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| Number | Title | Issue Date |
| 5082830 | End labeled nucleotide probe An oligo- or polynucleotide having at least one biotin directly or indirectly attached to each of the 5' and 3' end nucleotides thereof and a nucleic acid hybridization assay system for use therewith. The biotins are optionally attached through linkage gr... | 01/21/1992 |
| 5024933 | Method and kit for sample adherence to test substrate Disclosed is an improvement relating to adhesion of samples onto a surface for nucleic acid hybridization assay to detect a target polynucleotide. In one aspect, the invention provides a method of adhering a tissue, cell or other target polynucleotide-con... | 06/18/1991 |
| 5013831 | Detectable molecules, method of preparation and use A detectable molecule of the formula A3 --(--X--R1 --E--Detb)m where A3 is A2 or a polymer, where A3 has at least one modifiable reactive group selected from the group consisting of amino,... | 05/07/1991 |
| 5002885 | Detectable molecules, method preparation and use A detectable molecule of the formula A3 --(--X--R1 --E--Detb)m where A3 is A2 or a polymer, where A3 has at least one modifiable reactive group selected from the group consisting of amino,... | 03/26/1991 |
| 4994373 | Method and structures employing chemically-labelled polynucleotide probes Polynucleotide sequences in a sample of biological or nonbiological material are detected by a method involving fixing of the sequences on a solid support and forming an entity between the fixed sequences and chemically-labeled polynucleotide or oligonucl... | 02/19/1991 |
| 4987065 | In vivo labelling of polynucleotide sequences In vivo labelled polynucleotides, processes for in vivo labelling of polynucleotides, and detection methods and kits characterized by those labelled polynucleotides. The in vivo on biologically-labelled polynucleotides of this invention are useful in the ... | 01/22/1991 |
| 4952685 | Detectable molecules, method of preparation and use A detectable molecule of the formula A3 --(--X--R1 --E--Detb)m where A3 is A2 or a polymer, where A3 has at least one modifiable reactive group selected from the group consisting of amino,... | 08/28/1990 |
| 4943523 | Detectable molecules, method of preparation and use A detectable molecule of the formula A3 --(--X--R1 --E--Detb)m where A3 is A2 or a polymer, where A3 has at least one modifiable reactive group selected from the group consisting of amino,... | 07/24/1990 |
| 4900659 | Nucleotide sequence composition and method for detection of Neisseria gonorrhoeae and method for screening for a nucleotide sequence that is specific for a genetically distinct group This invention relates to specific discrete nucleotide sequences. More precisely, this invention relates to a composition comprising discrete nucleotide sequences that are specific for Neisseria gonorrhoeae, as defined hereinbelow, i.e. the compositions o... | 02/13/1990 |
| 4894325 | Hybridization method for the detection of genetic material This invention provides methods for the detection of a target genetic material having a desired base sequence or gene. Also disclosed are methods for the detection of mutations. Also provided are components for use in such methods. The methods are based u... | 01/16/1990 |
| 4889798 | Heterologous system for the detection of chemically labeled DNA and other biological materials providing a receptor or target moiety thereon In accordance with the practices of this invention, there is provided a heterologous detection system and components useful in conjunction therewith and kits for carrying out the heterologous detection system. The heterologous detection system employs a h... | 12/26/1989 |
| 4868103 | Analyte detection by means of energy transfer A method is disclosed to detect the presence of an analyte. The method involves forming a complex comprising the analyte and a binding entity. The binding entity comprises a first partner of an energy transfer system. The complex is then contacted with a ... | 09/19/1989 |
| 4849208 | Detectable molecules, method of preparation and use A detectable molecule of the formula wherein A3 is A2 or a polymer, where A3 has at least one modifiable reactive group selected from the group consisting of amino, hydroxy, cis .OH, halides, aryl, imidazoly, carbonyl, carboxy,... | 07/18/1989 |
| 4849505 | Detectable molecules, method of preparation and use A detectable molecule of the formula where A3 is A2 or a polymer, where A3 has at least one modifiable reactive group selected from the group consisting of amino, hydroxy, cis OH, halides, aryl, imidazoyl, carbonyl, carboxy, th... | 07/18/1989 |
| 4843122 | Detectable molecules, method of preparation and use A detectable molecule of the formula where A3 is A2 or a polymer, where A3 has at least one modifiable reactive group selected from the group consisting of amino, hydroxy, cis .OH, halides, aryl, imidazoyl, carbonyl, carboxy, t... | 06/27/1989 |
| 4772548 | Radioisotopicassay using isotope transfer to chelator-target recognition molecule conjugate A method of forming a therapeutic or diagnostic agent labeled with a radioactive metal ion, which comprises: contacting an unlabeled therapeutic or diagnostic agent, consisting of a substantially non-metal chelating portion and a chelating portion capable... | 09/20/1988 |
| 4767609 | Therapeutic and diagnostic processes using isotope transfer to chelator-target recognition molecule conjugate A method of forming a therapeutic or diagnostic agent labeled with a radioactive metal ion, which comprises: contacting an unlabeled therapeutic or diagnostic agent, consisting of a substantially non-metal chelating portion and a chelating portion capable... | 08/30/1988 |
| 4755458 | Composition and method for the detection of the presence of a polynucleotide sequence of interest The present invention relates to a wide range of genetic analyses using the technique of nucleic acid hybridization. These genetic analyses include, for example, the diagnosis of infections by foreign microbes and the detection of specific genetic traits ... | 07/05/1988 |
| 4746604 | Specific binding assays utilizing a viable cell as a label A method and composition for detecting analyte moieties by means of a signalling moiety capable of aggrandizement are disclosed. The signalling moiety can be attached to or not attached to the analyte moiety/analyte-specific moiety complex. The signalling... | 05/24/1988 |
| 4707440 | Nucleic acid hybridization assay and detectable molecules useful in such assay A detectable molecule of the formula where A3 is A2 or a polymer, where A3 has at least one modifiable reactive group selected from the group consisting of amino, hydroxy, cis OH, halides, aryl, imidazoyl, carbonyl, carboxy, th... | 11/17/1987 |
| 4707352 | Method of radioactively labeling diagnostic and therapeutic agents containing a chelating group A method of forming a therapeutic or diagnostic agent labeled with a radioactive metal ion, which comprises: contacting an unlabeled therapeutic or diagnostic agent, consisting of a substantially non-metal chelating portion and a chelating portion capable... | 11/17/1987 |
