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| Number | Title | Issue Date |
| 8182790 | Contrast agents A contrast agent of the general formula (I): Z1-L-V-Z2 (I) wherein at least one of Z1 and Z2 is present and are equal or different reporter moieties detectable in in vivo imaging of the human or animal body, V is a targeting moiety with binding... | 05/22/2012 |
| 8167864 | Spike-accommodating container holder A holding device for a container having a closure system to be pierced by a spike includes a base, a shield, and a mounting unit supporting the base. The base includes an elongate body having opposed first and second ends and an elongate body extending therebetween.... | 05/01/2012 |
| 8138332 | Synthesis of cyclen derivatives The invention relates to an improved process for preparation of protected DO3A, such as DO3A-tri-t-butyl ester (1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid tri-t-butyl ester). The compound is prepared as a salt. The process includes a work-up procedure givin... | 03/20/2012 |
| 8124806 | Contrast agents The present invention relates to a class of compounds and to diagnostic compositions containing such compounds where the compounds are iodine containing compounds. More specifically the iodine containing compounds are chemical compounds containing an aliphatic centr... | 02/28/2012 |
| 8071811 | Contrast agents The present invention relates to a class of compounds and to diagnostic compositions containing such compounds where the compounds are iodine containing compounds. More specifically the iodine containing compounds are chemical compounds containing an aliphatic centr... | 12/06/2011 |
| 8067637 | Contrast agents The present invention relates to a class of compounds and to diagnostic compositions containing such compounds where the compounds are iodine containing compounds. More specifically the iodine containing compounds are chemical compounds containing a hydrophilic alip... | 11/29/2011 |
| 8066974 | Contrast agents The present invention relates to a class of compounds and to diagnostic compositions containing such compounds where the compounds are iodine containing compounds. More specifically the iodine containing compounds are chemical compounds containing an aliphatic centr... | 11/29/2011 |
| 8066970 | Contrast agents The present invention relates to a class of compounds and to diagnostic compositions containing such compounds where the compounds are iodine containing compounds. More specifically the iodine containing compounds are chemical compounds containing an aliphatic centr... | 11/29/2011 |
| 8003077 | Method for the production of hyperpolarized Xe The present invention relates to a method for the production of hyperpolarized 129Xe and to a method for the production of a contrast agent. ... | 08/23/2011 |
| 7999135 | Crystallization of iodixanol using ultrasound This invention relates to the manufacture of iodixanol (1,3-bis(acetamido)-N,N′-bis[3,5-bis (2,3-dihydroxypropylaminocarbonyl)-2,4,6-triiodophenyl]-2-hydroxypropane), more specifically to the purification of iodixanol by crystallization by using ultrasound. ... | 08/16/2011 |
| 7999134 | Crystallization of iodixanol using milling This invention relates to the manufacture of iodixanol(1,3-bis(acetamido)-N,N′-bis[3,5-bis(2,3-dihydroxypropylaminocarbonyl)-2,4,6-triiodophenyl]-2-hydroxypropane), more specifically to the purification of iodixanol by crystallization by using wet milling. ... | 08/16/2011 |
| 7994134 | Peptide-based compounds The invention relates to new peptide-based compounds for use as diagnostic imaging agents or as therapeutic agents wherein the agents comprise targeting vectors which bind to integrin receptors. ... | 08/09/2011 |
| 7968745 | Purification process of iodixanol A process for the manufacture of iodixanol by performing a purification process of the crude product in a solvent comprising n-propanol. The crude product may be obtained in aqueous solution from dimerization of 5-acetamido-N,N′-bis(2,3-dihydroxypropyl)-2,4,6-trii... | 06/28/2011 |
| 7966056 | Magnetic resonance imaging method and compounds for use in the method The present invention relates to a magnetic resonance imaging (MRI) method, in particular to a MRI method enabling early detection of myocardial ischemia and to compounds for use as MR contrast agents in the method. ... | 06/21/2011 |
| 7931595 | Ultrasound triggering method to reduce cardiac arrhythmia The invention relates to a triggered ultrasound imaging method for imaging of the myocardium, minimizing the risk of eliciting cardiac arrhythmia. Particularly, the invention is directed to a method of assessing cardiac perfusion. Destruction pulses are triggered su... | 04/26/2011 |
| 7922707 | Devices and method for the penetration of a container stopper A spike for penetrating the elastomeric stopper of a container, for example a drug or reagent vial, is provided with an elongated body (5) with a blunt tip (47). The spike may be incorporated into a reagent cassette which accepts containers sealed with... | 04/12/2011 |
| 7919071 | Contrast agent The present invention relates to a contrast agent of Formula I V-L-Z Formula I where V is a non-peptidic vector having affinity for the Angiotensin II receptor, L is a bond, a spacer or a linker moiety and Z represents a moiety detectable in an in vivo imaging proce... | 04/05/2011 |
| 7897142 | Peptide based-compounds The invention relates to new peptide-based compounds and their use in diagnostic optical imaging techniques. More specifically the invention relates to the use of such peptide-based compounds as targeting vectors that bind to receptors associated with angiogenesis. ... | 03/01/2011 |
| 7892522 | Contrast agents Ultrasound contrast agents comprising microbubbles of biocompatible gas, e.g. a sulphur halide or a perfluorocarbon, stabilized by opsonisable amphiphilic material, e.g. a membrane-forming lipid such as a phospholipid, especially a negatively charged phospholipid su... | 02/22/2011 |
| 7875701 | Diagnostic compounds The invention relates to conjugates of formula (III) or (IIIa), or a salt thereof, their use as radiopharmaceuticals, processes for their preparation, and synthetic intermediates used in such processes. ... | 01/25/2011 |
| 7863484 | Method for reducing aminoisophthalic acid bisamide related impurities in preparation of non-ionic X-ray contrast agents This invention relates generally to the preparation of non-ionic X-ray contrast agents, iohexyl, ioversol, and iodixanol. It further relates to a method for improving the purity of 5-amino-N,N′-bis(2,3-dihydroxypropyl)-isophthalamide (or ABA), an intermediate in t... | 01/04/2011 |
| 7811551 | Imaging agents The invention relates to compounds of formula (I): and their use as targeting vectors that bind to receptors associated with angiogenesis. Such compounds may thus be used for diagnosis or therapy of, for example, malignant diseases, heart diseases, endometriosis, in... | 10/12/2010 |
| 7771390 | Syringe adapter with a driver for agitation of the syringe content Administration by injection or infusion to patients of an injectable liquid for diagnostic or therapeutic purposes is provided by a syringe adapter connectable with an automatic syringe pump and a syringe containing contents to be dispensed. The syringe adapter incl... | 08/10/2010 |
| 7763234 | Pharmaceutical compounds A pharmaceutical of the general formula Z—(L)n-V, wherein V denotes an amino acid sequence X1-X2-Val-Tyr-Ile-His-Pro-X8-X9-X10; L denotes a bond or a linker; Z denotes a group that optionally can ca... | 07/27/2010 |
| 7754920 | Solvent reduction in crystallisation of intermediate for non-ionic X-ray contrast agents This invention relates to an improved method for crystallizing 5-acetamido-N,N′-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide (“Compound A”), an intermediate in the industrial preparation of non-ionic X-ray contrast agents. In particular, the present in... | 07/13/2010 |
| 7754918 | Crystallization of iodixanol in isopropanol and methanol A process for the manufacture of iodixanol by performing a crystallization process of the crude product in a solvent mixture comprising water, methanol and isopropanol. The crude product may be obtained in aqueous solution from dimerisation of 5-acetamido-N,N′-bis... | 07/13/2010 |
| 7737252 | Peptide-based compounds This invention relates to new peptide-based compounds and their use in therapeutically effective treatments as well as for diagnostic imaging techniques. More specifically the invention relates to the use of such peptide-based compounds used as targeting vectors tha... | 06/15/2010 |
| 7696381 | Alternative dimerisation reagents for synthesis of iodixanol This invention relates generally to non-ionic X-ray contrast agents. It further relates to the synthesis of iodixanol. In particular, it relates to alternative dimerisation reagents in the conversion of 5-acetamido-N,N′-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisopht... | 04/13/2010 |
| 7662859 | Contrast agents The present invention relates to a class of compounds and to diagnostic compositions containing such compounds where the compounds are iodine containing compounds. More specifically the iodine containing compounds are chemical compounds containing an aliphatic centr... | 02/16/2010 |
| 7608243 | Fluorescein-labelled peptides The invention relates to new peptide-based compounds and their use in diagnostic optical imaging. More specifically the invention relates to the use of such peptide-based compounds as targeting vectors that bind to receptors associated with angiogenesis. The compoun... | 10/27/2009 |
| 7597877 | Administering a gravity segregation dispersion by continuous infusion Method and apparatus for continuous infusion to a subject of dispersions in which the dispersed phase is susceptible to flotation or sedimentation. The dispersion is controllably delivered from an upper or lower extremity of an essentially vertically positioned deli... | 10/06/2009 |
| 7575891 | Process for production of diphtheria toxin The present invention provides a method of purifying diphtheria toxin comprising (1) fermenting a microorganism strain capable of producing diphtheria toxin using glucose as a carbon source, said method comprising adding glucose to a growing culture whereby the addi... | 08/18/2009 |
| 7557573 | NMR-based methods for detecting ligands, where the ligand or target are hyperpolarized and the NMR-spectrum is compared with a reference spectrum of the ligand or target The invention relates to NMR-based methods comprising hyperpolarised ligands or targets for use in NMR-based assays. ... | 07/07/2009 |
| 7550970 | Multidimensional NMR spectroscopy of a hyperpolarized sample The present invention relates to methods of performing Nuclear Magnetic Resonance (NMR) spectroscopy adapted for a hyperpolarized sample. The methods comprise the steps of hyperpolarizing a sample using DNP, wherein at least a portion of the NMR active nuclei receiv... | 06/23/2009 |
| 7541019 | Process for the production of DTPA-bis anhydride Process for the production of DTPA-bis(anhydride) by reacting DTPA with acetic anhydride in pyridine under elevated temperature wherein the molar amount of pyridine is equal to or less than 6 times the molar amount of DTPA. ... | 06/02/2009 |
| 7521419 | Peptide-based compounds The invention relates to new peptide-based compounds for use as diagnostic imaging agents or as therapeutic agents wherein the agents comprise targeting vectors which bind to integrin receptors. ... | 04/21/2009 |
| 7459144 | Process for preparation of MR contrast agents The present invention provides a process for the preparation of an MR contrast agent, said process comprising: i) obtaining a solution in a solvent of a hydrogenatable, unsaturated substrate compound and a catalyst for the hydrogen... | 12/02/2008 |
| 7431914 | Contrast agent A contrast agent of formula I: V-L-R (I) where V is an organic group having binding affinity for an angiotensin II receptor site, L is a linear or branched amino acid-comprising biomodifier or linker moiety, and R is a reporter moiety detectable in in vivo imaging o... | 10/07/2008 |
| 7413727 | Contrast agents The invention provides a composition of matter of the formula (I): V-L-R, where V is a vector moiety having affinity for an angiogenesis-related endothelias cell receptor, L is a linker moiety or a bond and R is a detectable moiety, characterised in that V is a non-... | 08/19/2008 |
| 7410943 | Imaging agents The invention relates to compounds of formula (I): and their use as targeting vectors that bind to receptors associated with angiogenesis. Such compounds may thus be used for diagnosis or therapy of, for example, malignant diseases, heart diseases, endometriosis, in... | 08/12/2008 |
