Celebrity Inventors
Walt Disney was no Mickey Mouse inventor. He devised a serious animation camera which he patented. With the device, his company created "Snow White".
PatentStorm News
Make the Most of Our Site
See this month's Top Inventors and Most Cited Patents.
Stay on top of the latest innovations by subscribing to an RSS feed.
Registered users: Manage your profile.
| Number | Title | Issue Date |
| 7150872 | Polyalkylene oxide-modified single chain polypeptides The present invention relates to the chemical modification of single chain polypeptides by means of covalent attachment of strands of poly(ethylene glycol) PEG and similar poly(alkylene oxides) to single chain polypeptide binding molecules that have the three dimens... | 12/19/2006 |
| 6936597 | Prodrugs of anticancer agents employing substituted aromatic acids Polymeric prodrugs of the formula: wherein B is selected from the group consisting of OH, leaving groups, residues of amine-containing moieties and a residues of hydroxyl-containing m... | 08/30/2005 |
| 6872393 | Polyalkylene oxide-modified single chain polypeptides The present invention relates to the chemical modification of single chain polypeptides by means of covalent attachment of strands of poly(ethylene glycol) PEG and similar poly(alkylene oxides) to single chain polypeptide binding molecules that have the three dimens... | 03/29/2005 |
| 6824766 | Biodegradable high molecular weight polymeric linkers and their conjugates The present invention includes polymeric transport systems corresponding to the formula: wherein: R31 is a linear or branched polymer residue; Y10 and Y11 | 11/30/2004 |
| 6824782 | Polyalkylene oxide-modified single chain polypeptides The present invention relates to the chemical modification of single chain polypeptides by means of covalent attachment of strands of poly(ethylene glycol) PEG and similar poly(alkylene oxides) to single chain polypeptide binding molecules that have the three dimens... | 11/30/2004 |
| 6756037 | Polymer conjugates of biologically active agents and extension moieties for facilitating conjugation of biologically active agents to polymeric terminal groups The present invention is directed to polymer conjugates of biologically active agents and methods of preparing the same. In preferred aspects of the invention, the conjugates are of the formula wherein G is a linear or b... | 06/29/2004 |
| 6515110 | Multivalent antigen-binding proteins Compositions of, genetic constructions coding for, and methods for producing multivalent antigen-binding proteins are described and claimed. The methods include purification of compositions containing both monomeric and multivalent forms of single polypep... | 02/04/2003 |
| 6395266 | Terminally-branched polymeric linkers and polymeric conjugates containing the same The present invention is directed to polymeric-prodrug transport forms of the formula: ##STR1## wherein: ##STR2## E1-4 are independently selected from the group consisting of hydrogen, C1-6 alkyls, C3-12 branched alky... | 05/28/2002 |
| 6376470 | Polymer conjugates of ara-C and ara-C derivatives The present invention is directed to polymeric-prodrug transport forms of the formula: ##STR1## wherein: G is a linear or branched, terminally functionalized polymer residue; Y1 is O, S, or NR1 ; M is X or Q; wherein X is an electron with... | 04/23/2002 |
| 6333396 | Method for targeted delivery of nucleic acids The present invention is directed to a method of in vivo and ex vivo gene delivery, for a variety of cells. More specifically, it relates to a novel carrier system and method for targeted delivery of nucleic acids to mammalian cells. More specifically, th... | 12/25/2001 |
| 6323322 | Single-chain antigen-binding proteins capable of glycosylation, production and uses thereof The present invention relates to single-chain antigen-binding molecules capable of glycosylation. Compositions of, genetic constructions coding for, and methods for producing monovalent and multivalent single-chain antigen-binding molecules capable of gly... | 11/27/2001 |
| 6303569 | Trialkyl-lock-facilitated polymeric prodrugs of amino-containing bioactive agents The present invention is directed to double prodrugs containing polymeric-based transport forms. These polymeric compounds comprise the formula: ##STR1## wherein: B is H, OH, OSiR13, a residue of an amine-containing target moiety or a resi... | 10/16/2001 |
| 6251382 | Biodegradable high molecular weight polymeric linkers and their conjugates Polymeric compounds of the formula: (D)n --M--(R1)m (I) wherein (m) and (n) independently selected positive integers, preferably from about 1 to about 6 each; D is a residue of a biologically active moiety; M is a multifunctional l... | 06/26/2001 |
| 6214330 | Coumarin and related aromatic-based polymeric prodrugs The present invention is directed to double prodrugs containing polymeric-based transport forms. These polymeric prodrugs are preferably of the formula: ##STR1## wherein: ##STR2## B is H, OH, OSiR13, a residue of an amine-containing target... | 04/10/2001 |
| 6194580 | High yield method for stereoselective acylation of tertiary alcohols The present invention is directed to methods of forming esters of tertiary alcohols. The methods include reacting a compound containing a tertiary alcohol with an acyl heteroaromatic ion-based compound of the formula: ##STR1## wherein R1 is an ... | 02/27/2001 |
| 6180095 | Polymeric prodrugs of amino- and hydroxyl-containing bioactive agents The present invention is directed to double prodrugs containing polymeric-based transport forms. These polymeric prodrugs are preferably of the formula: ##STR1## wherein: L1 is a bifunctional linking moiety; G is H or ##STR2## where B is H... | 01/30/2001 |
| 6177087 | Non-antigenic amine derived polymers and polymer conjugates Substantially non-antigenic polymers containing pI and/or pH optimum modulating moieties are disclosed. The polymers are useful as intermediates for synthesis of amine-based polymers and in the formation of activated polymers for conjugation with nucleoph... | 01/23/2001 |
| 6153655 | Terminally-branched polymeric linkers and polymeric conjugates containing the same The present invention is directed to polymeric- prodrug transport forms of the formula: ##STR1## wherein: B is a leaving group, OH, a residue of a hydroxyl-containing moiety or ##STR2## wherein B1 is a leaving group, OH or a resi... | 11/28/2000 |
| 6132713 | Arginine deiminase derived from mycoplasma arthritidis and polymer conjugates containing the same A purified arginine deiminase (ADI) obtained from Mycoplasma arthritidis having the amino acid sequence of SEQ ID NO:2 as well as an isolated nucleic acid molecule containing a nucleotide sequence encoding the amino acid sequence set forth in SEQ ID NO:1 ... | 10/17/2000 |
| 6127355 | High molecular weight polymer-based prodrugs The present invention is directed compositions of the formula: ##STR1## wherein: D is a residue of a biologically active moiety; X is an electron withdrawing group; Y and Y' are independently O or S; (n) is zero (0) or a positive integer, preferably from 1 to ... | 10/03/2000 |
| 6121424 | Multivalent antigen-binding proteins Compositions of, genetic constructions coding for, and methods for producing multivalent antigen-binding proteins are described and claimed. The methods include purification of compositions containing both monomeric and multivalent forms of single polypep... | 09/19/2000 |
| 6113906 | Water-soluble non-antigenic polymer linkable to biologically active material Branched, substantially non-antigenic polymers are disclosed. Conjugates prepared with the polymers and biologically active molecules such as proteins and peptides demonstrate extended circulating life in vivo. Substantially fewer sites on the biologicall... | 09/05/2000 |
| 6111107 | High yield method for stereoselective acylation of tertiary alcohols The present invention is directed to methods of forming esters of tertiary alcohols. The methods include reacting a compound containing a tertiary alcohol with an acyl heteroaromatic ion-based compound of the formula: ##STR1## wherein R1 i... | 08/29/2000 |
| 6103889 | Nucleic acid molecules encoding single-chain antigen-binding proteins Compositions of, genetic constructions coding for, and methods for producing multivalent antigen-binding proteins are described and claimed. The methods include purification of compositions containing both monomeric and multivalent forms of single polypep... | 08/15/2000 |
| 6042822 | Interferon polymer conjugates Compositions containing alpha interferon conjugated to a substantially non-antigenic polymer are disclosed in which at least about 30% of the conjugates include covalent attachment of the alpha interferon to the substantially non-antigenic polymer at a hi... | 03/28/2000 |
| 6027725 | Multivalent antigen-binding proteins Compositions of, genetic constructions coding for, and methods for producing multivalent antigen-binding proteins are described and claimed. The methods include purification of compositions containing both monomeric and multivalent forms of single polypep... | 02/22/2000 |
| 6025165 | Methods for producing multivalent antigen-binding proteins Compositions of, genetic constructions coding for, and methods for producing multivalent antigen-binding proteins are described and claimed. The methods include purification of compositions containing both monomeric and multivalent forms of single polypep... | 02/15/2000 |
| 6013283 | Alkyl or olefinic endcapped polyalkylene oxide solubilizer A method for rendering water-insoluble materials water-soluble is provided. The method is useful for solubilizing substantially water-insoluble bioactive materials such as drugs. This is accomplished by forming a non-covalently bonded complex between the ... | 01/11/2000 |
| 6011042 | Acyl polymeric derivatives of aromatic hydroxyl-containing compounds The present invention is directed to conjugates such as polymeric prodrugs of aromatic, hydroxyl-containing compounds and methods of making and using the same. These polymeric prodrugs are preferably esters of hydroxyl-containing aromatic compounds and ar... | 01/04/2000 |
| 5990275 | Linker and linked fusion polypeptides The invention is directed to a novel peptide linker useful for connecting polypeptide constituents into a novel linked fusion polypeptide. The peptide linker of the invention provides greater stability and is less susceptible to aggregation than previousl... | 11/23/1999 |
| 5985263 | Substantially pure histidine-linked protein polymer conjugates Substantially pure histidine-linked protein-polymer conjugates and processes for their preparation are disclosed. The processes include contacting a protein with an activated polymer under conditions sufficient to facilitate covalent attachment of at leas... | 11/16/1999 |
| 5981709 | -interferon-polymer-conjugates having enhanced biological activity and methods of preparing the same A process for preparing -interferon-polymer conjugates having high levels of retained interferon activity and relatively long circulating lives in vivo is disclosed. The process includes forming substantially non-antigenic -interferon-polyme... | 11/09/1999 |
| 5965566 | High molecular weight polymer-based prodrugs The present invention is directed compositions of the formula: ##STR1## wherein: D is a residue of biologically active moiety; X is an electron withdrawing group; Y and Y' are independently O or S; (n) is zero (0) or a positive integer, preferably from 1 to ab... | 10/12/1999 |
| 5965119 | Trialkyl-lock-facilitated polymeric prodrugs of amino-containing bioactive agents The present invention is directed to double prodrugs containing polymeric-based transport forms. These polymeric prodrugs are preferably of the formula: ##STR1## wherein: B is a leaving group or a residue of an amine-containing target moiety; G ... | 10/12/1999 |
| 5951974 | Interferon polymer conjugates Compositions containing alpha interferon conjugated to a substantially non-antigenic polymer are disclosed in which at least about 30% of the conjugates include covalent attachment of the alpha interferon to the substantially non-antigenic polymer at a hi... | 09/14/1999 |
| 5919455 | Non-antigenic branched polymer conjugates Branched, substantially non-antigenic polymers are disclosed. Conjugates prepared with the polymers and biologically active molecules such as proteins and peptides demonstrate extended circulating life in vivo. Substantially fewer sites on the biologicall... | 07/06/1999 |
| 5916793 | Arginine deiminase derived from Mycoplasma arthritidis and polymer conjugates containing the same A purified arginine deiminase (ADI) obtained from Mycoplasma arthritidis having the amino acid sequence of SEQ ID NO:2 as well as an isolated nucleic acid molecule containing a nucleotide sequence encoding the amino acid sequence set forth in SEQ ID NO:1 ... | 06/29/1999 |
| 5917021 | Stabilized monomeric protein compositions The present invention relates to a stabilized protein composition comprising a monomeric protein and a storage-stabilizing amount of sucrose, histidine or glycine, which is sufficient to inhibit aggregation of the protein molecules during freeze/thaw cycl... | 06/29/1999 |
| 5902588 | Non-antigenic amine derived polymers and polymer conjugates Substantially non-antigenic polymers containing pI and/or pH optimum modulating moieties are disclosed. The polymers are useful as intermediates for synthesis of amine-based polymers and in the formation of activated polymers for conjugation with nucleoph... | 05/11/1999 |
| 5900402 | Method of reducing side effects associated with administration of oxygen-carrying proteins A method of reducing side-effects associated with administering oxygen-carrying proteins to mammals is disclosed. The method includes: a) reacting an oxygen-carrying protein with a substantially non-antigenic polymer to form a oxygen-carrying protein-substanti... | 05/04/1999 |
