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Assignee: Entremed, Inc.


Location: Rockville, MD
No. of patents: 9

NumberTitleIssue Date
7498322Antiangiogenic agents
Compositions and methods for treating mammalian diseases or conditions characterized by undesirable angiogenesis by administering an effective amount of a compound of the formulae: wherein Ra is selected from —...
03/03/2009
7371741Estradiol derivatives and pharmaceutical compositions using same
Compositions and methods for treating mammalian disease characterized by undesirable angiogenesis by administering compounds of the general formula: wherein the variables are defined in the specification. ...
05/13/2008
7235540Methods of using 2-methoxyestradiol of high purity
2-methoxyestradiol having greater than 98% purity is obtained by synthetic or purification methods. This highly pure 2-methoxy estradiol, lacking estrogenic components, is particularly suitable for clinical use in humans. The purification methods of the invention in...
06/26/2007
7135581Antiangiogenic agents
Compositions and methods for treating mammalian disease characterized by undesirable angiogenesis by administering derivatives of 2-methoxyestradiol of the general formula: wherein the variables are defined in th...
11/14/2006
6518298Methods and compositions for inhibition of angiogenesis with EM-138
The present invention comprises a group of compounds that effectively inhibit angiogenesis. More specifically, the invention comprises the compound EM-138 and its use in the inhibition of angiogenesis and treatment of angiogenesis associate diseases, incl...
02/11/2003
6413513Compositions and methods for inhibiting endothelial cell proliferation and regulating angiogenesis using cancer markers
Compositions and methods for regulating angiogenic activity wherein the compositions comprise cancer markers including kallikreins such as prostate-specific antigen (PSA), serine protease homologs, or active fragments thereof are provided. Serine protease...
07/02/2002
6239123Use of estrogenic compounds as anti-fungal agents
The present invention provides compounds that are useful for inhibiting the proliferation of fungi. The compounds are estrogenic derivatives, such as 2ME2, or anti-estrogenic compounds. The compounds may be used for treating infections of fungi in humans ...
05/29/2001
5814666Encapsulated and non-encapsulated nitric oxide generators used as antimicrobial agents
This invention relates to compositions capable of releasing nitric oxide and therapeutic methods of use thereof for the treatment of microorganism-related disease states. The composition comprises one or more nitric oxide generators, preferably encapsulat...
09/29/1998
5720921Flow electroporation chamber and method
The present invention relates to a method and apparatus for the encapsulation of biologically-active substances in red blood cells, characterized by an optionally automated, continuous-flow, self-contained electroporation system which allows withdrawal of...
02/24/1998
 
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