Assignee: Genetics Institute, Inc.

Location: Cambridge, MA
No. of patents: 319

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Number	Title	Issue Date
7361738	Megakaryocyte stimulating factors Novel polypeptides of human megakaryocyte stimulating factors (MSFs). Pharmaceutical compositions containing same, and methods for their preparation and use are provided. ...	04/22/2008
7175843	Methods for selectively stimulating proliferation of T cells Methods for inducing a population of T cells to proliferate by activating the population of T cells and stimulating an accessory molecule on the surface of the T cells with a ligand which binds the accessory molecule are described. T cell proliferation occurs in the...	02/13/2007
7151086	Bone morphogenetic protein (BMP)-17 and BMP-18 compositions Purified BMP-17 and BMP-18 proteins and processes for producing them are disclosed. DNA molecules encoding the BMP-17 and BMP-18 proteins are also disclosed. The proteins may be used in the treatment of bone, cartilage, other connective tissue defects and disorders,...	12/19/2006
7144575	Methods for selectively stimulating proliferation of T cells Methods for inducing a population of T cells to proliferate by activating the population of T cells and stimulating an accessory molecule on the surface of the T cells with a ligand which binds the accessory molecule are described. T cell proliferation occurs in the...	12/05/2006
7138115	Use of IL-12 and IL-12 antagonists in the treatment of autoimmune diseases Method of treating autoimmune conditions are disclosed comprising administering to a mammalian subject IL-12 or an IL-12 antagonist. In certain preferred embodiments the autoimmune condition is one which is promoted by an increase in levels of IFN-γ or TNF-α. Suit...	11/21/2006
7122377	Acid-labile isotope-coded extractant (ALICE) and its use in quantitative mass spectrometric analysis of protein mixtures The method of the invention provides novel compounds, termed acid-labile isotope-coded extractants (ALICE), for quantitative mass spectrometric analysis of protein mixtures. The compounds contain a thiol-reactive group that is used to capture cysteine-containing pep...	10/17/2006
7112325	Antibodies to calcium independent cytosolic phospholipase A/B enzymes The invention provides a novel calcium-independent cytosolic phospholipase A2/B enzyme, polynucleotides encoding such enzyme, antibodies to such enzyme, and methods for screening unknown compounds for anti-inflammatory activity mediated by the arachidonic...	09/26/2006
7109307	TNF receptor death domain ligand proteins and inhibitors of ligand binding Novel TNF receptor death domain (“TNF-R1-DD”) ligand proteins are disclosed. Polynucleotides encoding the TNF-R1-DD ligand protein are also disclosed, along with vectors, host cells, and methods of making the TNF-R1-DD ligand protein. Pharmaceutical compositions...	09/19/2006
7105331	ICE/CED-3 like protease designated FMH-1 Polynucleotides encoding novel proteases designated “FMH-1” are disclosed. Host cells transformed with such polynucleotides and methods for making FMH-1 proteases are also disclosed. The invention also provides FMH-1 proteases and antibodies that react with them...	09/12/2006
7101550	PD-1, a receptor for B7-4, and uses therefor The invention identifies PD-1 as a receptor for B7-4. B7-4 can inhibit immune cell activation upon binding to an inhibitory receptor on an immune cell. Accordingly, the invention provides agents for modulating PD-1, B7-4, and the interaction between B7-4 and PD-1 in...	09/05/2006
7094402	Antibodies to human interleukin-11 receptor Polynucleotides encoding the human IL-11 receptor and fragments thereof are disclosed. IL-11 receptor proteins, methods for their production, antibodies to human IL-11 receptor, inhibitors of binding of human IL-11 and its receptor and methods for identification of ...	08/22/2006
7091007	DNA molecules encoding BMP receptor proteins Novel serine/threonine receptor proteins and BMP receptor proteins are disclosed, as well as DNA molecules encoding the BMP receptor proteins and methods of using the receptor proteins. Further disclosed are truncated BMP receptor proteins and molecules which act as...	08/15/2006
7049128	Platelet glycoprotein Ibα fusion polypeptides and methods of use thereof The present invention provides compositions and methods for treating or preventing vascular-associated disorders. ...	05/23/2006
7033992	Formulations for IL-11 Provided by the present invention are novel compositions and methods for obtaining concentrated preparations of IL-11 and formulations of IL-11 suitable for storage and administration. ...	04/25/2006
7034121	Antibodies against CTLA4 The invention provides an antibody-toxic moiety conjugates comprising an antibody that specifically recognizes a molecule expressed on the surface of a T cell which is expressed only on T cells and is only expressed transiently on T cells upon T cell activation. Pre...	04/25/2006
7030223	Megakaryocyte stimulating factors Novel polypeptides of human megakaryocyte stimulating factors (MSFs). Pharmaceutical compositions containing same, and methods for their preparation and use are provided. ...	04/18/2006
7026445	Human SDF-5 protein and compositions Purified human SDF-5 proteins and processes for producing them are disclosed. DNA molecules encoding the human SDF-5 proteins are also disclosed. The proteins may be used in regulating the binding of Wnt genes to their receptor. In preferred embodiments, the protein...	04/11/2006
7011833	Enhancing immune responses with B7-1 or B7-2 in the absence of a crosslinking agent Methods of enhancing immune responses in which soluble forms of costimulatory molecules, e.g., B7 molecules, are administered to augment immune responses to antigens, e.g., to tumor cells and infectious agents are provided. The subject methods are useful for both pr...	03/14/2006
6991796	Platlet glycoprotein IBα fusion polypeptides and methods of use thereof The present invention provides compositions and methods for treating or preventing vascular-associated disorders. ...	01/31/2006
6984383	Method of transplanting cells by contacting donor cells with B7-1-and B7-2-specific immunoglobulins The invention relates to a humanized anti-B7-2 antibody that comprises a variable region of nonhuman origin and at least a portion of an immunoglobulin of human origin. The invention also pertains to methods of treatment for various autoimmune diseases, transplant r...	01/10/2006
6979565	Cytosolic phospholipase A-gamma enzymes and polynucleotides encoding same The invention provides a novel calcium-independent cytosolic phospholipase A2-Gamma enzyme, polynucleotides encoding such enzyme and methods for screening unknown compounds for anti-inflammatory activity mediated by the arachidonic acid cascade. ...	12/27/2005
6972125	Humanized immunoglobulin reactive with B7-2 and methods of treatment therewith The invention relates to a humanized anti-B7-2 antibody that comprises a variable region of nonhuman origin and at least a portion of an immunoglobulin of human origin. The invention also pertains to methods of treatment for various autoimmune diseases, transplant r...	12/06/2005
6953777	Use of interleukin-11 to prevent immune-mediated cytotoxicity The use of interleukin-11 to prevent, to ameliorate, and to treat an immune-mediated disease in a mammal in need of such treatment is disclosed. ...	10/11/2005
6939545	Composition and method for treating inflammatory disorders Inhibitors of IL-22 are disclosed as well as pharmaceutical compositions and methods of using same. The inhibitors include IL-22 antibodies and are useful for treating inflammatory disorders. ...	09/06/2005
6933370	Methods for purifying highly anionic proteins The present invention provides a process for isolating and purifying highly anionic target proteins, for example, sulfated proteins. Sulfated proteins have five (5) or more, sulfations. In a preferred embodiment, the sulfated protein has six (6) sulfations, e.g., si...	08/23/2005
6905879	Isotope-coded ionization-enhancing reagents (ICIER) for high-throughput protein identification and quantitation using matrix-assisted laser desorption ionization mass spectrometry Arginine-containing cysteine-modifying compounds useful for MALDI-MS analysis of proteins are provided. These compounds termed isotope-coded ionization enhancement reagents (ICIER) can provide ionization enhancement in MALDI-MS, relative quantitation, and additional...	06/14/2005
6905680	Methods of treating HIV infected subjects Methods for inducing a population of T cells to proliferate by activating the population of T cells and stimulating an accessory molecule on the surface of the T cells with a ligand which binds the accessory molecule are described. T cell proliferation occurs in the...	06/14/2005
6905681	Methods for selectively stimulating proliferation of T cells Methods for inducing a population of T cells to proliferate by activating the population of T cells and stimulating an accessory molecule on the surface of the T cells with a ligand which binds the accessory molecule are described. T cell proliferation occurs in the...	06/14/2005
6902735	Antibodies to human IL-17F and other CTLA-8-related proteins Polynucleotides encoding human CTLA-8 (now known as IL-17F) and related proteins are disclosed. Human CTLA-8 and related proteins, including anti-human IL-17F antibodies, and methods for their production are also disclosed. Methods of treatment using human CTLA-8 pr...	06/07/2005
6899878	Antibodies to interleukin-1 receptor intracellular ligand proteins Antibodies to IL-1-R intracellular ligand proteins are disclosed. The antibodies arc useful for inhibiting the binding between IL-1-R and IL-1-R intracellular ligand proteins. ...	05/31/2005
6893838	DADD, death activator death domain protein Polynucleotides encoding DADD protein are also disclosed, along with vectors, host cells, and methods of making DADD protein. Methods of identifying inhibitors of DADD death domain binding and inhibitors identified by such methods are also disclosed. ...	05/17/2005
6887466	Methods for selectively stimulating proliferation of T cells Methods for inducing a population of T cells to proliferate by activating the population of T cells and stimulating an accessory molecule on the surface of the T cells with a ligand which binds the accessory molecule are described. T cell proliferation occurs in the...	05/03/2005
6887461	Method of using IL-11 for treating mucositis Provided by the present invention are topical formulations of Interleukin-11 and methods for treating a variety of disorders, including inflammatory bowel diseases (e.g., Crohn's disease, ulcerative colitis, indeterminate colitis, and infectious colitis), mucositis ...	05/03/2005
6881404	Highly purified mocarhagin, a cobra venom protease, polynucleotides encoding same and related proteases, and therapeutic uses thereof Highly purified mocarhagin, a cobra venom protease, is disclosed. Pharmaceutical compositions and therapeutic uses of the highly purified protease are also provided. Polynucleotides encoding such protease and related proteases are also disclosed. ...	04/19/2005
6861055	Human GDP-mannose 4,6-dehydratase The invention provides a novel GDP-mannose 4,6-dehydratase. ...	03/01/2005
6852508	Chemokine with amino-terminal modifications This invention provides polynucleotides comprising sequences encoding amino-terminal-modified chemokines, the encoded amino-terminal-modified chemokines, and uses thereof. ...	02/08/2005
6852497	Methods of identifying compounds which inhibit binding of SLIC-1 to PSGL-1 The invention provides isolated nucleic acids molecules, designated SLIC-1 nucleic acid molecules, which encode novel P-selectin glycoprotein ligand (PSGL-1) binding molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vect...	02/08/2005
6830751	Use of IL-12 antagonists in the treatment of rheumatoid arthritis Method of treating autoimmune conditions are disclosed comprising administering to a mammalian subject IL-12 or an IL-12 antagonist. In certain preferred embodiments the autoimmune condition is one which is promoted by an increase in levels of IFN-γ or TNF-α. Suit...	12/14/2004
6827934	Humanized immunoglobulin reactive with b7-2 and methods of treatment therewith The invention relates to a humanized anti-B7-2 antibody that comprises a variable region of nonhuman origin and at least a portion of an immunoglobulin of human origin. The invention also pertains to methods of treatment for various autoimmune diseases, transplant r...	12/07/2004
6824779	Methods for inhibiting the interaction of B7-2 with its natural ligand The present invention relates to, inter alia, methods for inhibiting the interaction of the B-lymphocyte antigen, B7-2, with its natural ligand on the surface of an immune cell are disclosed. The methods comprise contacting the immune cell with an agent which inhibi...	11/30/2004

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Assignee: Genetics Institute, Inc.