Did You Know...
...that two musicians were responsible for the invention of color print film? Fascinated by photography, Leopold Godowsky and Leopold Mannes worked together to produce an easy-to-use, practical color film. They worked full time as music teachers and gave concerts while experimenting during their off hours in Mannes' kitchen. Their success earned them full-time, well-paying jobs at Kodak and their efforts resulted in Kodachrome film, which was introduced in 1935.
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| Number | Title | Issue Date |
| 8168583 | 2-fluoronucleosides 2′-Fluoro-nucleoside compounds are disclosed which are useful in the treatment of hepatitis B infection, hepatitis C infection, HIV and abnormal cellular proliferation, including tumors and cancer. The compounds have the general formulae: | 05/01/2012 |
| 8147512 | Dual closing guide for a surgical instrument A hand-operated surgical instrument with sequentially engaged tip closing guides. The instrument includes first and second arms having tips that close during a closure operation. A slotted tip closure guide on the arms engages first during the closure operation. A p... | 04/03/2012 |
| 8114994 | 2′ and 3′-substituted cyclobutyl nucleoside analogs for the treatment viral infections and abnormal cellular proliferation Provided are cyclobutyl nucleosides and methods for their use in treatment of infections including Retroviridae (including HIV), Hepadnaviridae (including HBV), or Flaviviridae (including BVDV and HCV) infection, or conditions related to abnormal cellular proliferat... | 02/14/2012 |
| 8114884 | CXCR4 antagonists for the treatment of medical disorders The invention provides compounds, pharmaceutical compositions and methods of use of certain compounds that are antagonists of the chemokine CXCR4 receptor for the treatment of proliferative conditions mediated by CXCR4 receptors. The compounds provided interfere wit... | 02/14/2012 |
| 8101718 | Methods of administering porcine B-domainless fVIII The present invention provides a method of administering porcine B-domainless factor VIII (OBI-1) to a patient having factor VIII deficiency to provide more rapid and effective protection against bleeding episodes, compared to formerly available methods, or to provi... | 01/24/2012 |
| 8080659 | CXCR4 antagonists including diazine and triazine structures for the treatment of medical disorders The invention provides compounds, pharmaceutical compositions and methods of use of certain compounds that are antagonists of the chemokine CXCR4 receptor for the treatment of proliferative conditions mediated by CXCR4 receptors or for the treatment of viral infecti... | 12/20/2011 |
| 8071795 | HIF inhibitors HIF-1 inhibitors and methods of use thereof are provided. ... | 12/06/2011 |
| 8067537 | Composition and method for treatment of stomatitis A composition and a method effective in preventing or treating stomatitis are presented. The composition contains glutathione or a pharmaceutically acceptable salt thereof and/or orotic acid or a derivative thereof or a pharmaceutically acceptable salt thereof is pr... | 11/29/2011 |
| 8067424 | Selective inhibitors for cyclin-dependent kinases This invention provides a class of compounds which are useful for specifically inhibiting cyclin-dependent kinases. This class of compounds finds use in treating diseases resulting from inappropriate activity of cyclin-dependent kinases, including cancer, viral infe... | 11/29/2011 |
| 8034579 | Proteins with enhanced functionality and methods of making novel proteins using circular permutation The present disclosure is relates to novel proteins and peptides having novel and/or enhanced functions and/or behaviors with respect to a native protein or peptide, and methods of making the novel proteins and peptides using techniques of circular permutation and p... | 10/11/2011 |
| 8032335 | Evaluating magnetic resonance spectra Provided are methods, systems and computer program products evaluating magnetic resonance (MR) signals from a sample. The methods and systems can be used to evaluate MR signals from various constituents (e.g., metabolites, macromolecules) of the sample. ... | 10/04/2011 |
| 8008312 | CXCR4 antagonists for the treatment of HIV infection The invention provides compounds, pharmaceutical compositions and methods of use of certain compounds that are antagonists of the chemokine CXCR4 receptor, and in particular to inhibit viral entry of certain viruses. Certain compounds in particular can reduce entry ... | 08/30/2011 |
| 8003324 | Modulation of sodium channels by nicotinamide adenine dinucleotide The present invention relates to the use of oxidized nicotinamide adenine dinucleotide (NAD+) or of its reduced form, NADH, as sodium channel modulators. The present invention also relates to the use of compositions containing NAD+ or NADH to t... | 08/23/2011 |
| 7989649 | Tumor imaging compounds The invention provides novel amino acid compounds of use in detecting and evaluating brain and body tumors. These compounds combine the advantageous properties of α-aminoisobutyric acid (AIB) analogs namely, their rapid uptake and prolonged retention in tumors with... | 08/02/2011 |
| 7972311 | Cardioplegia catheter system A cardioplegia catheter system for delivery of a cardioplegia solution, comprising a cardioplegia catheter comprising an elongate tubular catheter body that defines a continuous central lumen and a flange that is connected to and extends therefrom an exterior surfac... | 07/05/2011 |
| 7960589 | Synthesis of sphingosines and their derivatives Embodiments of the present disclosure provide for methods of making sphingosines and derivatives thereof, and the like. ... | 06/14/2011 |
| 7918814 | Method for drug delivery to ocular tissue using microneedle Methods and devices are provided for administering a drug to a patient's eye. The methods include (a) inserting a hollow microneedle into the sclera or corneal stroma without penetrating across the sclera or corneal stroma; and (b) infusing a fluid drug formulation ... | 04/05/2011 |
| 7915244 | Methods for the treatment of a traumatic central nervous injury Methods of treating a subject with a traumatic central nervous system injury, more particularly, a traumatic brain injury, are provided. The methods comprise a therapy comprising a constant or a two-level dosing regime of progesterone. In one method, a subject in ne... | 03/29/2011 |
| 7846412 | Bioconjugated nanostructures, methods of fabrication thereof, and methods of use thereof Nanostructures, methods of preparing nanostructures, methods of detecting targets in subjects, and methods of treating diseases in subjects, are disclosed. An embodiment, among others, of the nanostructure includes a quantum dot and a hydrophobic protection structur... | 12/07/2010 |
| 7846123 | Conduit device and system for implanting a conduit device in a tissue wall Various embodiments of the present invention provide a conduit device including an attaching device configured for defining a helical pathway through a tissue wall and complementary ring in cooperation for securing the device within an aperture defined in the tissue... | 12/07/2010 |
| 7867982 | MVA expressing modified HIV envelope, gag, and pol genes The invention provides modified virus Ankara (MVA), a replication-deficient strain of vaccinia virus, expressing human immunodeficiency virus (HIV) env, gag, and pol genes. ... | 01/11/2011 |
| 7842705 | Curcumin analogs with anti-tumor and anti-angiogenic properties The present invention is directed to curcumin analogs exhibiting anti-tumor and anti-angiogenic properties, pharmaceutical formulations including such compounds and methods of using such compounds. ... | 11/30/2010 |
| 7837982 | Imaging agents The present invention provides novel amino acid compounds useful in detecting and evaluating brain and body tumors. These compounds have the advantageous properties of rapid uptake and prolonged retention in tumors and can be labeled with halogen isotopes such as fl... | 11/23/2010 |
| 7833978 | Thrombomodulin derivatives and conjugates The transmembrane human protein thrombomodulin (TM), as a critical regulator of the protein C pathway, represents the major anticoagulant mechanism that is operative in both normal and injured blood vessels under physiologic conditions in vivo. Compositions and meth... | 11/16/2010 |
| 7824672 | Method for coating living cells The invention comprises anti-inflammatory conformal barriers with controllable permeability properties that can be applied to living cells prior to transplant, and methods for coating living cells with conformal barriers. The coatings comprise polymer layers deposit... | 11/02/2010 |
| 7807181 | Neisseria mutants, lipooligosaccharides and immunogenic compositions Provided herein are mutant strains of Neisseria meningitidis which produce Kdo-free lipid A as well as the Kdo-free lipid A molecules and immunogenic compositions containing such Kdo-free lipid A molecules from a Neisseria strain containing a genetical... | 10/05/2010 |
| 7795017 | DNA expression vectors and methods of use The present invention relates to novel plasmid constructs useful for the delivery of DNA vaccines. The present invention provides novel plasmids having a transcription cassette capable of directing the expression of a vaccine nucleic acid insert encoding immunogens ... | 09/14/2010 |
| 7785839 | Methods to manufacture 1,3-dioxolane nucleosides This application provides a process for preparing enantiomerically pure β-D-dioxolane nucleosides. In particular, a new synthesis of (−)-DAPD, suitable for large scale development, is described. In one embodiment the invention provides a process for preparing a s... | 08/31/2010 |
| 7772208 | 2′,3′-dideoxynucleoside analogues for the treatment or prevention of infections A method for the treatment or prevention of Flaviviridae infections, in particular, hepatitis C virus infection, in a host, and in particular, a human, is provided that includes administering an effective amount of a β-L- or β-D-2′,3′-dideoxynucleoside or a ph... | 08/10/2010 |
| 7772185 | Method for promoting axonal outgrowth in damaged nerves The subject invention pertains to the therapeutic use of certain GAG-degrading enzymes, and enzyme combinations, to promote nerve repair and regeneration. ... | 08/10/2010 |
| 7744523 | Drive circuit for magnetic stimulation The inventive technique includes devices and methods for generating a magnetic field. One such device may include an inductor for generating a magnetic field and a power source for providing power. Such a device may also include a semiconductor switching device that... | 06/29/2010 |
| 7713708 | Immunological assay system and method An immunological or immunohematological assay system is disclosed that includes a filter vessel capable of containing an assay sample, an incubator, a sample separation system, an image acquisition system, and a robotic pipettor. The immunological assay system may a... | 05/11/2010 |
| 7713544 | Biological component comprising artificial membrane A biocompatible biological component is provided comprising a membrane-mimetic surface film covering a substrate. Suitable substrates include hydrated substrates, e.g. hydrogels which may contain drugs for delivery to a patient through the membrane-mimetic film, or ... | 05/11/2010 |
| 7691289 | Compositions, materials incorporating the compositions, and methods of using the compositions, and methods of using the compositions and materials Compositions, materials incorporating the compositions, and methods of use thereof, are disclosed. In one embodiment, the composition includes a metal nitrate selected from d-block metal nitrates and f-block metal nitrates and a metal salt having weakly bound counte... | 04/06/2010 |
| 7686781 | Catheter for modified perfusion A catheter adapted for use in passing fluids and medicines therethrough for use in the perfusion or reperfusion of blood or blood-fluid mixtures into the arteries, veins, tissues, conduits, or organs of a patient is disclosed. The catheter has an elongate tubular bo... | 03/30/2010 |
| 7662938 | 2′-fluoronucleosides A class of 2′-fluoro-nucleoside compounds are disclosed which are useful in the treatment of hepatitis B infection, hepatitis C infection, HIV and abnormal cellular proliferation, including tumors and cancer. The compounds have the general formula: | 02/16/2010 |
| 7655594 | Materials for degrading contaminants Briefly described, compositions, materials including the compositions, methods of using the compositions, and methods of degrading contaminants, are described herein. The composition can include a polyoxometalate/ cationic silica material. In addition, the compositi... | 02/02/2010 |
| 7652033 | HIF-1 inhibitors HIF-1 inhibitors and methods of their use are provided. In particular, 2,2-dimethylbenzopyran based compounds and methods of their use, for example in the treatment or prevention of hypoxia-related pathologies are provided. ... | 01/26/2010 |
| 7648993 | Methods of treating disorders with Group I mGluR antagonists mGluR5 antagonists are used for the treatment and prevention of disorders, including Fragile X, autism, mental retardation, schizophrenia and Down's Syndrome. The methods of the invention can be used to treat epilepsy and anxiety in a human having Fragile X syndrome... | 01/19/2010 |
| 7648845 | Porous materials embedded with nanospecies, methods of fabrication thereof, and methods of use thereof Briefly described, embodiments of this disclosure include structures, methods of forming the structures, and methods of using the structures. One exemplary structure, among others, includes a nanospecies and a porous material. The nanospecies has a first characteris... | 01/19/2010 |
