Quotables
"The abolishment of pain in surgery is a chimera. It is absurd to go on seeking it...knife and pain are two words in surgery that must forever be associated in the consciousness of the patient."
Dr. Alfred Velpeau, French surgeon ; 1839
PatentStorm News
Make the Most of Our Site
See this month's Top Inventors and Most Cited Patents.
Stay on top of the latest innovations by subscribing to an RSS feed.
Registered users: Manage your profile.
| Number | Title | Issue Date |
| 6719975 | Anti-hirudin polyclonal antibodies and their use for the identification, immunopurification and quantitative determination of hirudin A method of making antibodies to hirudin by immunizing with an immunogenic composition containing polymerized hirudin monomers in the absence of carrier protein is taught. ... | 04/13/2004 |
| 5656654 | Arylidene and heteroarylidene oxindole derivatives and process for their preparation Arylidene and heteroarylidene oxindole derivatives of formula (I) ##STR1## wherein, subject to provisos, Y is a bicyclic ring system chosen from naphthalene, tetralin, quinoline and isoquinoline; R is hydrogen or an oxo (.dbd.O) group when Y is tetralin; ... | 08/12/1997 |
| 5639884 | Arylidene-heterocyclic derivatives and process for their preparation The invention relates to compounds of formula ##STR1## wherein Ar is mono- or bicyclic ring system chosen from benzene, naphthalene, tetrahydronaphthalene, quinoline and indole; Het is ##STR2## R is hydrogen, halogen, hydroxy, C1 -C | 06/17/1997 |
| 5594105 | Peptide inhibitors of mitogenesis and motogenesis The invention in the field of cell biology relates to novel peptides able to interact with intracellular signal transducers, thus interfering with signal transduction pathways leading to cell proliferation and motility. The peptides of the invention may b... | 01/14/1997 |
| 5587373 | 2-acyloxycephem derivatives The present invention provides cephalosporin sulphones of formula (I) and the pharmaceutically and veterinarily acceptable salts thereof: ##STR1## wherein n is one or two: A and B are both or each independently hydrogen or an organic radical; R1... | 12/24/1996 |
| 5580865 | 2,2-disubstituted cephem sulphones The present invention provides cephalosporin sulphones or formula (I), and pharmaceutically or veterinarily acceptable salts thereof; ##STR1## wherein n is zero, one or two; R1 is hydrogen, halogen or an optionally substituted C1 | 12/03/1996 |
| 5576330 | Biologically active 3-substituted oxindole derivatives useful as anti-angiogenic agents The new use of a compound of formula (I) ##STR1## wherein Y is a bicyclic ring selected from naphthalene, tetralin, quinoline, isoquinoline and indole; n is zero or an integer of 1 to 3; R1 is hydrogen, C1 -C6 alkyl or C | 11/19/1996 |
| 5569720 | Polymer-bound paclitaxel derivatives A polymer conjugate consisting essentially of: from 90 to 99.9 mol % of units represented by the formula ##STR1## from 0.1 to 5 mol % of units represented by the formula ##STR2## wherein one of R1 and R2 is a copolymer resi... | 10/29/1996 |
| 5534539 | Biologically active ureido derivatives useful as anit-metastic agenst The invention relates to the use of compounds of formula (I) ##STR1## wherein each of m and n, being the same, is an integer of 1 to 3; and each of the R groups, which are the same, is a naphthyl group substituted by 1 to 3 sulfonic groups,or pharmac... | 07/09/1996 |
| 5514693 | Imidazolyl and pyridyl derivatives of phenyl substituted 1,4-dihydropyridines and process for their preparation Imidazolyl and pyridyl derivatives of phenyl substituted 1,4-dihydropyridines of formula (I) ##STR1## wherein Het is ##STR2## A represents a direct linkage, --CH2 --, CH2 --CH2 -- or, when Het is ##STR3... | 05/07/1996 |
| 5502079 | N-phenylalkyl substituted -amino carboxamide derivatives and process for their preparation N-phenylalkyl substituted -amino carboxamide derivatives of formula (I) ##STR1## wherein R is C1 -C8 alkyl, C3 -C8 cycloalkyl, furyl, thienyl, pyridyl or unsubstituted or substituted phenyl; A is a ... | 03/26/1996 |
| 5502044 | Fluorinated 4-aminoandrostadienone derivatives and process for their preparation The present invention relates to a compound of formula (I) ##STR1## wherein (x) and (y) are single or double bonds; A is a ##STR2## R and R3 are hydrogen or acyl; R1 is hydrogen or fluorine; and wherein: when (y) is a single bon... | 03/26/1996 |
| 5488057 | 2-oxindole compounds which have useful tyrosine kinase activity The present invention provides novel aryl- and heteroarylethenylene derivatives which are useful as tyrosine kinase activity inhibitors.... | 01/30/1996 |
| 5480880 | Penem derivatives The invention provides compounds of the general formula I ##STR1## wherein R1 is a hydrogen atom, a negative charge or an ester residue; R is: a) --(CH2)n --A--CO2 H, --(CH2)n--A--SO3 H or ... | 01/02/1996 |
| 5473055 | Polymer-bound paclitaxel derivatives A polymer conjugate consisting essentially of: from 90 to 99.9 mol % of units represented by the formula ##STR1## from 0.1 to 5 mol % of units represented by the formula ##STR2## wherein one of R1 and R2 is a copolymer resi... | 12/05/1995 |
| 5470836 | Paromomycin or its derivatives or salts thereof in combination with sodium stirogluconate for parenteral treatment of human parasitic diseases A compound of formula (I): ##STR1## wherein: R1 is a hydroxy group or an amino group optionally substituted with a C1 -C4 alkyl or phenyl-(C1 -C4) alkyl group, R2 is hydrogen or a hydr... | 11/28/1995 |
| 5459161 | Process for the preparation of substituted benzofuran derivatives Substituted benzofuran derivatives of the formula (I): ##STR1## wherein one of R1 and R2 is hydrogen or halogen and the other is, independently, an amino group or a C2 -C4 alkanoyl amino group; R3 | 10/17/1995 |
| 5457097 | Androst-4-eno[4,5-b]pyrrole derivatives This invention refers to compounds of formula (I) ##STR1## wherein x, y, z represent single or double bonds; R is hydrogen or C1 -C4 alkyl; R1 is hydrogen or an acyl group; R2 is hydrogen; C1 -C4 | 10/10/1995 |
| 5457193 | Hydroxy protecting group removal in penems The present invention relates the removal of t-butyldimethylsilyl protecting groups in the preparation of penems which are useful antibiotics. The invention provides a process for preparing a compound of the formula I: ##STR1## wherein R is a fr... | 10/10/1995 |
| 5449692 | Substituted (arylalkylaminobenzyl) aminopropionamide derivatives and process for their preparation The invention provides new compounds of formula (I) ##STR1## wherein n is an integer of 1 to 4; each of R and R1, which may be the same or different, is hydrogen, halogen, trifluoromethyl or C1 -C4 alkoxy; R2 is hydro... | 09/12/1995 |
| 5446066 | Substituted (arylalkoxybenzyl)aminopropanamide derivatives and process for their preparation The invention provides new compounds of formula (I) ##STR1## wherein, subject to a proviso, n is zero or an integer of 1 to 3; each of R and R1, which may be the same or different, is hydrogen, halogen, trifluoromethyl or C1 -C | 08/29/1995 |
| 5439820 | Anti-thrombin polypeptides The present invention relates to anti-thrombin polypeptides isolated from the leech Hirudinaria manillensis and to processes for their preparation. The polypeptides of the invention may be modified by way of amino acid extension at either or each end, and... | 08/08/1995 |
| 5436235 | 3-aryl-glycidic ester derivatives The present invention relates to 3-aryl-oxirane derivatives of the formula ##STR1## wherein Ar is 4'-quinoline or 5'-quinoline; each of R and R1 independently is hydrogen or C1 -C6 alkoxy; one of X and Y is hydrogen, ... | 07/25/1995 |
| 5430031 | Serotoninergic ergoline derivatives The present invention provides compounds of the formula (I) ##STR1## wherein A, R1, R2 and R3 are defined as in the specification, or a pharmaceutically acceptable salt thereof. A process for their preparation and the... | 07/04/1995 |
| 5424328 | Phenyl-imidazolidinone derivatives The invention relates to new derivatives of 1-imidazolylalkyl-3-phenyl-imidazolidin-2-ones of general formula (I) ##STR1## wherein n is 1, 2 or 3; each of R, R1 and R2, which may be the same or different, is hydrogen, halogen, h... | 06/13/1995 |
| 5424308 | Condensed pyrazole 3-oxo-propanenitrile derivatives Condensed pyrazole 3-oxo-propanenitrile derivatives of formula (I) ##STR1## wherein X represents a --CH(R4)-- group, an oxygen atom or a --S(O)n -- group where n is 0, 1 or 2; R1 represents C1 -C6 | 06/13/1995 |
| 5409949 | Methylen-oxindole derivatives compositions and tyrosine kinase inhibition therewith The invention provides new methylen-indole derivatives of formula (I) ##STR1## wherein R is a group ##STR2## in which R4 is hydrogen, hydroxy, C1 -C6 alkoxy, C2 -C6 alkanoyloxy, carboxy, ni... | 04/25/1995 |
| 5401750 | Derivatives of substituted imidazol-2-one and process for their preparation Derivatives of 1-phenyl-3-azabicycloalkylimidazolidin-2-ones are provided of general formula (I) ##STR1## in which inter alia R3 represents a group ##STR2## wherein n is an integer of 1 or 2 and R8 is hydrogen, C1 | 03/28/1995 |
| 5399679 | (1'R,3S,4R)4-acylthio azetidinones There is provided a process for preparing a compound of formula (I) ##STR1## wherein R is H or a hydroxy protecting group, R2 is an organic residue and R3 is H or a nitrogen protecting group, which process comprises reacting tog... | 03/21/1995 |
| 5387578 | New linker for bioactive agents Conjugate of general formula 1: [A--O--W-Z]a -T 1 wherein the moity A--O--is the residue of drug of formula A--O--H in which --O--H is a primary or secondary hydroxyl group; a is an integer of from 1 to 30; W is... | 02/07/1995 |
| 5382669 | Process for the preparation of ergoline derivatives The invention provides a process for the preparation of ergoline derivatives of the formula I ##STR1## the process comprising reacting an ergoline amide of the formula II with an isocyanate of formula III ##STR2## in presence of a metal cat... | 01/17/1995 |
| 5374626 | 5'-alkylphosphonylnucleosides as antivirals The present invention relates to the use as antivirals of compounds of formula: ##STR1## wherein B is a purinic or pyrimidinic heterocycle; X is oxygen or sulphur; R1 is a hydroxyl group or a hydrogen atom; R2 is a linear, ... | 12/20/1994 |
| 5364854 | Derivatives of substituted imidazo benzoxazin-1-one and process for their preparation Derivatives of 2,3,3a,4-tetrahydro-2-azabicyclo alkyl-1H-imidazo[5,1,-c][1,4]benzoxazin-1-one are provided of general formula (I) ##STR1## in which inter alia R3 represents ##STR2## wherein n is an integer of 1 or 2 and R8 | 11/15/1994 |
| 5364768 | Process for the preparation of penems An in vitro process for preparing 6((1R)-hydroxyethyl) penem acids by hydrolyzing the carboxylic ester derivative thereof using an enzyme capable of selectively hydrolyzing the ester group at the 3-position of the carboxylic acid ester using an esterase, ... | 11/15/1994 |
| 5362831 | Polymer-bound paclitaxel derivatives A polymer conjugate consisting essentially of: from 90 to 99.9 mol % of units represented by the formula ##STR1## from 0.1 to 5 mol % of units represented by the formula ##STR2## wherein one of R1 and R2 is a copolymer resi... | 11/08/1994 |
| 5362740 | Dihydrobenzofuran carboxamides and process for their preparation A compound of formula (I) ##STR1## wherein R' is hydrogen or methyl, m is zero or 1 and the symbol means that the azabicyclic rings may be in the or the ଲ orientation, and the pharmaceutically acceptable salts thereof, are useful ... | 11/08/1994 |
| 5356888 | 1,1-dioxo-cephem-4-carbothiolic acid derivatives There are provided compounds I ##STR1## wherein A is a hydrogen atom or an organic group, R1 is hydrogen or halogen atom or an organic group, R2 is hydrogen or halogen atom, C1 -C4 alkyl or acyloxy group, R... | 10/18/1994 |
| 5304641 | Process for the synthesis of exomethylenecephams The present invention relates to a process for the preparation of exomethylene cephams, which are useful intermediates in the production of many useful ଲ-lactam antibiotics. More particularly there is provided a process for preparing a compound of f... | 04/19/1994 |
| 5302588 | Crystalline (5R,6S)-2-carbamoyloxymethyl-6-[(1R)-hydroxyethyl]-2-penem-carboxylic acid and its pharmaceutical formulation A crystalline form of (5R,6S)-2-carbamoyloxymethyl-6-[(1R)-hydroxyethyl]-2-penem-3-carboxylic acid incorporates two molecules of water per molecule of the acid and is useful as an antibacterial agent.... | 04/12/1994 |
| 5288855 | Extracellular form of the human fibroblast growth factor receptor The present invention provides a polypeptide which is capable of binding specifically human basic fibroblast growth factor and human acidic fibroblast growth factor, a DNA sequence which encodes the polypeptide of the invention and a vector which incorpor... | 02/22/1994 |
