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Lawrence Welk, the bandleader who entertained millions of Americans over a generation of broadcasting his TV show, once received a patent: for a music-themed design of an ashtray.
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| Number | Title | Issue Date |
| 8153604 | CNS-tumor treatment method and composition A method, aerosol composition, and aerosolizing device for treating a brain tumor in a subject are disclosed. The method includes intranasally administering to the subject, an amount of a telomerase inhibitor, such as an oligonucleotide telomerase inhibitor, effecti... | 04/10/2012 |
| 8153428 | Use of TGF beta superfamily antagonists and neurotrophins to make neurons from embryonic stem cells This invention provides a system for efficiently producing differentiated cells from pluripotent cells, such as human embryonic stem cells. Rather than permitting the cells to form embryoid bodies according to established techniques, differentiation is effected dire... | 04/10/2012 |
| 8148151 | Differentiation of primate pluripotent cells to hepatocyte-lineage cells Methods for differentiating primate pluripotent stem cells into hepatocyte-lineage cells are provided. In certain embodiments, the methods utilize sequential culturing of the primate pluripotent stem cells in certain growth factors to produce hepatocyte-lineage cell... | 04/03/2012 |
| 8148148 | Neural progenitor cell populations This invention provides populations of neural progenitor cells, differentiated neurons, glial cells, and astrocytes. The populations are obtained by culturing stem cell populations (such as embryonic stem cells) in a cocktail of growth conditions that initiates diff... | 04/03/2012 |
| 8097458 | Micro-carrier culture system for rapid expansion of human embryonic stem cells This disclosure provides an improved system for culturing human pluripotent stem cells. Traditionally, pluripotent stem cells are cultured on a layer of feeder cells (such as mouse embryonic fibroblasts) to prevent them from differentiating. In the system described ... | 01/17/2012 |
| 8093049 | Differentiation of primate pluripotent stem cells to hematopoietic lineage cells The invention provides methods of differentiating primate pluripotent stem cells into cells of hematopoietic lineage. The invention further provides hematopoietic lineage cells differentiated from primate pluripotent stem cells, as well as methods of using the same ... | 01/10/2012 |
| 7998938 | Cancer treatment by combined inhibition of proteasome and telomerase activities A method and kit for inhibiting the proliferation of cancer cells are disclosed, based on a combination of a proteasome inhibitor and a telomerase inhibitor. When used in cancer therapy, the two compounds in combination enhance the anti-cancer treatment efficacy obt... | 08/16/2011 |
| 7989603 | 2′-arabino-fluorooligonucleotide N3′-P5′ phosphoramidates: their synthesis and use Oligonucleotides with a novel sugar-phosphate backbone containing at least one 2′-arabino-fluoronucleoside and an internucleoside 3′-NH—P(═O)(OR)—O-5′ linkage, where R is a positively charged counter ion or hydrogen, and methods of synthesizing and using... | 08/02/2011 |
| 7989428 | Combined telomerase inhibitor and gemcitabine for the treatment of cancer A method and kit for inhibiting the proliferation of cancer cells are disclosed, based on a combination of a gemcitabine and a telomerase inhibitor. When used in cancer therapy, the two compounds in combination enhance the anti-cancer treatment efficacy obtained wit... | 08/02/2011 |
| 7906330 | Two cell population comprising chondrocyte precursors and human embryonic stem cells This invention provides a system for obtaining cells of the chondrocyte lineage by differentiating primate pluripotent stem cells. The process involves culturing the cells as a micromass or other aggregate form in a cocktail of differentiation agents that facilitate... | 03/15/2011 |
| 7897389 | Direct differentiation method for making cardiomyocytes from human embryonic stem cells This invention provides a new procedure for generating cardiomyocyte lineage cells from embryonic stem cells for use in regenerative medicine. Differentiating by way of embryoid body formation or in serum is no longer required. Instead, the stem cells are plated ont... | 03/01/2011 |
| 7846904 | Compositions and methods for increasing telomerase activity The present invention relates to methods for increasing telomerase activity in cells. Such compositions include pharmaceutical, including topical, and nutraceutical formulations. The method and compositions are useful for treating diseases subject to treatment by an... | 12/07/2010 |
| 7879609 | Regulatory segments of the human gene for telomerase reverse transcriptase The invention provides compositions and methods related to human telomerase reverse transcriptase (hTRT), the catalytic protein subunit of human telomerase. The polynucleotides and polypeptides of the invention are useful for diagnosis, prognosis and treatment of hu... | 02/01/2011 |
| 7851167 | Compound screening using cardiomyocytes This invention provides populations human cells of the cardiomyocyte lineage. The cells are obtained by causing cultures of pluripotent stem cells to differentiate in vitro, and then harvesting cells with certain phenotypic features. Differentiated cells bear cell s... | 12/14/2010 |
| 7824849 | Cellular telomerase vaccine and its use for treating cancer The invention provides dendritic cell (DC) preparations that present a telomerase reverse transcriptase (TRT) peptide in the context of an MHC class I or MHC class II molecule. The DCs may be pulsed with a TRT polypeptide, or may comprise a recombinant polynucleotid... | 11/02/2010 |
| 7799324 | Using undifferentiated embryonic stem cells to control the immune system This disclosure provides a system for minimizing the alloreactivity of tissue transplants. The patient is administered with undifferentiated embryonic stem cells or early progenitor cells. This induces a state of inflammatory quiescence or immune unresponsiveness, w... | 09/21/2010 |
| 7763464 | Differentiation protocol for making human cardiomyocytes This invention provides populations human cells of the cardiomyocyte lineage. The cells are obtained by causing cultures of pluripotent stem cells to differentiate in vitro, and then harvesting cells with certain phenotypic features. Differentiated cells bear cell s... | 07/27/2010 |
| 7763463 | Use of cyclic AMP and ascorbic acid to produce dopaminergic neurons from embryonic stem cells This disclosure provides improved methods for obtaining populations of dopaminergic neurons from pluripotent stem cells. The process involves taking a population of neural precursor cells derived from a line of human embryonic stem cells, and culturing the cells in ... | 07/27/2010 |
| 7750121 | Antibody to telomerase reverse transcriptive The invention provides compositions and methods related to human telomerase reverse transcriptase (hTRT), the catalytic protein subunit of human telomerase. The polynucleotides and polypeptides of the invention are useful for diagnosis, prognosis and treatment of hu... | 07/06/2010 |
| 7732402 | Mammalian telomerase Nucleic acids comprising the RNA component of a mammalian telomerase are useful as pharmaceutical, therapeutic, and diagnostic reagents. ... | 06/08/2010 |
| 7732199 | Process for making transplantable cardiomyocytes from human embryonic stem cells This invention provides populations human cells of the cardiomyocyte lineage. The cells are obtained by causing cultures of pluripotent stem cells to differentiate in vitro, and then harvesting cells with certain phenotypic features. Differentiated cells bear cell s... | 06/08/2010 |
| 7622549 | Human telomerase reverse transcriptase polypeptides The invention provides compositions and methods related to human telomerase reverse transcriptase (hTRT), the catalytic protein subunit of human telomerase. The polynucleotides and polypeptides of the invention are useful for diagnosis, prognosis and treatment of hu... | 11/24/2009 |
| 7585966 | Inhibitory polynucleotides directed against the RNA component of telomerase This invention provides inhibitory polynucleotides, such as antisense molecules, directed against accessible regions in the telomerase ribonucleoprotein. The polynucleotides are useful for inhibiting the activity of telomerase in cells and for treating cancer. ... | 09/08/2009 |
| 7585622 | Increasing the proliferative capacity of cells using telomerase reverse transcriptase The invention provides compositions and methods related to human telomerase reverse transcriptase (hTRT), the catalytic protein subunit of human telomerase. The polynucleotides and polypeptides of the invention are useful for diagnosis, prognosis and treatment of hu... | 09/08/2009 |
| 7563618 | Oligonucleotide conjugates Oligonucleotide conjugates, where an oligonucleotide is covalently attached to an aromatic system, are provided. In particular embodiments the oligonucleotide is complementary to the RNA component of human telomerase and is covalently attached to a nucleobase via an... | 07/21/2009 |
| 7560437 | Nucleic acid compositions for eliciting an immune response against telomerase reverse transcriptase The present invention is directed to pharmaceutical compositions comprising a telomerase reverse transcriptase polypeptide or a polypeptide homologous to a telomerase reverse transcriptase. The present invention is also directed to pharmaceutical compositions compri... | 07/14/2009 |
| 7560281 | Use of TGF beta superfamily antagonists to make dopaminergic neurons from embryonic stem cells This invention provides a system for efficiently producing differentiated cells from pluripotent cells, such as human embryonic stem cells. Rather than permitting the cells to form embryoid bodies according to established techniques, differentiation is effected dire... | 07/14/2009 |
| 7517971 | Muteins of human telomerase reverse transcriptase lacking telomerase catalytic activity The invention provides compositions and methods related to human telomerase reverse transcriptase (hTRT), the catalytic protein subunit of human telomerase. The polynucleotides and polypeptides of the invention are useful for diagnosis, prognosis and treatment of hu... | 04/14/2009 |
| 7494982 | Modified oligonucleotides for telomerase inhibition Compounds comprising an oligonucleotide moiety covalently linked to a lipid moiety are disclosed. The oligonucleotide moiety comprises a sequence that is complementary to the RNA component of human telomerase. The compounds inhibit telomerase activity in cells with ... | 02/24/2009 |
| 7485717 | Synthesis of protected 3′-amino nucleoside monomers Orthogonally protected 3′-amino nucleoside monomers and efficient methods for their synthesis are described. The methods employ selective protection of the 3′-amino group in the presence of the unprotected nucleoside base. ... | 02/03/2009 |
| 7473555 | Protocols for making hepatocytes from embryonic stem cells This disclosure provides a newly developed strategy and particular options for differentiating pluripotent stem cells into cells of the hepatocyte lineage. Many of the protocols are based on a strategy in which the cells are first differentiated into early germ laye... | 01/06/2009 |
| 7455983 | Medium for growing human embryonic stem cells This disclosure provides an improved system for culturing human pluripotent stem cells. Traditionally, pluripotent stem cells are cultured on a layer of mouse embryonic fibroblast feeder cells to prevent them from differentiating. In the system described here, the r... | 11/25/2008 |
| 7452718 | Direct differentiation method for making cardiomyocytes from human embryonic stem cells This invention provides a new procedure for generating cardiomyocyte lineage cells from embryonic stem cells for use in regenerative medicine. Differentiating by way of embryoid body formation or in serum is no longer required. Instead, the stem cells are plated ont... | 11/18/2008 |
| 7425448 | Cardiomyocyte precursors from human embryonic stem cells This invention provides populations human cells of the cardiomyocyte lineage. The cells are obtained by causing cultures of pluripotent stem cells to differentiate in vitro, and then harvesting cells with certain phenotypic features. Differentiated cells bear cell s... | 09/16/2008 |
| 7413904 | Human embryonic stem cells having genetic modifications This disclosure provides a system for obtaining genetically altered primate pluripotent stem (pPS) cells. The role of the feeder cells is replaced by supporting the culture on an extracellular matrix, and culturing the cells in a conditioned medium. The cells can be... | 08/19/2008 |
| 7413902 | Feeder-free culture method for embryonic stem cells or primate primordial stem cells Methods and materials for culturing primate-derived primordial stem cells are described. In one embodiment, a cell culture medium for growing primate-derived primordial stem cells in a substantially undifferentiated state is provided which includes a low osmotic pre... | 08/19/2008 |
| 7413864 | Treating cancer using a telomerase vaccine The invention provides compositions and methods related to human telomerase reverse transcriptase (hTRT), the catalytic protein subunit of human telomerase. The polynucleotides and polypeptides of the invention are useful for diagnosis, prognosis and treatment of hu... | 08/19/2008 |
| 7410798 | Culture system for rapid expansion of human embryonic stem cells This disclosure provides an improved system for culturing human pluripotent stem cells. Traditionally, pluripotent stem cells are cultured on a layer of feeder cells (such as mouse embryonic fibroblasts) to prevent them from differentiating. In the system described ... | 08/12/2008 |
| 7402307 | Method for identifying and killing cancer cells The invention provides a method for activating a T lymphocyte by contacting the T lymphocyte with a dendritic cell (DC) that presents a telomerase reverse transcriptase (TRT) peptide in the context of an MHC class I or MHC class II molecule. The DC may be pulsed wit... | 07/22/2008 |
| 7378244 | Telomerase promoters sequences for screening telomerase modulators Telomerase reverse transcriptase is part of the telomerase complex responsible for maintaining telomere length and increasing the replicative capacity of progenitor cells. Telomerase activity is turned off in mature differentiated cells, but is turned back on again ... | 05/27/2008 |
