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3M employee and church chorister Art Fry needed something to temporarily mark pages in his hymnal. He was in luck because his colleague, Spencer Silver, accidentally developed a glue that was too weak for other purposes. After initially discouraging consumer response, Post-it Notes became a hit in 1979.
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| Number | Title | Issue Date |
| 8101155 | Sequence of STRO-1 antibody variable region The amino acid sequence of the heavy chain polypeptide and the light chain polypeptide of the STRO-1 antibody is disclosed. Also disclosed are methods for detecting and isolating cells expressing the STRO-1 cell surface protein. ... | 01/24/2012 |
| 8071377 | Methods for immortalizing cells The present invention provides methods for immortalizing precursor cells that are non-terminally differentiated cells such as stem cells, said methods comprising culturing the precursor cells in the presence of a Notch agonist and one or more growth factors that sup... | 12/06/2011 |
| 8014957 | Genes associated with progression and response in chronic myeloid leukemia and uses thereof The invention provides molecular markers that are associated with the progression of chronic myeloid leukemia (CML), and methods and computer systems for monitoring the progression of CML in a patient based on measurements of these molecular markers. The present inv... | 09/06/2011 |
| 7993681 | Methods, compositions and devices for inducing stasis in tissues and organs The present invention concerns the use of oxygen antagonists for inducing stasis in tissue, including all or part of organs. It includes methods and apparatuses for achieving stasis in tissue, so as to preserve and/or protect them. In specific embodiments, preservat... | 08/09/2011 |
| 7972791 | Methods for haplotyping genomic DNA The present invention provides a novel method for specifically isolating and separating large segments of genomic DNA that can subsequently be used to determine a genomic haplotype. The invention relies on using a solid phase having a flat surface arrayed with oligo... | 07/05/2011 |
| 7959916 | Negative immunomodulation of immune responses by ERp5 The present invention relates to methods of treating immune disorders and cancers. In particular the invention provides methods of inhibiting the negative immunomodulatory effects of ERp-5 on T cells and dendritic cells, in conjunction with other surface receptors. | 06/14/2011 |
| 7892770 | Monoclonal antibody which binds cMet (HGFR) in formalin-fixed and paraffin-embedded tissues and related methods In a wide variety of human solid tumors, an aggressive, metastatic phenotype and poor clinical prognosis are associated with expression of the receptor tyrosine kinase Met. Disclosed herein are (a) a monoclonal antibody named Met4, which antibody is specific for Met... | 02/22/2011 |
| 7795411 | Vectors for expressing in vivo biotinylated recombinant proteins The present invention provides compositions and methods for generating in vivo biotinylated, secreted recombinant polypeptides comprising recombinantly co-expressing in a yeast cell (a) a secreted recombinant polypeptide comprising a biotin accepting site; and (b) a... | 09/14/2010 |
| 7771718 | Soluble MIC polypeptides as markers for diagnosis, prognosis and treatment of cancer and autoimmune diseases or conditions The present invention provides prognostic and diagnostic methods for cancer, as well as methods for monitoring or staging cancer. Methods involve assaying for tumor-derived soluble MIC polypeptide—either MICA or MICB or both—in a sample from a subject. Assays ca... | 08/10/2010 |
| 7729863 | Methods and materials for canine breed identification In one aspect, the invention provides methods for determining the contributions of canid populations to a canid genome. The methods comprise the steps of: (a) obtaining the identity of one or both alleles in a test canid genome for each of a set of markers; and (b) ... | 06/01/2010 |
| 7666417 | Methods and compositions for treating autoimmune diseases or conditions The present invention relates to methods of treating immune disorders, particularly autoimmune and inflammatory disorders such as rheumatoid arthritis, and methods of producing antibodies for use in therapeutic strategies for treating such disorders. Generally, the ... | 02/23/2010 |
| 7625704 | Methods and compositions for identifying bacteria associated with bacteria vaginosis The present invention provides methods and compositions for identifying bacteria associated with bacterial vaginosis and diagnosing bacterial vaginosis in a subject. ... | 12/01/2009 |
| 7615350 | Methods for haplotyping genomic DNA The present invention provides a novel method for specifically isolating and separating large segments of genomic DNA that can subsequently be used to determine a genomic haplotype. The invention relies on using a solid phase having a flat surface arrayed with oligo... | 11/10/2009 |
| 7560610 | p27-deficient mouse exhibiting tissue hypertrophy Hypercellular nonhuman organisms have functionally inactivated expression of a cyclin inhibitor gene, especially p27. The growth rate of nonhuman organisms are increased such that a desired size is attained more quickly than as compared to nonvariant organisms. Inhi... | 07/14/2009 |
| 7560117 | Foamy virus mutant reverse transcriptase The present invention relates to a highly processive reverse transcriptase having DNA polymerase activity and substantially reduced protease activity. More specifically, the invention relates to an isolated reverse transcriptase from foamy virus comprising a substan... | 07/14/2009 |
| 7514406 | Methods for inhibiting deacetylase activity A method for identifying a compound that inhibits the NAD+-dependent deacetylase activity of a SIR2 protein is disclosed. These compounds are useful for the treatment of cancers and other diseases, through the activation of silenced genes, through the pro... | 04/07/2009 |
| 7491865 | Mouse models of prostate cancer development and metastasis through expression of a hepsin transgene Transgenic, non-human animal model of cancer, methods of making such animals and methods of using such animals to screen test compounds are provided. ... | 02/17/2009 |
| 7449186 | Methods of blocking the interaction between stromal cells and hemopoietic cells with anti-VCAM-1 antibodies A therapeutic method of modulating the immune response, by administering to a patient an amount of IL-4 effective to promote peripheral blood lymphocyte adhesion to microvascular endothelial cells in lymphoid organs. The IL-4 is preferably coadministered with IL-1β... | 11/11/2008 |
| 7435591 | Compositions and methods for increasing animal size growth rate The present invention relates to germ line and somatic cells comprising a mutant p27kip1 protein lacking a Cdk2 phosphorylation site. Also provided are transgenic animals and methods of making such transgenic animals which have increased size and/or growt... | 10/14/2008 |
| 7399633 | Methods for immortalizing cells The present invention provides methods for immortalizing precursor cells that are non-terminally differentiated cells such as stem cells, said methods comprising culturing the precursor cells in the presence of a Notch agonist and one or more growth factors that sup... | 07/15/2008 |
| 7300755 | Methods for haplotyping genomic DNA The present invention provides a novel method for specifically isolating and separating large segments of genomic DNA that can subsequently be used to determine a genomic haplotype. The invention relies on using a solid phase having a flat surface arrayed with oligo... | 11/27/2007 |
| 7250505 | Isolation and expression of a disabled protein gene mDab1 and methods A mammalian homology of Drosophila Disabled protein has been identified and cloned. In particular, the murine homolog designated mDab1 has been cloned and expressed. mDab1, when tyrosine phosphorylated, binds to the SH2 domain of Src, Abl and Fyn. Antibodies ... | 07/31/2007 |
| 7241804 | Compositions and methods for modulating apoptosis in cells over-expressing Bcl-2 family member proteins The present invention provides agents and compositions for modulating the apoptotic state of a cell. The agents comprise derivatives of antimycins which bind to an anti-apoptotic Bcl-2 family member protein. Further, the agents preferentially induce apoptosis in cel... | 07/10/2007 |
| 7238668 | Inhibition of lymphocyte adherence with CS-1-peptides and fragments thereof The present invention relates to a method for inhibiting the adhesion of one cell to another comprising interfering with the interaction between the extracellular matrix receptor and its ligand. The invention is based upon the discovery that the α4β1 extrac... | 07/03/2007 |
| 7230089 | Methods for increasing plant cell proliferation by functionally inhibiting a plant cyclin inhibitor gene The present invention provides methods for modulating the growth and/or yield of plants. In particular the methods comprise the use of agents which functionally inhibit the expression of plant D-like cyclin inhibitors including isolated polynucleotide sequences whic... | 06/12/2007 |
| 7208315 | Compositions and methods for efficient AAV vector production The present invention provides packaging cell lines for the efficient production of an Adeno-associated virus (AAV) vector which does not require “helper” virus function for the replication and encapsidation of the AAV vector particles. Packaging cells, methods ... | 04/24/2007 |
| 7173063 | Topoisomerase poisons for the treatment of proliferative disorders Methods for the treatment of a proliferative disorder are provided in which a subject in need of such treatment is administered an effective amount of a compound selected from: compounds of formula (I) or a pharmaceutically acceptable salt thereof, wherein X1 | 02/06/2007 |
| 7129086 | Human marrow stromal cell lines which sustain hematopoiesis Immortalized human stromal cell lines sustain and expand human hematopoietic precursor cells. The precursor cells are obtained from a blood product and inoculated into a culture medium conditioned by exposure to a human stromal cell line. Preferred human stromal cel... | 10/31/2006 |
| 7122312 | Methods for drug target screening The present invention provides methods for identifying targets of a drug in a cell by comparing (i) the effects of the drug on a wild-type cell, (ii) the effects on a wild-type cell of modifications to a putative target of the drug, and (iii) the effects of the drug... | 10/17/2006 |
| 7037509 | Immunologically significant herpes simplex virus antigens and methods for using same The invention provides HSV antigens that are useful for the prevention and treatment of HSV infection. Disclosed herein are epitopes confirmed to be recognized by T-cells derived from herpetic lesions. T-cells having specificity for antigens of the invention have de... | 05/02/2006 |
| 6946266 | Gene transfer in chicken bursal stem cells The invention relates to a method of expressing proteins in higher eukaryotes in vitro. In general, the invention sets forth a method of expressing exogenous proteins as fusion partners with the immunoglobulin molecules of avian species specifically chickens. The te... | 09/20/2005 |
| 6825034 | Human RRN3 and compositions and methods relating thereto Polynucleotide sequences encoding eukaryotic Rrn3 polypeptides are provided. Rrn3 is a eukaryotic RNA polymerase I transcription factor. The Rrn3 polypeptides, and antibodies thereto, can be used as diagnostic tools, as therapeutic agents and to identify agonist and... | 11/30/2004 |
| 6596501 | Method of diagnosing autoimmune disease The present invention relates to diagnostic applications. For autoimmune diseases more particularly, it is demonstrated herein that individuals with SLE, APLA, MCDS and PSS have antibodies that are specific for SR proteins. Thus, in particular aspects the... | 07/22/2003 |
| 6461807 | Methods for drug target screening The present invention provides methods for identifying targets of a drug in a cell by comparing (i) the effects of the drug on a wild-type cell, (ii) the effects on a wild-type cell of modifications to a putative target of the drug, and (iii) the effects ... | 10/08/2002 |
| 6461864 | Methods and vector constructs for making non-human animals which ubiquitously express a heterologous gene Transgenic non-human animals one having a general deletor construct and a second having a general reporter construct are described. The general deletor animals express a heterologous recombinase under the control of an ubiquitously expressed endogenous pr... | 10/08/2002 |
| 6444463 | Neurogenic differentiation gene neurod3 and methods for inducing differentiation of cells Provided are methods of classifying and prognosticating human neuroectodermal tumors by analyzing a sample of the tumor to determine whether various bHLH proteins are detectably expressed in the sample. In the methods disclosed herein, expression of the b... | 09/03/2002 |
| 6420374 | Use of xanthines as immunosuppressants and to inhibit allograft reactions A family of compounds effective in suppressing lymphocyte activation is comprised of 7-(oxoalkyl)1,3-dialkyl xanthines, other than denbufylline, of the formula ##STR1## in which R1 and R2 are the same or different and are selected ... | 07/16/2002 |
| 6413518 | Immunologically significant herpes simplex virus antigens and methods for identifying and using same The invention provides HSV antigens that are useful for the prevention and treatment of HSV infection. Disclosed herein are epitopes confirmed to be recognized by T-cells derived from herpetic lesions. T-cells having specificity for antigens of the invent... | 07/02/2002 |
| 6368862 | Polymerase I promoter plasmid and vector constructs rDNA promoter constructs useful in plasmids and vectors directing transcription of RNAs in a Pol I-specific manner constructed of four elements in a serial array: a first nucleotide sequence, capable of hybridizing under stringent conditions to an rDNA pr... | 04/09/2002 |
| 6355774 | Isolated p27 protein An isolated protein designated p27 is disclosed. The p27 protein has an apparent molecular weight of about 27 kD, and is capable of binding to and inhibiting the activation of a cyclin E-Cdk2 complex. A nucleic acid sequence encoding p27 protein is disclo... | 03/12/2002 |
