Did You Know...
...that to encourage use of his new invention, the shopping cart, market owner Sylvan Goldman hired fake shoppers to push the carts around his store in Oklahoma City? Seems his customers were reluctant to give up their hand-carried baskets.
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| Number | Title | Issue Date |
| 8163488 | Methods and nucleic acids for analysis of colon proliferative disorders The invention provides methods, nucleic acids and kits for detecting colon cell proliferative disorders. The invention discloses genomic sequences the methylation patterns of which have utility for the improved detection of and differentiation between said class of ... | 04/24/2012 |
| 8129107 | Bisulfite conversion of DNA The present invention relates to an improved method for the bisulfite conversion of DNA. In certain time-temperature ranges the efficacy of the bisulfite conversion is clearly improved. By combination with denaturating solvents, new reaction conditions and new purif... | 03/06/2012 |
| 8101359 | Method for determining risk of relapse of breast cancer following tamoxifen adjuvant therapy The present invention relates to modified and genomic sequences, to oligonucleotides and/or PNA-oligomers for detecting the cytosine methylation state of genomic DNA, as well as to a method for predicting the response of a subject with a cell proliferative disorder ... | 01/24/2012 |
| 8029996 | Method for the determination of cystosine methylation in CpG islands A method for the detection of cytosine methylation in DNA samples is described. First, DNA is extracted from a sample and bound to a surface. In the second step, a genomic DNA sample is preferably treated with a bisulfite (=disulfite, hydrogen sulfite), such that al... | 10/04/2011 |
| 7972784 | Method for quantification of methylated DNA The present invention relates to a method for the quantification of methylated cytosines in DNA. In the first step of the invention unmethylated cytosines in the DNA to be analysed are chemically converted into uracil while 5-methylcytosines remain unchanged. In a s... | 07/05/2011 |
| 7968295 | Bisulfite conversion of DNA The present invention provides an improved method for the bisulfite conversion of DNA, and facilitates the analysis of cytosine methylation of genomic DNA. Novel combinations of denaturing solvents, new reaction conditions and new purification methods provide surpri... | 06/28/2011 |
| 7951563 | Methods and nucleic acids for analysis of cellular proliferative disorders Aspects of the invention provide methods, nucleic acids and kits for detecting, or for detecting and distinguishing between or among liver cell proliferative disorders or for detecting, or for detecting and distinguishing between or among colorectal cell proliferati... | 05/31/2011 |
| 7943308 | Methods and nucleic acids for the detection of metastasis of colon cell proliferative disorders The invention provides methods, nucleic acids and kits for detecting metastasis of colon cell proliferative disorders. The invention discloses genomic sequences the methylation patterns of which have utility for the improved detection of metastasis of colon cell pro... | 05/17/2011 |
| 7932027 | Method for determining the methylation pattern of a polynucleic acid Particular aspects relate to a method for determining the methylation pattern of a polynucleic acid, comprising: a) preparing a solution comprising a mixture of fragments of the polynucleic acid; b) coupling the fragments with a substance being detectable with a det... | 04/26/2011 |
| 7867701 | Method for the simultaneous amplification of multiple sequences in a PCR reaction and marking thereof A method is described for the amplification of nucleic acids, in which the segments to be amplified are first hybridized with at least two primer oligonucleotides that have two domains, wherein the sequence-specific domain found at the 3-end hybridizes to the segmen... | 01/11/2011 |
| 7824852 | Method for detecting cytosine methylation in DNA samples Described is a method for detecting 5-methylcytosine in genomic DNA samples. First, a genomic DNA from a DNA sample is chemically converted with a reagent, 5-methylcytosine and cytosine reacting differently, and the pretreated DNA is subsequently amplified using a p... | 11/02/2010 |
| 7756643 | Method for determining the biological effect and/or activity of at least one drug, chemical substances and/or pharmaceutical composition based on their effect on the methylation status of DNA This invention is related to methods, systems and computer program products for determining the biological effect and/or activity of drugs, chemical substances and/or pharmaceutical compositions using their effect on DNA-methylation as a marker for their biological ... | 07/13/2010 |
| 7749702 | Methods and nucleic acids for the analyses of cellular proliferative disorders The invention provides methods, nucleic acids and kits for detecting, or for detecting and distinguishing between or among liver cell proliferative disorders or for detecting, or for detecting and distinguishing between or among colorectal cell proliferative disorde... | 07/06/2010 |
| 7723026 | Method for investigating cytosine methylation in DNA by means of DNA repair enzymes The following invention concerns a method for investigating cytosine methylation by means of DNA repair enzymes. Here, the DNA is first converted so that unmethylated cytosines are converted to uracil, while 5-methylcytosine remains unchanged. Then the DNA is hybrid... | 05/25/2010 |
| 7700282 | Method for the carry-over protection in DNA amplification systems targeting methylation analysis achieved by a modified pre-treatment of nucleic acids Particular aspects provide methods for specific amplification of template DNA in the presence of potentially contaminating PCR products from previous amplification experiments. Particular embodiments comprise, in a first step, contacting DNA with a bisulfite solutio... | 04/20/2010 |
| 7670777 | Method for detecting DNA methylation using labelled S-adenosylmethionine analogs The invention relates to a method for detecting the methylation status in DNA samples. According to the invention, a DNA methyl transferase and a labeled S-adenosylmethionine derivative allow a detectable label to be covalently bonded to the DNA, in accordance with ... | 03/02/2010 |
| 7534570 | Method for the detection of cytosine methylations in immobilized DNA samples A method is described for the analysis of cytosine methylation patterns in genomic DNA samples. In the first method step, the genomic DNA is isolated from cells or other accompanying materials and bound essentially irreversibly to a surface. Then the DNA bound to th... | 05/19/2009 |
| 7524629 | Method for detecting cytosine methylation in DNA samples Described is a method for detecting 5-methylcytosine in genomic DNA samples. First, a genomic DNA from a DNA sample is chemically converted with a reagent, 5-methylcytosine and cytosine reacting differently, and the pretreated DNA is subsequently amplified using a p... | 04/28/2009 |
| 7407749 | Method for the detection of cytosine methylations in immobilized DNA samples A method is described for the analysis of cytosine methylation patterns in genomic DNA samples. In the first method step, the genomic DNA is isolated from cells or other accompanying materials and bound essentially irreversibly to a surface. Then the DNA bound to th... | 08/05/2008 |
| 7405040 | Ligase/polymerase method for detecting cytosine methylation in DNA samples Described is a method for detecting 5-methylcytosine in genomic DNA samples. First, a genomic DNA from a DNA sample is chemically converted with a reagent, 5-methylcytosine and cytosine reacting differently, and the pretreated DNA is subsequently amplified using a p... | 07/29/2008 |
| 7381808 | Method and nucleic acids for the differentiation of prostate tumors The present invention relates to chemically modified genomic sequences, to oligonucleotides and/or PNA-oligomers for detecting the cytosine methylation state of genomic DNA, as well as to a method for ascertaining genetic and/or epigenetic parameters of genes for us... | 06/03/2008 |
| 7285394 | Discovery and diagnostic methods using 5-methylcytosine DNA glycosylase The present invention provides methods for identification of methylated, and/or potentially methylatable CpG dinucleotides in genomic DNA sequences, and methods for isolating genomic DNA sequences comprising methylated CpG dinucleotide sequences. The present inventi... | 10/23/2007 |
| 7229759 | Highly sensitive method for the detection of cytosine methylation patterns The present invention concerns a method for the detection of cytosine methylation in DNA samples, wherein the following steps are conducted: (a) a genomic DNA sample, which comprises the DNA to be investigated and background DNA, is chemically treated in such a way ... | 06/12/2007 |
| 7195870 | Diagnosis of diseases associated with gene regulation Chemically modified genomic sequences of genes associated with gene regulation, to oligonucleotides and/or PNA-oligomers for detecting the cytosine methylation state of genes associated with gene regulation which are directed against the sequence are disclosed. In a... | 03/27/2007 |
| 7179594 | Method for distinguishing 5-position methylation changes of cytosine bases and cytosine-to-thymine mutations and for detecting single nucleotide polymorphisms (SNPs) or point mutations in genomic DNA A method is described for distinguishing 5-position methylation changes of cytosine bases and cytosine-to-thymine mutations and for the detection of single nucleotide polymorphisms (SNPs) or point mutations in genomic DNA, in which: | 02/20/2007 |
| 7153671 | Method for relative quantification of methylation of cytosine bases in DNA samples A method is described for the relative quantification of the methylation of cytosine bases in DNA samples, wherein the following method steps are conducted: a) a genomic DNA sample is chemically converted with a reagent, wherein 5-... | 12/26/2006 |
| 7118868 | Method for detecting cytosine methylations A method is described for the detection of 5-methylcytosine in genomic DNA samples. First, a genomic DNA from a DNA sample is chemically converted with a reagent, whereby 5-methylcytosine and cytosine react differently. Then the pretreated DNA is amplified with the ... | 10/10/2006 |
| 7112404 | Process for high throughput DNA methylation analysis There is disclosed an improved high-throughput and quantitative process for determining methylation patterns in genomic DNA samples based on amplifying modified nucleic acid, and detecting methylated nucleic acid based on amplification-dependent displacement of spec... | 09/26/2006 |
| 7008770 | Method for the controlled implementation of complex PCR amplifications A method is described for controllably conducting complex PCR amplifications, wherein at least the following steps are conducted: a) PCR amplification with at least 50 primers of a first type (type 1) of different sequence, which a... | 03/07/2006 |
| 6977146 | Method of identifying cytosine methylation patterns in genomic DNA samples The invention concerns a method for the identification of cytosine methylation patterns in genomic DNA samples, wherein a) a genomic DNA sample is chemically treated such that cytosine and 5-methylcytosine react differently and a d... | 12/20/2005 |
| 6960436 | Quantitative methylation detection in DNA samples Described is a method for methylation detection in a DNA sample. An isolated genomic DNA sample is treated in a manner capable of distinguishing methylated from unmethylated cytosine bases. The pretreated DNA is amplified using at least one oligonucleotide primer, a... | 11/01/2005 |
| 6936419 | Oligomer array with PNA and/or DNA oligomers on a surface An oligomer array with PNA (peptide nucleic acid) and/or DNA oligomers on a surface is described, which comprises oligomers of between 6 and 20 monomers or nucleobases each, whereby each of these contains at least one sequence of the general formula DDCGDD or of the... | 08/30/2005 |
| 6888131 | Sample support for mass spectrometers A sample holder is described, which is loaded with metal or glass slides. This arrangement serves for the analysis of DNA arrays in the MALDI-TOF mass spectrometer. ... | 05/03/2005 |
| 6819843 | Device and method for photolithographically irradiating biological substances A device and a method for the photolithographic exposure of biological substances is described, which comprises at least one light source, a bundle of optical fibers and a control unit, whereby each of the optical fibers can be controlled by light independently from... | 11/16/2004 |
