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...Daniel Webster invented a "bull plow" to pull out tree stumps. It didn't catch on because it was huge and required four oxen to pull it!
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| Number | Title | Issue Date |
| 8041090 | Method of, and apparatus and computer software for, performing image processing A computer-implemented method of performing image processing for images of biological objects includes: storing definitions of a plurality of descriptors; receiving image data relating to an image of a reference population of biological objects; receiving image data... | 10/18/2011 |
| 8034558 | Acridone derivatives as labels for fluorescence detection of target materials Disclosed are new acridone dye derivatives having characteristic fluorescence lifetimes. Also disclosed are methods for labelling target biological materials employing the acridone dyes and use of the labelled materials in biological assays. The acridone derivatives... | 10/11/2011 |
| 7978885 | Analysing biological entities A method of analysing a plurality of biological entities using an imaging apparatus. The method comprises: providing a marker for said plurality of biological entities, said marker being capable of identifying objects within said plurality of biological entities whe... | 07/12/2011 |
| 7905996 | Interface patch clamping The present invention relate to methods and devices for holding a cell and positioning recording electrodes inside it. ... | 03/15/2011 |
| 7897741 | Cell cycle phase markers The present invention relates to polypeptide and nucleic acids constructs which are useful for determining the cell cycle status of a mammalian cell. Host cells transfected with these nucleic acid constructs can be used to determine the effects that test agents have... | 03/01/2011 |
| 7881509 | Method of, and apparatus and computer software for, imaging biological objects A method of imaging one or more biological objects using imaging apparatus capable of capturing an image across an imaging area. The method includes: placing the one or more biological objects (236) in an environment; providing in the environment, outside of ... | 02/01/2011 |
| 7767829 | Water-soluble fluoro-substituted cyanine dyes as reactive fluorescence labelling reagents Disclosed are cyanine dyes that are useful for labelling and detecting biological and other materials. The dyes are of formula (I): in which at least one of groups R1, R2, R3, R4,... | 08/03/2010 |
| 7727739 | Methods for measuring enzyme activity The invention relates to fluorescence methods for measuring enzyme activity, in particular enzyme cleaving and joining activities. The invention also relates to fluorogenic substrates which are useful for measuring enzyme activity and as in vitro and in vivo imaging... | 06/01/2010 |
| 7674584 | Method for measuring binding of a test compound to a G-protein coupled receptor The invention provides a method for measuring binding of a test compound to a G-Protein Coupled Receptor (GPCR). The invention also provides a method for identifying and measuring the effect that an agent has upon modulating the binding of a test compound to a G-Pro... | 03/09/2010 |
| 7662973 | Fluorescent detection method and reagent Disclosed is a method for increasing the fluorescence of a Cyanine dye molecule comprising at least one NO2 group characterized by the reduction of the at least one NO2 group to NHOH or NH2 by the action of a nitroreductase. The cyan... | 02/16/2010 |
| 7612189 | Cell cycle phase markers The present invention relates to polypeptide and nucleic acids constructs which are useful for determining the cell cycle status of a mammalian cell. Host cells transfected with these nucleic acid constructs can be used to determine the effects that test agents have... | 11/03/2009 |
| 7579140 | Method and reagent for measuring nitroreductase enzyme activity Disclosed are nitro-substituted squaraine reporter dyes and methods using such dyes for detecting nitroreductase enzyme activity and nitroreductase gene expression in cellular assays. The dyes are of the structure: in which... | 08/25/2009 |
| 7527940 | Method for the determination of changes in a cellular morphological parameter Disclosed is method for measuring a change in a cellular morphological parameter, for example, the position and/or the shape of a cell. The method comprises labelling a population of cells with a marker substance which is in a non-detectable state, but which may be ... | 05/05/2009 |
| 7511155 | Reagents and a method for saturation labelling of proteins A matched set of fluorescent dyes is provided, wherein each dye of the set is capable of covalent attachment to a protein and wherein each of the dyes has a molecular structure and a charge that is matched one with the other, such that relative electrophoretic mobil... | 03/31/2009 |
| 7470350 | Process for tritium removal from light water A process for light water detritiation which includes the steps of water distillation for tritium stripping and enriching, followed by chemical conversion of tritium enriched water to elemental hydrogen, and finally by one or more thermal diffusion columns for final... | 12/30/2008 |
| 7445902 | Fluorescent nucleotide analogues The present invention provides fluorescent cyanine dye-based nucleotide analogues, in which the cyanine dye is coupled to the γ-phosphate group of a nucleoside triphosphate. Preferred embodiments of the invention are directed to fluorescent cyanine dye-based GTP an... | 11/04/2008 |
| 7369696 | Classification of cells into subpopulations using cell classifying data A method of classifying cells into subpopulations using cell classifying data is described. The method comprises receiving and analyzing image data to identify object areas in the image data to determine, for at least one selected first cell, one or more measurement... | 05/06/2008 |
| 7335771 | Quinacridone derivatives as labelling reagents for fluorescence detection of biological materials Disclosed are new quinacridone dye derivatives having characteristic fluorescence lifetimes. Also disclosed are methods for labelling target biological materials employing the quinacridone dyes and use of the labelled materials in biological assays. The quinacridone... | 02/26/2008 |
| 7332352 | Separation particles A composition comprising colloidal Fe3O4 particles coated with streptavidin is disclosed. These particles can be used in a method for separating biotinylated compounds from a solution in which the biotinylated compounds bind to the streptavidin... | 02/19/2008 |
| 7300762 | Fluorescent proteins and methods of using same The present invention provides novel engineered derivatives of green fluorescent protein (GFP) which have an amino acid sequence which is modified by amino acid substitution compared with the amino acid sequence of wild type Green Fluorescent Protein (SEQ ID NO: 2).... | 11/27/2007 |
| 7264921 | No synthase assay particles and method The invention relates to particles for use in a scintillation proximity assays. In particular, the invention relates to particles for use in a scintillation proximity assay for detecting nitric oxide synthase activity in a sample. The invention also relates to a met... | 09/04/2007 |
| 7235401 | Method for determining cell cycle position The invention provides a novel, non-destructive and dynamic process for determining the cell cycle position of living cells. The invention also provides DNA constructs, and cell lines containing such constructs, that exhibit activation and deactivation of a detectab... | 06/26/2007 |
| 7214539 | Scintillation proximity test The invention concerns scintillation proximity assays performed in multiwell plates where a charge coupled device is used to image the wells. Conventional phosphors emit blue light (350–450 nm) which is absorbed by yellow or brown assay components. This problem is... | 05/08/2007 |
| 7133782 | Sequencing method and apparatus In a method of identifying an unknown nucleotide sequence using base addition, a sequence of bases is obtained from a template, a base in the sequence is identified as an unknown base, an “unknown” indicator is included in the sequence, and an output sequence is... | 11/07/2006 |
| 7125682 | Methods for measuring protein kinase and phosphatase activity The invention provides fluorescence-based assays for determining the phosphorylating or the dephosphorylating activity of an enzyme acting on a substrate molecule. The substrate comprises at least one moiety that is capable of being phosphorylated or dephosphorylate... | 10/24/2006 |
| 7101719 | Support and method for cell based assays Disclosed is a method for the measurement of a cellular process, or for the measurement of the effect of a test compound on a cellular process, in one or more different populations of cells. The method comprises providing separate samples of one or more different po... | 09/05/2006 |
| 7091317 | Fluorescent proteins The present invention provides novel engineered derivatives of green fluorescent protein (GFP) which have an amino acid sequence which is modified by amino acid substitution compared with the amino acid sequence of wild type Green Fluorescent Protein. The modified G... | 08/15/2006 |
| 7081365 | Scintillation proximity test The invention concerns scintillation proximity assays performed in multiwell plates where a charge coupled device is used to image the wells. Conventional phosphors emit blue light (350–450 nm) which is absorbed by yellow or brown assay components. This problem is... | 07/25/2006 |
| 7078499 | Nucleotide analogues comprising a reporter moiety and a polymerase enzyme blocking moiety Nucleotides comprising a reporter moiety and a polymerase enzyme blocking moiety in which the reporter moiety does not also act as a polymerase enzyme blocking moiety are described. Also described are compounds of Formula (I): wherein W is a phosphate group, B is a ... | 07/18/2006 |
| 7072036 | Fluorescence reference plate A multi-modality fluorescence reference plate comprising wells coated with a fluorogenic compound is described, together with a method of producing such a plate. The plate has utility for calibrating fluorescent plate readers and imaging systems for measuring steady... | 07/04/2006 |
| 7056670 | Sequencing method Disclosed is a single molecule sequencing method comprising the steps of: a) attaching a molecule to a solid phase; b) incubating the molecule with a first composition comprising a first reporter moiety; c) detecting incorporation of said first reporter moiety; d) p... | 06/06/2006 |
