Celebrity Inventors
Glam girl Heddy Lamar may have used her good looks to good effect on the silver screen, but she put her smarts to better use as an inventor. During World War II, she co-patented a frequency-switching system for torpedo guidance that was considered years ahead of its time.
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| Number | Title | Issue Date |
| 6653113 | High efficiency gene targeting in mouse embryonic stem cells The present invention provides novel methods for modifying the genome of an animal cell which typically comprise the steps of: constructing a DNA molecule in which desired sequence modifications are contained in a segment of DNA (a "targeting DNA") that i... | 11/25/2003 |
| 5981175 | Methods for producing recombinant mammalian cells harboring a yeast artificial chromosome The present invention provides methods and compositions for transferring large transgene polynucleotides and unlinked selectable marker polynucleotides into eukaryotic cells by a novel method designated co-lipofection. The methods and compositions of the ... | 11/09/1999 |
| 5643763 | Method for making recombinant yeast artificial chromosomes by minimizing diploid doubling during mating The present invention provides methods for construction of recombinant Yeast Artificial Chromosomes ("YAC") by homologous recombination between YACs during meiosis. In particular, conditions are provided for the step of mating haploid cells and for the st... | 07/01/1997 |
| 5633425 | Transgenic non-human animals capable of producing heterologous antibodies The invention relates to transgenic non-human animals capable of producing heterologous antibodies, i.e., antibodies encoded by immunoglobulin heavy and light chain genes not normally found in the genome of that species of non-human animal. In one aspect ... | 05/27/1997 |
| 5612205 | Homologous recombination in mammalian cells The invention relates to methods for intracellularly producing DNA segments by homologous recombination of smaller overlapping DNA fragments and transgenic mammalian cells and transgenic non-human mammals produced by such methods.... | 03/18/1997 |
| 5569825 | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes The invention relates to transgenic non-human animals capable of producing heterologous antibodies of multiple isotypes. Heterologous antibodies are encoded by immunoglobulin heavy chain genes not normally found in the genome of that species of non-human ... | 10/29/1996 |
| 5545806 | Ransgenic non-human animals for producing heterologous antibodies The invention relates to transgenic non-human animals capable of producing heterologous antibodies and transgenic non-human animals having inactivated endogenous immunoglobulin genes. In one aspect of the invention, endogenous immunoglobulin genes are sup... | 08/13/1996 |
| 5434340 | Transgenic mice depleted in mature T-cells and methods for making transgenic mice Transgenic mice having a phenotype characterized by the substantial absence of mature T lymphocytes otherwise naturally occurring in said mice. The phenotype is conferred in the transgenic mouse by a transgene contained in at least the precursor stem cell... | 07/18/1995 |
| 5304489 | DNA sequences to target proteins to the mammary gland for efficient secretion Described is a method of targeting specific genes to the mammary gland which results in the efficient synthesis and secretion of biologically important molecules. Further, there is described as a composition of matter, a transgenic mammal having the abili... | 04/19/1994 |
| 5174986 | Method for determining oncogenic potential of a chemical compound Methods are provided for determining the oncogenic potential of chemical compounds which utilizes a transgenic mouse predisposed to T-cell lymphomas. The transgenic mouse expresses a pim-1 oncogene and as a consequence is predisposed to the spontaneous on... | 12/29/1992 |
| 5175384 | Transgenic mice depleted in mature T-cells and methods for making transgenic mice Transgenic mice having a phenotype characterized by the substantial absence of mature T lymphocytes otherwise naturally occurring in said mice. The phenotype is conferred in the transgenic mouse by a transgene contained in at least the precursor stem cell... | 12/29/1992 |
