Did You Know...
...that the inventor of the electric motor was a blacksmith named Thomas Davenport? Described as "a brilliantly unsuccessful inventor", Davenport invented the first rotary electric motor. In 1836 he headed out -- on foot -- from his Vermont home to file a patent application at the Patent Office in Washington, D.C. By the time he got there, he had squandered away his money and couldn't afford the $30 filing fee so he turned around and went home. When he later mailed in his application with money he'd raised, the Patent office was destroyed in a fire. He did finally get credit for his invention on Feb. 5, 1837.
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| Number | Title | Issue Date |
| 6620792 | Pharmaceutical compositions containing monosialoganglioside GM1 or derivative thereof suitable for the treatment of parkinson's disease The present invention refers to pharmaceutical compositions containing monosialoganglioside GM1 or a derivative thereof, namely, the inner ester AGF2 and the methyl ester AGF4, suitable for the treatment of Parkinson's disease. A fur... | 09/16/2003 |
| 6533820 | Biomaterials for bone replacements The present invention involves compositions for use as granular bone replacements. The compositions of the present invention are comprised of hyaluronic acid esters or salts of hyaluronic acid in association with a pharmacologically active compound wherei... | 03/18/2003 |
| 6407072 | Lysoganglioside derivatives Novel N-acyl-lysogangliosides obtained from gangliosides by deacyation of the ceramide group, wherein the acyl group is derived from an aliphatic acid having from 2 to 24 carbon atoms, substituted by one or more polar groups. The N-acyl-lysogangliosides o... | 06/18/2002 |
| 6251876 | Autocross-linked hyaluronic acid and related pharmaceutical compositions for the treatment of arthropathies The present invention relates to compositions containing an autocross-linked form of hyaluronic acid as a first component in a mixture with a second component noncross-linked hyaluronic acid, and possibly also in combination with another pharmacologically... | 06/26/2001 |
| 6224857 | Pharmaceutical preparations comprised of salts of hyaluronic acid with local anaesthetics Pharmaceutical preparations are described, comprised of salts of hyaluronic acid with a basic anesthetic containing aliphatics and/or amino groups, particularly salts with benzydamine or bupivacaine.... | 05/01/2001 |
| 6066340 | Process for the preparation of microspheres containing biologically active components The present invention is directed to a microsphere for the controlled release of a biologically active molecule which comprises a biologically active molecule and an ester of hyaluronic acid or mixtures of said esters of hyaluronic acids, and wherein said... | 05/23/2000 |
| 6039970 | Process for the preparation of microspheres containing biologically active components The present invention is directed to a microsphere for the controlled release of a biologically active molecule which comprises a biologically active molecule and an ester of hyaluronic acid or mixtures of said esters of hyaluronic acids, and wherein said... | 03/21/2000 |
| 5925626 | Hyaluronic acid fractions having pharmaceutical activity, and pharmaceutical compositions containing the same Two pharmaceutically useful fractions of hyaluronic acid are obtained comprising a first fraction with a molecular weight between 50,000 and 100,000 which is useful for wound healing, and a second fraction having a molecular weight between 500,000 and 730... | 07/20/1999 |
| 5879359 | Biodegradable guide channels comprised of esters of hyaluronic acid for use in tissue repair as surgical aids The present invention is drawn to medical devices comprising biodegradable guide channels for use in the repair and regeneration of nerve tissue. The guide channels of the present invention comprise interlaced threads imbedded in a matrix, wherein both th... | 03/09/1999 |
| 5849717 | O-sulfated gangliosides and lyso-ganglioside derivatives Disclosed are derivatives of gangliosides and of N-acyl-N-lyso-gangliosides, of N'-acyl-N'-lyso-gangliosides and N,N'-di- or poly-acyl-N,N'-di-lyso-gangliosides, in which at least one of the hydroxyl groups in the saccharide, sialic or ceramide residues i... | 12/15/1998 |
| 5795869 | Sulfated lyso-ganglioside derivatives Semisynthetic analogues of gangliosides selected from the group consisting of N-sulfo-, N-hydrocarbyl-sulfonyl- and N-hydrocarbyloxy-sulfonyl-N,N'-dilyso-gangliosides and the N'-acyl derivatives thereof, N'-sulfo-, N'-hydrocarbylsulfonyl- and N'-hydr... | 08/18/1998 |
| 5735863 | Biodegradable and bioabsorbable guide channels for use in nerve treatment and regeneration The present invention is drawn to medical devices comprised of biodegradable guide channels for use in repair and regeneration of nerve tissue. The guide channels are comprised of threads embedded in a matrix and coextruded with active factors wherein bot... | 04/07/1998 |
| 5709877 | Gels in the form of highly hydrated self-supporting film, the process for their preparation, and their use in the therapy of cutaneous lesions and/or pathologies This invention provides new gels in the form of highly hydrated self-supporting film, comprising one or more alkaline alginates, an alkaline earth alginate, a polyalcohol and a natural, synthetic or semisynthetic polymer of hydrophilic nature, and their p... | 01/20/1998 |
| 5676964 | Crosslinked carboxy polysaccharides Inter and/or intramolecular cross-linked esters of acid polysaccharides are disclosed in which a part or all of the carboxy groups are esterified with hydroxyl groups of the same molecule and/or of different molecules of the acid polysaccharide. These inn... | 10/14/1997 |
| 5677285 | Derivatives of neuraminic acid Provided are new derivatives of neuraminic acid of formula (I), where Ac represents an acyl residue of an aliphatic, araliphatic, aromatic, alicyclic, or heterocyclic carboxylic acid, including carboxylic amides, their 2-hydrocarbyl-glycosides, and their ... | 10/14/1997 |
| 5650164 | Process for preparing artificial skin with biocompatible perforated membranes The invention relates to biocompatible membranes constructed of materials of natural, synthetic or semisynthetic origin, and having a thickness of between 10 and 500 μ, characterised by containing an ordered series of holes of a constant size between 10 ... | 07/22/1997 |
| 5646129 | Method of using low molecular weight hyaluronic acid for stimulating bone formation The present invention is drawn to hyaluronic acid fractions having molecular weights in the range of from about 20,000 to about 60,000 daltons, wherein these hyaluronic acid fractions possess osteoinductive activity. The present invention further includes... | 07/08/1997 |
| 5583142 | Analgesic and nootropic drugs Compounds of general formula: ##STR1## where: Ar=phenyl or beta-naphtyl, or aromatic heterocyclic 6-membered ring containing one or two nitrogen atoms; R1 =one or more substituents of the Ar nucleus, preferably in para position, and select... | 12/10/1996 |
| 5559104 | Procedure for the purification of hyaluronic acid and fraction of pure hyaluronic acid for ophthalmic use A highly pure fraction of hyaluronic acid is disclosed which is non-inflammatory and avoids post-operative complications in ocular surgery. Also disclosed is a process for the preparation of hyaluronic acid characterized by converting hyaluronic acid into... | 09/24/1996 |
| 5556843 | Therapeutic use of phosphoryl-L-serine-N-acyl-sphingosine The present invention relates to a therapeutic use of phosphoryl-L-serine-N-acyl-sphingosine comprising a mixture of compounds of instant formula I or II that are herein disclosed.... | 09/17/1996 |
| 5538730 | Carboxylic polysaccharide derivatives Copolymers of the formula: ##STR1## wherein the bonds between the glucoside units are ଲ (1.fwdarw.4), the degree of polymerization referred to a single glucoside unit varies from about 50 to 50,000, R is a free or esterified carboxy group and S... | 07/23/1996 |
| 5529918 | Process for preparing neuraminidase Process for preparing neuraminidase, by using as the bacterial strain the Arthrobacter Sp in a culture containing low concentrations of N-acetyl-neuraminic acid.... | 06/25/1996 |
| 5523093 | Gels in the form of highly hydrated self-supporting film, the process for their preparation, and their use in the therapy of cutaneous lesions and/or pathologies This invention provides new gels in the form of highly hydrated self-supporting film, comprising one or more alkaline alginates, an alkaline earth alginate, a polyalcohol and a natural, synthetic or semisynthetic polymer of hydrophilic nature, and their p... | 06/04/1996 |
| 5521164 | Method for the preparation and purification of a mixture of glycosphingolipids free from contamination by non-conventional viruses The process of the invention relates to a process for the preparation of a ganglioside mixture, free from contaminants associated with non-conventional, life-threatening viruses, without altering the biological and pharmacological characteristics of the m... | 05/28/1996 |
| 5519007 | Lysosphingolipid derivatives Novel derivatives of lysophingolipids free from sialic acids which are N-acyllysosphingolipids having one of the two formulae: ##STR1## in which --A-- stands for the group --CH.dbd.CH-- or --CH2 --CH2 --, n1 is a whol... | 05/21/1996 |
| 5503848 | Spongy material consisting essentially of hyaluronic acid or its derivatives, and its use in microsurgery The present invention relates to a new spongy material consisting essentially of hyaluronic acid or its derivatives. The characteristics of the new pharmaceutical preparations consist in assuring high concentrations of active principle for a long period o... | 04/02/1996 |
| 5466461 | Polysaccharide esters New polysaccharide esters are disclosed, and more precisely esters of acidic polysaccharides chosen from the group formed by carboxymethylcellulose, carboxymethyl starch and carboxymethylchitin. These new esters and some esters of the type already known a... | 11/14/1995 |
| 5442053 | Salts and mixtures of hyaluronic acid with pharmaceutically active substances, pharmaceutical compositions containing the same and methods for administration of such compositions Two pharmaceutically useful fractions of hyaluronic acid are obtained comprising a first fraction with a molecular weight between 50,000 and 100,000 which is useful for wound healing, and a second fraction having a molecular weight between 500,000 and 730... | 08/15/1995 |
| 5424294 | Modified gangliosides and the functional derivatives thereof N-acyl-N,N'-di-lysogangliosides, N'-acyl-N,N'-di-lysogangliosides and N,N'-diacyl-N,N'-di-lysogangliosides, in which the acyl groups are derived from an organic acid of the aliphatic, aromatic, araliphatic, alicyclic or heterocyclic series and in which at... | 06/13/1995 |
| 5416205 | New esters of alginic acid Partial esters of alginic acid and salts thereof possess important bioplastic and pharmaceutical qualities and are useful in various fields including medical, surgical, cosmetics and foods.... | 05/16/1995 |
| 5373853 | Portable device for thermal stimulus sensitivity tests Portable device for thermal stimulus sensitivity tests, in particular for tests in patients affected by neuropathies of diabetic origin, comprising four detecting probes arranged in a single block provided with a handgrip, and each of said probes having a... | 12/20/1994 |
| 5350841 | Ganglioside derivatives Novel ganglioside derivatives comprised of a basic natural or semisynthetic ganglioside, in which the carboxyl group in the sialic part of the natural or semisynthetic ganglioside is converted into a carboxylamide with an aliphatic amino acid with a carbo... | 09/27/1994 |
| 5336767 | Total or partial esters of hyaluronic acid The invention concerns the esters of hyaluronic acid in which all or only a portion of the carboxylic groups of the acid are esterified, and the salts of the partial esters with metals or with pharmacologically acceptable organic bases. The compounds poss... | 08/09/1994 |
| 5336668 | Esters of alginic acid Total and partial esters of alginic acid which possess important bioplastic and pharmaceutical qualities and are useful in various fields including medical, surgical, cosmetics and foods.... | 08/09/1994 |
| 5332809 | Partial esters of gellan The present invention is directed to total and partial esters of gellan in which the esterifying alcohol component is derived from aliphatic, araliphatic, cycloaliphatic or heterocyclic alcohols, and salts of said partial esters with inorganic or organic ... | 07/26/1994 |
| 5326356 | Biocompatible perforated membranes, processes for their preparation, their use as a support in the in vitro growth of epithelial cells, the artificial skin obtained in this manner, and its use in skin grafts It is provided biocompatible membranes constructed of materials of natural, synthetic or semisynthetic origin, and having a thickness of between 10 and 500μ, characterised by containing an ordered series of holes of a constant size between 10 and 1000μ,... | 07/05/1994 |
| 5300493 | Ulcer treatment using choline esters of polysaccharides Acidic polysaccharide esters containing carboxylic groups are useful for protecting against and curing ulcers of the gastro-enteric system. These esters include choline esters with acidic polysaccharide selected from the group consisting of hyaluronic aci... | 04/05/1994 |
| 5264424 | Modified gangliosides and the functional derivatives thereof N-acyl-N,N'-di-lysogangliosides, N'-acyl-N,N'-di-lysogangliosides and N,N'-diacyl-N,N'-di-lysogangliosides, in which the acyl groups are derived from an organic acid of the aliphatic, aromatic, araliphatic, alicyclic or heterocyclic series and in which at... | 11/23/1993 |
| 5264422 | Esters of alginic acid with steroidal alcohols Partial esters of alginic acid and salts thereof possess important bioplastic and pharmaceutical qualities and are useful in various fields including medical, surgical, cosmetics and foods.... | 11/23/1993 |
| 5250541 | Kynurenic acid derivatives, their preparation and pharmaceutical compositions containing them Kynurenic acid derivatives useful as therapeutic agents in treating neurological disorders, for example, thiokynurenic acid, 7-chloro-thio-kynurenic acid, 7-trifluoromethyl-thiokynurenic acid, 7-methoxy-thiokynurenic acid and 5-fluoro-thiokynurenic acid.... | 10/05/1993 |
