Did You Know...
...that when IBM conducted a market study of Chester Carlson's invention in 1959, the company concluded that it would take only 5000 units of his new product to saturate the market? IBM therefore declined to be part of the new product introduction. Too bad for IBM. Carlson's invention was the xerography process, and his new product was the beginning of the Xerox Corporation. It is estimated that every day, worldwide, 3,000,000,000 copies are made!!
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| Number | Title | Issue Date |
| 8147860 | Porous calcium phosphate bone material Porous calcium phosphate implant compositions that approximate the chemical composition of natural bone mineral are provided. In addition to calcium phosphate, the compositions include an effervescent agent to promote the formation of interconnected pores and a cohe... | 04/03/2012 |
| 8003133 | Calcium phosphate delivery vehicles for osteoinductive proteins A composition for delivery of osteogenic proteins is disclosed. The composition comprises an osteogenic protein, a calcium phosphate material as a carrier, and an effective amount of an effervescent agent. Methods of making the compositions and methods of using the ... | 08/23/2011 |
| 7771755 | Injectable calcium phosphate solid rods and pastes for delivery of osteogenic proteins Osteogenic proteins are delivered via an injectable solid rod or hardenable paste. The formulation comprises a calcium phosphate material, an osteogenic protein, and optional additives and active ingredients such as a bone resorption inhibitor. Methods of making inj... | 08/10/2010 |
| 7622139 | Calcium phosphate delivery vehicles for osteoinductive proteins A composition for delivery of osteogenic proteins is disclosed. The composition comprises an osteogenic protein, a calcium phosphate material as a carrier, and an effective amount of an effervescent agent. Methods of making the compositions and methods of using the ... | 11/24/2009 |
| 7517539 | Method of preparing a poorly crystalline calcium phosphate and methods of its use The present invention provides a novel process for producing a calcium phosphate cement or filler which hardens in a temperature dependent fashion in association with an endothermic reaction. In the reaction a limited amount of water is mixed with dry calcium phosph... | 04/14/2009 |
| 7413753 | Calcium phosphate delivery vehicles for osteoinductive proteins A composition for delivery of osteogenic proteins is disclosed. The composition comprises an osteogenic protein, a calcium phosphate material as a carrier, and an effective amount of an effervescent agent. Methods of making the compositions and methods of using the ... | 08/19/2008 |
| 7318841 | Synthesis of calcium phosphates by mechano-chemical process A low crystallinity calcium phosphate powder is prepared by mechanically grinding a calcium phosphate solid under grinding forces local heating sufficient to mechanically alloy the calcium phosphate solid and reduce the crystalline domains of the calcium phosphate s... | 01/15/2008 |
| 7150879 | Neutral self-setting calcium phosphate paste The present invention provides a novel process for producing a calcium phosphate cement or filler which hardens in a temperature dependent fashion in association with an endothermic reaction. In the reaction a limited amount of water is mixed with dry calcium phosph... | 12/19/2006 |
| 6972130 | Bioceramic compositions The present invention provides a synthetic, poorly crystalline apatite (PCA) calcium phosphate containing a biologically active agent and/or cells (preferably tissue-forming or tissue-degrading cells). The compositions provided by the present invention are useful fo... | 12/06/2005 |
| 6953594 | Method of preparing a poorly crystalline calcium phosphate and methods of its use The present invention provides a novel process for producing a calcium phosphate cement or filler which hardens in a temperature dependent fashion in association with an endothermic reaction. In the reaction a limited amount of water is mixed with dry calcium phosph... | 10/11/2005 |
| 6840961 | Machinable preformed calcium phosphate bone substitute material implants The present invention provides machinable calcium phosphate bone substitute material implants having mechanical properties comparable to those of natural bone. The implants include intimately mixed solid precursor materials that react under physiological conditions ... | 01/11/2005 |
| 6599516 | Malleable implant containing solid element that resorbs or fractures to provide access channels A malleable implant for implantation into living tissue is prepared having access means for cells into the interior of the implant. The implant is capable of being deformed under pressure required to insert the implant into an implant site. The access mea... | 07/29/2003 |
| 6582470 | Surface modification of medical implants A method of obtaining a porous titanium surface suitable for medical implants is provided. The titanium surface is exposed to a plasma comprising a reactive plasma gas, the reactive plasma gas comprising an active etching species and a sputtering gas. The... | 06/24/2003 |
| 6544290 | Cell seeding of ceramic compositions The present invention provides a synthetic, poorly-crystalline apatitic (PCA) calcium phosphate material seeded with cells. Preferably, the cells are tissue-forming or tissue-degrading cells. The compositions provided by the present invention are useful f... | 04/08/2003 |
| 6541037 | Delivery vehicle The present invention provides delivery vehicles comprising a synthetic, poorly crystalline apatite (PCA) calcium phosphate and a biologically active agent. The PCA calcium phosphate offers many advantages over known delivery materials and is particularly... | 04/01/2003 |
| 6464889 | Surface modification of medical implants An irregularly etched metallic medical implant device is provided having random non-uniform relief patterns on the surface ranging from about 0.3 μm to less than about 20 μm in depth. The random, irregular surface as defined by the etch micromorphology ... | 10/15/2002 |
| 6331312 | Bioresorbable ceramic composites A composite material is provided including a strongly bioresorbable, poorly crystalline apatitic calcium phosphate composite and a supplementary material. The poorly crystalline apatitic calcium phosphate is characterized in that, when placed in an intram... | 12/18/2001 |
| 6287341 | Orthopedic and dental ceramic implants A method for treating a bone defect is provided by identifying a bone site suitable for receiving an implant; and introducing a strongly resorbable, poorly crystalline apatitic calcium phosphate at the implant site, whereby bone is formed at the implant s... | 09/11/2001 |
| 6277151 | Cartilage growth from cell seeded ceramic compositions The present invention provides a synthetic, poorly-crystalline apatitic (PCA) calcium phosphate material seeded with cells. Preferably, the cells are tissue-forming or tissue-degrading cells. The compositions provided by the present invention are useful f... | 08/21/2001 |
| 6214368 | Bone substitution material and a method of its manufacture The present invention provides a novel process for converting a standard inert amorphous calcium phosphate precipitate into highly reactive amorphous solids. The amorphous solids can be used to react with other calcium phosphate solids to form a poorly-cr... | 04/10/2001 |
| 6139578 | Preparation of cell seeded ceramic compositions The present invention provides a synthetic, poorly-crystalline apatitic (PCA) calcium phosphate material seeded with cells. Preferably, the cells are tissue-forming or tissue-degrading cells. The compositions provided by the present invention are useful f... | 10/31/2000 |
| 6132463 | Cell seeding of ceramic compositions The present invention provides a synthetic, poorly-crystalline apatitic (PCA) calcium phosphate material seeded with cells. Preferably, the cells are tissue-forming or tissue-degrading cells. The compositions provided by the present invention are useful f... | 10/17/2000 |
| 6117456 | Methods and products related to the physical conversion of reactive amorphous calcium phosphate The present invention provides a novel process for producing a calcium phosphate cement or filler which hardens in a temperature dependent fashion in association with an endothermic reaction. In the reaction a limited amount of water is mixed with dry cal... | 09/12/2000 |
| 6033582 | Surface modification of medical implants An irregularly etched medical implant device is provided having random non-uniform relief patterns on the surface ranging from about 0.3 μm to less than about 20 μm in depth. The random, irregular surface as defined by the etch micromorphology and respe... | 03/07/2000 |
| 6027742 | Bioresorbable ceramic composites A composite material is provided including a strongly bioresorbable, poorly crystalline apatitic calcium phosphate composite and a supplementary material. The poorly crystalline apatitic calcium phosphate is characterized in that, when placed in an intram... | 02/22/2000 |
| 5980482 | Mixing device A mixer for the mixing of components, comprising a continuous inner surface that is non-retaining to the components, wherein a first portion of the inner surface opposably contacts a second portion of the inner surface during mixing, and a means for suppl... | 11/09/1999 |
| 5958504 | Hydroxyapatite coatings and a method of their manufacture A process for the production of a hydroxyapatite coated article includes contacting a coating comprising hydroxyapatite with a recrystallization medium, pressurizing the recrystallization medium, heating the coated article under conditions of reduced oxyg... | 09/28/1999 |
| 5843289 | Surface modification of medical implants A method of obtaining a porous titanium surface suitable for medical implants is provided. The titanium surface is exposed to a plasma comprising a reactive plasma gas, the reactive plasma gas comprising an active etching species and a sputtering gas. The... | 12/01/1998 |
| 5795330 | Mixing device A mixer for the mixing of a first and a second component, comprising a flexible pouch which contains said first component and which has an inner surface that is non-retaining to the components; means for supplying the second component to the chamber for m... | 08/18/1998 |
| 5783217 | Low temperature calcium phosphate apatite and a method of its manufacture A method of preparing a low crystallinity calcium phosphate apatite is described in which a low crystallinity calcium phosphate is precipitated from an aqueous solution comprising calcium and phosphate ions; collected from the solution; and dehydrated in ... | 07/21/1998 |
| 5763092 | Hydroxyapatite coatings and a method of their manufacture A process for the production of a hydroxyapatite coated article includes contacting a coating comprising hydroxyapatite with a recrystallization medium, pressurizing the recrystallization medium, heating the coated article under conditions of reduced oxyg... | 06/09/1998 |
| 5683461 | Synthesis of reactive amorphous calcium phosphates The present invention provides a novel process for converting a standard inert amorphous calcium phosphate precipitate into highly reactive amorphous solids. The amorphous solids can be used to react with other calcium phosphate solids to form a poorly-cr... | 11/04/1997 |
| 5676976 | Synthesis of reactive amorphous calcium phosphates The present invention provides a novel process for converting a standard inert amorphous calcium phosphate precipitate into highly reactive amorphous solids. The amorphous solids can be used to react with other calcium phosphate solids to form a poorly-cr... | 10/14/1997 |
| 5650176 | Synthesis of reactive amorphous calcium phosphates The present invention provides a novel process for converting a standard inert amorphous calcium phosphate precipitate into highly reactive amorphous solids. The amorphous solids can be used to react with other calcium phosphate solids to form a poorly-cr... | 07/22/1997 |
| 5543019 | Method of coating medical devices and device coated thereby The invention features a method of depositing a coating on a medical device. The method includes: a) placing the medical device in an evacuated chamber, b) introducing a noble gas into the chamber, c) providing at least one target in the chamber, spaced f... | 08/06/1996 |
| 5306305 | Methods of coating implants with bony structure Implants associated with bone are coated with natural bony tissue by incubating the implant with osteoblasts under conditions where the osteoblasts grow and lay down a bony coating. Different methods are provided for maintaining the osteoblasts in contact... | 04/26/1994 |
| 5258044 | Electrophoretic deposition of calcium phosphate material on implants The invention features a method for preparing coated implants. The method includes the steps of: (a) providing a gel of amorphous calcium phosphate having a calcium to phosphorous ratio of 0.5 to 1.6; (b) dispersing the gel of amorphous calcium phosphate ... | 11/02/1993 |
