Assignee: Eisai Co., Ltd.

Location: Tokyo, JP
No. of patents: 41

Number	Title	Issue Date
8071085	Primary cultured adipocytes for gene therapy The present invention relates to primary cultured adipocytes for gene therapy, where the adipocytes stably maintain a foreign gene encoding a protein that is secreted outside of cells. This invention provides cells suitable for gene therapy, which can replace bone m...	12/06/2011
7528152	Hemiasterlin derivatives and uses thereof in the treatment of cancer The present invention provides compounds having formula (I): and additionally provides methods for the synthesis thereof and methods for the use thereof in the treatment of cancer, wherein R1	05/05/2009
7390490	Uses of anti-CX3CR1 antibody, anti-fractalkine antibody and fractalkine There are provided uses of an antibody directed to CX3CR1 and fractalkine. Killer lymphocytes can be readily identified, eliminated and separated by using an anti-CX3CR1 antibody. Further, there can be provided an antibody drug for suppressing chemotaxis and cytotox...	06/24/2008
7390793	Micelles The present invention provides micelles, solutions comprising micelles, methods for preparing micelles, and methods for delivering micelles to patients. The micelles have fixed, preselected hydrodynamic diameters and are formed from basic or acidic amphiphilic compo...	06/24/2008
7375236	Methods for producing cyclic benzamidine derivatives In the present invention, the methods of producing a fluorinated cyclic benzamidine derivative (A), or a salt thereof, comprise the step of reacting a specific novel compound with ammonia or imide. The methods of this invention for producing a morpholine-subs...	05/20/2008
7371843	Cultured cell lines expressing mutant gene Using protein visualization techniques, cell lines stably expressing GFP-fused full-length and mutant APCs were obtained from cultured Xenopus laevis renal epithelial A6 cells. The use of these cells showed that mutant APCs, whose C-terminal region is absent,...	05/13/2008
7371777	Cyclic compound and PPAR agonist The present invention provides a novel compound having an excellent PPAR agonist action. More specifically, it provides a compound represented by the following formula, a salt thereof, an ester thereof or a hydrate of them. ...	05/13/2008
7314940	Jun kinase inhibitors The present invention provides novel compounds of formula I and their use in the inhibition of c-Jun N-terminal kinases. The present invention further provides the use of these compounds in medicine, in particula...	01/01/2008
7314936	Deazapurines and uses thereof The present invention provides compounds having formula (I), wherein R1, R2, R3 and n are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the...	01/01/2008
7291630	Azaindoles as inhibitors of c-Jun N-terminal kinases The present invention relates to novel 5-substituted 7-azaindole compounds of formula (I), their use in the inhibition of c-Jun N-terminal kinases, their use in medicine and particularly in the prevention and/or treatment of neurodegenerative disorders related to ap...	11/06/2007
7256178	Physiologically active substances Compounds represented by the following general formula (I), pharmacologically acceptable salts thereof or hydrates of the same: (I) wherein W represents and R3, R7, R16, R17	08/14/2007
7253178	Carboxylic acids The present invention provides a novel carboxylic acid derivative, a salt thereof or a hydrate of them which is useful as an insulin sensitizer, and a medicament comprising the derivative as the effective ingredient. More specifically, it provides a carboxylic acid ...	08/07/2007
7244861	Benzene compound and salt thereof The present invention provides a medicament comprising a benzene compound useful as an insulin sensitizer, a salt thereof or a hydrate of them and a derivative of them as the active ingredient. Specifically, it provides a benzene compound represented by the followin...	07/17/2007
7229551	Diffusion promoting device for low flow velocity gradient high performance liquid chromatography Device for improving detection sensitivity in low flow velocity high performance liquid chromatographic apparatus. Preferredly, diffusion promoting device connected at just before separation column and having function of improving detection sensitivity for use in lo...	06/12/2007
7230014	Pharmaceutical formulation comprising glycine as a stabilizer The present invention provides pharmaceutical formulations suitable for intravenous injection comprising a lyophilized anti-ulcerative agent reconstituted in isotonic solutions suitable for intravenous administration, such as 5% dextrose or 0.9% sodium chloride. The...	06/12/2007
7220855	Process for producing methylcobalamin The present invention provides a novel industrially excellent and ecological process for producing methylcobalamin which is useful as a medicament etc. More specifically, it provides a process for producing methylcobalamin by reducing cyanocobalamin or hydroxocobala...	05/22/2007
7217723	Heterocyclic compound having oxime group The present invention provides a compound that has an excellent inhibitory activity on STAT6 activation and is effective against allergic diseases, and a medicinal composition thereof. According to the present invention, disclosed is the compound represented by the ...	05/15/2007
7202234	Compounds and methods for treating Toll-like receptor 2-related diseases and conditions The present invention relates to compounds and methods useful in the prevention or treatment of diseases or conditions associated with Toll-like receptor 2 activation. ...	04/10/2007
7192972	Hemiasterlin derivatives and uses thereof The present invention provides compounds having formula (I): and additionally provides methods for the synthesis thereof and methods for the use thereof in the treatment of cancer, wherei...	03/20/2007
7189717	Medicinal compositions promoting bowel movement The present invention provides a medicament having a gentle but strong defecation-promoting action without causing diarrhea. That is, it provides a defecation-promoting agent comprising a compound having an adenosine A2 receptor antagonism, preferably an ...	03/13/2007
7105540	Cholinesterase inhibitors to treat disorders of attention The present invention provides novel methods of treating disorders of attention or improving attention in humans by administering an effective amount of a cholinesterase inhibitor. ...	09/12/2006
7074798	Xanthine derivative and DPPIV inhibitor The present invention provides novel compounds exhibiting an excellent DPPIV inhibition effect. The compounds are represented by the formula: wherein, m is 0 or 1; n is 0; R3...	07/11/2006
RE39112	Purine derivatives and adenosine A2 receptor antagonists serving as preventives/remedies for diabetes The present invention provides a preventive or therapeutic agent of a new type for diabetes mellitus and diabetic complications on the basis of an adenosine A2 receptor antagonist action. A purine compound represented by the formula (I), its pharmacologically...	05/30/2006
6884808	Heterocycle-containing carboxylic acid derivative and drug containing the same Described is a heterocycle-containing carboxylic acid derivative represented by the following formula (I): wherein A represents, for example, a heteroaryl group which contains at least one nitrogen atom and may have a ...	04/26/2005
6790844	Certain 1,3-disubstituted isoquinoline derivatives Condensed pyridine compounds represented by formula (I): wherein: R1 and R3 are, independently, hydrogen, halogen, lower alkyl, or lower alkoxy; R2 represents an amino substituent; ring A...	09/14/2004
6649367	Human cancer cell line malignantly altered by expression of angiogenic factor A method for producing a cell to which angiogenesis-inducing ability has been imparted, comprising the steps of introducing a gene of an angiogenic factor into a human or animal cell having low angiogenesis-inducing ability, and selecting a cell that over...	11/18/2003
6630463	Heterocycle-containing carboxylic acid derivative and drug containing the same Described is a heterocycle-containing carboxylic acid derivative represented by the following formula (I): ##STR1## wherein A represents, for example, a heteroaryl group which contains at least one nitrogen atom and may have a substituent, B represents, f...	10/07/2003
6541474	Heterocycle-containing carboxylic acid derivative and drug containing the same Described is a heterocycle-containing carboxylic acid derivative represented by the following formula (I): ##STR1## wherein A represents, for example, a heteroaryl group which contains at least one nitrogen atom and may have a substituent, B represents, f...	04/01/2003
6455544	Use of cholinesterase inhibitors to treat disorders of attention The present invention provides novel methods of treating disorders of attention or improving attention in humans by administering an effective amount of a cholinesterase inhibitor....	09/24/2002
6281214	Biphenyl derivatives A biphenyl derivative represented by the following formula (I) or a pharmacologically acceptable salt thereof: ##STR1## wherein R1, R2, R3, R4, and R5 are defined in the specification, is clinically u...	08/28/2001
6036974	Method and apparatus for preparation of molded tablet and thereby prepared molded tablet Active ingredients such as medicines are mixed with excipient and then kneaded together with binder and solvent such as alcohol or water to prepare a wetted paste. A mold is filled with this paste. Top and bottom surfaces of the paste within the mold are ...	03/14/2000
5854279	Therapeutic agent for dermatosis The present invention provides a therapeutic agent for fundamentally preventing, treating or ameliorating dermatosis, such as, non-infectious dermatosis, which include psoriasis and atopic dermatitis. The therapeutic agent comprises a glycerol derivative ...	12/29/1998
5705402	Method and apparatus for magnetic microparticulate based luminescence assay including plurality of magnets Disclosed and claimed are methods and apparatus for performing a binding assay for an analyte of interest present in a sample based upon measurement of electrochemiluminescence at an electrode. The method uses magnetically responsive particles. The method...	01/06/1998
5390469	Filling/sealing apparatus for ampule or the like and method for monitoring this apparatus A filling/sealing apparatus used for ampules generally has a feed star wheel feeding ampules, a turntable transporting the ampules delivered from the feed star wheel, and an intermediate star wheel interposed between the feed star wheel and the turntable....	02/21/1995
5319139	Naphthalene derivatives Compounds of the formula: ##STR1## where R1 is a hydrogen atom or a lower alkyl group; R2 is a lower alkoxy group; R3 is a group ##STR2## Z is represented by the formula: ##STR3## where R2 and R	06/07/1994
5245060	Terpene derivatives and process for preparing the same A terpene derivative represented by the general formula (I): ##STR1## wherein R1 represents a lower alkyl group; R2 represents an alkyl group, a cycloalkyl group, a cycloalkylalkyl group, an aryl group, an arylalkyl group or a h...	09/14/1993
5047417	Butenoic or propenoic acid derivatives A butenoic or propenoic acid derivative having the following formula in which G is an aryl or a heterocyclic ring, R11 and R12 are hydrogen or an alkyl, X is sulfur or oxygen, R2 and R3 are hydrogen, an substituent such as an alkyl and J is pyridyl or phe...	09/10/1991
4603126	Therapeutic and preventive agent containing dolichol Dolichol or phosphate thereof is useful as a therapeutically treating and preventive agent, in particular, for hyperuricuria, hyperlipemia, diabetes and hepatic diseases....	07/29/1986
4574736	Milking apparatus A milking apparatus comprises sets of electrodes for detecting milk flows sucked by individual teat cups capped on individual teats, tubes connected to pressure chambers of the respective teat cups, change-over valves operative to supply atmospheric press...	03/11/1986
4514395	Phenothiazine derivatives and anti-psychotic drugs containing the same New phenothiazine derivatives having the general formula: ##STR1## wherein R represents a straight or branched alkyl group or alkenyl group having 5-15 carbon atoms, their acid addition salts and anti-psychotic drugs containing such new compounds....	04/30/1985

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Assignee: Eisai Co., Ltd.