Assignee: G.D. Searle & Co.

Location: Chicago, IL
No. of patents: 154

Number	Title	Issue Date
7232817	α- and β-amino acid hydroxyethlamino sulfonyl urea derivatives useful as retroviral protease inhibitors α- and β-amino acid hydroxyethylamino sulfonyl urea derivative compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. ...	06/19/2007
7202258	α- and β-amino acid hydroxyethylamino sulfamic acid derivatives useful as retroviral protease inhibitors Certain Alpha- and Beta-amino acid hydroxyethylamino sulfamic acid derivatives represented by the following formula are useful as retroviral protease inhibitors: ...	04/10/2007
7199158	Succinoylamino hydroxyethylamino sulfonyl urea derivatives useful as retroviral protease inhibitors Succinoylamino hydroxyethylamino sulfonyl urea derivatives of the formula: wherein R1–R6, R7, R7′, R8, R30–R34, X′, Y, Y′, t,...	04/03/2007
7192983	N-protected/N-substituted-beta-amino hydroxy sulfonates N-protected/N-substituted alpha-amino aldehydes, which are useful as pharmaceuticals and pharmaceutical intermediates, can be stored and shipped in a more stable form as N-protected/N-substituted-beta-amino hydroxy sulfonates which can be readily converted back into...	03/20/2007
7189864	Method of preparing intermediates useful in synthesis of retroviral protease inhibitors A synthesis is described for intermediates which are readily amenable to the large scale preparation of hydroxyethylurea-based chiral HIV protease inhibitors. The method includes forming a diastereoselective epoxide from a chiral alpha amino aldehyde. ...	03/13/2007
7141609	α- and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors α- and β-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. ...	11/28/2006
7115618	α- and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors α- and β-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. ...	10/03/2006
7060851	Method of preparing retroviral protease inhibitor intermediates Chiral hydroxyethylamine, hydroxyethylurea or hydroxyethylsulfonamide isostere containing retroviral protease and renin inhibitors can be prepared by multi-step syntheses that utilize key chiral amine intermediates. This invention is a cost effective method of obtai...	06/13/2006
7045518	Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors Selected sulfonylalkanoylamino hydroxyethylamine sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, rela...	05/16/2006
7038084	Succinoylamino hydroxyethylamino sulfonamides useful as retroviral protease inhibitors Succinoylamino hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. ...	05/02/2006
7030161	α-and β-amino acid hydroxyethylamino sulfonyl urea derivatives useful as retroviral protease inhibitors α- and β-amino acid hydroxyethylamino sulfonyl urea derivative compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. ...	04/18/2006
7030153	3,4-diaryl thiophenes and analogs thereof having use as antiinflammatory agents A class of 3,4-diaryl substituted thiophene, furan and pyrrole derivatives and analogs thereof, pharmaceutical compositions containing them and methods of using them to treat inflammation and inflammation-related disorders. Compounds of particular interest are defin...	04/18/2006
7026485	Retroviral protease inhibitors N-heterocyclic moiety containing hydroxyethylamine compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. ...	04/11/2006
6974876	Method for preparing intermediates useful in synthesis of retroviral protease inhibitors A synthesis is described for intermediates which are readily amenable to the large scale preparation of hydroxyethylurea-based chiral HIV protease inhibitors. The method includes forming a diastereoselective epoxide from a chiral alpha amino aldehyde. ...	12/13/2005
6943189	Combination therapy employing ileal bile acid transport inhibiting benzothiepines and HMG CO-A reductase inhibitors Provided are novel benzothiepines, derivatives, and analogs thereof; pharmaceutical compositions containing them; and methods of using these compounds and compositions in medicine, particularly in the prophylaxis and treatment of hyperlipidemic conditions such as th...	09/13/2005
6858636	1-phenyl imidazol-2-one biphenylmethyl compounds for treatment of circulatory disorders A class of 1-phenyl imidazol-2-one biphenylmethyl compounds is described for use in treatment of circulatory disorders. Compounds of particular interest are angiotensin II antagonists of the formula wherein each of R	02/22/2005
6806360	Nucleic acids encoding human tissue factor inhibitor A cDNA clone having a base sequence for human tissue factor inhibitor (TFI) has been developed and characterized and the amino acid sequence of the TFI has been determined. ...	10/19/2004
6806288	Substituted benzopyran derivatives for the treatment A class of benzopyran, derivatives is described for use in treating cyclooxygenase-2 mediated disorders. Compounds of particular interest are defined by Formula I′ wherein X, A1, A2, A3	10/19/2004
6727282	Succinoylamino hydroxyethylamino sulfonamides useful as retroviral protease inhibitors Succinoylamino hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. ...	04/27/2004
6677364	Substituted sulfonylphenylheterocycles as cyclooxygenase-2 and 5-lipoxygenase inhibitors This invention is in the field of antiinflammatory pharmaceutical agents and specifically relates to compounds, compositions and methods for treating disorders mediated by cyclooxygenase-2 or 5-lipoxygenase, such as inflammation....	01/13/2004
6677488	Substituted biphenyl compounds for the treatment of inflammation A class of substituted biphenyl compounds is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula III: ##STR1## wherein each of R11 through R13 is inde...	01/13/2004
6667307	Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors Selected sulfonylalkanoylamino hydroxyethylamine sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particu...	12/23/2003
6653350	Methods of treating osteoarthritis with inducible nitric oxide synthase inhibitors Methods of treating osteoarthritis by administering an therapeutically effective amount of NOS inhibitor are provided....	11/25/2003
6642268	Combination therapy employing ileal bile acid transport inhibiting benzothipines and HMG Co-A reductase inhibitors Provided are novel benzothiepines, derivatives, and analogs thereof; pharmaceutical compositions containing them; and methods of using these compounds and compositions in medicine, particularly in the prophylaxis and treatment of hyperlipidemic conditions...	11/04/2003
6630497	1-phenyl imidazol-2-one biphenylmethyl compounds for treatment of circulatory disorders A class of 1-phenyl imidazol-2-one biphenylmethyl compounds is described for use in treatment of circulatory disorders. Compounds of particular interest are angiotensin II antagonists of the formula ##STR1## wherein each of R1, R2 an...	10/07/2003
6617345	Immunosuppressive effects of administration of a cyclooxygenase-2 inhibitor, a leukotriene B4 receptor inhibitor and a cyclosporin Treatment with a cyclooxygenase-2 inhibitor and a leukotriene B4 receptor antagonist is described as being useful in reducing recipient rejection of transplanted organs and for treatment of autoimmune diseases....	09/09/2003
6610703	Method for treatment of glycolipid storage diseases A novel method is disclosed for the treatment of a patient affected with Gaucher's disease or other such glycolipid storage diseases. The method comprises administering to said patient a therapeutically effective amount of a long-chain N-alkyl derivative ...	08/26/2003
6599934	3,4-diaryl thiopenes and analogs thereof having use as antiinflammatory agents A class of 3,4-diaryl substituted thiophene, furan and pyrrole derivatives and analogs thereof, pharmaceutical compositions containing them and methods of using them to treat inflammation and inflammation-related disorders. Compounds of particular interes...	07/29/2003
6586603	Substituted pyrazolyl benzenesulfonamides for the treatment of inflammation A class of pyrazolyl benzenesulfonamide compounds is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula II: ##STR1## wherein R2 is selected from hydrido, alkyl,...	07/01/2003
6515028	Glucamine compounds for treating hepatitis virus infections N-Substituted glucamine compounds of Formula I are effective in treatment of hepatitis infections, including hepatitis B and hepatitis C. In treating hepatitis infections, the compounds of Formula I may be used alone, or in combination with another antivi...	02/04/2003
6515162	Method of preparing retroviral protease inhibitor intermediates Chiral hydroxyethylamine, hydroxyethylurea or hydroxyethylsulfonamide isostere containing retroviral protease and renin inhibitors can be prepared by multi-step syntheses that utilize key chiral amine intermediates. This invention is a cost effective meth...	02/04/2003
6506876	LTA4 hydrolase inhibitor pharmaceutical compositions and methods of use The present invention provides compounds of the formula Ar1 --Q--Ar2 --Y--R--Z and pharmaceutically acceptable salts thereof wherein Ar1 and Ar2 are optionally substituted aryl moieties, Z is an optionally subst...	01/14/2003
6492390	Substituted benzopyran analogs for the treatment of inflammation A class of benzopyrans, benzothiopyrans, dihydroquinolines, dihydronaphthalenes, and analogs thereof, is described for use in treating cyclooxygenase-2 mediated disorders. Compounds of particular interest are defined by Formula I' ##STR1## wherein X,...	12/10/2002
6492413	3.4-diaryl thiophenes and analogs thereof having use as antiinflammatory agents A class of 3,4-diaryl substituted thiophene, furan and pyrrole derivatives and analogs thereof, pharmaceutical compositions containing them and methods of using them to treat inflammation and inflammation-related disorders. Compounds of particular interes...	12/10/2002
6479552	Use of substituted N, N-disubstituted diamino compounds for inhibiting cholesteryl ester transfer protein activity The invention relates to substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating...	11/12/2002
6476057	Use of substituted N, N-disubstituted cycloalkyl aminoalcohol compounds for inhibiting cholesteryl ester transfer protein activity The invention relates to use of substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for t...	11/05/2002
6476075	Use of substituted N, N-bis-benzyl aminoalcohol compounds inhibiting cholesteryl ester transfer protein activity The invention relates to substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating...	11/05/2002
6472407	଱ and ଲ-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors ଱- and ଲ-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease....	10/29/2002
6469040	Method of using cyclooxygenase-2 inhibitors in the treatment and prevention of neoplasia This invention relates to the use of cyclooxygenase-2 inhibitors or derivatives thereof in preventing and treating neoplasia. In particular, the invention describes the method of preventing and treating epithelial cell neoplasia in a subject, said method ...	10/22/2002
6462091	Combinations of cholesteryl ester transfer protein inhibitors and HMG coA reductase inhibitors for cardiovascular indications The present invention provides combinations of cardiovascular therapeutic compounds for the prophylaxis or treatment of cardiovascular disease including hypercholesterolemia, atherosclerosis, or hyperlipidemia. Combinations disclosed include an HMG CoA re...	10/08/2002

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Assignee: G.D. Searle & Co.