Assignee: Genetics Institute, LLC

Location: Cambridge, MA
No. of patents: 23

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Number	Title	Issue Date
8048984	Human GIL-19/AE289 proteins Novel human GIL-19/AE289 protein is disclosed which shows a high degree of homology to interleukin-10 (IL-10). Polynucleotides encoding such protein are also enclosed. ...	11/01/2011
8012475	Use of IL-12 and IL-12 antagonists in the treatment of autoimmune diseases Method of treating autoimmune conditions are disclosed comprising administering to a mammalian subject IL-12 or an IL-12 antagonist. In certain preferred embodiments the autoimmune condition is one which is promoted by an increase in levels of IFN-γ or TNF-α. Suit...	09/06/2011
7976840	Use of anti-GL50 antibodies for the downmodulation of an immune response The invention provides isolated nucleic acids molecules, designated GL50 nucleic acid molecules, which encode novel GL50 polypeptides. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing GL50 nucleic acid molecules...	07/12/2011
7927835	Nucleic acids encoding P-selectin ligand fusion proteins A novel P-selectin ligand glycoprotein is disclosed, comprising the amino acid sequence set forth in SEQ ID NO:2 or by the amino acid sequence set forth in SEQ ID NO:4. DNA sequences encoding the P-selectin ligand protein are also disclosed, along with vectors, host...	04/19/2011
7842669	Methods and compositions for healing and repair of articular cartilage Methods and compositions are provided for the treatment of articular cartilage defects and disease involving the combination of tissue, such as osteochondral grafts, with active growth factor. The active growth factor is preferably a composition containing at least ...	11/30/2010
7709214	Methods for upregulating an immune response with agents that inhibit the intereaction between PD-L2 and PD-1 The invention provides isolated nucleic acids molecules, designated PD-L2 nucleic acid molecules, which encode novel B7-related molecules which are ligands for PD-1. The invention also provides antisense nucleic acid molecules, recombinant expression vectors contain...	05/04/2010
7705123	MU-1, member of the cytokine receptor family Polynucleotides encoding the MU-1 hematopoietin receptor superfamily chain and fragments thereof are disclosed. MU-1 proteins and methods for their production are also disclosed. ...	04/27/2010
7678885	Recombinant bone morphogenetic protein heterodimers, compositions and methods of use The present invention relates to a methods for producing recombinant heterodimeric BMP proteins useful in the field of treating bone defects, healing bone injury and in wound healing in general. The invention also relates to the recombinant heterodimers and composit...	03/16/2010
7674591	Methods of using antibodies to human IL-13bc for inhibiting IL-13 binding Polynucleotides encoding the IL-13 receptor and fragments thereof are disclosed. IL-13 receptor proteins, methods for their production, inhibitors of binding of IL-13 and its receptor and methods for their identification are also disclosed. ...	03/09/2010
7666421	Methods of treatment of autoimmune diseases using humanized immunoglobulin reactive with B7-2 The invention relates to a humanized anti-B7-2 antibody that comprises a variable region of nonhuman origin and at least a portion of an immunoglobulin of human origin. The invention also pertains to methods of treatment for various autoimmune diseases, transplant r...	02/23/2010
7638604	Monoclonal antibodies against interleukin-22 Antibodies and antigen-binding fragments thereof that bind interleukin-22 (IL-22), in particular, human IL-22, and their uses in regulating IL-22-associated immune responses are disclosed. The antibodies disclosed herein are useful in diagnosing, preventing, or trea...	12/29/2009
7638492	Methods of upmodulating an immune response with non-activating forms of B7-4 The invention identifies PD-1 as a receptor for B7-4. B7-4 can inhibit immune cell activation upon binding to an inhibitory receptor on an immune cell. Accordingly, the invention provides agents for modulating PD-1, B7-4, and the interaction between B7-4 and PD-1 in...	12/29/2009
7608580	Injectable carrier formulations of hyaluronic acid derivatives for delivery of osteogenic proteins An injectable formulation is disclosed for delivery of osteogenic proteins. The formulation comprises a pharmaceutically acceptable admixture of an osteogenic protein; and formulations comprising osteogenic protein, hyaluronic acid derivatives and tricalcium phospha...	10/27/2009
7601813	Anti-GL50 antibodies The invention provides isolated nucleic acids molecules, designated GL50 nucleic acid molecules, which encode novel GL50 polypeptides. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing GL50 nucleic acid molecules...	10/13/2009
7592007	Methods of inhibiting T cell proliferation or IL-2 accumulation with CTLA-4 specific antibodies Isolated ligands which bind a molecule expressed on the surface of T cells and induce antigen specific apoptosis in activated T cells are disclosed. Preferably, the T cell surface molecule is CTLA4 and the ligand is a monoclonal anti-CTLA4 antibody that binds to an ...	09/22/2009
7585646	Human GIL-19/AE289 polynucleotides and methods of producing the encoded polypeptides Novel human GIL-19/AE289 protein is disclosed which shows a high degree of homology to interleukin-10 (IL-10). Polynucleotides encoding such protein are also enclosed. ...	09/08/2009
7576178	DADD, death activator death domain protein Polynucleotides encoding DADD protein are also disclosed, along with vectors, host cells, and methods of making DADD protein. Methods of identifying inhibitors of DADD death domain binding and inhibitors identified by such methods are also disclosed. ...	08/18/2009
7569669	Calcium independent cytosolic phospholipase A/B enzymes The invention provides a novel calcium-independent cytosolic phospholipase A2/B enzyme, polynucleotides encoding such enzyme and methods for screening unknown compounds for anti-inflammatory activity mediated by the arachidonic acid cascade. ...	08/04/2009
7563760	P-selectin ligand protein A novel P-selectin ligand glycoprotein is disclosed, comprising the amino acid sequence set forth in SEQ ID NO:2 or by the amino acid sequence set forth in SEQ ID NO:4. DNA sequences encoding the P-selectin ligand protein are also disclosed, along with vectors, host...	07/21/2009
7534430	Use of IL-12 and IL-12 antagonists in the treatment of autoimmune diseases Method of treating autoimmune conditions are disclosed comprising administering to a mammalian subject IL-12 or an IL-12 antagonist. In certain preferred embodiments the autoimmune condition is one which is promoted by an increase in levels of IFN-γ or TNF-α. Suit...	05/19/2009
7521532	GL50 polypeptides The invention provides isolated nucleic acids molecules, designated GL50 nucleic acid molecules, which encode novel GL50 polypeptides. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing GL50 nucleic acid molecules...	04/21/2009
7507706	Cytokine receptor chain Polynucleotides encoding the IL-13 receptor and fragments thereof are disclosed. IL-13 receptor proteins, methods for their production, inhibitors of binding of IL-13 and its receptor and methods for their identification are also disclosed. Methods of medical treatm...	03/24/2009
7479269	Methods for selectively enriching TH1 and TH2 cells Methods for inducing a population of T cells to proliferate by activating the population of T cells and stimulating an accessory molecule on the surface of the T cells with a ligand which binds the accessory molecule are described. T cell proliferation occurs in the...	01/20/2009

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Assignee: Genetics Institute, LLC