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| Number | Title | Issue Date |
| 8105824 | Integrated chip carriers with thermocycler interfaces and methods of using the same Methods and systems are provided for conducting a reaction at a selected temperature or range of temperatures over time. An array device is provided. The array device contains separate reaction chambers and is formed as an elastomeric block from multiple layers. At ... | 01/31/2012 |
| 8105553 | Crystal forming devices and systems and methods for using the same The present invention provides for microfluidic devices and methods for their use. The invention further provides for apparatus and systems for using the microfluidic devices, analyze reactions carried out in the microfluidic devices, and systems to generate, store,... | 01/31/2012 |
| 8105550 | Method and system for microfluidic device and imaging thereof A biological substrate, e.g., microfluidic chip. The substrate includes a rigid substrate material, which has a surface region capable of acting as a handle substrate. The substrate also has a deformable fluid layer coupled to the surface region. One or more well re... | 01/31/2012 |
| 8104514 | Microfabricated fluidic circuit elements and applications A microfabricated fluidic unidirectional valve includes a microfabricated elastomer material having a flow through channel. The microfabricated fluidic unidirectional valve also includes an elastomer flap attached to the elastomer material in the flow through channe... | 01/31/2012 |
| 8058630 | Microfluidic devices and methods Embodiments of the present invention provide improved microfluidic devices and related apparatus, systems, and methods. Methods are provided for reducing mixing times during use of microfluidic devices. Microfluidic devices and related methods of manufacturing are p... | 11/15/2011 |
| 8055034 | Methods and systems for image processing of microfluidic devices A method of processing data associated with fluorescent emissions from a microfluidic device. The method includes performing an auto-focus process associated with a first image of the microfluidic device and performing an auto-exposure process associated with the fi... | 11/08/2011 |
| 8050516 | Methods and systems for determining a baseline during image processing A method of determining a plurality of positions associated with a plurality of reaction chambers of a microfluidic device includes a) providing a baseline image; b) providing a template image of a reaction chamber; and c) selecting a region of the baseline image. T... | 11/01/2011 |
| 8048378 | Optical lens system and method for microfluidic devices An apparatus for imaging one or more selected fluorescence indications from a microfluidic device. The apparatus includes an imaging path coupled to least one chamber in at least one microfluidic device. The imaging path provides for transmission of one or more fluo... | 11/01/2011 |
| 8007746 | Microfluidic devices and methods of using same An M×N matrix microfluidic device for performing a matrix of reactions, the device having a plurality of reaction cells in communication with one of either a sample inlet or a reagent inlet through a via formed within an elastomeric block of the device. Methods pro... | 08/30/2011 |
| 7974380 | Method and system for crystallization and X-ray diffraction screening An integrated fluidic circuit includes a substrate layer and a first structure coupled to the substrate layer and including a plurality of channels. The first structure is configured to provide for flow of one or more materials through the plurality of channels. The... | 07/05/2011 |
| 7906072 | Optical lens system and method for microfluidic devices An apparatus for imaging one or more selected fluorescence indications from a microfluidic device. The apparatus includes an imaging path coupled to least one chamber in at least one microfluidic device. The imaging path provides for transmission of one or more fluo... | 03/15/2011 |
| 7883669 | Analysis engine and database for manipulating parameters for fluidic systems on a chip Systems for managing workflows to perform chemical or biological reactions using microfluidic devices. ... | 02/08/2011 |
| 7867763 | Integrated chip carriers with thermocycler interfaces and methods of using the same Methods and systems are provided for conducting a reaction at a selected temperature or range of temperatures over time. An array device is provided. The array device contains separate reaction chambers and is formed as an elastomeric block from multiple layers. At ... | 01/11/2011 |
| 7867454 | Thermal reaction device and method for using the same An M×N matrix microfluidic device for performing a matrix of reactions, the device having a plurality of reaction cells in communication with one of either a sample inlet or a reagent inlet through a via formed within an elastomeric block of the device. Methods pro... | 01/11/2011 |
| 7837946 | Microfluidic device and methods of using same A variety of elastomeric-based microfluidic devices and methods for using and manufacturing such devices are provided. Certain of the devices have arrays of reaction sites to facilitate high throughput analyzes. Some devices also include reaction sites located at th... | 11/23/2010 |
| 7820427 | Microfluidic device and methods of using same A variety of elastomeric-based microfluidic devices and methods for using and manufacturing such devices are provided. Certain of the devices have arrays of reaction sites to facilitate high throughput analyses. Some devices also include reaction sites located at th... | 10/26/2010 |
| 7815868 | Microfluidic reaction apparatus for high throughput screening An SBS-formatted microfluidic device where the geometry of the plate defines an array of interrogation areas, and where each interrogation area encompasses at least one reaction site. ... | 10/19/2010 |
| 7792345 | Image processing method and system for microfluidic devices A method for processing an image of a microfluidic device. The method includes receiving a first image of a microfluidic device. The first image corresponds to a first state. Additionally, the method includes receiving a second image of the microfluidic device. The ... | 09/07/2010 |
| 7749737 | Thermal reaction device and method for using the same An M times.N matrix microfluidic device for performing a matrix of reactions, the device having a plurality of reaction cells in communication with one of either a sample inlet or a reagent inlet through a via formed within an elastomeric block of the device. Method... | 07/06/2010 |
| 7704735 | Integrated chip carriers with thermocycler interfaces and methods of using the same Methods and systems are provided for conducting a reaction at a selected temperature or range of temperatures over time. An array device is provided. The array device contains separate reaction chambers and is formed as an elastomeric block from multiple layers. At ... | 04/27/2010 |
| 7695683 | Method and system for microfluidic device and imaging thereof A biological substrate, e.g., microfluidic chip. The substrate includes a rigid substrate material, which has a surface region capable of acting as a handle substrate. The substrate also has a deformable fluid layer coupled to the surface region. One or more well re... | 04/13/2010 |
| 7691333 | Microfluidic device and methods of using same A variety of elastomeric-based microfluidic devices and methods for using and manufacturing such devices are provided. Certain of the devices have arrays of reaction sites to facilitate high throughput analyses. Some devices also include reaction sites located at th... | 04/06/2010 |
| 7666361 | Microfluidic devices and methods of using same A variety of elastomeric-based microfluidic devices and methods for using and manufacturing such devices are provided. Certain of the devices have arrays of reaction sites to facilitate high throughput analyses. Some devices also include reaction sites located at th... | 02/23/2010 |
| 7640947 | Microfabricated fluidic circuit elements and applications Microfabricated fluidic devices of the present invention include switches that can be opened and closed to allow or block the flow of fluid through a channel in response to the pressure level in a gate of the switch. The microfabricated fluidic switches may be coupl... | 01/05/2010 |
| 7604965 | Thermal reaction device and method for using the same An M×N matrix microfluidic device for performing a matrix of reactions, the device having a plurality of reaction cells in communication with one of either a sample inlet or a reagent inlet through a via formed within an elastomeric block of the device. Methods pro... | 10/20/2009 |
| 7588672 | Optical lens system and method for microfluidic devices An apparatus for imaging one or more selected fluorescence indications from a microfluidic device. The apparatus includes an imaging path coupled to least one chamber in at least one microfluidic device. The imaging path provides for transmission of one or more fluo... | 09/15/2009 |
| 7583853 | Image processing method and system for microfluidic devices A method for processing an image of a microfluidic device. The method includes receiving a first image of a microfluidic device. The first image corresponds to a first state. Additionally, the method includes receiving a second image of the microfluidic device. The ... | 09/01/2009 |
| 7526741 | Microfluidic design automation method and system The present invention generally relates to microfluidics and more particularly to the design of customized microfluidic systems using a microfluidic computer aided design system. In one embodiment of the present invention a microfluidic circuit design method is prov... | 04/28/2009 |
| 7476363 | Microfluidic devices and methods of using same An M×N matrix microfluidic device for performing a matrix of reactions, the device having a plurality of reaction cells in communication with one of either a sample inlet or a reagent inlet through a via formed within an elastomeric block of the device. Methods pro... | 01/13/2009 |
| 7442556 | Microfluidic-based electrospray source for analytical devices with a rotary fluid flow channel for sample preparation This invention provides microfluidic devices and methods for using the same. Microfluidic devices of the present invention comprises a first elastic layer, a fluid flow channel within the elastic layer; and a means for providing a fluid sample from the fluid flow ch... | 10/28/2008 |
| 7392827 | Microfabricated fluidic circuit elements and applications The present invention provides microfabricated fluidic systems and methods. Microfabricated fluidic devices of the present invention include switches that can be opened and closed to allow or block the flow of fluid through a channel in response to the pressure leve... | 07/01/2008 |
| 7368163 | Polymer surface modification The present invention is directed to a surface modified polymer comprising a surface which is covalently bonded to a surface modifying compound. Formation of the covalent bond between the polymer and the surface modifying compound is achieved by a reaction between a... | 05/06/2008 |
| 7312085 | Microfluidic particle-analysis systems The invention provides systems, including apparatus, methods, and kits, for the microfluidic manipulation and/or detection of particles, such as cells and/or beads. The invention provides systems, including apparatus, methods, and kits, for the microfluidic manipula... | 12/25/2007 |
| 7307802 | Optical lens system and method for microfluidic devices An apparatus for imaging one or more selected fluorescence indications from a microfluidic device. The apparatus includes an imaging path coupled to least one chamber in at least one microfluidic device. The imaging path provides for transmission of one or more fluo... | 12/11/2007 |
| 7291512 | Electrostatic/electrostrictive actuation of elastomer structures using compliant electrodes A valve structure comprises an elastomeric block formed with first and second microfabricated recesses separated by a membrane portion of the elastomeric block. The valve is actuated by positioning a compliant electrode on a first side of the first recess proximate ... | 11/06/2007 |
| 7279146 | Crystal growth devices and systems, and methods for using same High throughput screening of crystallization of a target material is accomplished by simultaneously introducing a solution of the target material into a plurality of chambers of a microfabricated fluidic device. The microfabricated fluidic device is then manipulated... | 10/09/2007 |
| 7217367 | Microfluidic chromatography The present invention is directed to a microfluidic chromatography apparatus comprising a microfabricated fluid delivery system and a chromatography column which is in fluid communication with the fluid delivery system, and a method for producing and using the same.... | 05/15/2007 |
| 7118910 | Microfluidic device and methods of using same A variety of elastomeric-based microfluidic devices and methods for using and manufacturing such devices are provided. Certain of the devices have arrays of reaction sites to facilitate high throughput analyses. Some devices also include reaction sites located at th... | 10/10/2006 |
| 7075162 | Electrostatic/electrostrictive actuation of elastomer structures using compliant electrodes A valve structure includes an elastomeric block formed with first and second microfabricated recesses separated by a membrane portion of the elastomeric block. The valve is actuated by positioning a compliant electrode on a first side of the first recess proximate t... | 07/11/2006 |
| 7059348 | Drug delivery system An implantable drug delivery system has a housing, a collapsible reservoir, a microfabricated flow channel, and at least one magnet. The collapsible reservoir is disposed in the housing. The microfabricated flow channel is connected at one end to the collapsible res... | 06/13/2006 |
