Assignee: Georgetown University

Location: Washington, DC
No. of patents: 187

Number	Title	Issue Date
8163805	Small molecule antagonists of Bcl-2 family proteins The present invention relates to naturally occurring and chemically synthesized small molecule antagonists of Bcl-2 family proteins. In particular, the present invention provides gossypol compounds (e.g., isomers, enantiomers, racemic compounds, metabolites, derivat...	04/24/2012
8153657	Dopamine-, norepinephrine- and serotonin-transporter-selective heterocyclic compounds and their therapeutic applications One aspect of the invention relates to piperidine compounds that are useful as inhibitors of monoamine transporters. The invention also relates to pharmaceutical compositions, comprising a piperidine compound of the invention. Another aspect of the present invention...	04/10/2012
8138749	Optical imaging and patterning based on a magnetically controlled ferrofluid Methods, systems, and apparatus for optical imaging and patterning based on a magnetically controlled ferrofluid are described. One such system includes a substrate and an active region including multiple magnetic field generators. The active region is positioned ad...	03/20/2012
8124052	Method for identifying targeting domains and methods and compositions comprising the same The present invention is directed to a method of identifying tissue targeting domains. In particular, the invention relates to methods for identifying a polynucleotide encoding a targeting domain which directs tumor cell localization to secondary sites, to methods o...	02/28/2012
8097472	System and method for the separation of analytes A separation module operates to fractionate or separate an analyte into fractions according to pI, i.e., pI bands, utilizing capillary isoelectric focusing (“CIEF”) within a first microchannel. The fractions are stacked to form plugs, the number of which is dete...	01/17/2012
8067600	Histone deacetylase inhibitors and methods of use thereof One aspect of the invention relates to HDAC inhibitors. Methods of sensitizing a cancer cell to the cytotoxic effects of radiotherapy are also provided. The invention also provides methods for treating cancer and methods for treating neurological diseases. Additiona...	11/29/2011
8044103	Cyclic dipeptides and azetidinone compounds and their use in treating CNS injury and neurodegenerative disorders The present invention provides 4-substituted-2-azetidinone compounds, bicyclic 2-5-diketopiperazine compounds, and pharmaceutical compositions thereof that are potent, safe and effective neuroprotective agents. Due to their strong central nervous system (CNS) activi...	10/25/2011
8037535	System and method for detecting malicious executable code A system and method for detecting malicious executable software code. Benign and malicious executables are gathered; and each are encoded as a training example using n-grams of byte codes as features. After selecting the most relevant n-grams for prediction, a plura...	10/11/2011
8030300	Ligands for nicotinic acetylcholine receptors, and methods of making and using them One aspect of the present invention relates to heterocyclic compounds that are ligands for nicotinic acetylcholine receptors. A second aspect of the invention relates to the use of a compound of the invention for modulation of a mammalian nicotinic acetylcholine rec...	10/04/2011
8012679	Papillomavirus vaccines Seven polyclonal and monoclonal antibodies were characterized for their ability to react specifically with either conformational or non-conformational epitopes of the HPV-1 virion. Using these antibodies, it was shown that the HPV-1 L1 protein (when expressed by an ...	09/06/2011
7989491	Use of artemisinin for treating tumors induced by oncogenic viruses and for treating viral infections In certain aspects, the invention relates to methods of treating proliferative cervical disorders (such as cervical cancer and cervical dysplasia) and treating virus infections by administering artemisinin-related compounds. In certain aspects, the invention relates...	08/02/2011
7931592	Systems and methods for monitoring health and delivering drugs transdermally The present invention pertains to a system and method for transdermal sampling, comprising: at least one sampler for retrieving and transferring at least one analyte obtained transdermally from the skin of a subject; at least one detector system for identifying and ...	04/26/2011
7888509	Chiral 1,8-diarylnaphthalenes, methods of making them, and their use as sensors One aspect of the invention relates to 1,8-diarylnaphthalene compounds. In certain embodiments, a compound of the invention is an N-oxide of a 1,8-diarylnaphthalene. In certain embodiments, the aryl group is an optionally substituted acridyl group. In certain embodi...	02/15/2011
7888485	Anti-pleiotrophin antibodies and methods of use thereof The present invention concerns antibodies that neutralize at least one biological activity of pleiotrophin. The antibodies can inhibit cancer cell growth and angiogenesis in vitro or in vivo. The present invention provides for methods of inhibiting cancer cell growt...	02/15/2011
7872027	Low molecular weight Myc-max inhibitors Compounds and compositions for interfering with the association of Myc and Max are described herein. These compounds and compositions are useful in methods inhibiting growth or proliferation of a cell. Methods of inhibiting growth or proliferation of a cell are prov...	01/18/2011
7863010	Method of assessing progress of kidney regeneration The present invention relates to methods, reagents, and kits for assessing organ damage, such as damage due to ischemia reperfusion injury, in the course of a transplantation therapy and/or for assessing organ regeneration following transplantation therapy. The inve...	01/04/2011
7842835	Histone deacetylase inhibitors and methods of use thereof The invention provides novel classes of HDAC inhibitors. Methods of sensitizing a cancer cell to the cytotoxic effects of radiotherapy are also provided as well as methods for treating cancer and methods for treating neurological diseases. Additionally, the inventio...	11/30/2010
7825216	Phenylanine derivatives The present invention provides phenylalanine derivatives that inhibit SH2 domain binding with a phosphoprotein. These derivatives include compounds of the formula: W—Y-(AA)n-Z wherein n is 0 to 15; Y is a phenylalanyl radical having a phenyl ring, an am...	11/02/2010
7803595	Mammalian sphingosine kinase type 2 isoforms, cloning, expression and methods of use thereof Nucleic acids encoding mouse and human sphingosine kinase type 2 isoforms, methods for detecting agents or drugs which inhibit or promote sphingosine activity and therapeutic agents containing peptides or antibodies to peptides encoded by such nucleic acids. ...	09/28/2010
7780882	Simplified and improved method for preparing an antibody or an antibody fragment targeted immunoliposome for systemic administration of a therapeutic or diagnostic agent A method of preparing an antibody- or antibody fragment-targeted cationic immunoliposome or polymer complex comprises the steps of (a) preparing an antibody or antibody fragment; (b) mixing said antibody or antibody fragment with a cationic liposome to form a cation...	08/24/2010
7763734	Synthesis, structure and use of bisoxazolidines for asymmetric catalysis and synthesis One aspect of the invention relates to chiral bisoxazolidines and their use in asymmetric catalysis. The chiral bisoxazolidines are a novel class of compounds that is expected to find multiple applications, for example, in asymmetric synthesis. For example, a bisoxa...	07/27/2010
7756722	Clinical management system from chronic illnesses using telecommunication Patients with chronic illnesses resist using conventional automated healthcare management systems to supply necessary clinical data because such systems feel impersonal, preferring to actually visit a clinic where the patient interacts with various healthcare practi...	07/13/2010
7750133	Vascular endothelial cell growth inhibitor, VEGI-192a This invention discloses two new VEGI isoforms named VEGI-192a and VEGI-192b consisting of 192 amino acid residues. These isoforms show endothelial cell-specific expression and share a C-terminal 151-residues segment with the previously describ...	07/06/2010
7749745	Viral vectors and their use in therapeutic methods The invention provides viral vectors (e.g., herpes viral vectors) and methods of using these vectors to treat disease. ...	07/06/2010
7725565	System and method for detecting, collecting, analyzing, and communicating event related information A system and method involves detecting operational social disruptive events on a global scale, assigning disease event staging and warnings to express data in more simplistic terms, modeling data in conjunction with linguistics analysis to establish responsive actio...	05/25/2010
7655477	System and method for the separation of analytes A separation module operates to fractionate or separate an analyte into fractions according to pI, i.e., pI bands, utilizing capillary isoelectric focusing (“CIEF”) within a first microchannel. The fractions are stacked to form plugs, the number of which is dete...	02/02/2010
7618827	Thyroid hormone analysis by mass spectrometry Methods, systems and kits for the simultaneous or sequential analysis of one or more hormones by mass spectrometry are disclosed. The methods require minimal sample size and minimal preparation time. The methods include ionizing the hormones and analyzing the hormon...	11/17/2009
7615355	Peripheral-type benzodiazepine receptor expression level as an index of organ damage and regeneration The present invention relates to methods, reagents, and kits for assessing organ damage, such as damage due to ischemia reperfusion injury, in the course of a transplantation therapy and/or for assessing organ regeneration following transplantation therapy. The inve...	11/10/2009
7608264	Antibodies that bind to pleiotrophin growth factor receptor This invention relates to the discovery that pleiotrophin binds to and activates a pleiotrophin-receptor which is responsible for the events associated with pleiotrophin activity including tumorigenesis, cell proliferation, and cell invasion. By interfering with tha...	10/27/2009
7528109	Pleiotrophin growth factor receptor for the treatment of proliferative, vascular and neurological disorders This invention relates to the discovery that pleiotrophin binds to and activates a pleiotrophin-receptor which is responsible for the events associated with pleiotrophin activity including tumorigenesis, cell proliferation, and cell invasion. By interfering with tha...	05/05/2009
7507828	Histone deacetylase inhibitors and methods of use thereof One aspect of the invention relates to HDAC inhibitors. Methods of sensitizing a cancer cell to the cytotoxic effects of radiotherapy are also provided. The invention also provides methods for treating cancer and methods for treating neurological diseases. Additiona...	03/24/2009
7498407	Vascular endothelial cell growth inhibitor, VEGI-192a This invention discloses two new VEGI isoforms named VEGI-192a and VEGI-192b consisting of 192 amino acid residues. These isoforms show endothelial cell-specific expression and share a C-terminal 151-residues segment with the previously describ...	03/03/2009
7479276	Antibody fragment-targeted immunoliposomes for systemic gene delivery Nucleic acid-immunoliposome compositions useful as therapeutic agents are disclosed. These compositions preferably comprise (i) cationic liposomes, (ii) a single chain antibody fragment which binds to a transferrin receptor, and (iii) a nucleic acid encoding a wild ...	01/20/2009
7473560	Steroid hormone analysis by mass spectrometry Methods, systems and kits for the simultaneous or sequential analysis of a multitude of steroid hormones by mass spectrometry are disclosed. The methods require minimal sample size and minimal preparation time. The methods include ionizing the hormones and analyzing...	01/06/2009
7442520	Gene BRCC-3 and diagnostic and therapeutic uses thereof A gene that is a modulator of tumor growth and metastasis in certain cancer types is provided. This gene and corresponding polypeptide have diagnostic and therapeutic application for detecting and treating cancers that involve expression of BRCC-3 such as breast can...	10/28/2008
7427689	ErbB-2 selective small molecule kinase inhibitors A novel method for erbB-2 kinase inhibition by compounds identifies through computational modeling and data processing and/or rational and de novo drug design is provided the compounds bind erbB-2 kinase molecules and which can be used as erbB-2 kinase agonists or a...	09/23/2008
7419814	Mammalian sphingosine kinase type 2 isoforms, cloning, expression and methods of use thereof Methods for detecting agents or drugs which inhibit or promote an activity of sphingosine kinase type 2 isoform involving providing a recombinant DNA construct into a cell such that sphingosine kinase type 2 isoform is produced in the cell, adding at least one drug ...	09/02/2008
7381745	Ligands for metabotropic glutamate receptors and inhibitors of NAALADase The present invention relates to novel compounds and formulations thereof which compounds are ligands, e.g., agonists or antagonists, for a metabotropic glutamate receptor or a NAALADase enzyme or both. The present invention also relates to methods of modulating the...	06/03/2008
7378403	Akt inhibitors, pharmaceutical compositions, and uses thereof Disclosed are inhibitors of the serine/threonine kinase Akt, pharmaceutical compositions comprising such inhibitors, and a method of preventing or treating a disease or condition in an animal by the use of such inhibitors. The Akt inhibitors have the formula (I) whe...	05/27/2008
7351811	Gene SCC-112 and diagnostic and therapeutic uses thereof A gene that is a modulator of tumor growth and metastasis in certain cancer types is provided. SCC-112 (about 150 kDa) and/or a mutant form of SCC-112 (about 65 kDa) is a tumor suppressor molecule. This gene and corresponding polypeptide have diagnostic and therapeu...	04/01/2008

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Assignee: Georgetown University