Assignee: Gen-Probe Incorporated

Location: San Diego, CA
No. of patents: 164

Number	Title	Issue Date
8183359	Kits for amplifying DNA Kits for amplifying DNA which include a priming oligonucleotide that hybridizes to a 3′-end of a DNA target sequence, a displacer oligonucleotide that hybridizes to a target nucleic acid containing the DNA target sequence at a position upstream from the priming ol...	05/22/2012
8153772	Oligonucleotide probes and primers comprising universal bases for diagnostic purposes Aspects of the invention relate to novel oligonucleotides comprising universal and generic bases for use as primers and probes, as well as, methods of using said oligonucleotides for the diagnosis of disease. ...	04/10/2012
8145435	Real-time amplification and monitoring system incorporating vector-based algorithm for analyzing polynucleotide-containing samples System for analyzing a polynucleotide-containing sample using real-time amplification and monitoring. The system includes a computer or processing device with software for performing a vector analysis of growth curves. The vector analysis advantageously simplifies p...	03/27/2012
8137620	Temperature-controlled incubator having an arcuate closure panel An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations, or modules, in which discrete aspects of the assay are performed on fluid samples contained in reaction receptacles. The analyzer includes stations for automat...	03/20/2012
8124335	Compositions and assays to detect influenza virus A and B nucleic acids Methods for detecting influenza virus A and influenza virus B nucleic acids in biological samples by using in vitro amplification and detection are disclosed. Compositions that are target-specific nucleic acid sequences and kits comprising target-specific nucleic ac...	02/28/2012
8097409	Kits for detecting group B Compositions, methods and kits for detecting Group B streptococci. Particularly described are oligonucleotides that are useful as amplification primers and hybridization probes for detecting very low levels of Group B streptococci nucleic acids. ...	01/17/2012
8071301	Method of isolating nucleic acids from a biological sample Method of preparing a biological sample appropriate for use in a subsequent in vitro nucleic acid amplification reaction. The method involves a rapid, transient exposure to alkaline conditions which can be achieved by mixing an alkaline solution with a pH-buffered s...	12/06/2011
8063197	Compositions and methods for detection of hepatitis A virus nucleic acid Nucleic acid oligomeric sequences and in vitro nucleic acid amplification and detection methods for detecting the presence of HAV RNA sequences in samples are disclosed. Kits comprising nucleic acid oligomers for amplifying and detecting HAV nucleic acid sequences a...	11/22/2011
8058006	Method for obtaining and initiating amplification of a target nucleic acid sequence The present invention relates to oligonucleotides useful for determining the presence of Mycobacterium tuberculosis complex organisms in a test sample. The oligonucleotides of the present invention may be incorporated into detection probes, helper probes, cap...	11/15/2011
8057762	Penetrable cap A cap having a core structure dimensioned to receive a pipette therethrough. The cap includes two axially aligned frangible seals that are affixed to the core structure in a spaced-apart relationship. The frangible seals are constructed so that air passageways are f...	11/15/2011
8052944	Penetrable cap A cap having a core structure dimensioned to receive a pipette therethrough. The cap includes two axially aligned frangible seals that are affixed to the core structure in a spaced-apart relationship. The frangible seals include a foil layer and are constructed so t...	11/08/2011
8052929	Gravity-assisted mixing methods A receptacle having a plurality of interconnected chambers arranged to permit multiple process steps or processes to be performed independently or simultaneously. The receptacles are manufactured to separate liquid from dried reagents and to maintain the stability o...	11/08/2011
8048375	Gravity-assisted mixing methods A receptacle having a plurality of interconnected chambers arranged to permit multiple process steps or processes to be performed independently or simultaneously. The receptacles are manufactured to separate liquid from dried reagents and to maintain the stability o...	11/01/2011
8047086	Method and apparatus for stripping a contact-limiting element from a pipette probe An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations, or modules, in which discrete aspects of the assay are performed on fluid samples contained in reaction receptacles. The analyzer includes stations for automat...	11/01/2011
8038967	Method for accessing the contents of a closed vessel containing a specimen retrieval device Method for obtaining a fluid from a collection device assembled to isolate a specimen retrieval device from the pathway of a fluid transfer device used to penetrate a cap of the collection device and to draw and remove the fluid from the collection device for analys...	10/18/2011
8034570	Tagged oligonucleotides and their use in nucleic acid amplification methods Disclosed are methods for selective amplification of target nucleic acid sequence using a tagged oligonucleotide comprising a target hybridizing sequence that hybridizes to a 3′-end of the target nucleic acid and a tag sequence situated 5′ to the target hybridiz...	10/11/2011
8034554	Methods and compositions to detect nucleic acids in a biological sample Methods of the invention separate a target nucleic acid from a sample by using at least one capture probe oligonucleotide that contains a target-complementary region and a member of a specific binding pair that attaches the target nucleic acid to an immobilized prob...	10/11/2011
8026066	Detection of nucleic acids from multiple types of human papillomaviruses Nucleic acid oligonucleotide sequences are disclosed which include amplification oligomers and probe oligomers which are useful for detecting multiple types of human papillomaviruses (HPV) associated with cervical cancer. Methods for detecting multiple HPV types in ...	09/27/2011
8012419	Temperature-controlled incubator having rotatable door An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations, or modules, in which discrete aspects of the assay are performed on fluid samples contained in reaction receptacles. The analyzer includes stations for automat...	09/06/2011
8008066	System for performing multi-formatted assays An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations in which discrete aspects of the assay are performed on fluid samples contained in sample vessels. The analyzer includes stations for automatically preparing a ...	08/30/2011
8008017	Compositions and methods for detecting the presence of cryptosporidium organisms in a test sample The present invention describes novel oligonucleotides targeted to nucleic acid sequences derived from Cryptosporidium organisms, and Cryptosporidium parvum organisms in particular, which are useful for determining the presence of Cryptosporidium	08/30/2011
7993853	Methods of nucleic acid target capture Methods for efficiently capturing a target nucleic acid from a sample by using a mixture that contains a capture probe specific for the target nucleic acid, the target nucleic acid, and a denaturant chemical, which mixture is incubated at elevated temperature for a ...	08/09/2011
7964413	Method for continuous mode processing of multiple reaction receptacles in a real-time amplification assay An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations in which discrete aspects of the assay are performed on fluid samples contained in sample vessels. The analyzer includes stations for automatically preparing a ...	06/21/2011
7941904	Method and apparatus for stripping a contact-limiting element from a pipette probe An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations, or modules, in which discrete aspects of the assay are performed on fluid samples contained in reaction receptacles. The analyzer includes stations for automat...	05/17/2011
7939264	DNA sequencing method The present invention pertains to a method for determining the sequence of a polynucleotide, the method relying on the detection of a conformational change in an enzyme that interacts with and processes along the polynucleotide. The detection of a conformational cha...	05/10/2011
7939260	Method for making available a priming oligonucleotide The present invention is directed to novel methods of synthesizing multiple copies of a target nucleic acid sequence which are autocatalytic (i.e., able to cycle automatically without the need to modify reaction conditions such as temperature, pH, or ionic strength ...	05/10/2011
7932081	Signal measuring system for conducting real-time amplification assays An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations in which discrete aspects of the assay are performed on fluid samples contained in sample vessels. The analyzer includes stations for automatically preparing a ...	04/26/2011
7930106	Quantitative method employing adjustment of pre-defined master calibration curves Methods and kits for preparing and adjusting pre-defined master calibration curves of the type used for quantifying analyte polynucleotides by real-time nucleic acid amplification. Particularly disclosed are methods of preparing one or more master calibration curves...	04/19/2011
7927549	Method for accessing the contents of a closed collection device with a modified pipette tip A method for accessing the contents of a closed collection device having a cap and a fluid-holding vessel in fixed association. The method includes penetrating one or more materials of the cap with an air displacement pipette, thereby forming one or more passageways...	04/19/2011
7910067	Sample tube holder A sample tube holder having sample tube compartments with sets of spaced finger springs provided therein for maintaining sample tubes in substantially upright orientations. A guide structure having a series of openings is used to direct sample tubes into the sample ...	03/22/2011
7897337	Method for performing multi-formatted assays An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations in which discrete aspects of the assay are performed on fluid samples contained in sample vessels. The analyzer includes stations for automatically preparing a ...	03/01/2011
7888073	Method for sequencing nucleic acid molecules The sequence of a target polynucleotide can be determined by: (i) contacting the target polynucleotide with a polymerase enzyme and one of the nucleotides A, T(U), G and C under conditions suitable for the polymerase reaction to proceed; (ii) measuring the time take...	02/15/2011
7879581	Nucleic acid amplification and detection of mycobacterium species Oligonucleotides used to prime in vitro nucleic acid amplification of 16S rRNA sequences or DNA encoding 16S rRNA sequences for many species within the genus Mycobacterium are disclosed. Kits including such oligonucleotides are disclosed. Methods of detecting...	02/01/2011
7875441	Oligonucleotides for detecting human papilloma virus in a test sample Oligonucleotides targeted to HPV Type 16 and/or Type 18 nucleic acid sequences which are particularly useful to aid in detecting HPV type 16 and or 18 are described. The oligonucleotides can aid in detecting HPV Type 16 and/or Type 18 in different ways such as by ac...	01/25/2011
7867777	Method for obtaining sample material A sample carrier comprising a frame and one or more sample tube receiving structures pivotally connected to the frame. Each sample tube receiving structure includes a bottom member adapted to receive a plurality of sample tubes and a top member having a plurality of...	01/11/2011
7858347	Compositions and methods for determining the presence of in a test sample Oligonucleotides for use in determining the presence of Chlamydophila pneumoniae in a test sample. The oligonucleotides are incorporated into detection probes, capture probes, and amplification oligonucleotides, and can be used in various combinations thereof...	12/28/2010
7833716	Tagged oligonucleotides and their use in nucleic acid amplification methods A method for selective amplification of at least one target nucleic acid sequence, comprising the steps of: treating a sample with a tagged oligonucleotide comprising a target hybridizing sequence that hybridizes to a 3′-end of the target nucleic acid sequence, an...	11/16/2010
7831417	Parametric calibration method Method of preparing a calibration curve and determining the amount of an analyte polynucleotide present in a test sample, particularly using real-time amplification data. The method involves determining indicia of amplification for both the internal calibrator and a...	11/09/2010
7824922	Method for removing a fluid substance from a closed system A cap which can form an essentially leak-proof seal with an open-ended vessel capable of receiving and holding fluid specimens or other materials for analysis. To minimize potentially contaminating contact between a fluid sample present in the vessel and humans or t...	11/02/2010
7815858	Automated sampling system A sample carrier including a lower support wall, a base joined to or in fixed proximity to a bottom end of the lower support wall, and sample tube receiving areas in fixed proximity to the lower support wall for receiving and holding a plurality of sample tubes in s...	10/19/2010

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Assignee: Gen-Probe Incorporated