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| Number | Title | Issue Date |
| 8080542 | S1P receptor modulating compounds and use thereof The present invention relates to amides that have activity as SIP receptor modulating agents and the use of such compounds to treat diseases associated with inappropriate S1P receptor activity. The compounds may be used as immunomodulators, e.g., for treating or pre... | 12/20/2011 |
| 7855193 | S1P receptor modulating compounds and use thereof The present invention relates to compounds of the general formula (I) that have activity as S1P receptor modulating agents and the use of such compounds to treat diseases associated with inappropriate S1P receptor activity. The compounds may be used as immunomodulat... | 12/21/2010 |
| 7412279 | Systems and methods for targeted magnetic resonance imaging of the vascular system This invention relates to MRI-based methods and systems useful for diagnosing and clinically assessing the presence, location, and size of cardiovascular disease-associated stationary targets, e.g., thrombi and atherosclerotic lesions, within the vascular system. Me... | 08/12/2008 |
| 7238341 | Peptide-based multimeric targeted contrast agents Peptides and peptide-targeted multimeric contrast agents are described, as well as methods of making and using the contrast agents. ... | 07/03/2007 |
| 7229606 | Diagnostic imaging contrast agents with extended blood retention The present invention relates to contrast agents for diagnostic imaging with prolonged blood retention. In particular, this invention relates to novel compounds that are characterized by an image enhancing moiety (IEM); a protein plasma binding moiety (PPBM); and a ... | 06/12/2007 |
| 7186797 | Polypeptide conjugates with extended circulating half-lives The present invention relates to compounds and methods for synthesizing compounds wherein the compounds exhibit extended circulating half-life in the blood. The increase in circulating half-life is achieved by conjugating polypeptides to binding groups that exhibit ... | 03/06/2007 |
| 7175829 | Contrast-enhanced diagnostic imaging method for monitoring interventional therapies The present invention relates to a contrast-enhanced diagnostic imaging method for monitoring the efficacy of interventional therapies. The contrast agents useful in this method comprise an image-enhancing moiety (IEM) and a state-dependent tissue binding moiety (SD... | 02/13/2007 |
