Did You Know...
...that the inventor of the electric motor was a blacksmith named Thomas Davenport? Described as "a brilliantly unsuccessful inventor", Davenport invented the first rotary electric motor. In 1836 he headed out -- on foot -- from his Vermont home to file a patent application at the Patent Office in Washington, D.C. By the time he got there, he had squandered away his money and couldn't afford the $30 filing fee so he turned around and went home. When he later mailed in his application with money he'd raised, the Patent office was destroyed in a fire. He did finally get credit for his invention on Feb. 5, 1837.
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| Number | Title | Issue Date |
| 6551794 | Stable biotinylated biomolecule composition Stable compositions containing biotinylated molecules, such as enzymes, are provided. The compositions include a biotinylated biomolecule, a biomolecule protectant, a buffer, a bulking agent selected from one or more water soluble, nonionic polymers and p... | 04/22/2003 |
| 6387082 | Ostomy appliance and wound drainage device and method of using the same An ostomy appliance or wound drainage device having a receptacle side component including a receptacle for receiving and storing waste solids and fluids and a bodyside component for adhering to the patient's skin around the stoma in which the two componen... | 05/14/2002 |
| 6117885 | Biphenyl-substituted quinoline derivatives Compounds of the formula ##STR1## wherein X, R1, R2, R3, R4, R5, R6, A, B, D and E are as defined herein. These compounds inhibit the action of angiotensin II and are useful, therefore... | 09/12/2000 |
| 6087349 | Method for blocking neoplastic transformation of cells induced by ras oncogenes A method is provided by blocking or preventing the prenylation of CAAX box containing proteins including ras oncogene products thereby preventing and/or treating ras-related tumors which includes the step of administering a therapeutically effective amoun... | 07/11/2000 |
| 6066773 | Thin film dressing with absorbent border A thin film device for medical applications such as a wound dressing including an occlusive layer having an edge portion about at least a portion of the thin film device and a non-continuous, hydrocolloid-containing polymeric support layer overlying the e... | 05/23/2000 |
| 6046024 | Method of producing a fibrin monomer using a biotinylated enzyme and immobilized avidin Compositions and methods for avidin immobilized on an inert support material, e.g. agarose, are disclosed. The compositions have high activity levels of avidin and may further include a bulking agent, e.g., maltose, and a protectant to maintain the stabil... | 04/04/2000 |
| 6030794 | Genetically engineered mice and cell lines containing alterations in the genes encoding retinoic acid receptor and retinoid X receptor proteins The present invention provides mice which are deficient in the normal expression of one or more members of the RAR or RXR class of receptors, mice which are heterozygous for such deficiency, and to cell lines, preferably pluripotent or totipotent cell lin... | 02/29/2000 |
| 5968024 | Ostomy appliance and wound drainage device with self adhering drain system An ostomy appliance or wound drainage device having a lower end with an adhesive composition thereon so that when the lower end is folded upon itself, the drainage opening is closed off, or, alternatively, the lower end is made of a material having intrin... | 10/19/1999 |
| 5942406 | Gel, slurry or suspension containing immobilized avidin having high biotin binding activity Compositions and methods for avidin immobilized on an inert support material, e.g., agarose, are disclosed. The compositions have high activity levels of avidin and may further include a bulking agent, e.g., maltose, and a protectant to maintain the stabi... | 08/24/1999 |
| 5859187 | Antiviral peptides Inhibition of UL42 stimulation of herpesvirus DNA polymerase activity is exhibited by novel compounds of the formulas W'--A1 --A2 --A3 --A4 --A5 --A6 --A7 --A8 --A9 | 01/12/1999 |
| 5859239 | Mercaptoalkanoylamino and acylmercaptoalkanoylamino benzoxazepines and benzothiazepines Compounds of the formula ##STR1## wherein X1 is ##STR2## are disclosed. These compounds possess inhibitory activity against angiotensin converting enzyme and neutral endopeptidase and thus useful as cardiovascular agents.... | 01/12/1999 |
| 5856477 | Azepinones useful as intermediates in the preparation of inhibitors of angiotensin converting enzyme and neutralendopeptidase The azepine intermediates of the formula ##STR1## wherein R6 and R7 are other than hydrogen are disclosed. These intermediates can be reacted with acylmercaptocarboxylic acids of the formula ##STR2## to give the pharma... | 01/05/1999 |
| 5856476 | Processes for preparing azepiones useful as intermediates in the preparation of inhibitors of angiotensin converting enzyme and neutral endopeptidase Processes are disclosed for preparing the azepine intermediates of the formula ##STR1## These intermediates can be reacted with acylmercaptocarboxylic acids of the formula ##STR2## to give the pharmaceutically active products.... | 01/05/1999 |
| 5830200 | Ostomy coupling It would be desirable to have improved designs of ostomy couplings which embody a springy or resilient split ring as a locking ring. In an ostomy coupling, first and second coupling members 50, 60 are held together by a springy flexible split locking ring 70. ... | 11/03/1998 |
| 5827868 | Prostaglandin analogs Thromboxane receptor antagonist activity is exhibited by compounds of the formula ##STR1## wherein: V is --(CH2)m --, --O--, or ##STR2## but if V is --O--or ##STR3## R3 and R4 must complete a... | 10/27/1998 |
| 5811292 | Lipase esterification processes for resolution of enantiomeric mixtures of intermediates in the preparation of taxanes Methods for the enzymatic resolution of mixtures of enantiomers, such as ଲ-lactam compounds, which may be employed as intermediates in the preparation of taxanes such as taxol, the latter useful in the pharmaceutical field.... | 09/22/1998 |
| 5789197 | Microsomal triglyceride transfer protein Nucleic acid sequences, particularly DNA sequences, coding for all or part of the high molecular weight subunit of microsomal triglyceride transfer protein, expression vectors containing the DNA sequences, host cells containing the expression vectors, and... | 08/04/1998 |
| 5776933 | Method of inhibiting protease Novel aminediol compounds, pharmaceutical compositions containing these compounds, and methods of using these compounds in inhibiting retroviral protease, particularly useful in the treatment and/or prevention of HIV infection (AIDS).... | 07/07/1998 |
| 5760036 | Aminediol protease inhibitors Novel aminediol compounds, pharmaceutical compositions containing these compounds, and methods of using these compounds in inhibiting retroviral protease, particularly useful in the treatment and/or prevention of HIV infection (AIDS).... | 06/02/1998 |
| 5723609 | Bis (hydroxymethyl) cyclobutyl purines Antiviral activity is exhibited by compounds having the formula ##STR1## and its pharmaceutically acceptable salts wherein R1 is ##STR2## wherein R2 is hydrogen, methyl, fluoro, chloro, bromo, iodo, hydroxy or amino; or tri... | 03/03/1998 |
| 5723457 | Acylmercaptoalkanoylamino and mercaptoalkanoylamino benzazepines Compounds of the formula ##STR1## wherein X1 is ##STR2## are disclosed. These compounds possess inhibitory activity against angiotensin converting enzyme and neutral endopeptidase and thus are useful as cardiovascular agents.... | 03/03/1998 |
| 5714232 | Alginate fabric, its use in wound dressings and surgical haemostats and a process for its manufacture The invention is a wound dressing prepared from alginate fibers which have good structural integrity, whereby layers are firmly joined together, e.g. by stitching or calendering at a plurality of points to produce a composite fabric.... | 02/03/1998 |
| 5705645 | Hereroaryl derivatives of monocyclic beta-lactam antibiotics Antibacterial activity is exhibited by novel compounds having the formula ##STR1## where R1, R2, and M are as defined herein and X is --(CH2)n -- wherein n is 0, 1, 2, 3 or 4 or CR3 R4 ... | 01/06/1998 |
| 5691152 | Stable avidin composition Compositions and methods for avidin immobilized on an inert support material, e.g., agarose, are disclosed. The compositions have high activity levels of avidin and may further include a bulking agent, e.g., maltose, and a protectant to maintain the stabi... | 11/25/1997 |
| 5690955 | Sustained release alginate fibre and process for the preparation thereof An alginate fibre is provided which includes one or more medicaments incorporated into the fibre core such that the one or more medicaments can be released in a sustained manner over time and, optionally, one or more medicaments attached to the surface of... | 11/25/1997 |
| 5686298 | Enzymatic reduction method for the preparation of compounds useful for preparing taxanes An enzymatic reduction method, particularly a stereoselective enzymatic reduction method, for the preparation of compounds useful as intermediates in the preparation of taxanes.... | 11/11/1997 |
| 5677344 | Method for treating Parkinson's disease employing an ATP-sensitive potassium channel blocker A method is provided for treatment of Parkinson's disease or controlling movement of a Parkinsonian patient by administering an ATP-sensitive potassium channel blocker, such as a sulfonyl urea, (for example, tolbutamide), or quinine.... | 10/14/1997 |
| 5665576 | Callus cell induction and the preparation of taxanes A method for the production of taxanes such as taxol. The method includes inducing formation of callus cells by contacting an explant tissue with a liquid medium without complete submergence of the tissue in the medium. The callus cells formed are employe... | 09/09/1997 |
| 5662628 | Coupling A coupling, which may be an ostomy coupling but could be any kind of tube or pipe coupling, includes a first coupling member 10 and a second coupling member 30 which are mutually interengageable and which surround an orifice 70. The coupling also includes... | 09/02/1997 |
| 5647861 | Ostomy coupling It would be desirable to have improved designs of ostomy couplings which embody a springy or resilient split ring as a locking ring. In an ostomy coupling, first and second coupling members 80, 90 are held together by a springy flexible split locking ring 100.... | 07/15/1997 |
| 5643234 | Ostomy bag with multi-stage filter The ostomy bag includes a multi-stage filter system that provides contamination protection for a deodorizing filter in the system. The multi-stage filter system also includes protection elements that are impassable to semi-liquid waste material but permit... | 07/01/1997 |
| 5620876 | Enzymatic hydrolysis and esterification processes for the preparation of HMG-CoA reductase inhibitors and intermediates thereof Enzymatic hydrolysis and esterification processes for the preparation of compounds useful as HMG-CoA reductase inhibitors and/or as intermediates in the preparation of HMG-CoA reductase inhibitors.... | 04/15/1997 |
| 5603845 | Liquid separation apparatus and method In a process of separating a liquid sample having phase portions of different densities by centrifugal separation, a phase separator container is employed. The phase separator container comprises a housing having concentric inner and outer cylindrical wal... | 02/18/1997 |
| 5595883 | Method of diagnosing alzheimer's disease by measuring acetylcholinesterase activity in ocular fluid A method is provided for diagnosing of senile dementia of the Alzheimer type (Alzheimer's disease) by measuring acetylcholinesterase (AChE) activity in ocular fluids and determining if such AChE activity is elevated over that found in ocular fluids of pat... | 01/21/1997 |
| 5594153 | Process for the preparation of 1,3-dioxane derivatives useful in the preparation of HMG-COA reductase inhibitors A novel, overall process for the preparation of a compound of the formula I: ##STR1## where R1 and R2 are each independently hydrogen, an alkyl group, a cycloalkyl group, an aryl group or, taken together with the carbon atom ... | 01/14/1997 |
| 5593396 | Bag for containing liquid A combination of a liquid-containing bag and a tube 28 is disclosed. The bag may be a urine drainage bag and is made up of a pair of superposed sheets 20, 22, joined by a weld 24 whose configuration is chosen to define in a single welding operation the ou... | 01/14/1997 |
| 5593971 | Method for preventing onset of hypertension employing a cholesterol lowering drug A method is provided for preventing or reducing the risk of hypertension in normotensive patients having insulin resistance by administering a cholesterol lowering drug, such as pravastatin, alone or in combination with an ACE inhibitor, especially one co... | 01/14/1997 |
| 5591820 | Polyurethane pressure-sensitive adhesives Pressure-sensitive adhesives which possess absorptivity and/or permeability properties to remove transepidermal water loss and/or other bodily fluids that come into contact with the adhesive, in combination with a fine balance of cohesion and adhesion pro... | 01/07/1997 |
| 5589372 | Squalene synthetase Nucleic acid sequences, particularly DNA sequences, coding for all or part of a squalene synthetase, expression vectors containing the DNA sequences, host cells containing the expression vectors, and methods utilizing these materials. The invention also c... | 12/31/1996 |
| 5563170 | Substituted cyanoimino benzopyranes Novel compounds are disclosed having the formula ##STR1## and R1, R2, R3, R4, R5, R6 and R7 are as defined herein. These compounds are useful, for example, as cardiovascular... | 10/08/1996 |
