflavone derivatives having the structure of Formula I which are useful as ALDH-2 inhibitors for treating mammals for dependence upon drugs of addiction, for example addiction to dopamine-producing age...	04/17/2012
8153801	Process and intermediates for preparing integrase inhibitors The invention provides synthetic processes and synthetic intermediates that can be used to prepare 4-oxoquinolone compounds having useful integrase inhibiting properties. ...	04/10/2012
8148376	3, 4-dihydroquinoxalin-2(1H)-ones for use as stearoyl CoA desaturase inhibitors The present invention discloses 3,4-dihydroquinoxalin-2(1H)-ones for use as inhibitors of stearoyl-CoA desaturase. The compounds are useful in treating and/or preventing various human diseases, mediated by stearoyl-CoA desaturase (SCD) enzymes, especially diseases r...	04/03/2012
8148374	Modulators of pharmacokinetic properties of therapeutics The present application provides for a compound of Formula IV, or a pharmaceutically acceptable salt, solvate, and/or ester thereof, compositions containing such compounds, therapeutic methods that include the administratio...	04/03/2012
8143394	Pyrido(3,2-d)pyrimidines useful for treating viral infections 2-amino-pyrido(3,2-d)pyrimidine derivatives with a specific substitution pattern on positions 4 and 6 of the core structure are useful in the treatment or prevention of an infection due to a virus from the Flaviviridae family, especially HCV, when administered to a ...	03/27/2012
8143249	Prodrugs of Aadenosine receptor antagonists Disclosed are prodrugs of A2B adenosine receptor antagonists of the formula: wherein R1 and R2 are independently lower alkyl; R4 is optionally substituted...	03/27/2012
8134000	Imidazolyl pyrimidine inhibitor compounds A compound of general Formula (I) having histone deacetylase (HDAC) and/or Cyclin-dependent kinase (CDK) inhibitory activity, a pharmaceutical composition comprising the compound, and a method useful to treat diseases using the compound.	03/13/2012
8133879	Myocardial perfusion imaging methods and compositions The present disclosure provides 2-adenosine N-pyrazole compounds of structural formula shown below that are potent and selective agonists for A2A adenosine receptor, compositions comprising these compounds, and methods for using these compounds in a varie...	03/13/2012
8124764	Fused heterocyclyc inhibitor compounds The present invention provides a compound of general Formula (I) having histone deacetylase (HDAC) and/or Cyclin-dependent kinase (CDK) inhibitory activity, a pharmaceutical composition comprising the compound, and a method useful to treat diseases using the compoun...	02/28/2012
8106183	Process for preparing an A-adenosine receptor agonist and its polymorphs Disclosed is a synthesis suitable for large scale manufacture of an A2A-adenosine receptor agonist, and also relates to polymorphs of that compound, and to methods of isolating a specific polymorph. ...	01/31/2012
8106054	Crystalline pyridazine compound A crystalline compound of formula (1) and its salts and solvates are provided for the treatment or prophylaxis of hepatitis C virus infections Methods of making and formulating crystalline compound (1) are provided. ...	01/31/2012
8106029	Use of Aadenosine receptor agonists Myocardial imaging methods are provided that are accomplished by administering doses of a pharmaceutical composition comprising one or more adenosine A2A receptor agonists, in particular regadenoson, useful for, among other indications, myocardial imaging...	01/31/2012
8088792	Triazolopyridinone derivatives for use as stearoyl CoA desaturase inhibitors The present invention discloses triazolopyridinone derivatives for use as inhibitors of stearoyl-CoA desaturase having the structure of Formula I: The compounds are useful in treating and/or preventing various human disease...	01/03/2012
8088771	Cycloalkylidene and heterocycloalkylidene inhibitor compounds The present invention provides a compound of general Formula (I) having histone deacetylase (HDAC) inhibitory activity, a pharmaceutical composition comprising the compound, and a method useful to treat diseases using the compound.	01/03/2012
8088770	Modulators of pharmacokinetic properties of therapeutics The present application provides for a compound of Formula IV: or a pharmaceutically acceptable salt, solvate, and/or ester thereof, compositions containing such compounds, therapeutic methods that include the administratio...	01/03/2012
8088754	Anti-proliferative compounds, compositions, and methods of use thereof Compounds and compositions of Formula I are described, useful as anti-proliferative agents, and in particular anti-HPV, wherein: Y1A and Y1B are independently Y1...	01/03/2012
8088368	Antiviral compounds The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds. ...	01/03/2012
8071566	Methods of coronary imaging The present invention provides methods of myocardial perfusion imaging and increasing coronary blood flow of a mammal that are accomplished by administering doses of a compound that is a selective partial A2A receptor agonist with a short duration of acti...	12/06/2011
8067449	Modulators of pharmacokinetic properties of therapeutics The present application provides for a compound of Formula I, or a pharmaceutically acceptable salt, solvate, and/or ester thereof, compositions containing such compounds, therapeutic methods that include the administration of such compounds, and therapeutic methods...	11/29/2011
8022083	Antiviral phosphonate analogs The invention is related to phosphorus substituted compounds with antiviral activity, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing su...	09/20/2011
8012942	Carba-nucleoside analogs for antiviral treatment Provided are thieno[3,4-d]pyrimidin-7-yl and furo[3,4-d]pyrimidin-7-yl ribosides, riboside phosphates and prodrugs thereof as well as intermediates and methods of preparation. The compounds, compositions, and methods provided are useful for the treatment of Flavivir...	09/06/2011
8012941	Carba-nucleoside analogs for antiviral treatment Provided are imidazo[1,5-f][1,2,4]triazinyl, imidazo[1,2-f][1,2,4]triazinyl, and [1,2,4]triazolo[4,3-f][1,2,4]triazinyl nucleosides, nucleoside phosphates and prodrugs thereof. The compounds, compositions, and methods provided are useful for the treatment of Flavivi...	09/06/2011
8008287	Integrase inhibitors Tricyclic compounds, protected intermediates thereof, and methods for inhibition of HIV-integrase are disclosed. ...	08/30/2011
8008264	1′-substituted carba-nucleoside analogs for antiviral treatment Provided are pyrrolo[1,2-f][1,2,4]triazinyl, imidazo[1,5-f][1,2,4]triazinyl, imidazo[1,2-f][1,2,4]triazinyl, and [1,2,4]triazolo[4,3-f][1,2,4]triazinyl nucleosides, nucleoside phosphates and prodrugs thereof, wherein the 1′ position of the nucleoside sugar is subs...	08/30/2011
7998950	Antiviral compounds The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds. ...	08/16/2011
7973029	Inhaled aztreonam lysine for the treatment of deficits in health-related quality-of-life in lung diseases Provided is a method of treating the health-related quality-of-life (HRQOL) symptoms of a lung disease, comprising the administration of an inhalable aerosol of aztreonam lysine. The method is suitable for the short term and sustainable long term treatment of HRQOL ...	07/05/2011
7973013	2'-fluoro substituted carba-nucleoside analogs for antiviral treatment Provided are pyrrolo[1,2-f][1,2,4]triazinyl, imidazo[1,5-f][1,2,4]triazinyl, imidazo[1,2-f][1,2,4]triazinyl, and [1,2,4]triazolo[4,3-f][1,2,4]triazinyl nucleosides, nucleoside phosphates and prodrugs thereof, wherein the 2′ position of the nucleoside sugar is subs...	07/05/2011
7968544	Modulators of toll-like receptor 7 The present application includes a compound of Formula I or II: or a pharmaceutically acceptable-salt, solvate, and/or ester thereof, compositions containing such compounds, therapeutic methods that include the administrati...	06/28/2011
7964572	High affinity nucleic acid ligands of complement system proteins Methods are described for the identification and preparation of high-affinity Nucleic Acid Ligands to Complement System Proteins. Methods are described for the identification and preparation of high affinity Nucleic Acid Ligands to Complement System Proteins C1q, C3...	06/21/2011
7956184	Pyridazine compound and use thereof A compound of formula (1) and its salts and solvates are provided for the treatment or prophylaxis of hepatitis C virus infections Methods of making and formulating compound (1) are provided. ...	06/07/2011
7956179	Process for preparing an A2A-adenosine receptor agonist and its polymorphs Disclosed is a synthesis suitable for large scale manufacture of an A2A-adenosine receptor agonist, and also relates to polymorphs of that compound, and to methods of isolating a specific polymorph. ...	06/07/2011
7951813	Quinazolinone derivatives as ALDH-2 inhibitors Disclosed are novel quinazolinone derivatives of formula: wherein: R1 is optionally substituted phenyl or optionally substituted heteroaryl; R2 is 3-...	05/31/2011
7943118	Aerosolized fosfomycin/aminoglycoside combination for the treatment of bacterial respiratory infections A fosfomycin plus tobramycin combination formulation for delivery by aerosolization is described. The concentrated fosfomycin tobramycin combination formulation containing an efficacious amount of fosfomycin plus tobramycin is able to inhibit susceptible bacteria. F...	05/17/2011
7939654	Platelet derived growth factor (PDGF) nucleic acid ligand complexes This invention discloses a method for preparing a complex comprised of a PDGF Nucleic Acid Ligand and a Non-Immunogenic, High Molecular Weight Compound or Lipophilic Compound by identifying a PDGF Nucleic Acid Ligand by SELEX methodology and associating the PDGF Nuc...	05/10/2011
7939553	Modulators of pharmacokinetic properties of therapeutics The present application provides for a compound of Formula I, or a pharmaceutically acceptable salt, solvate, and/or ester thereof, compositions containing such compounds, therapeutic methods that include the administration...	05/10/2011
7939509	Partial and full agonists of Aadenosine receptors Disclosed are novel compounds a compound of Formula I that are partial and full A1 adenosine receptor agonists, useful for treating various disease states, in particular dyslipidemia, diabetes, decreased insulin ...	05/10/2011

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Assignee: Gilead Sciences, Inc.