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Felix Hoffmann, a German chemist, was searching for something to relieve his father's arthritis. In doing so, he "rediscovered" acetylsalicylic acid and in 1900, patented a stable process for developing it. Hence, we have aspirin.
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| Number | Title | Issue Date |
| 5049504 | Bioadhesive coding sequences Vectors are provided that are capable of expressing, in microbial transformants, a protein having the native amino acid sequence of a bioadhesive precursor protein of a marine animal selected from the group consisting of mussels, barnacles, and oysters. T... | 09/17/1991 |
| 5013652 | Composite yeast vectors A DNA sequence comprising: (a) a hybrid first yeast promoter comprising the functional segment of the DNA sequence encoding the upstream activation site of a gene selected from the group consisting of GAL1, GAL7 and GAL10, operably linked to the functiona... | 05/07/1991 |
| 4990452 | Combining mutations for stabilization of subtilisin The invention relates to modified subtilisin enzymes which have increased thermal stability. The modified subtilisin enzymes have at least two or more amino acid mutations which confer increased thermal stability. It has been discovered that combining ind... | 02/05/1991 |
| 4980288 | Subtilisin with increased thermal stability Cloned DNA is mutated by creating a single-stranded target region in a cloned DNA segment, and introducing a mutation into the single-stranded target region by treating the target region with a chemical or biological mutagenizing agent capable of introduc... | 12/25/1990 |
| 4977247 | Immobilized protein G variants and the use thereof Immobilized IgG binding proteins and the use thereof to effect affinity chromatography and separate the subclasses of IgG. Disclosed are cysteine-containing IgG binding proteins which have high binding capacity for human IgG and mouse monoclonal IgG.... | 12/11/1990 |
| 4956296 | Cloned streptococcal genes encoding protein G and their use to construct recombinant microorganisms to produce protein G A cloned gene encoding Protein G, or functionally active portions thereof, vectors containing the cloned gene, and microorganisms transformed by those vectors are disclosed.... | 09/11/1990 |
| 4954618 | Cloned streptococcal genes encoding protein G and their use to construct recombinant microorganisms to produce protein G A cloned gene encoding Protein G, or functionally active portions thereof, vectors containing the cloned gene, and microorganisms transformed by those vectors are disclosed.... | 09/04/1990 |
| 4946778 | Single polypeptide chain binding molecules The invention pertains to a single polypeptide chain binding molecule which has binding specificity and affinity substantially similar to the binding specificity and affinity of the light and heavy chain aggregate variable region of an antibody, to geneti... | 08/07/1990 |
| 4939666 | Incremental macromolecule construction methods A preferred embodiment of the invention is a method for constructing a polypeptide chain having a substantially predetermined conformation. Preferably a known stable well-mapped polypeptide structure is used as a starting point, and additional peptide uni... | 07/03/1990 |
| 4908773 | Computer designed stabilized proteins and method for producing same Proteins, such as enzymes having enhanced stability are designed through the use of a computer method. The method identifies amino acid residues of a protein which may be replaced with a cysteine residue in order to promote the formation of a protein-stab... | 03/13/1990 |
| 4881175 | Computer based system and method for determining and displaying possible chemical structures for converting double- or multiple-chain polypeptides to single-chain polypeptides A computer based system and method determines and displays possible chemical structures for converting two naturally aggregated but chemically separated polypeptide chains into a single polypeptide chain which will fold into a three dimensional structure ... | 11/14/1989 |
| 4853871 | Computer-based method for designing stablized proteins A computer-based method evaluates the structure of a protein to thereby identify sites in the protein molecule at which the natural amino acid residues can be replaced with cysteine residues in order to permit the formation of a potentially stabilizing di... | 08/01/1989 |
| 4828994 | Bacillus strains with reduced extracellular protease levels Bacillus strains having reduced levels of extracellular protease are produced by replacing the native chromosomal DNA sequence comprising the gene for an extracellular protease, such as subtilisin, with a partially homologous DNA sequence having an inacti... | 05/09/1989 |
| 4801537 | Vector for expression of polypeptides in bacilli A replicable plasmidic expression vector, capable of high levels of expression and secretion of polypeptides in a bacillus is disclosed. The vector contains a DNA sequence comprising the promoter and regulatory regions which control expression and secreti... | 01/31/1989 |
| 4798791 | Vector for high level gene expression Methods and vectors for high level expression of genes in bacteria are disclosed. A terminal mRNA sequence from a gene coding for a stable bacterial protein mRNA is ligated to a gene coding for the desired protein adjacent the translation termination codo... | 01/17/1989 |
| 4771003 | Heat stable alkaline proteases produced by a bacillus Novel enzymes exhibiting proteolytic activity in alkaline media and stability at high temperatures and under alkaline conditions are produced by a novel Bacillus strain designated GX6638 or its mutants or variants. These enzymes are especially well-suited... | 09/13/1988 |
| 4764470 | Alkaline protease produced by a bacillus A novel enzyme exhibiting proteolytic activity in alkaline media and stability under alkaline conditions is produced by a novel Bacillus strain designated GX6644 or by its mutants or variants. The enzyme is well-suited for inclusion in washing composition... | 08/16/1988 |
| 4757015 | Phenylalanine ammonia lyase-producing strains Phenylalanine ammonia-lyase (PAL) producing Rhodotorula graminis, high PAL specific activity, strain GX 6000 its progeny, and PAL producing mutants thereof can be utilized for phenylalanine production from cinnamate. In this strain, PAL can be induced syn... | 07/12/1988 |
| 4721673 | Recovery and activation process for microbially produced calf prochymosin A process for the extraction and activation of microbially produced bovine prochymosin is disclosed.... | 01/26/1988 |
| 4681850 | Phenylalanine ammonia lyase-producing microbial cells This invention relates to novel microbial strains which produce phenylalanine ammonia-lyase in the absence of an inducer. Also disclosed is a method for making phenylalanine.... | 07/21/1987 |
| 4636466 | Phenylalanine ammonia lyase-producing microbial cells This invention relates to novel microbial strains which produce phenylalanine ammonia-lyase. These novel microbial strains have the ability to grow on minimal essential media which contain, as substantially the sole carbon source, L-tyrosine. Also disclos... | 01/13/1987 |
| 4617266 | Production of Protein A Novel Protein A-producing Gram-positive bacterial strains and methods for their preparation are disclosed. Also disclosed are methods for producing Protein A using the novel Gram-positive strains.... | 10/14/1986 |
