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| Number | Title | Issue Date |
| 7919610 | Yeast bacterial two-hybrid system and methods of use thereof A combined yeast/bacterial two-hybrid system is disclosed. ... | 04/05/2011 |
| 7829671 | Gene encoding a DNA repair enzyme and methods of use thereof An isolated nucleic acid molecule encoding a human DNA repair enzyme, MED1, is disclosed. Like other mismatch repair genes which are mutated in certain cancers, MED1, encoding nucleic acids, proteins and antibodies thereto may be used to advantage in genetic or canc... | 11/09/2010 |
| 7755068 | Laser-accelerated proton therapy units and superconducting electromagnet systems for same Compact particle selection and collimation devices are disclosed for delivering beams of ions with desired energy spectra. These devices are useful with laser-accelerated ion therapy systems, in which the initial ions have broad energy and angular distributions. Sup... | 07/13/2010 |
| 7736848 | Cellular targets for treatment of retroviral infection Cellular targets for anti-retroviral drug development are disclosed. The cellular targets comprise ATR kinase and its relevant substrates, based on the identification of the ATR kinase as required for the final step of retroviral DNA integration. Assays for identify... | 06/15/2010 |
| 7705021 | Isoindolone compounds, compositions containing the same, and methods of use thereof for the treatment of viral infections related to the etiology of cancer Isoindolone derivatives, compositions containing the same, and methods of use thereof for the treatment or prophylaxis of viral infection are disclosed. ... | 04/27/2010 |
| 7618817 | Genetically modified human natural killer cell lines The invention provides a natural killer cell, NK-92, modified to express an Fc receptor on the surface of the cell, such as CD16 (FcγRIII-A), or other Fcγ or Fc receptors. The modified NK-92 cell can be further modified to concurrently express an associated access... | 11/17/2009 |
| 7615528 | Methods for alleviating deleterious effects of 3-deoxyglucosone Disclosed is a class of compounds which inhibit the enzymatic conversion of fructose-lysine into fructose-lysine-3-phosphate in an ATP dependent reaction in a recently discovered metabolic pathway. According to the normal functioning of this pathway, fructose-lysine... | 11/10/2009 |
| 7491807 | Gene encoding a DNA repair enzyme and methods of use thereof An isolated nucleic acid molecule encoding a human DNA repair enzyme, MED1, is disclosed. Like other mismatch repair genes which are mutated in certain cancers, MED1, encoding nucleic acids, proteins and antibodies thereto may be used to advantage in genetic or canc... | 02/17/2009 |
| 7452884 | Methods for inhibiting angiogenesis Novel methods for inhibiting angiogenesis and treating diseases associated with angiogenesis are described. The methods may comprise administering to a patient an effective amount of a 1,2-dithiol-3-thione derivative or metabolite thereof. Preferred compounds for us... | 11/18/2008 |
| 7416840 | Replication of hepatitis C virus in non-hepatic epithelial and mouse hepatic cells Cells and cell lines which replicate HCV of non-hepatic human and non human origin are disclosed. Also provided are methods of using such cells and cell lines to identify anti-HCV agents for the treatment of HCV infection. ... | 08/26/2008 |
| 7332585 | Bispecific single chain Fv antibody molecules and methods of use thereof Bispecific single chain antibody molecules are disclosed which may be used to advantage to treat various forms of cancer associated with the overexpression of members of the EGFR protein family. ... | 02/19/2008 |
| 7332580 | Bispecific single chain Fv antibody molecules and methods of use thereof Bispecific single chain antibody molecules are disclosed which may be used to advantage to treat various forms of cancer associated with the overexpression of members of the EGFR protein family. ... | 02/19/2008 |
| 7317192 | High energy polyenergetic ion selection systems, ion beam therapy systems, and ion beam treatment centers Devices and methods are provided for generating laser-accelerated high energy polyenergetic positive ion beams that are spatially separated and modulated based on energy level. The spatially separated and modulated high energy polyenergetic positive ion beams are us... | 01/08/2008 |
| 7312026 | MRP-related ABC transporter encoding nucleic acids and methods of use thereof Novel human MOAT genes and their encoded proteins are provided herein. The MRP-related ABC transporters encoded by the disclosed nucleic acid sequences play a pivotal role in the efflux of pharmacologically beneficial reagents from tumor cells. MOAT genes and their ... | 12/25/2007 |
| 7268358 | Method of modulating laser-accelerated protons for radiation therapy Methods of optimizing a laser-accelerated proton radiation dose to a targeted region are disclosed. Disclosed methods include providing a plurality of modulated polyenergetic proton beamlets and irradiating the targeted region with the plurality of modulated beamlet... | 09/11/2007 |
| 7208583 | Antibodies immunologically specific for a DNA repair endonuclease and methods of use thereof An isolated nucleic acid molecule encoding a human DNA repair enzyme, MED1, is disclosed. Like other mismatch repair genes which are mutated in certain cancers, MED1, encoding nucleic acids, proteins and antibodies thereto may be used to advantage in genetic or canc... | 04/24/2007 |
| 7199122 | Methods for inhibiting angiogenesis Novel methods for inhibiting angiogenesis and treating diseases associated with angiogenesis are described. The methods may comprise administering to a patient an effective amount of a 1,2-dithiol-3-thione derivative or metabolite thereof. Preferred compounds for us... | 04/03/2007 |
| 7183251 | hCG therapy for the treatment of breast cancer This invention relates to the field of cancer therapy. More particularly, the invention relates to the treatment of mammary tumor, clinically manifest mammary tumor (breast cancer) and metastatic mammary tumor by administration of human Chorionic Gonadotropin (hCG).... | 02/27/2007 |
| 7071298 | Compounds and methods for treating glycogen storage disease and other pathological conditions resulting from formation of age-proteins Disclosed is a class of compounds which inhibit the enzymatic conversion of fructose-lysine into fructose-lysine-3-phosphate in an ATP dependent reaction in a newly discovered metabolic pathway. According to the normal functioning on this pathway, fructose-lysine-3-... | 07/04/2006 |
| 7053194 | Compositions and methods for p53-mediated repression of gene expression Compositions and methods are provided for identifying novel therapeutic agents for the treatment of cancer and other cellular proliferative disorders. ... | 05/30/2006 |
| 6803184 | MPR-related ABC transporter encoding nucleic acids and methods of use thereof Novel human MOAT genes and their encoded proteins are provided herein. The MRP-related ABC transporters encoded by the disclosed nucleic acid sequences play a pivotal role in the efflux of pharmacologically beneficial reagents from tumor cells. MOAT genes and their ... | 10/12/2004 |
| 6699980 | Nucleic acid molecule encoding a mismatch endonuclease and methods of use thereof Nucleic acid molecules encoding a mismatch endonuclease and its method of use for the detection of mutations in targeted polynucleotide sequences are provided, which facilitate the localization and identification of mutations, mismatches and genetic polym... | 03/02/2004 |
| 6653074 | Methods for identifying agents which affect cellular morphology, locomotion and death An isolated nucleic acid molecule is provided which encodes a mammalian signal mediator protein, HEF-1, involved in regulation of cellular morphological alterations. The encoded protein comprises an amino-terminal SH3 domain, an internal domain containing... | 11/25/2003 |
| 6599700 | Methods for detection of transition single-nucleotide polymorphisms An isolated nucleic acid molecule encoding a human DNA repair enzyme, MED1, is disclosed. Like other mismatch repair genes which are mutated in certain cancers, MED1, encoding nucleic acids, proteins and antibodies thereto may be used to advantage in gene... | 07/29/2003 |
| 6593098 | Genes encoding proteins involved in mitotic checkpoint control and methods of use thereof Novel human BUB genes and their encoded proteins are provided herein. The kinases encoded by the disclosed BUB1A and BUB1B genes play a pivotal role in mitotic checkpoint control. BUB3 is a substrate of these kinases, BUB genes and their encoded proteins ... | 07/15/2003 |
| 6391557 | Nucleic acid molecule encoding a mismatch endonuclease and methods of use thereof Nucleic acid molecules encoding a mismatch endonuclease and its method of use for the detection of mutations in targeted polynucleotide sequences are provided, which facilitate the localization and identification of mutations, mismatches and genetic polym... | 05/21/2002 |
| 6326150 | Yeast interaction trap assay The present invention provides an improved yeast interaction trap method and reagents for the detection of novel protein-protein interactions. The invention comprises a dual bait system which improves the accuracy of library screens with an immediate sele... | 12/04/2001 |
| 6150511 | Chimeric enzyme for promoting targeted integration of foreign DNA into a host genome The present invention provides novel chimeric and fusion proteins useful for facilitating site-specific integration of foreign DNA into a host genome. The chimeric enzymes of the invention comprise a DNA binding moiety fused to a retroviral integrase moie... | 11/21/2000 |
| 6124434 | Signal mediator protein that induces cellular morphological alterations An isolated nucleic acid molecule is provided which encodes a mammalian signal mediator protein involved in regulation of cellular morphological alterations. The encoded protein comprises an amino-terminal SH3 domain, an Internal domain containing several... | 09/26/2000 |
| 6100384 | Antibodies immunologically specific for a signal mediator protein that induces cellular morphological alterations An isolated nucleic acid molecule is provided which encodes a mammalian signal mediator protein involved in regulation of cellular morphological alterations. The encoded protein comprises an amino-terminal SH3 domain, an internal domain containing several... | 08/08/2000 |
| 6004958 | Compounds and methods for therapeutic intervention in preventing diabetic complications and procedures for assessing a diabetic's risk of developing complications and determining the efficacy of therapeutic intervention The present invention is based on the discovery of a metabolic pathway in which a specific kinase converts fructose-lysine into fructose-lysine-3-phosphate in an ATP dependent reaction. Fructose-lysine-3-phosphate (FL3P) is then broken down to form free ... | 12/21/1999 |
| 5935937 | Compositions and methods for inducing apoptosis Compositions and methods for the treatment of malignant cells are disclosed, particularly antisense nucleic acid molecules and their use in inhibiting the deregulated cellular proliferation of tumor cells, while not adversely affecting the growth of norma... | 08/10/1999 |
| 5869650 | Dendroamide compounds and their use in chemosensitizing multidrug resistant cells Dendroamide derivatives are disclosed which are useful in cancer therapy, especially in treating multidrug resistant cells.... | 02/09/1999 |
| 5869245 | Mismatch endonuclease and its use in identifying mutations in targeted polynucleotide strands An endonuclease and its method of use for the detection of mutations in targeted polynucleotide sequences are provided, which facilitate the localization and identification of mutations, mismatches and genetic polymorphisms.... | 02/09/1999 |
| 5821338 | Antibodies specific for OVCA DNA encoded proteins and methods for their use This invention provides a novel gene, OVCA1, isolated from human chromosome 17p13.3. Disruption of the OVCA1 gene is associated with cellular proliferation and tumor development. The OVCA1 gene, along with its encoded protein and antibodies thereto, provi... | 10/13/1998 |
| 5801041 | Gene associated with suppression of tumor development This invention provides a novel gene, OVCA1, isolated from human chromosome 17p13.3. Disruption of the OVCA1 gene is associated with cellular proliferation and tumor development. The OVCA1 gene, along with its encoded protein and antibodies thereto, provi... | 09/01/1998 |
| 5770717 | Nucleic acid encoding a stress-responsive subunit of human RNA polymerase II An isolated nucleic acid is provided, which encodes a stress-responsive subunit of mammalian RNA polymerase II, RPB4. In a preferred embodiment, the human RPB4 subunit (hsRPB4) is provided. Also provided are oligonucleotides that specifically hybridize wi... | 06/23/1998 |
| 5741646 | Cell lines and methods for screening growth regulatory compounds This invention provides a novel murine cultured cell line which is derived from primary mouse embryo fibroblasts and which exhibits inducer-regulated growth kinetics. The cell line has the potential to grow either linearly or exponentially depending on ex... | 04/21/1998 |
| 5723319 | Cultured cell line that inducibly expresses the hepatitis B virus genome, and uses thereof for screening antiviral substances Novel cell lines and methods are provided for inducibly expressing the Hepatitis B virus (HBV) genome within cultured cells. Cells are stably transformed with an HBV genome under control of an operator/promoter target sequence which can activate expressio... | 03/03/1998 |
| 5716782 | Nucleic acid encoding a signal mediator protein that induces cellular morphological alterations An isolated nucleic acid molecule is provided which encodes a mammalian signal mediator protein involved in regulation of cellular morphological alterations. The encoded protein comprises an amino-terminal SH3 domain, an internal domain containing several... | 02/10/1998 |
