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| Number | Title | Issue Date |
| 5773620 | Quaternary ammonium salts of aromatic amine compounds, their preparation and pharmaceutical compositions in which they are present Amine compounds of the formula (Ia): ##STR1## where m, Ar', N, T and Z are defined herein and J is a group ##STR2## are useful as precursors in the production of quaternary amines and for the treatment of pathological phenomena involving the neu... | 06/30/1998 |
| 5770735 | Polycyclic amine compounds and their enantiomers, their method of preparation and pharmaceutical compositions in which they are present The invention relates to polycyclic amine compounds of formula (I) ##STR1## and their enantiomers, useful as neurokinin receptor antagonists.... | 06/23/1998 |
| 5739340 | Indolizine derivatives with pharmaceutical activity The invention relates to indolizine derivatives of general formula: ##STR1## in which: X denotes an --S or --SO2 -- group, each of R1 and R2, which are identical or different, denotes hydrogen, the methyl or ethyl radical ... | 04/14/1998 |
| 5674881 | Quaternary ammonium salts of aromatic amine compounds, their preparation and pharmaceutical compositions in which they are present The present invention relates to quaternary ammonium salts of the formula ##STR1## in which: J is either a group Ar--CXX'--CX" or a group Ar--(CH2)x CH1, in which: Ar is a substituted or unsubstituted phenyl, a cycloalkyl,... | 10/07/1997 |
| 5576328 | Method for the secondary prevention of ischemic events The invention relates to a new method for the secondary prevention of ischemic events comprising administering to a man in need thereof a therapeutically effective amount of a compound selected from clopidogrel and its pharmaceutically acceptable acid add... | 11/19/1996 |
| 5567827 | 4-Hydroxyphenylthio derivatives, their preparation and their use for the preparation of aminoalkoxyphenylsulphonyl derivatives The subject of the invention is 4-hydroxyphenylthio derivatives of general formula: ##STR1## in which: R1 and R2, which are identical or different, each represent hydrogen, a methyl or ethyl radical or a halogen atom, R represen... | 10/22/1996 |
| 5534530 | 5-acylamino-1,2,4-thiadiazoles, their preparation and pharmaceutical compositions containing them The invention relates to thiadiazole derivatives corresponding to the general formula ##STR1## in which Ar represents a nitrogen-containing aromatic heterocycle, in particular indolyl which is substituted or unsubstituted on the nitrogen atom wi... | 07/09/1996 |
| 5514659 | 3-deoxy oligosaccharides and pharmaceutical compositions containing them The invention relates to 3-deoxy oligosaccharides of formula I: ##STR1## in which X represents an --OSO3- radical, a radical of formula R--O, a radical of formula: ##STR2## or a radical of formula: ##STR3## Y repr... | 05/07/1996 |
| 5508431 | 4-hydroxyphenylthio derivatives, their preparation and their use for the preparation of aminoalkoxyphenylsulphonyl derivatives The subject of the invention is 4-hydroxyphenylthio derivatives of general formula: ##STR1## in which: R1 and R2, which are identical or different, each represent hydrogen, a methyl or ethyl radical or a halogen atom, R represen... | 04/16/1996 |
| 5482844 | Enzyme intended for the fragmentation of N-acetylheparosan, production of preparations containing this enzyme and fragmentation processes using this enzyme The invention relates to an enzyme capable of fragmenting a high molecular mass N-acetylheparosan. This enzyme was obtained with the strain Escherichia coli (K5), strain SEBR 3282.... | 01/09/1996 |
| 5477001 | Recombinant DNA coding for a novel protein having ଲ-1,3-glucanase activity, bacteria containing this DNA, transformed plant cells and plants The invention provides a protein, isolated from soybean, having ଲ-1,3-glucanase activity and comprising the amino acid sequence of SEQ ID No: 1. DNA constructs encoding said protein, and transformed plants expressing the protein, are also provided.... | 12/19/1995 |
| 5468750 | Heterocycle-coupled substituted pyrrolo[3,2-c]pyridin-2-carboxylic acids A compound of formula ##STR1## in which A represents S; R1 is selected from the group consisting of OH, (C1 -C12)alkyl, (C1 -C12)alkoxy, benzyloxy, phenyl, benzyl (C1 -C4)al... | 11/21/1995 |
| 5464847 | Branched alkylamino derivatives of thiazole, processes for preparing them and pharmaceutical compositions containing them The invention relates to the derivatives of formula I: ##STR1## in which R1 represents a phenyl or naphthyl radical (optionally substituted), R2 represents a hydrogen or halogen atom or an alkyl, hydroxymethyl or formyl radical,... | 11/07/1995 |
| 5455343 | Polysaccharide, its applications, its production by fermentation and the pseudomonas strain which produces it This polysaccharide consists of repeating units which are composed of a backbone, comprising 2 radicals of D-mannose, 2 of D-glucose, 1 of D-galactose, 1 of D-glucuronic acid, 1 of D-xylose, 1 of L-lyxose and 1 of L-fucose, on which pyruvic acid groups ma... | 10/03/1995 |
| 5446138 | Recombinant DNA coding for a protein with endochitinase activity Recombinant DNA which codes for a protein with endochitinase activity or for a precursor thereof, comprising the sequence (a1) (SEQ ID NO. 1).... | 08/29/1995 |
| 5420300 | Substituted 2-ethylbenzo [b] thiophene, process for preparation thereof and use thereof as synthetic intermediate The subject of the invention is 2-(1-bromoethyl)benzo[b]thiophene of formula: ##STR1## as well as a process for the preparation thereof, characterised in that 2-ethylbenzo[b]thiophene is reacted, in a solvent, with a brominating agent in the pre... | 05/30/1995 |
| 5411971 | N-alkylenepiperidino compounds, their enantiomers and pharmaceutical compositions The invention relates to N-alkylenepiperidino compounds of formula ##STR1## as well as their enantiomers, and pharmaceutical compositions containing them that are useful as antagonists of neurokinin receptors in the treatment of substance P- and/or n... | 05/02/1995 |
| 5403933 | Indolizine derivatives, with pharmaceutical activity The invention relates to indolizine derivatives of general formula: ##STR1## in which: X denotes an --S or --SO2 -- group, each of R1 and R2, which are identical or different, denotes hydrogen, the methyl or ethyl rad... | 04/04/1995 |
| 5401855 | 4-hydroxyphenylthio derivatives, their preparation and their use for the preparation of aminoalkoxyphenylsulphonyl derivatives The subject of the invention is 4-hydroxyphenylthio derivatives of general formula: ##STR1## in which: R1 and R2, which are identical or different, each represent hydrogen, a methyl or ethyl radical or a halogen atom, R represen... | 03/28/1995 |
| 5380736 | Heterocyclic substituted 2-acylamino-5-thiazoles, their preparation and pharmaceutical compositions containing them Heterocyclic substituted 2-acylamino-5-thiazoles, their preparation and pharmaceutical compositions containing them. A 2-Acylaminothiazole of formula: ##STR1## in which R1 is H, an alkyl or a substituted alkyl; RIV is a cycloalk... | 01/10/1995 |
| 5352788 | N-substituted heterocyclic derivatives The invention relates to processes for preparing N-substituted heterocyclic compounds of formula (I) ##STR1## wherein the substituents are as described in the specification, and to intermediates. The compounds are useful for antagonizing angiotensin ... | 10/04/1994 |
| 5344657 | Microbeads of diltiazem, a process for their manufacture and a substained-release pharmaceutical composition containing them The microbeads are composed of a core containing the active ingredient and a microporous membrane, insoluble in aqueous medium, consisting of a film-forming polymer, a plasticizer and a filling material. The membrane has a thickness such that diltiazem is rele... | 09/06/1994 |
| 5340822 | Polycyclic amine compounds and their enantiomers, their method of preparation and pharmaceutical compositions in which they are present The invention relates to polycyclic amine compounds of formula (I) ##STR1## where Y. m. Ar', n, p, Q, T, q and Z are defined herein. The invention also relates to methods of making the compounds of formula (I) and pharmaceutical compositions which co... | 08/23/1994 |
| 5340820 | Cycloaminoalkoxyphenyl derivatives, a process for their preparation as well as the compositions containing them Cycloaminoalkoxyphenyl derivatives useful for the treatment of certain pathological syndromes of the cardiovascular system and ocular diseases of formula: in which: B represents a --S--, --SO-- or --SO2 -- group, R1 and R2, wh... | 08/23/1994 |
| 5338755 | N-sulfonylindoline derivatives, their preparation and the pharmaceutical compositions in which they are present The invention relates to N-sulfonyl derivatives of formulae (I)" and (I)' ##STR1## and to pharmaceutical compositions in which they are present. The compounds have an affinity for the vasopressin and ocytocin receptors.... | 08/16/1994 |
| 5314889 | Heterocyclic substituted 2-acylamino-5-thiazoles, their preparation and pharmaceutical compositions containing them A 2-Acylaminothiazole of formula: ##STR1## in which R1 is H, an alkyl or a substituted alkyl; RIV is a cycloalkyl, an aromatic group such as phenyl or a heterocyclic group which are unsubstituted or substituted; RV is... | 05/24/1994 |
| 5314876 | High molecular mass N,O-sulphated heparosans, process for their preparation and the pharmaceutical compositions which contain them The subject of the invention is new high molecular mass N,O-sulphated heparosans consisting of chains or of a mixture of chains having a molecular mass of between 1.5×104 and 4.0×106 D, characterised by a repeating disaccharide str... | 05/24/1994 |
| 5312961 | 2-amino-7-hydroxytetralin carboxylalkyl ethers The invention relates to 2-amino-7-hydroxytetralin carboxyalkyl ethers of formula ##STR1## wherein Alk represents a straight or branched (C3 -C5)alkylene group, and R is hydrogen or (C1 -C4)alkyl, useful as... | 05/17/1994 |
| 5296354 | Kit for the specific assay of angiotensin II The present invention relates to a kit for the specific assay of Angiotension II, comprising: the anti-Ang II antibody, a solution of labelled Ang II, solutions containing the Ang II standards at known and increasing concentrations, the requisite washing solut... | 03/22/1994 |
| 5292745 | Use of 4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine derivatives as free radical scavengers The invention concerns the use of a compound of formula (I) ##STR1## wherein R and R1, each independently, represent a hydrogen atom or a methyl group, and its pharmaceutically acceptable acid addition salts, as free radical scavengers. Th... | 03/08/1994 |
| 5290951 | Intermediates useful in preparing propenone oxime ethers The invention relates to new propenone oxime ethers, a method of preparing them and pharmaceutical compositions containing them. Said new propenone oxime ethers have the formula ##STR1## in which Ar and Ar' each independently denotes a phenyl group n... | 03/01/1994 |
| 5288895 | Process for the preparation of a biphenyl derivative The subject of the invention is a process for the preparation of 4-methyl-2'-cyanobiphenyl of formula: ##STR1## wherein a benzonitrile halide of general formula: ##STR2## in which Hal represents a halogen atom, is reacted, in the presence of a ... | 02/22/1994 |
| 5286734 | Arylpiperidine derivative, process for the preparation thereof and pharmaceutical compositions containing it A compound of formula ##STR1## and its acid addition salts are useful in the treatment of sexual dysfunctions in male mammals.... | 02/15/1994 |
| 5284838 | Use of 2,2-dimethylchroman-3-ol derivatives in the treatment of asthma The invention relates to 2,2-dimethylchroman-3-ol derivatives of the formula: ##STR1## in which: A, between N and CO, represents the group --CH.dbd.CH--E.dbd.CH-- or the group ##STR2## Z represents a halogen or a cyano, acetyl, trifluoroace... | 02/08/1994 |
| 5276036 | 3-(N-azabicycloalkyl)aminopyridazine derivatives and pharmaceutical compositions in which they are present The invention relates to 3-aminopyridazine derivatives. These compounds have the formula ##STR1## in which: RV is a linear or branched C1 -C4 alkyl group; R6 is hydrogen, a C1 -C3 alkoxy or a hy... | 01/04/1994 |
| 5270341 | Method of treatment or prophylaxis of depression and stress The invention concerns a method of treatment and prophylaxis of depression and stress by means of a phenylethanolaminotetralin of formula (I) ##STR1## wherein A is a (C1 -C4)alkylene radical and R represents a hydrogen atom or a... | 12/14/1993 |
| 5270320 | Use of a 1-(2-naphthylethyl)-4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridi ne for the manufacture of a medicament for the treatment of cerebral and neuronal diseases The invention concerns the use of i.a. 1-[2-(2-naphthyl)ethyl]-4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyri dine and its pharmaceutically acceptable addition salts for the preparation of medicaments suitable for the treatment and/or prophylaxis of ne... | 12/14/1993 |
| 5270317 | N-substituted heterocyclic derivatives, their preparation and the pharmaceutical compositions in which they are present The invention relates to N-substituted heterocyclic derivatives and its salts. These derivatives have the formula ##STR1## in which the substituents are as defined in the specification. Application: Angiotensin II antagonists... | 12/14/1993 |
| 5268375 | Dinitrogen heterocyclic derivatives N-substituted by a biphenylmethyl group, and the pharmaceutical compositions in which they are present This invention relates to compounds of formula ##STR1## in which: R1 and R2 are similar or different and are each independently hydrogen or a group selected from CO2 N.dbd.C(NH2)2, CONHNHCONH | 12/07/1993 |
| 5266573 | Trifluoromethylphenyltetrahydropyridines for the treatment and/or prophylaxis of intestinal motility disorders A method of prophylaxis and/or treatment of intestinal motility disorders, in particular of constipation, in mammals which comprises administering to a mammal in need of such a treatment a prophylactically and/or therapeutically effective amount of a comp... | 11/30/1993 |
